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TRANSCRIPT
Quality issues
Dr Gaby Vercauteren
Essential Health TechnologiesWorld Health Organization
HIV/AIDS HIV/AIDS DIAGNOSTIC DIAGNOSTIC
SUPPORTSUPPORT
INCREASED ACCESS TO HIV ARV THERAPY ….
INCREASED ACCESS TO LABORATORY SERVICES …
BUT WHAT ABOUT QUALITY ?
Why is QUALITY of diagnostic support important?
BLOOD SAFETYSURVEILLANCE - prevalence, drug resistanceDIAGNOSIS - VCT, PMTCMONITORING - safety and efficacy of ARV therapyQUALITY OF CARE - opportunistic infections
Quality health care
Effective treatment
Diagnosis
Diagnostic testing is the entry Diagnostic testing is the entry point for provision of high point for provision of high quality, cost effective health carequality, cost effective health care
Provision of Quality Healthcare
This is only true
if the laboratory provides accurate and reliable results
HIV tests
CD4 counts
viral load
basic laboratory tests
QUALITY
The strategy
3. Capacity building
2. Affordable prices
1. Appropriate technology
4. Reliable laboratory systems
HDS
Appropriate technology
Evaluate the quality of HIV diagnostic tests
HIV test kits, whole blood, urine, saliva
Develop appropriate testing strategies for VCT services
Whole blood (fingerprick)
Appropriate technologyAppropriate technology
CD4 T-cell enumeration technologies: operational researchMulti centre evaluation of CD4 methods : • Panleucogating, • Cyflow green or counter (Partec). Guave• Dynabeads ( light microscope versus IF, different staining
solutions ), • Cytosphere, Sembio
Viral load tests:real time PCR, p 24 antigen tests dried blood spot
Novel technologiesEasyCount (back to drawing board), Dipstick CD4 Dipstick NAT tests (principle of concept supported)
Appropriate technologyAppropriate technology
WHO providing information on appropriate diagnostics for resource poor countriesFocus Focus -- resource limited settingsresource limited settings
•SIMPLICITY -- HIV cartridge testsHIV cartridge tests•HIGH QUALITY -- evaluated by WHOevaluated by WHO•APPROPRIATE -- no equipment or electricity requiredno equipment or electricity required•ESSENTIAL -- very useful in VCT and antenatal clinicsvery useful in VCT and antenatal clinics
Affordable prices
Access to commoditiesAccess to commodities
WHO Bulk Procurement list reviewed annually CONSIDERABLE SAVINGS
2004 list will include:- HIV tests - CD4 technologies - Viral Load tests- HIV DNA test (early detection neonates)
- Equipment + maintenance contracts - Sources and Prices 2004 documentProcurement and supply management guide
Capacity building
Guidelines for appropriate laboratory monitoring of ARV therapyTraining materials for CD4 and Viral Load testing Workshops on CD4 technologies are being conducted
2003: 2 workshop in Africa and 1 workshop in SEA region2004: 2 workshops in South America and WP region
Workshops on Viral load testing planned 2005Training for basic laboratory tests and diagnosis of opportunistic infectionsTraining in procurement and supplies managementTraining in maintenanceDevelop strategies for implementation of HIV/AIDS diagnostic support
Building capacity Building capacity
Strengthening clinical laboratory services
Screening for anaemiaBasic clinical laboratory tests including liver and renal function testsManagement of opportunistic infectionsQuality assurance and equipment maintenance (including microscopes)
Reliable laboratory systems
Implementation of Quality ManagementMonitor the quality of laboratory performance
EQAS for HIV testing Internal Quality Control Samples EQAS for CD4 measurements
QC for manual CD4 methods
Reference preparations HIV NAT testingQC samples for Viral Load tests
Reliable laboratory systemsReliable laboratory systems
Future perspectives
Scaling up diagnostic support related to VCTContinue to ensure safe blood through appropriate diagnosticsExpand bulk procurement scheme and supplies managementReinforce basic laboratory services, including laboratory monitoring of ARV therapy at district and centralized hospitalsScaling up activities related to HIVAIDS diagnostic support and laboratory issues
ACCURATE DIAGNOSIS - EFFECTIVE TREATMENT- QUALITY OF CARE
2004 2004 -- 2005 and beyond2005 and beyond
Conclusion:Conclusion:
Access to safe, appropriate Access to safe, appropriate and reliable laboratory and and reliable laboratory and diagnostic services are diagnostic services are essential to the provision ofessential to the provision ofquality health care,quality health care, which which ultimately leads to the ultimately leads to the reduction of poverty and to reduction of poverty and to economic developmenteconomic development