hiv vaccine research and hiv drugs in the pipeline hiv vaccine research and hiv drugs in the...
TRANSCRIPT
Presented by: <your name here>
From Bench to Bedside
An up-to-date look at HIV Vaccine Research and HIV drugs in the pipeline
HIV Globally
40 million infected with HIV worldwide
Over 20 million have died since 1981
5 million were infected in 2004
600 new infections every hour
The World needs an HIV Vaccine
The World needs an HIV Vaccine
AIDS kills more people than any other infectious disease
History of Public Health Initiatives
Economics
AIDS kills more people than any other infectious disease
History of Public Health Initiatives
Economics
Is an AIDS vaccine really possible?
Is an AIDS vaccine really possible?
In 1984 researchers predicted that a vaccine was right around the corner…
In 1984 researchers predicted that a vaccine was right around the corner…
What are the steps in Vaccine development?What are the steps in Vaccine development?
Phase I: 10-30 volunteers, 8-12 months
Phase II: 50-500 volunteers,18-24 months
Phase III: Thousands of volunteers, 3 or more years
Phase I: 10-30 volunteers, 8-12 months
Phase II: 50-500 volunteers,18-24 months
Phase III: Thousands of volunteers, 3 or more years
Progress toward AIDS vaccine since 2000
Progress toward AIDS vaccine since 2000
30 AIDS vaccines in small-clinical trials
Developing countries taking a leadDemonstration that large scale AIDS
vaccine trials can be conducted
30 AIDS vaccines in small-clinical trials
Developing countries taking a leadDemonstration that large scale AIDS
vaccine trials can be conducted
What are the animal models for HIV
vaccines?
What are the animal models for HIV
vaccines?
MacaquesChimpanzees
What types of HIV vaccines are being
tested?
What types of HIV vaccines are being
tested?Peptide epitopes (protein fragments)
Status: In phase I trials
Live attenuated HIVStatus: Non-human primates
Whole, killed HIVStatus: Not under study in primates
Naked DNAStatus: Phase I trials
What types of HIV vaccines are being
tested?
What types of HIV vaccines are being
tested?Recombinant Viral ProteinsStatus: Phase II and III trials
Live bacterial vectorsStatus: Phase I trials
Live Viral VectorsStatus: Phase II trials
PseudovirionsStatus: Pre-clinical trials
What are the possible HIV vaccine outcomes?What are the possible HIV vaccine outcomes?
Sterilizing ImmunityTransient InfectionLong-term controlled infectionAltruistic vaccine
Who is organizing the HIV vaccine trial movement?
“Our goal is to develop safe and effective preventive HIV vaccines that will work everywhere on the globe, against all strains of HIV, in all people.”
What are some of the current HIV vaccine
trials?
What are some of the current HIV vaccine
trials?Phase I trial-
Product: AVX101Company: Alphavax Inc.
Safety of an HIV vaccine in HIV uninfected volunteers in United States and South Africa
What are some of the current HIV vaccine
trials?
What are some of the current HIV vaccine
trials?Phase II
Product: rgp 120 MNCompany: VaxGen
Study the immune system response to vaccine in Brazil, Haiti, Trinidad and Tobago
What are some of the current HIV vaccine
trials?
What are some of the current HIV vaccine
trials?Phase III
Products: ALVAC vCP1521/
AIDSVAX B/ECompany: Aventis,
VaxGenAssessing immunogenicity and ability to prevent HIV infection in Thailand
Where are these vaccines being tested?
What needs to happen to actually have an HIV vaccine?
Imagine a world without AIDS
Imagine a world without AIDS
No country, region or community is immune to HIV
All must play a role in vaccine development
No country, region or community is immune to HIV
All must play a role in vaccine development
What can you do to stay informed about HIV vaccines
and HIV/AIDS?
What can you do to stay informed about HIV vaccines
and HIV/AIDS?
Join HPSAAN and stay informed!www.amsa.org/global/hpsaan.cfm
Participate in an AIDS Vaccine Trial: www.hvtn.org
Join HPSAAN and stay informed!www.amsa.org/global/hpsaan.cfm
Participate in an AIDS Vaccine Trial: www.hvtn.org
Go to www.iavi.org/callforaction and sign-on !
Sources:Sources:International AIDS vaccine initiative
http://www.iavi.org/HVTN
http://www.hvtn.org/index.htmlDNA vaccines
http://people.ku.edu/~jbrown/dnavac.htmThe Pipeline Project
http://chi.ucsf.edu/vaccines/vaccines?page=vc-00-00
NIAID Division of AIDShttp://www.niaid.nih.gov/daids/vaccine/overview.htm
International AIDS vaccine initiativehttp://www.iavi.org/
HVTNhttp://www.hvtn.org/index.html
DNA vaccineshttp://people.ku.edu/~jbrown/dnavac.htm
The Pipeline Projecthttp://chi.ucsf.edu/vaccines/vaccines?page=vc-00-
00NIAID Division of AIDS
http://www.niaid.nih.gov/daids/vaccine/overview.htm