hiv treatment adherence counseling intervention for people ... treatment... · contacted research...
TRANSCRIPT
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Supported by the National Institute of Mental Health and
National Institute of Nursing Research R01 MH/NR62287
HIV Treatment Adherence Counseling
Intervention for People Living with HIV
and Limited Health Literacy
Seth C. Kalichman
University of Connecticut
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HEALTH LITERACY
Institute of Medicine:
"the degree to which individuals have the
capacity to obtain, process, and understand
basic health information and services needed
to make appropriate health decisions."
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Limited health literacy is associated
with…
Poorer Type 2 diabetes glycemic control and
higher rates of retinopathy. (Schillinger, 2002)
Higher mortality rates within a managed care
setting. (Baker et al 2007)
Poorer understanding of medical
labels/instructions, and greater likelihood of taking
medicines incorrectly. (Bennett et al., 2009;
Soroui et al., 2008)
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Health Literacy and
Adherence to
Antiretroviral Therapies
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Literacy and HIV Health Status
Lower Literacy Higher Literacy
CD4 < 300 74% 55% *
Prescribed ART 59% 73% *
Undetectable Viral Load 8% 36% *
*p<.05
Kalichman et al., 2000
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Literacy and ART Adherence
Lower Literacy Higher Literacy
> 75% Adherent 69% 82%*
> 90% Adherent 55% 70%*
*p<.05
Kalichman et al., 2002
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Stick-To-It
Individualized
ART Adherence Counseling
for Low-Literacy Adults Living with HIV
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Stick-To-It
2-60 min. Sessions +
1 30-min booster
Pictographic Flip-Chart
Personalized Feedback
Custom Adherence Plan
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Doak et al.’s (1996) Principles ____________________________________________________
Set Realistic Objectives Limit to the targeted goals
Use a planning sheet
Focus on Behaviors/ Skills Emphasize skills
Enhance motivation
Present Context Before State the purpose
new Information Relate to the person’s life
Partition Complex Break information up
Instructions Create opportunities for
success
Use Interactive Instructions Demonstrate, practice,
problem solve
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Comparison Interventions
Standard (Untailored)
Adherence Counseling
General Health Improvement Skills
(Not ART Adherence)
Nutrition and Stress Reduction
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Contacted Research Site
N = 1385
>90% Correct TOFHLA N = 417
Not Taking ART N = 374
Not HIV+ = 120
< 90% Correct on TOFHLA & Taking ART
Attended Intake Session N = 474
Pictograph Guided
N = 148
Standard Adherence
N = 157
Health Improvement
N = 141
Baseline ACASI, Viral Load
Randomized N= 446
Did not return
for baseline
assessment
N=28
** Entry Criteria: HIV+ treated with ART, 18 or older, TOFHLA
Score < 90% correct
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Contacted Research Site
N = 1385
>90% Correct TOFHLA N = 417
Not Taking ART N = 374
Not HIV+ = 120
< 90% Correct on TOFHLA & Taking ART
Attended Intake Session N = 474
Pictograph Guided
N = 148
Standard Adherence
N = 157
Health Improvement
N = 141
Baseline ACASI, Viral Load
Randomized N= 446
Did not return
for baseline
assessment
N=28
Completed Counseling
Session 1 97%
Session 2 91%
Session 3 84%
Completed Counseling
Session 1 97%
Session 2 95%
Session 3 90%
Completed Counseling
Session 1 95%
Session 2 91%
Session 3 86%
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Follow-up for
9-months post-
counseling was
> 85% for all
conditions & all
assessments
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Characteristics of clinical trial participants.
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Literacy Groups X Condition
TOFHLA
Score
(Correct)
Pictographic
Adherence
Standard
Adherence
General
Health
85-90% 62 73 84
< 85% 86 84 57
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Primary Outcomes
ART Adherence
via unannounced
pill counts & HIV
RNA (Viral Load)
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Adherence 3 (Condition) X 2 (Literacy Groups) X 9
(Unannounced Pill Counts)
Outcome Analyses
Viral load 3 (Condition) X 2 (Literacy Groups)
GEE Models controlling for baseline
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Adherence Outcomes
Intervention condition
X literacy group interaction
Pictographic and Standard
counseling improved ART
adherence for people with moderate
literacy, but not lower-literacy
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Perc
ent
> 9
5%
Adhe
rent
GEE Model Condition X Literacy Group Interaction, Wald X2 =5.93, p < .05
Moderate Health Literacy
(85% to 90% on TOFHLA)
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Perc
ent
> 9
5%
Adhe
rent
Lower Health Literacy
(< 85% on TOFHLA)
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% U
ndete
cta
ble
Vir
al Load a
t 9
-month
follo
w-u
p
GEE Model Condition X Literacy Group Interaction, Wald X2 =2.05, p < .01
Percent Undetectable
Viral Load at Follow-up
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% U
ndete
cta
ble
Vir
al Load a
t 9
-month
follo
w-u
p
GEE Model Condition X Literacy Group Interaction, Wald X2 =2.05, p < .01
Percent Undetectable
Viral Load at Follow-up
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Participants who
entered the trial with
detectable viral loads
and achieved
undetectable viral
loads.
Optimal Outcomes
Pellowski et al., in process
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% C
han
ge
to U
nde
tecta
ble
Vir
al Lo
ad
Optimal Viral Load
Outcomes
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Optimal Outcomes
Pellowski et al., in process
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Multivariate Logistic Regression
Predicting Optimal Outcomes
Pellowski et al., in process
Predictor Adjusted OR 95%CI
Gender 1.82 0.92-3.60
Alcohol use 0.85* 0.74-0.99
Stress 0.91 0.83-1.01
Health Literacy 2.15* 1.15-4.01
Note all predictors significant in bivariate analyses,
* p < .05
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Brief counseling improves ART adherence for people
with moderate literacy.
Tailoring counseling for moderately literate patients
seems unnecessary.
Lower literacy participants demonstrated little if any
benefit from adherence counseling.
Dose-proximal interventions may be needed for
people with low literacy skills: Modified DOT, Wisepill,
cell-phone and SMS assisted counseling.
Conclusions
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The SHARE Project
Lisa Eaton Chauncey Cherry
Demetria Cain Moira Kalichman
Christina Amaral Denise White
Tamar Grebler Chris Washington
Megan McKerey Ginger Hoyt
Cyndi Merely Brandi Welles
Daniel Driffin Harlan Smith
Jennie Pellowski Star Chen
Marcus Henderson
Supported by Grant R01 MH/NR62287