histology for pathology lymphoid organs theresa kristopaitis, md associate professor director of...
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![Page 1: Histology for Pathology Lymphoid Organs Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP](https://reader035.vdocuments.us/reader035/viewer/2022062305/56649caf5503460f94972c6c/html5/thumbnails/1.jpg)
Histology for PathologyLymphoid Organs
Theresa Kristopaitis, MDAssociate Professor
Director of Mechanisms of Human Disease
Kelli A. Hutchens, MD, FCAPAssistant Professor
Assistant Director of Mechanisms of Human Disease
Loyola Stritch School of Medicine
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Lymphoid OrgansLymph Nodes, Spleen, Thymus
• List the main function(s) of lymph nodes.• On an H&E stained section of a lymph node identify the capsule,
subcapsular sinus, cortex, and medulla.• Identify the germinal center of a secondary lymphoid follicle. • Outline the path of lymph through a lymph node.• On an H&E stained slide of the spleen, identify the capsule, white pulp
(central artery, nodule) and red pulp.• Summarize the key functions of the white pulp and red pulp of the spleen. • On an H&E stained section of an infant/child thymus identify the cortex
and medulla of thymic lobules. • Define “Hassal corpuscle” and identify on a histologic section. • Summarize the key function(s) of the thymus. • Define “Mucosa-Associated Lymphatic Tissues” and list in which organs
they are found.
![Page 3: Histology for Pathology Lymphoid Organs Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP](https://reader035.vdocuments.us/reader035/viewer/2022062305/56649caf5503460f94972c6c/html5/thumbnails/3.jpg)
Lymph Node
CapsuleCortex
MEDULLA
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Lymph node
Subcapsular Sinus
![Page 5: Histology for Pathology Lymphoid Organs Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP](https://reader035.vdocuments.us/reader035/viewer/2022062305/56649caf5503460f94972c6c/html5/thumbnails/5.jpg)
Lymph Node Follicle with Germinal Center (Secondary Follicle)
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Pale medullary sinuses surrounding darker medullary cords. You can see many stellate reticular cells which, with reticular fibers, make a meshwork through the sinuses. Lymph "percolates" through the meshes of the sinuses while debris of foreign matter in it is phagocytized.
![Page 7: Histology for Pathology Lymphoid Organs Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP](https://reader035.vdocuments.us/reader035/viewer/2022062305/56649caf5503460f94972c6c/html5/thumbnails/7.jpg)
Spleen
Red pulp White pulp
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SpleenWhite pulpRed pulp
![Page 9: Histology for Pathology Lymphoid Organs Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP](https://reader035.vdocuments.us/reader035/viewer/2022062305/56649caf5503460f94972c6c/html5/thumbnails/9.jpg)
White PulpCentral arteryLymphoid nodule
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Spleen Red Pulp
Red pulp consists of open sinuses and cellular cords
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ThymusInfant
Medulla
cortex
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Thymus Medulla
Hassall’s Corpuscle
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Adult Thymus
Panoramic view of adult thymus, largely replaced with adipose tissue. There are recognizable remnants of thymic lymphatic tissue, however,and Hassall's corpuscles are still present in the medulla.
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Mucosa Associated Lymphoid Tissue
Stomach