histology 1.12: molecular basis of cross-striation and muscle contraction lm micrographs of striated...

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HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTION AND MUSCLE CONTRACTION LM micrographs of striated muscle LM micrographs of striated muscle Low power EM micrograph Low power EM micrograph High power EM micrograph High power EM micrograph

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Page 1: HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTION LM micrographs of striated muscle Low power EM micrograph High power EM micrograph

HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTIONAND MUSCLE CONTRACTION

LM micrographs of striated muscleLM micrographs of striated muscle

Low power EM micrographLow power EM micrograph

High power EM micrographHigh power EM micrograph

Page 2: HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTION LM micrographs of striated muscle Low power EM micrograph High power EM micrograph

Structure of the myofibrils

Myofilaments:

Thick (myosin)

Thin (actin)

Sarcomer: 2,2-2,5 m

Page 3: HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTION LM micrographs of striated muscle Low power EM micrograph High power EM micrograph

Myofilaments 1. The thin filament

F-actin (made up by

several G-actins)

Further proteins involved:

6-9 nm

Page 4: HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTION LM micrographs of striated muscle Low power EM micrograph High power EM micrograph

Arrangement of the myosin molecules within the filament (250-350 molecule/filament)

Bipolar structure

Myofilaments 2. The thick filament

Building block: the myosin molecule

12- 15 nm

Heads

L-chains H-chains

Myosin heads

Page 5: HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTION LM micrographs of striated muscle Low power EM micrograph High power EM micrograph

The „sliding filament” mechanism of the contraction

Page 6: HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTION LM micrographs of striated muscle Low power EM micrograph High power EM micrograph

Cytoskeletal proteins within the sarcomer

Page 7: HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION AND MUSCLE CONTRACTION LM micrographs of striated muscle Low power EM micrograph High power EM micrograph

The sarcoplasmic reticulum and the transverse tubular system (T-system)

triads

Triad: T-tubule + two adjacent terminal cisterns of the sarcoplasmic reticulum

Sarcoplasmic reticulumLongitudinal tubules

Terminal cisterns

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