histo-blood group antigens as allo- and/or autoantigens
DESCRIPTION
Histo-blood group antigens as allo- and/or autoantigens. Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany [email protected] - www.immune-complex.ch 4th International Congress Autoimmunity Budapest 2004. - PowerPoint PPT PresentationTRANSCRIPT
Histo-blood group antigens as allo- and/or autoantigens
Nydegger, U.E. and Flegel, W.A.
University of Bern, Switzerland and University of Ulm, Germany
[email protected] - www.immune-complex.ch
4th International Congress Autoimmunity Budapest 2004
Blood group antigens assigned to systems
0
10
20
30
40
50
60
ABO P LU LE JK YT SC CO CH/RG XK CR IN
No of antigens
Intrinsic antigens defined byred cell membrane proteins
Intrinsic antigens defined byglycosyltransferase genes
Acquired antigens (notintrinsic to red cell)
Slide courtesy of D. Anstee 1997
World Wide Web sites for Blood Group Antigens
• http://www.bioc.aecom.yu.edu/bgmut/index.htm
• http://www.uni-ulm.de/~wflegel/RH/
• http://jove.prohosting.com/~scarfex/blood/groups.html
Nydegger UE, Flegel WA 2004
Blood group antigens as autoantigens
• I/i
• P
• Kell
• Lewis
• MN
• Cold agglutinins
• Cold agglutinins
• Donath-Landsteiner antibodies
• Warm-reactive autoantibodies
• Helicobacter pylori– molecular mimicry
• Treponema pallidum– molecular mimicry
Nydegger UE, Flegel WA 2004
Blood groups on the RBC
Gerbich
Knops
Kell
Lutheran
LW
Duffy
MNS
ABOIi
RhIndian
Cromer
Yt
Diego
Slide courtesy of E. Sjoberg-Wester
Chemical basisof the ABO and Lewis blood group system
ß-D-Gal(1-3)ß-D-GlcNAc
O
O
O
N
H
O
O
R
ß
Gal
ß(1-3)
Type 1 Precursur Substance
-L-Fuc(1-2) ß-D-Gal(1-3)ß-D-GlcNAc
H type 1
O
O
O
N
H
O
O
A type 1
-D-GalNAc(1-3) [-L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc
B type 1
-D-Gal(1-3) [-L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc
O
O
O
H
O
O
Leb
-L-Fuc(1-2) ß-D-Gal(1-3)[-L-Fuc(1-4)]ß-D-GlcNAcß-D-Gal(1-3)[-L-Fuc(1-4)]ß-D-GlcNAc
Lea
Nyd
eg
ger U
E, F
lege
l WA
200
4
Disappearance of B and appearance of H Antigen
Ko
estn
er et al. Lan
cet 3
63(2004)1523
B type O type O typeMonoclonal antibodies Lectin
M
on
ths
po
st t
ran
spla
nt
Co
ntr
ols
36
3
0
1
4
2
ABOI heart allograft: follow up for 44 months post transplant
B Antigen
H Antigen
Post transplant: 12 24 36 44 months
Nyd
eg
ger U
E, F
lege
l WA
200
4
Conclusion
• Numerous blood group system antigens– occur not only on red blood cells
– but are also expressed on cells of various other tissues
• Hence, autoantibodies – known to impinge on red cells
– are also reactive for various other tissues
• Blood group antigens– might be more frequently involved as tissue autoantigens
– and should be more often considered in this context
Nydegger UE, Flegel WA 2004