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Screening Library, compound library, chemical library, high throughput screening for cell signaling and oncology research. These Chemical & Screening libraries are suitable for HTS, HCS and chemical biology applications.

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Page 2: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Selleck Screening Libraries offer easy, ready-to-use alternatives for the analysis of biochemical pathways and pharmaceutical-related applications. Our library contains a unique and diverse collection of over 700 bioactive compounds suitable for high-throughput screening (HTS), cell based high-content screening (HCS), chemical and

biological applications.

Library Advantages

Selleck Screening Libraries

Structurally diverse, medicinally active and cell permeable

Rich documentation with structure, IC50 and customer reviews

NMR and HPLC to ensure the high purity

The collection of unique small molecules is focused on over 200 targets in more than 20 signaling pathways, such as PI3K / mTOR / Akt, MAPK and apoptosis. We provide compound position information, physical information, biological activityand chemical properties for each plate.

www.selleckchem.com/screening/screening-library.html

Chemical Library TotalA collection of 712 bioactive compounds.

Inhibitor LibraryA collection of 335 inhibitors.

Kinase Inhibitor LibraryA collection of 150 kinase inhibitors.

FDA Approved Drug LibraryA collection of 381 FDA approved drugs.

Natural Product LibraryA collection of 130 natural products.

Chemotherapeutic Agent LibraryA collection of 40 chemotherapeutic agents.

Tyrosine Kinase Inhibitor LibraryA unique collection of 86 tyrosine kinase inhibitors.

Page 3: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Chemical Library Total (96-well)

Chemical Library Total

Toll Free:(877)796-6397 www.selleckchem.com [email protected]

Phone:+1-832-582-8158---USA and Canada only---

A unique collection of 712 bioactive compounds for high throughput screening (HTS) and high content screening (HCS)

Bioactivity and safety confirmed by preclinical research and clinical trials

Some compounds have been approved by FDA

Includes most Selleck inhibitors, APIs, natural products and chemotherapeutic agents Structurally diverse, medicinally active and cell permeable

Rich documentation with structure, IC50 and customer reviews NMR and HPLC to ensure the high purity

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������Chemical Library Total

Product

712

Compounds

L1700

Catalog No.Powder Pre-dissolved in DMSO

Size

You can select compounds, quantities, format������������ ����plate map and concentration to meet your specific requirement.

Customize Your Library

Num

ber o

f com

poun

ds

0

100

200

400

300

Inhibitors Kinase Inhibitors FDA Approved Drugs Natural Products Chemotherapeutic Agents

335

150

381

130

40

Tyrosine Kinase Inhibitors

86

Download the Library TotalSDF

Download the Library TotalXLSX

ww.selleckchem.com

DownloadSDFSDF

Download comprehensive documentation on this library:

Page 4: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Inhibitor Library

Terrific Quality, Validation, Customer Review & Tech Support

Inhibitor Library (96-well)A unique collection of 335 inhibitors for high throughput screening (HTS) and high content screening (HCS) Bioactivity and safety confirmed by preclinical research and clinical trialsSome inhibitors have been approved by FDA

Structurally diverse, medicinally active and cell permeable

Rich documentation with structure, IC50 and customer reviews

NMR and HPLC to ensure the high purity

Targets PI3K, VEGFR and RTK pathway, HDAC, Aurora Kinase, CDK and Cell Cycle regulators, Integrase/Proteasome etc

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������������ ��������Inhibitor Library 335 L1100

������

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Product Compounds Catalog No.Powder Pre-dissolved in DMSO

Size

18

11

3 3

1

1 1 1 1 1 1 1 1 1 1 1 1 1 1

12

2 2 2 2 2 2 2 2

27

16 1615

14 14

11

7 7

1

88

4

4 4 4

2 2

121211

1 1 1 1 1 1 1

3

3333

7 7

44

2 2

11

5

5 5

5666

66 6

31

99910

0

2

4

6

8

10

12

14

16

18

20

22

24

26

28

30

32

0

2

4

6

8

10

PI3K

mTOR

AKT

GSK-3

DNA-PK

&'

S6 kinase

VEGFR

EGFR

PDGFR

c-Kit

!* ��

Bcr-Abl

SRC

IGF-1R

HER2

ALK

Syk

Tie-2

/��/;

FGFR

HIF

VDA

Bcl-2

TNF-alpha

p53

Survivin

JAK

STAT

#<= &>?

Pim

M?

Raf

JNK

Kinesin Spindle Protein

Aurora Kinase

HDAC HSP

Topoisomerase

Sirtuin

Antimetabolites

CDK

�!����Q��/���"����

PARP

PLK

ROCK

CHK

Telomerase

PKC

�Z&�[Z&synthesis

Dihydrofolate Reductas

5-HT receptor

COX

HistamineReceptor

Gamma-secretase

mAChRs

GABAreceptor

Dopamine Receptor

Hedgehog

Wnt

AdrenergicReceptors

ETA-receptor

5-alpha-reductase

Estrogen Receptor

AndrogenReceptor

RAAS

Aromatase

CalciumChannel

Sodium Channel

PotassiumChannel

P450

Factor Xa

PDE

Aminopeptidase

Dehydrogenase

Proteasome

HCVProtease

DPP-4

HIV Protease

CCR5

ReverseTranscriptase

CFTR

Integrase

Others

Download the Inhibitor LibrarySDF

Download the Inhibitor LibraryXLSX

Terr

Download SDFSDF

Download comprehensive documentation on this library:

Page 5: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Kinase Inhibitor Library (96-well)

Kinase Inhibitor Library

Toll Free:(877)796-6397 www.selleckchem.com [email protected]

Phone:+1-832-582-8158---USA and Canada only---

A unique collection of 150 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS)

Bioactivity and safety confirmed by preclinical research and clinical trialsSome kinase inhibitors have been approved by FDA

Targets kinases such as RTKs, PI3K, Aurora Kinase, CDK and MEK

Most are ATP competitive

Structurally diverse, medicinally active and cell permeable

Rich documentation with structure, IC50 and customer reviews

NMR and HPLC to ensure the high purity

���!"����!�!��#������$�"��������%���"������������� ����#"���"#"��!��!����"����to meet your specific requirement.

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������������ ��������Kinase Inhibitor Library 150 L1200������

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Product Compounds Catalog No.Powder Pre-dissolved in DMSO

Size

18

28

11

3 32

1514

4

11 11

7 7

10 10

8

22

12

15

666

8

2

44

2 21 1 1 1

0

2

4

6

8

10

12

14

16

18

20

22

24

26

28

PI3K

mTOR

AKT

GSK-3

&'

VEGFR

EGFR

PDGFR

JAK

M?

Raf

#<= &>?

c-Kit

!* ��

Bcr-Abl

SRC

IGF-1R

HER2

ALK

Syk

Tie2

/��/�?

FGFR

Aurora

CDK

PLK

PKC

S6 Kinase

TGF-beta

CHK

JNK

Others

Download the Kinase InhibitorLibrary SDF

Download the Kinase InhibitorLibrary XLSX

www.selleckchem.co

DownloadLibrary SDSDF

Download comprehensive documentation on this library:

Page 6: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Tyrosine Kinase Inhibitor Library (96-well)A unique collection of 86 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS)

���!"����!�!��#������$�"��������%���"������������� ����#"���"#"��!��!����"����to meet your specific requirement.

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������������ ��������Tyrosine Kinase Inhibitor Library 86 L1800 ������

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Product Compounds Catalog No.Powder Pre-dissolved in DMSO

Size

Terrific Quality, Validation, Customer Review & Tech Support

Bioactivity and safety confirmed by preclinical research and clinical trials

Some tyrosine kinase inhibitors have been approved by FDA

Targets tyrosine kinases such as EGFR, VEGFR, SRC, c-Met and JAK

Structurally diverse, medicinally active and cell permeable

Rich documentation with structure, IC50 and customer reviews

NMR and HPLC to ensure the high purity

Num

ber o

f tyr

osin

e kin

ase

inhi

bito

rs

Tyrosine Kinase Inhibitor Library

30

15

12 12

8

18

6

43

1

109 9

7

2

6

1

0

2

4

6

8

10

12

14

16

18

20

22

24

26

28

30

VEGFR EGFR PDGFR JAK Rafc-Kit !* �� Bcr-AblIGF-1RHER2 ALKSyk SRCTie2 /��/�?FGFR Wee1

Download the Tyrosine Kinase Inhibitor Library SDF

Download the Tyrosine Kinase Inhibitor Library XLSX

Te

DownloadInhibitor LiSDF

Download comprehensive documentation on this library:

Page 7: High Throughput Screening| Compound Library | Chemical Library | Screening Library

FDA Approved Drug Library

FDA Approved Drug Library (96-well)A unique collection of 381 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS)

Helps to locate new targets for old drugs

Bioactivity and safety confirmed by clinical trials

All compounds have been approved by FDA

Structurally diverse, medicinally active and cell permeable

Rich documentation with structure, IC50 and customer reviews

NMR and HPLC to ensure the high purity

Related to oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc

���!"����!�!��#������$�"��������%���"������������� ����#"���"#"��!��!����"����to meet your specific requirement.

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������������ ��������FDA Approved Drug Library 381 L1300

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Product Compounds Catalog No.Powder Pre-dissolved in DMSO

Size

0

10

20

30

40

50

60

70

80

65

77

40

2531

20

69

59

8

Cancer

Infection

Endocrinology

��"Q��!Disease

Inflammation

Immunology

NeurologicalDisease

CardiovascularDisease

RespiratoryDiseases

Num

ber o

f FD

A ap

prov

ed d

rugs

Toll Free:(877)796-6397 www.selleckchem.com [email protected]

Phone:+1-832-582-8158---USA and Canada only---

Download the FDA Approved Drug Library SDF

Download the FDA ApprovedDrug Library XLSX

www.selleckchem.co

DownloadDrug LibraSDF

Download comprehensive documentation on this library:

Page 8: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Natural Product Library (96-well)

Natural Product Library

A unique collection of 130 natural products for high throughput screening (HTS) and high content screening (HCS)

Structurally diverse, bioactive and cell permeable

Rich documentation with structure and IC50

NMR and HPLC to ensure the high purity

Library includes:

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������������ ��������Natural Product Library 130 L1400

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Product Compounds Catalog No.Powder Pre-dissolved in DMSO

Size

Steroid saponins

Benzoquinones

Tannins

Alkaloids

PPGs

Penzaldehydes

Saccharides

Anthraquinones

Phenanthraquinones

Phenylcarbinols

Pyrimidines

Flavones

Synthetic derivatives

Phenethylamines

Acid amides

Steroids

Peptides

Terrific Quality, Validation, Customer Review & Tech Support

Download the Natural ProductLibrary XLSX

Download the Natural Product Library SDF

Te

Download Library SDSDF

Download comprehensive documentation on this library:

Page 9: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Chemotherapeutic Agent Library

Chemotherapeutic Agent Library (96-well)A unique collection of 40 chemotherapeutic agents for high throughput screening (HTS) and high content screening (HCS)

Structurally diverse, medicinally active and cell permeable

Rich documentation with structure, IC50 and customer reviews

NMR and HPLC to ensure the high purity

Bioactivity and safety confirmed by clinical trials

Some agents have been approved by FDA for both oncological and non-oncological purposes

���!"����!�!��#������$�"��������%���"������������� ����#"���"#"��!��!����"����to meet your specific requirement.

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������������ ��������Chemotherapeutic Agent Library 40 L1500

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Product Compounds Catalog No.Powder Pre-dissolved in DMSO

Size

0

2

4

6

8

10

12

14

6

13

34 4

10

Alkylatingagents

Anti-metabolites

Plant alkaloidsand terpenoids

Topoisomeraseinhibitors

Cytotoxicantibiotics

Other antitumouragents

Num

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f che

mot

hera

peut

ic ag

ents

Toll Free:(877)796-6397 www.selleckchem.com [email protected]

Phone:+1-832-582-8158---USA and Canada only---

Download the ChemotherapeuticAgent Library XLSX

Download the ChemotherapeuticAgent Library SDF

www.selleckchem.co

Download thAgent LibrarSDF

Download comprehensive documentation on this library:

Page 10: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Guaranteed Quality and Support

Guaranteed Quality and Support

The purity of each reagent in Selleck screening libraries is confirmed by HPLC and H-NMR.In addition, all libraries are supplied with a detailed documentation set including compound position information, physical information, biological activity and chemical properties in SDF and Excel files.

Certificate of AnalysisMolecular Formula: C17H15BrClFN4O3

Molecular Weight: 457.68 CAS No.: 606143-52-6 Storage: at -20℃ 2 years

Molecular Structure:

AU

0.00

0.50

1.00

1.50

2.00

2.50

3.00

inutes2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00 20.00 22.00 24.00 26.00 28.00 30.00

15.6

7616

.152

17.8

75

11.

693

8.3

79 7

.892

7.7

22 7

.589

7.5

87 7

.584

7.5

81 7

.252

7.2

51 7

.247

7.2

30 7

.228

7.2

25 6

.353

6.3

43 6

.331

6.3

21

4.6

94 4

.691

3.8

82 3

.839

3.5

33 3

.311

3.3

09

2.4

83 2

.479

2.4

76 2

.475

2.0

63 2

.059

-0.0

25 -0

.028

1.00 0.96

1.00 0.94 1.00 3.01 2.00

2.00 1.00 1.00 0.91

12 10 8 6 4 2 0 >>

����=���� ��*�]

HN

Cl

BrFNN

HN O

OHO

USER: -- DATE: Apr 2 2011

Nuts - $S100810 AZD6244

Std proton;blank line86723 , 12561 :d1STP 4.4123 :1FO 5608 :1WS794.001 :2F536.993 :1F

0.0 :BL 8 :ANces 0.2 :DPsu 2.7 :WPlup2s :XE

Physical and chemical properties

S1008 AZD6244 (Selumetinib)

SD File

XLSX File

Having doubts on Selleck’s products? Following data from our customers is to assure you the high quality of Selleck Screening Libraries.

Data from [ Nature Biotechnology����_ "�!`j�{|���*]�}Vorinostat (SAHA) purchased from Selleck

Data from [ Cancer Cell����_~���j�{|���<}Rapamycin (Sirolimus) purchased from Selleck

Data from [ Nature����_Z����Q��j�]=|{]=*{��}AZD6244 (Selumetinib) purchased from Selleck

Terrific Quality, Validation, Customer Review & Tech Support

Page 11: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Customize Your Library

Customize Your LibraryA cherry pick service is available to let you customize your own libraries.

Please contact us at [email protected] to check the details of your library.

You could select

Specific Compounds Quantities Format ������������ ���������� Plate map Concentration

Toll Free:(877)796-6397 www.selleckchem.com [email protected]

Phone:+1-832-582-8158---USA and Canada only---

Page 12: High Throughput Screening| Compound Library | Chemical Library | Screening Library

Tel:

Web:

RussiaCOPRAS

Email:+74 953331163

[email protected]

AustraliaLife Research Pty LtdTel:Email:

Web:

+61 [email protected]

AustriaeubioTel:Email:Web:

+43 [email protected]

CanadaCedarlaneTel:Email:

Web:

+1 289 288 [email protected]

www.cedarlanelabs.com

ChinaBinXin Bio, Co LtdTel:Email:

Web:

+86 22 [email protected]@163.com

ChinaCafion ScientificTel:Email:Web:

+86 21 3376 [email protected]

AustraliaStratech Scientific APACTel:Email:

Web:

+61 (0)2 9973 [email protected]

FranceEUROMEDEXTel:Email:Web:

+33 (3) 88 18 07 [email protected]

DenmarkSMS-gruppenTel:

Email:Web:

+45 [email protected]

NetherlandsDivbio ScienceTel:Email:

Web:

+31 (0)76 565 [email protected]

NetherlandsNuclilab B.VTel:

Email:Web:

+31 318 636 [email protected]

GermanyAbsource Diagnostics GmbHTel:Email:

Web:

+49 89 8296 [email protected]

GermanyICS International Clinical Service GmbH

Tel:Email:

Web:

+49 (0)[email protected]

Tel:

NAMIKI SHOJI CO., LTD.

Email:Web:

+81 3 3354 4026

[email protected]

Japan

ItalyAurogeneTel:Email:

Web:

+39 06 9818 5510

[email protected]

JapanCOSMO BIO CO., LTDTel:Email:

Web:

+81 3 5632 9610

[email protected]

Wako Pure Chemical Industries, Ltd.Tel:Email:

Web:

+81 1 20052099

www.wako-chem.co.jp

[email protected]

Japan

KoreaKim & Friends, Inc.Tel:Email:Web:

+82 226476611kim and [email protected]@gmail.com

SpainDELTACLON S.L.Tel:Email:Web:

+34 [email protected]

SingaporePRECISION TECHNOLOGIES PTE LTD

Tel:Email:

Web:

+65 [email protected]

RussiaRUSCHEMBIOTel:Email:

Web:

+74 [email protected]

Email: "�;������!��������##�������_!��

USAVWR International LLCTel:

Web:

+1 800 932 5000

www.vwr.com

UKStratech Scientific Ltd.Tel:

Email:Web:

+44 (0)1638782600

[email protected]

Email: [email protected]

USAThermoFisherTel:

Web:

+1 800 766 7000

www.thermofisher.com

Email: [email protected]:

Web:

SwedenSMS-gruppen

+46 42120240

www.sms-gruppen.dk

Web:

Tel:Email:

www.lumtec.com.tw

TaiwanLumtec

+88 [email protected]

Web:

Tel:Email:

www.lubio.ch

SwitzerlandLuBioScience GmbH

+41 [email protected]

Worldwide Distributors

HeadquartersTel: +1-617-399-8136Fax: +1-713-796-9816E-mail: [email protected]

Tel: +49-89-46148500Fax: +49-89-461485022E-mail: [email protected]

For detailed product information, please visit us online:

www.selleckchem.com