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High-Throughput, Scalable Nanomanufacturing of Nanocomposites via Micellular Electrospray Jessica O. Winter William G. Lowrie Dept. of Chemical and Biomolecular Engineering, Department of Biomedical Engineering, The Ohio State University, Columbus, OH http://nano4neuro.com/

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Page 1: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

High-Throughput, Scalable

Nanomanufacturing of Nanocomposites via

Micellular Electrospray

Jessica O. Winter

William G. Lowrie Dept. of Chemical and Biomolecular Engineering,

Department of Biomedical Engineering,

The Ohio State University, Columbus, OH

http://nano4neuro.com/

Page 2: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Nanocomposite Particles

Quantum Dots

Broad Excitation

Narrow Emission

Bandwidths

Low photobleaching

High Quantum Yield

Magnetic Nanoparticles

Reduce T2 relaxation

(MRI)

Biocompatible

Biodegradable

Exert force in magnetic

field

Gu et al., JACS, 2004, 5664

Core-Shell

Deng et al., Nanotech., 2010, 145605.

Interfacial Doping

Page 3: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Self-Assembled Micellar Nanocomposites

Ruan et al., Nano Letters, 2010, 2220;

Ruan et al. J Nanoeng Nanosys, 2010, 81

Ruan, Winter, Nano Letters. 2011, 941.

Page 4: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Interfacial Instability

Zhu JT, Hayward RC. Journal of the American Chemical Society. 2008;130:7496-502.

Granek R, Ball RC, Cates ME. Journal De Physique Ii. 1993;3:829-49.

Animation by A. Duong

1 batch ~ 0.1 mg

Page 5: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Introduction to Electrospray

High Positive

Voltage Applied

Organic Solvent,

Polymer,

Nanoparticles

Aqueous Solution:

Water, Surfactant

Ground

Collection Dish

(Water)

Collaboration with Barbara Wyslouzil, ChBE, OSU

Manuscript in Preparation

Page 6: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Process Optimization

Q=3, Qo/Qi=14

Q=3.5, Qo/Qi=2.5

10

20

30

40

50

60

70

0 10 20 30 40 50 60

Co

llec

tio

n T

em

pe

ratu

re ( C

)

PS-PEO Concentration in Organic (mg/ml)

Spheres

Mix Worms & Spheres

Not Viable

Spheres Batch 2

Mix Worms & SpheresBatch 2

40 C

30 C

2 mg/ml 5 mg/ml 10 mg/ml

Page 7: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Wormlike Micelles

Worms with QDs

concentrated in

globular regions

Spherical micelles

Page 8: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Yield and Size Distribution

30 fold increase in yield

15% size distribution

Page 9: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Particles Produced and Uses

25 nm

MultiDot:

QDs

Imaging

50 nm

MagDot:

Magnetic

QDs

Separations

PolyDot:

Polymer

NPs

Drug Delivery

Page 10: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Conclusions

• Micellar nanocomposites can be synthesized by

interfacial instability.

• Nanocomposites can be synthesized by electrospray

increasing yield and with potential for continuous

fabrication.

• Synthesis is robust, with little change in

particles produced over a wide range of

process parameters.

• Alternative structures can be created by

altering polymer characteristics.

• Several types of particles can be produced

using this approach.

• Particles have applications in several fields.

Page 11: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

The Winter Group

Funding

NSF Awards: CBET-0854015 , CMMI-0900377, CBET-0707969, MCB-1052623, EEC-0914790

(NSEC), DMR-0820414 (MRSEC), CMMI-1344567

NIH: 1RC2AG036559 – 01

DOE: Center for Integrated Nanotechnologies (CINT)

The Ohio State University: Institute for Materials Research, Department of Chemical and

Biomolecular Engineering, Women in Philanthropy, H.C. “Slip” Slider Professorship

Collaborators: Jeff Chalmers (ChBE, OSU), Barbara Wyslouzil (ChBE, OSU), R. Sooryakumar

(Physics, OSU), Maryam Lustberg (Med. Oncol., OSU), George Bachand (Sandia), Peter Kner

(University of Georgia)

Page 12: High-Throughput, Scalable Nanomanufacturing of ... · Spheres Batch 2 Mix Worms & Spheres Batch 2 40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml . Wormlike Micelles Worms with QDs concentrated

Imaging

Manipulation Biomimetics Drug Delivery

The Winter Lab at

http://nano4neuro.com

Nano-toolbox


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