hierarchical modularity in metabolic networksregan.med.harvard.edu/pdf/talks/hier_metab.pdf ·...
TRANSCRIPT
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Hierarchical Modularity inHierarchical Modularity in
Metabolic NetworksMetabolic Networks
Erzsébet RavaszErzsébet Ravasz
Center for Nonlinear Studies, Los Alamos National LaboratoryCenter for Nonlinear Studies, Los Alamos National Laboratory
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Networks?
Many different components A variety of interactions
The cell is not regular
Systems Biology Data on system level Methods and focus shift Asking for statistical physics
Not a lattice!
System as a whole:network!
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Networks in life
Genetic regulation Protein-protein interactions Food webs Neuron networks
Biology
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Networks in life
Metabolic pathways
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Networks in life
Do these networks haveanything in common
???
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Degree distribution
Not random networks!
Proteininteractions
Metabolic networks
Food webs
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Clustering
Clustering coefficient
Modular organization protein complexes regulatory modules pathways
High average in real networks Scale-free model: C ~ (ln N) 2/N
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Module hierarchy
Hierarchical model
Modular And Scale-free?
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Hierarchy in Biology
Protein-protein interaction Regulatory networks
Metabolic networks
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The metabolism of E. Coli
Biochemical reduction
Topological reduction
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Finding the modules
Hierarchical clustering
Similarity matrix
Average linkage clustering(UPGMA)
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Module lethality
Pyrimidine metabolism Genome-wide lethalitymeasurement
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http://www.nd.edu/~networks
Thank you!
Thanks to:•Albert László Barabási•Zoltán Oltvai