hemoglobin level significantly impacts the tumour cell survival fraction in humans after internal...
TRANSCRIPT
Hemoglobin level significantly impacts the tumour cell survival fraction in humans after internal radiotherapy:
application of a preclinical radiobiology model to clinical data.
Stephan Walrand, Renaud Lhommel, Pierre Goffette, Marc Van den Eynde, Stanislas Pauwels, François Jamar
Cliniques Universitaires Saint Luc,Université Catholique de Louvain,Avenue Hippocrate 10,1200 Brussels, Belgium
OER
R2 = 0.53
10
11
13
13
13.4
13.4
14.3
14.8
HEF x D
tum
or c
ells
sur
viva
l fra
ction
Hb
Hb
(Gy)
Hb Enhancement Factor
UCL Brussels
HEF = 1 + k (Hb – 13)
HEF
Hb
1
k>0
HEF
Hb
1
k=0
k = 0.00
Dose-effect relationship labeled with patient Hb level
let see in the following animationwhat will happen if we increase k
-R2 = 0.53
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.01
HEF x D
R2 = 0.56
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.02
HEF x D
R2 = 0.60
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.03
HEF x D
R2 = 0.63
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.04
HEF x D
R2 = 0.66
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.05
HEF x D
R2 = 0.69
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.06
HEF x D
R2 = 0.72
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.07
HEF x D
R2 = 0.75
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.08
HEF x D
R2 = 0.78
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.09
HEF x D
R2 = 0.80
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.10
HEF x D
R2 = 0.83
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.11
HEF x D
R2 = 0.85
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.12
HEF x D
R2 = 0.87
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.13
HEF x D
R2 = 0.89
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.14
HEF x D
R2 = 0.90
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.15
HEF x D
R2 = 0.91
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.16
HEF x D
R2 = 0.92
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.17
HEF x D
R2 = 0.93
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.18
HEF x D
R2 = 0.93
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.19
HEF x D
R2 = 0.93
tum
or c
ells
sur
viva
l fra
ction
(Gy)
UCL Brussels
k = 0.21
HEF x D
R2 = 0.93
tum
or c
ells
sur
viva
l fra
ction
(Gy)
Hb level (g/dL)
8 10 12 14 16
HE
F
0
1
2
UCL Brussels
k = 0.23
R2 optimum
Hb level (g/dL)
8 10 12 14 16
HE
F
0
1
2
R=0·94optimal HEF per patient
HEF x D