hec pmt meeting tallinn 10 july 2008 brainstorming session: what interest can there be in thinking...

HeC PMT Meeting Tallinn 10 July 2008

Brainstorming session: what interest can there be in thinking about a possible new HeC 2 project to follow-up the current one, after its end by 2009

Edwin Morley-Fletcher, Lynkeus

2 Health-e-Child, July 10th, 2008 [email protected]

ICT Work Programme

Structure:• A limited set of Challenges• Each of which is addressed through a limited

set of Objectives • That form the basis of Calls for Proposals• A total of 25 Objectives expressed within 7

Challenges


Focus on application-led challenges• New technology-based systems, products and

services that provide step-changes in the capabilities of the resulting application solution

• Evolution and interoperability of service platforms • Scale and complexity in dynamic, distributed

heterogeneous environments, including open service networks

• Advanced user-driven open innovation methodologies integrating all relevant actors in a flexible service and technology innovation ecosystem

• Standardisation, recognised as important research outcome and as visible way to promote research results


Focus on ICT tools for sustainable and personalised healthcare

• Ensuring delivery of quality healthcare at affordable costs contributing to greater efficiency of health systems

• Saving lives and resources by focusing on:• prevention and prediction of diseases • improved patient safety by optimising medical

interventions and preventing errors • Developing new ICT-based environments for

biomedical research and predictive medicine • that push the boundaries of technologies like grid

computing, modelling and simulation


Challenge 5: Towards sustainable and personalised healthcare

• Looking for changes in the way healthcare is delivered and the way medical knowledge is managed and transferred to clinical practice

• Recent capabilities of modelling, simulation and biomedical imaging, combined with the latest knowledge about diseases, give rise to a new generation of predictive medicine

• In this challenge, support will go to highly interdisciplinary research


Two Objectives within the ICT Work Programme 2009-10

• Objective ICT for Patient Safety (within Call 4)

• Objective Virtual Physiological Human(within Call 6)


Objective ICT for Patient Safety

b) ICT for integration of clinical research and clinical care

• Seamless, secure and consistent integration of clinical care information in electronic health records (EHR) with information in clinical research information systems

• Research focusing on areas improving semantic interoperability between EHR and clinical research systems

• Definition and validation of core data set enabling scalable and standardised link between clinical research systems and EHR repositories

• Leading to well defined use cases with high potential for improving patient safety

Possible budget distribution for a) and b): IP/STREP – around 30 M€ The objective is to support at least 1 IP under a) and at least 1 IP under

b) in addition to STREPs


Objective Virtual Physiological Human (1)

a) Development of patient-specific computer based models and simulation of the physiology of human organs and pathologies

• The models should be multiscale by integrating relevant aspects

of anatomy and physiology across different levels (from molecular and cellular to tissue and organ levels)

• The emphasis should be on the integration of existing models rather than on development of new models.

• The use and benefits of the models must be demonstrated for a specific clinical need covering prediction of disease and/or early diagnosis

• Any organ or pathology could be targeted as clinical application. • If an initial phase of basic clinical research or data collection is

needed it will represent less than 25% of the total effort



b) Development of ICT tools, services and specialised infrastructure for the bio-medical researchers to support at least two of the following three activities: • i) to share data and knowledge needed for a new integrative research

approach in medicine (biomedical informatics), • ii) to share or jointly develop multiscale models and simulators, • iii) to create collaborative environments supporting this highly multidisciplinary

field. • When necessary, computing power and data management could be

sought through access to existing advanced grid• New tools, services and applications will also be evaluated on their

effectiveness and their ability to interface with existing medical research infrastructures. Their targeted services will facilitate the clinical use of computer based organ and disease models as well as biomedical data

• These tools and services will complement and be compatible with existing methods and standards (terminologies, ontologies, mark-up languages)

• International Cooperation in this field is encouraged.



• Possible budget distribution for a) and b) IP/STREP – around 60 M€

• with more than 50% to IPs • with a minimum of 3 IPs including at least one

under a) and at least one under b)


HeC’s new possible goals

Establishing itself as the paediatric platform by: • Broadening and deepening its clinical

scope• Multiplying the number of paediatric

hospitals being active members of HeC• Increasing its overall technological

integration by moving from being a SOA to becoming a SOKU


Specifically with reference to call 4

Establishing HeC as the paediatric paltform also by:• Assuring advanced risk-management and

improved patient safety by checking internal hospital communication, appropriateness of procedures and prescriptions according to clinical indicators, and by making use of specific DSS tools

• Anticipating the development of EHR within paediatric hospitals by establishing common standards of electronic data input and data retrieval on HeC’s Grid platform


What does SOKU mean?• The evolution of Grid from a tool to solve compute-

and data-intensive problems towards a general-purpose infrastructure enabling complex business processes and work flows across virtual organisations spanning multiple administrative domains

• Three complementary dimensions:• an end-user perspective (simplicity of access to and use

of Grid technologies)• an architectural perspective (where the Grid is seen as a

large evolutionary system made of billions of interconnected nodes of any type)

• a software perspective (a fully programmable and customisable Grid)


David Manset’s SOKU flower


Getting ready for Call 4?

Advantages of:• Submitting a proposal for Call 4 (Patient safety),

keeping open the default solution of submitting also a proposal for Call 6 (Virtual Physiological Human) a year later, if unsuccessful in the first attempt

• Starting in time a complex decision-making process within HeC, and getting appropriate feed-back from the ICT for Health Unit of the EC, which seems willing to support HeC’s further development


When to communicate with ICT for Health Unit?

• Need to express appropriate interests in the specific definition of Call 4

• Tight timing:• Any expression of interest should be signaled in the

coming weeks• The Call is due to be issued by the Fall of 2008• The deadline for submission will be in Spring 2009

April• If successful, funding could then start in 2010


What specific clinical and technological developments should

we focus on?

• Giacomo• Martin

hec pmt meeting tallinn 10 july 2008 brainstorming session: what interest can there be in thinking...

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