heartcyc, a cardiac cycle process ontology based - ceur-ws.org
TRANSCRIPT
!"#$%&'()*#*&#$+,#(*&'(-"*.$/("00*12%/-/3'*4#0"+*,2*%5"*12%/-/3'*/6*.5'0,(0*6/$*4,/-/3'*
!"#$%&'()'*++,-./.0.'1$23"&'4"&56$2,$0.'1"78%&&'()'9%"&0.':+;%'()<)'1%=$#+/.':+3#'>)'4%##"?$0'
'-!%@"?AB%#A'+C'D3E;$+&+FE'G'H$+@3E;$2;'
/!%@"?AB%#A'+C'H$+&+F$2"&'IA?J2AJ?%'0!$K$;$+#'+C'H$+B%5$2"&'"#5'>%"&A3'L#C+?B"A$2;'
I23++&'+C'1%5$2$#%.'M#$K%?;$AE'+C'N";3$#FA+#.'I%"AA&%.'NO.'MIO'
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
:"';/$+0U'T#A+&+FE.'Q$+@3E;$2;.'A3%?B+5E#"B$2;.'@?+2%;;%;.'2"?5$"2'2E2&%'
<***=2%$/+>(%,/2*
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
83$23' A3%' 3%"?A' 5%2?%";%;' $#' K+&JB%' $#' "'23"?"2A%?$;A$2'8"E'A+'@?+@%&'Q&++5'A3?+JF3'A3%'
';A"A%B%#A'5%;2?$Q%;';+B%'+22J??%#2%;' 5J?$#F' 2"?5$"2' 2+#A?"2A$+#.' $A'&"2,;'A3%'5%A"$&.';A?J2AJ?%.'"#5'?$F+?'+C'@?+2%;;',#+8&%5F%' C+?B"&&E' %#2+5%5' $#' _J"#A$A"A$K%'B"A3%B"A$2"&' B+5%&;' +C' 2"?5$"2' B%23"#$2;'"#5'Q&++5'C&+8'V%)F).'Y`R-aZW)'TJ?'F+"&'3";'Q%%#'A+'5%K%&+@';%B"#A$2;'"#5'+#A+&+F$2"&'B%A3+5;'QE' 83$23' A3%' Q$+@3E;$2"&' 2+#A%#A' +C' ;J23'B+5%&; A3%'@3E;$2"&'@"?A$2$@"#A;.'J#5%?&E$#F'Q$+@3E;$2;.' "#5' @?+2%;;' ,#+8&%5F% 2"#' Q%'B"5%'"K"$&"Q&%'$#'&+F$2"&'C+?B)'P+'5%K%&+@'"#5'A%;A' A3%;%' B%A3+5;.' 8%' 3"K%' 3%?%A+C+?%.'C+2J;%5' +#' "##+A"A$#F' "#5' B%?F$#F'Q$+;$BJ&"A$+#'B+5%&;'Yb.'--.'-/Z.'B+;A'?%2%#A&E'$#' A3%'2+#A%7A'+C' A3%'XJ?+@%"#'M#$+#'<$?AJ"&'D3E;$+&+F$2"&' >JB"#' @?+=%2A' V<D>' Y-0ZW "'&"?F%R;2"&%.' $#A%?#"A$+#"&' %CC+?A' A+' $#A%F?"A%'"#5' 2+##%2A' Q$+B%5$2"&' 5"A"' 8$A3' Q$+R;$BJ&"A$+#'B+5%&;)'
*
*
!"! #$%&'()$%!*+,!! -+.&/&01)*/!233(&*)4!
"56!7&8*1+!9+&:/$,0$;!! <1&34=%1)%!&>!.4$!?*(,1*)!?=)/$!!
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
4*&$"''"'# ,'# ,2("2+"+# (&# 5"2"*).,?"# (&# )..#'4)(,&("34&*).# '$)."';# ="# %"*"# +"'$*,1"# &/*#@")*(A-$# &2(&.&5-# (%)(# "2$&+"'# (%"# ("34&*).#$%)25"'# ,2#4%-',$).#4*&4"*(-#<)./"#+/*,25# (%"#
!,55"*'#+,)5*)3#B9,5/*"#CD7#
"5"!@$*(.?=)!A83/$8$+.*.1&+!! *+,!B&'()$!-+.&/&01$%!
@")*(A-$# ,'# "2$&+"+# ,2# E!FC# /',25# (%"#G*&(H5H# I7C# &2(&.&5-# "+,(&*7# !"# %)<"#,34."3"2("+# (%"# @")*(A-$# &2(&.&5-# /',25#$.)''"'# )2+# *".)(,&2'# 6*&3# (%*""# '&/*$"#&2(&.&5,"'J#
8%"#E2(&.&5-# &6# G%-',$'# 6&*# K,&.&5-# BEGK#LCC;#CIMD#4*&<,+"'# (%"#*&&(#$.)''"'# (%)(#)*"#":("2+"+# (&# "2$&+"# @")*(A-$# $.)''"'# (%)(#)*"# '4"$,6,$# (&# (%"# $)*+,)$# $-$."# /'"0$)'"7#
4*"6,:7# @")*(A-$# '/1$.)''"'# (%)(# ":("2+#EGK# #
8%"#9&/2+)(,&2).#N&+".#&6#>2)(&3-#B9N>#LI;# COMD# ,'# (%"# '&/*$"# &6# )2)(&3,$).#'(*/$(/*).# P2&=."+5"# &6# (%"# %")*(# )2+#(%&'"# 4)*('# (%)(# 4)*(,$,4)("# ,2# (%"# $)*+,)$#$-$."7#9N>#$.)''"'#$)**-#)2# #
8%"# Q".)(,&2# E2(&.&5-# BQE# LCRMD;# )2+# (%"#!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
C##8"$%2,$)..-;# (%"*"# )*"# '&3"# $%).."25"'# (&#*"4*"'"2(,25# (%,'# P2&=."+5"# ,2# E!F0SF7# 8%"'"#("$%2,$).# +"(),.'# )*"# &/(',+"# (%"# '$&4"# &6# (%,'#4)4"*;#)2+#&*(%&5&2).#(&#&/*#)*5/3"2(7#
!
!!"#$%&'()!"!#$%%&'(!)$*%'*+!%'*,-$.*//0!'&,'&(&12(!2-&!.*')$*.!.0./&!*(!.34/)!5&!'&.3')&)!)4'$1%!*!,-0($3/3%$.*/!&6,&'$+&127!*(!.3+,42&)!50!*!5$3($+4/*2$31!+3)&/7!3'!*(!&6,/*$1&)!23!*!(24)&128!95(&':*5/&!,-0($.*/!,'3,&'2$&(!*'&!/*5&/&)!31!2-&!'$%-2!;<$2-!.*/$5'*2&)! (.*/&(! 31! 2-&! /&= >
>/$%-2&)!*(!)$(.4((&)!$1!2-&!2&628!
!
!"!# $%&'())# !*+&,&-.# /0123# 4%&567(#)+8*78%769(7# %(,8+6&*)# ):';# 8)# %&<!"#$%&'(#%&<)"*%!"#$+,+!"-$3# 8*7# %&<!#.,././%01# +&#(*'&7(# %(,8+6&*)# =(+>((*# &*+&,&-.# ',8))()?#
4%(@6A?#
!"" #$%&'()*+",-".-'/0/1)"" /2"'3$"(%&45%*"()*0$"
B&# 6*+%&7:'(# +;(# C(8%+D.'# &*+&,&-.3# >(#7()'%6=(# @&:%# E(.# 8)4('+)# &@# &:%#%(4%()(*+8+6&*8,# 844%&8';# +&# @(8+:%()#76)4,8.(7# 6*# +;(# F6--(%)# 768-%8G?# 2+#*$3# >(#7()'%6=(#&=)(%58=,(#4;.)6'8,#4%&4(%+6()#):';#8)#
3.,&-/3#>(#7()'%6=(#+(G4&%8,#4)+#/3#
>(#7()'%6=(#)+8+(# +%8H('+&%6()#8*7#)+8+(#(5(*+)#+;8+# 8%(# '%&))I4%&7:'+)# &@# 4%&4(%+6()# 8*7#+(G4&%8,# 6*+(%58,)?#5"*$613# >(# 7(@6*(# 7.*8G6'#4%&'())()# 8)# +;(%G&7.*8G6'# (*+6+6()# +;8+# 8%(#G8*6@()+(7#=.#)+8+(#+%8H('+&%6()#8*7#(5(*+)?#F(#76)':))#;&>#+;6)#844%&8';#-(*(%8,69()#+&#&+;(%#4%&'())# 7&G86*)# 8*7# ;&># 6+# ):44&%+)# +;(#+(G4&%8,# 8*7# )+%:'+:%8,# 7('&G4&)6+6&*# &@#4;.)6'8,#4%&'())()?#
!67"8&/9$&'5$:"/2"83):5*%0";-'5'5$:"'3%'"8%&'5*59%'$"5-"'3$"(%&45%*"()*0$"
B;(#@6%)+#+8)E#6)#+&#(*'&7(#8#C(8%+D.'#',8))#@&%#(8';#&@#+;(#4;.)6'8,#4%&4(%+6()#+;8+#8%(#*8G(7#8,&*-#+;(#%6-;+#;8*7#)67(#&@#+;(#768-%8G?#J8';#):';#4%&4(%+.# 6)#8# ):=',8))#&@#!$"<71-"8+,"69!#&!.#$1# +;8+# 6)#%(,8+(7# +#4;.)6'8,#(*+6+.#=.#8*#!$"<!)1*+,"6%!#&!.#$1%&'#%(,8+6&*?#J*'&76*-#
(A8G4,()3#>(#;85(#K);&>*#8)#LMN#+%64,()O<#PQ;(8%+D.'<$%()):%(#&@#=,&&7#6*#8&%+8R#Q%7@)<):=D,8))!@R#############Q&4=<N,:67#4%()):%(RS#PQ;(8%+D.'<$%()):%(#&@#=,&&7#6*#8&%+8R#Q&4=<4;.)6'8,T4%&4(%+.T&@R#############Q@G8<",&&7#6*#8&%+8RS#
PQ;(8%+D.'<J,('+%&'8%76&-%8G#4&+(*+68,R#Q%7@)<):=D,8))!@R#############Q&4=<J,('+%6'8,#4&+(*+68,RS#PQ;(8%+D.'<J,('+%&'8%76&-%8G#4&+(*+68,R#Q&4=<4;.)6'8,T4%&4(%+.T&@R#############Q@G8<"&7.#):%@8'(RS#
M:%6*-#+;(#'8%768'#'.',(#4;.)6'8,#4%&'())()#;85(# '(,,:,8%# 8*7# G&,(':,8%# 48%+6'648*+)# @&%#>;6';# +;(%(# 6)# *&# )6*-,(# NUV# ',8))?# N&%#
(A8G4,(3# 8# G:,+6)'8,(# F6--(%)# 768-%8G# '&:,7#WW# '&*'(*+%8+6&*# &@#
5(*+%6':,8%#G.&'.+( #8)#8#4;.)6'8,#4%&4(%+.#K8*#&4=<:).8+,"69 ,&-,.-$#"$+&-O# +;8+# G:)+# =(#'&G4&)(7# @%&G# ',8))()# 6*# &+;(%# =6&G(76'8,#&*+&,&-6()# :)6*-# L!# )+%:'+:%8,# %(,8+6&*)?# F(#
#/0X2?#M.*8G6'8,# 4%&4(%+6()# 8%(# *&+3# &@# '&:%)(3#
6*7(4(*7(*+#&@#(8';#&+;(%?#L8+;(%3#+;(6%#58,:()#';8*-(# 8''&%76*-# +&# 4;.)6'8,# ,8>)?# N&%#(A8G4,(3# +;(# 4%()):%(# 8*7# 5&,:G(# &@# +;(# ,(@+#5(*+%6',(#7(4(*7#:4&*#(8';#&+;(%#8''&%76*-#+#
@,&># %8+(# 7(4(*7)# &*# +;(# 5(*+%6':,8%Y8&%+6'#4%()):%(# 76@@(%(*'(# 8*7# +;(# 58,
F(#;85(#7(5(,&4(7#8*7#:)(#)(G8*+6'#G(+;&7)#KZ(G[(*# /\3# 0]2O# @&%# (*'&76*-# ):';# 4;.)6'8,#4%&4(%+6()# 8*7# 7(4(*7(*'6()# 8)# )(G8*+6'#*(+>&%E)# +;8+# '8*# =(# 7('&G4&)(7# 8*7#%('&G4&)(7#8''&%76*-#+.)6'8,#4%6*'64,()?###
^*#8776+6&*#+&#=6&4;.)6'8,#7('&G4&)6+6&*3#8)#8=&5(3# 4%&4(%+6()# G8.# =(# 7('&G4&)(7# K&%#'&G4&)(7O# @%&G# &+;(%# 4%&4(%+6()# 8''&%76*-# +&#)+%:'+:%8,# E*&>,(7-(# (*'&7(7# 6*# +;(# NUV?#B;:)3# &*(# '&:,7# _:(%.# 8*# (A+(*7(7#C(8%+D.'3#@&%#(A8G4,(3#+L)'&5(%#+;8+#8#4%&4(%+.#&@# +;(#,(@+# 5(*+%6':,8%# >8,,# 6)# 8,)&# 8# 4%&4(%+.# &@# +;(#
+8A&*&G.?#
!6<""=$>9/&%0"?-'$&@%0:"'3%'".**A&"" BA&5-1"'3$"(%&45%*"()*0$""
B;(#*(A+#)+(4#@&%#C(8%+D.'#6)#+&#(*'&7(#',8))()#@&%#(8';# +(G4&%8,# 6*+(%58,#
XO# 8)# ,8=(,(7# 8+# +;(# +&4# 8*7# =&++&G# &@#
M68)+&,(5(*+%6',(# %8+;(%# +;8*# &@# +;(# %6-;+# 5(*+%6',(3# &%#&@#
'.',(#6*+(%58,#K).)+&,(#W#768)+&,(O#>(#'8*#(*'&7(#8#):=):G4+6&*#;6(%8%';.<##!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
"!!#!$%&'())!*(+,+-!./0.(!&$(121,3!4/5!6(!4&7(0(7!&1!&1(!824(9)'/0(!/)!&'':%%21,!21!/!8(4$&%/0!21)8/18-!5(8!4/5!6(!4&7(0(7!&1!/1&8;(%!824(9)'/0(!/)!&'':%%21,!21!/!8(4$&%/0!218(%./0+!!
!"#$!"#$%&'()"*+,+-%! !"#$!"#$%&'(),*+"&.'(%
&'()*+,-$/0)1-1+%("),*+"&.'(%%&'()*+,-$/0)2,'1+%("),*+"&.'(%&'()*+,-$3"'&+)4-4("),*+"&.'(%%
.--!)/012% *!% 3024)'% 56% *'7"!)(8% 01*')9(8:%;!"#$!"#$%&'() ,*+"&.'(<% ()'% /'7()-(*'/% (1/%#!41/'/% #,% *'7"!)(8% 01:*(1*:% ;!"#$!"#$%&'(),*1+'*+
% =>%
;(1/% ?0(:*!8'% #'201:<% (*% *&'% 01:*(1*% *&(*% *&'%
&'()*+,-$56070'(."8(%1"1),*1+'*+%(1/%&'()*+,-$%5%&+,40'(."8(%1"1) ,*1+'*+% (:% :4#-8(::':% !@%!"#$!"#$%&'(),*1+'*+A%%
B&'% *'7"!)(8% )'8(*0!1:% !@% *&':'% 01*')9(8:%(1/% 01:*(1*:% -(1% #'% '1-!/'/% #,% :*)4-*4)(8%)'8(*0!1:% *!% '1-!/'% *&'%"()*=C&!8'% )'8(*0!1:%!@%*&'%01*')9(8:$%
DE&'()*+,-$3"'&+)4-4("),*+"&.'(9):)!$;'17$'&+9))))))))):%&'()*+,-$/0)1-1+%("),*+"&.'(FG%DE&'()*+,-$3"'&+)4-4("),*+"&.'(9):)!$;'17$'&+9)))))))):%&'()*+,-$/0)2,'1+%("),*+"&.'(FG%
H1*')9(8:% (1/% 01:*(1*:% -(1% #'% *'7"!)(88,%!)/')'/% 4:012% *&'% IJK% )'8(*0!1%!"#$+"#$%&'((-7$&"4"2"1% :!% *&(*6% @!)% 'L(7"8'6%
*'7"!)(8% #!41/(),%%
DE&'()*+,-$/0)1-1+%("),*+"&.'(9):!"#$+"#$%&'((-7$&"4"2"19%%%%%%%%E&'()*+,-$5%&+,40'(."8(%1"1),*1+'*+FG%DE&'()*+,-$5%&+,40'(."8(%1"1),*1+'*+9%E!"#$+"#$%&'((-7$&"4"2"19%%%%%%%%E&'()*+,-$/0)2,'1+%("),*+"&.'(FG%B&'% '1-!/012% !@% *'7"!)(8% 01:*(1*:% (1/%
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
01*')9(8:%(1/%01:*(1*:A%3!)%'L(7"8'6%")'7(*4)'%9'1*)0-48()% -!1*)(-*0!1% ;J>+<% 0:% (% 9'1*)0-48()%:,:*!8'%*&(*%!--4):%")0!)%*!%(*)0(8%:,:*!8'A%
!
"#"!$%&'()*+%,(-!&%(!.%+--/0%+12)*-!+3!0%+4(%*,(-!&51!$(64+%&7!85*,*,(-!
B&'%9(84':%!@% (%"&,:0-(8% ")!"')*,% ;'A2A6% 9(84':%
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
%
!!"#$%&'(!"#$%&"'()*+$'','"-."/012!"#$%&'()*+,&-$$)-./%/#0"
!!!"#$%&'()*+,$%-.*/((/($+-/$
0&/-1.2'3+1)*$435)5)/($
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
B7-!$02),$#+3+! 3+! ,$%,! ,$#-()'0*%(31+4! %!+#,! )>! 2$0+31%5! 2-3*1325#+! ,$%,! ,-%*+1#*'!+2%,3),#(2)-%5! +1%5#+! %*'! 2$0+31%5! ')(%3*+4!2-)&3'#+! %! 7*3>03*8! >-%(#;)-<! >)-! >)-(%550!'#>3*3*84! C7%*,3>03*84! %*'! #*1)'3*8! ?3)5)831%5!'0*%(31%5! 2-)1#++#+9! D$7+4! ;#! 2-)2)+#! ,)!'#>3*#! )2?E!"#$%&'$() *+,'-..!1)*,-)54! ,-%*+>)-(%,3)*4! )-! '3++32%,3)*! )>!,$#-()'0*%(31! #*#-80! ;3,$3*! )-! ?#,;##*!2%-,3132%,3*8! #*#-8#,31! 2$0+31%5! #*,3,3#+!
2)+3,+! ,$%,! ,$#! )117--#*1#! )>! ?3)5)831%5!2-)1#++#+! 3+! *#1#++%-350! %,,#*'#'! ?0! ,$#! >5);!%*'! '3++32%,3)*! )>! ,$#-()'0*%(31! #*#-80! FGH4!IJK!,$%,!%-#!'#+1-3?#'!?0!,$#!5%;+!%*'!%A3)(+!)>! 15%++31%5! 2$0+31+9! L+! +$);*! ?0! M387-#! N4!,$#+#!3'#%+!%-#!1%2,7-#'!3*!,$#!BOP!+1$#(%!>)-!?3)5)831%5!2-)1#++#+!,$%,!-#5%,#+!,$#!'0*%(31%5!
2-)2#-,3#+! )>! 2$0+31%5! #*,3,3#+! ,)! 2-)1#++!2-)2#-,3#+! ,$%,! %-#! ,$#! #*#-80! >5);! -%,#+! ,$%,!)117-! '7-3*8! %! 2-)1#++! '7#! ,)! 1$%*8#+! 3*!'0*%(31%5!2-)2#-,0!&%57#+9!!
D$#! 1%-'3%1! 1015#! 15#%-50! C7%53>3#+! %+! %*!)2?E!"#$%&'$() *+,'-..! ?#1%7+#! 3,+! ?3)5)831%5!2%-,3132%*,+! Q,$#! $#%-,4! 3,+! 2%-,+4! %*'! ,$#3-!1)*,#*,+R! 2%-,3132%,#! 3*! %*! )&#-%55! 1%-'3%1!1)*,-%1,35#!2-)1#++!,$%,!3*157'#+!%!+#,!)>!53*<#'!2-)1#++#+E!
,$#!/+$#.0,+%$/&,#!)>!(0)1%-'3%5!1$#(31%5!#*#-80!3*,)!(0)1%-'3%5!(#1$%*31%5!+,-%3*!#*#-804!!,$#!/+$#.0,+%$/&,#!)>!(0)1%-'3%5!+,-%3*!#*#-80!3*,)!>573'!2-#++7-#!#*#-80!)>!&#*,-3175%-!?5))'4!%*'!!,$#!/+$#.0,+%$/&,#!)>!&#*,-3175%-!>573'!2-#++7-#!#*#-80!3*,)!<3*#,31!#*#-80!)>!%)-,31!?5))'!>5);9!!D$#-#! %-#! +#&#-%5! %22#%5+! ,)! ,$3+!
,$#-()'0*%(31! $02),$#+3+9! M3-+,4! 3,! 03#5'+! ,)!3*,73+#-&#! ;#55! >)-! #*&3+3)*3*8! %*'! #*1)'3*8!2-)1#++#+! 0#,! #%1$! +71$! 2-)1#++! 1%*! ?#!-38)-)7+50!'#>3*#'!%*'!C7%*,3,%,32!&%53'%,#'!>)-! '%,%! +#,+! %*'! ?3)+3(75%,3)*+9! =#1)*'4!
2-)1#++#+! ,$%,! %2253#+! %+! ;#55! ,)! 1$#(31%5!<3*#,31!+0+,#(+!%+!,)!(#1$%*31%5!%*'!>573'!>5);!+0+,#(+9! D$3+! )>>#-+! %! -#'71,3)*! 3*! 1)(25#A3,0!?0! 1)(?3*3*8! ,$#! &%57#+! )>! ')(%3*@+2#13>31!2$0+31%5! 2-)2#-,3#+! 3*,)! %! 1)(()*! C7%*,3,04!#*#-804! ,$%,! -#>5#1,+! ,$#! ,$#-()'0*%(31! +,%,#!
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
!
!"# $%!&'((# $)%*+&+$),*(-# ./+%01# 2'&)3('# ','%45#+(# )# &!,('%6'0# 73),*+*51# !,'# &),# *%)&'# */'#'""'&*(# !"# !,'# $%!&'((1# ()5# 85!"+2%+99)%#&!,*%)&*+!,1# */%!34/# &!8$9':# (5(*'8(# *!#0'*'%8+,'# '""'&*# !,# !*/'%# ',*+*+'(1# (3&/# )(#6',*%+&39)%#29!!0#"9!; #
!"""#$%%&'("&)*"+,-.$--,/)"
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
<'# "3%*/'%# 0+(*+,43+(/# *+,*-+/%-$1#/+'0-&/,+%-$1# ),0# %./-+1'($# *!# 2'#
$%!&'(('(# */'8('96'(-# E)*/'%1# ;'# $!(+*# */'#,''0# "!%# )# 3,+"5+,4# */'!%5# !"# 2+!9!4+&)9#$%!&'(('(#),0#$%!$!('#*/'%8!05,)8+&(#)(#*/)*#*/'!%5-# F5# 0'"+,+,4# $/5(+&)9# $%!&'(('(# )(# */'#&!,6'%(+!,# ),0# )&&3839)*+!,# !"#*/'%8!05,)8+&#','%45#G"!%#;/+&/#*/'#*'8$!%)9#*%)B'&*!%+'(# )%'# 4!6'%,'0# 25# */'# 9);(# ),0#0'"+,+*+!,(#!"#&9)((+&)9#$/5(+&(H#;'#&),#&!,,'&*#2+!8'0+&)9#$%!&'((#!,*!9!4+'(#*!#)#%+&/#9'4)&5#!"#$%+!%# ;!%@# +,# $/5(+&(I2)('0# 8)*/'8)*+&)9#8!0'9(#!"#2+!9!4+&)9#$%!&'(('(-#
0121'1).1-"
J-# K'4*5)%',@!1#L-1#0'#M)*!(1#D-1#N,,+(1#M-1#>)(*+,4(1#O-1# P2+,0',1# M-1# M&Q)34/*1# R-1# '*# )9-1# ?/NFSA# )#0)*)2)('# ),0# !,*!9!45# "!%# &/'8+&)9# ',*+*+'(# !"#2+!9!4+&)9# +,*'%'(*-#Q3&9'+&#R&+0(#E'(1)TUGK)*)2)('#+((3'H1#KTVVITWX1#YXXZ-#
Y-# [,+"+'0#M'0+&)9#\),43)4'#]5(*'81#/**$A^^;;;-,98-,+/-4!6^%'(')%&/^389(^#
T-# ]Q_MNK#?.1#/**$A^^;;;-+/*(0!-!%4^(,!8'0I&*^#V-# `!3,0)*+!,)9#M!0'9#!"#R,)*!851#
/**$A^^(+4-2+!(*%-;)(/+,4*!,-'03^$%!B'&*(^"8^#W-# E'&*!%1#R-\-1#E!4'%(1#O-N-1#P),(*%)1#D-N-1#a#C),#K'%#
>)%+,41# N-1# _$',bR\NQA# !$',# (!3%&'# 8'0+&)9#*'%8+,!9!45# ),0# *!!9(-# RMSR# R,,3# ]58$# D%!&1#cZY1#YXXT-#
U-# \';+(1#]-N-1#b','#_,*!9!45A#9!!@+,4#2)&@;)%0(#),0#"!%;)%0(-#b',!8'#F+!91)UGJH1#JXT1#YXXW-#
d-# L'%&@/!""(1# E-?-1# Q')91# M-\-1# b31# e-1#F)((+,4*/;)+4/*'1#O-F-1#_8',(1#O->-1#a#M&?399!&/1#R-K-1# ?!3$9+,4# !"# )# TK# "+,+*'# '9'8',*# 8!0'9# !"#&)%0+)&# 6',*%+&39)%# 8'&/),+&(# *!# 938$'0# (5(*'8(#8!0'9(# !"# */'# (5(*'8+&# ),0# $398!,+&# &+%&39)*+!,-#R,,#F+!8'0#N,41)TWGJH1#JIJZ1#YXXd-#
Z-# M&?399!&/1#R-K-1#M!0'9+,4#*/'#/38),#&)%0+!8'#+,#(+9+&!-#O#Q3&9#?)%0+!91)dGWH1#VcUIVcc1#YXXX-#
c-# Q')91# M-\-1# F)((+,4*/;)+4/*'1# O-F-1# ]32B'&*I($'&+"+&# 8!0'9# '(*+8)*+!,# !"# &)%0+)&# !3*$3*# ),0#29!!0#6!938'#03%+,4#/'8!%%/)4'-#?)%0+!6)(&#N,41)dGTH1#cdIJYX1#YXXd-#
JX-# Q!29'1#K-1#M!0'9+,4# */'#/')%*II"%!8#4','(# *!# &'99(#*!#*/'#;/!9'#!%4),-#]&+',&'1)YcWGWWUXH1#JUdZIJUZY1#YXXY-#
JJ-# C+%*3)9#D/5(+!9!4+&)9#>38),#Q'*;!%@#!"#N:&'99',&'1#/**$A^^;;;-6$/I,!'-'3^#
JY-# ?!!@1# K-\-1# M'B+,!1# O-\-1# Q')91# M-\-1# a# b',,)%+1#O->-1# F%+04+,4# 2+!9!4+&)9# !,*!9!4+'(# ),0#2+!(+839)*+!,A#*/'#_,*!9!45#!"#D/5(+&(#"!%#F+!9!45-#RMSR#R,,3#]58$#D%!&1#JTUIJVX1#YXXZ-#
JT-# _,*!9!45#!"#D/5(+&(#"!%#F+!9!451#/**$A^^2+!$!%*)9-2+!!,*!9!45-!%4^!,*!9!4+'(^VVZdY#
JV-# `!3,0)*+!,)9#M!0'9#!"#R,)*!851#/**$A^^(+4-2+!(*%-;)(/+,4*!,-'03^$%!B'&*(^"8)^%'9')('^+,0':-/*89#
JW-# E!(('1# ?-1# M'B+,!1# O-\-C-1# O%-1# GYXXdH-# ./'#`!3,0)*+!,)9# M!0'9# !"# R,)*!85# _,*!9!45-# S,# R-#F3%4'%1#K-#K)6+0(!,#a#E-#F)90!&@#GN0(-H1#2.'/,3#)4./,(,5%-$) 6,+) 7%,%.6,+3'/%&$8) !+%.&%*(-$) '.9)!+'&/%&-#G$$-#WcIJJdH-#Q';#f!%@A#]$%+,4'%-#
JU-# ]8+*/1# F-1# ?'3(*'%(1# <-1# L9)44'(1# F-1# L!/9'%1# O-1#L38)%1#R-1#\!8):1#O-1#'*#)9-1#E'9)*+!,(#+,#2+!8'0+&)9#!,*!9!4+'(-#b',!8'#F+!91)UGWH1#EVU1#YXXW-#
Jd-## _=4!60'# R-1# b%3,+,4'%# M-1# GYXJXH# `!3,0)*+!,)9#D%!&'((#E'9)*+!,(# +,#F+!I_,*!9!4+'(-# S,A#b)9*!,#R1#M+=!43&/+# E1# '0+*!%(-# `!%8)9# _,*!9!45# +,#S,"!%8)*+!,#]5(*'8(A#S_]#D%'((-#
JZ-# b',,)%+1# O->-1#Q')91#M-\-1#b)90=+&@+1#M-1#a#?!!@1#K-\-1# M39*+$9'# !,*!9!4+'(# +,# )&*+!,A# ?!8$!(+*'#),,!*)*+!,(# "!%# 2+!(+839)*+!,# 8!0'9(-# O# F+!8'0#S,"!%81)VVGJH1#JVUIJWV1#YXJJ-#
Jc-# b',,)%+1# O->-1#Q')91#M-\-1#?)%9(!,1#F-N-1#a#?!!@1#K-\-1# S,*'4%)*+!,# !"# 839*+I(&)9'# 2+!(+839)*+!,#8!0'9(# 6+)# 9+4/*I;'+4/*# ('8),*+&(-# D)&# ]58$#F+!&!8$3*1#VJVIVYW1#YXXZ-#
YX-# Q')91#M-\-1#b',,)%+1# O->-1#R%*(1#.-1#a#?!!@1#K-\-1#R06),&'(#+,#('8),*+&#%'$%'(',*)*+!,#"!%#839*+(&)9'#2+!(+839)*+!,A#)#&)('#(*305#+,#8'%4+,4#8!0'9(-#D)&#]58$#F+!&!8$3*1#TXVITJW1#YXXc-#
YJ-# D')&!&@'1# R-E-1# GJcZTH-# 2.) %./+,9:&/%,.) /,) /"-)*"#$%&'() &"-3%$/+#) ,6) ;%,(,5%&'() ,+5'.%<'/%,.-#_:"!%01#[LA#?9)%',0!,#D%'((-#
YY-# D'%'9(!,1# R-]-1# Q'*;!%@# */'%8!05,)8+&(-# R,#!6'%6+';-#F+!$/5(#O1)JWGdH1#UUdIUZW1#JcdW-#