heart failure / cardiac failure

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Heart Failure Heart Failure Dr. Fuad Farooq Dr. Fuad Farooq Consultant Cardiologist Consultant Cardiologist The most common reason for hospitalization in adults >65 years old.

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Page 1: Heart failure / cardiac failure

Heart FailureHeart FailureDr. Fuad FarooqDr. Fuad Farooq

Consultant CardiologistConsultant Cardiologist

The most common reason for hospitalization in adults >65 years old.

Page 2: Heart failure / cardiac failure

• Heart Failure-Heart Failure- Clinical syndrome … can result from Clinical syndrome … can result from any structural or functional cardiac disorder that impairs any structural or functional cardiac disorder that impairs ability of ventricle to fill with or eject bloodability of ventricle to fill with or eject blood

• Impact!Impact!– 5 million Americans- have heart failure

– 500,000 new cases every year

– 25-50 billion dollars a year to care for people with HF

– 6,500,000 hospital days / year and 300,000 deaths/year6,500,000 hospital days / year and 300,000 deaths/year

Page 3: Heart failure / cardiac failure

Heart FailureHeart FailureDefinitionDefinition

• It is the pathophysiological process in which the heart as a pump is unable to meet the metabolic requirements of the tissue for oxygen and substrates despite the venous return to heart is either normal or increased

Page 4: Heart failure / cardiac failure

Heart FailureHeart FailureKey ConceptsKey Concepts

• Cardiac output (CO) = Stroke Volume (SV) x Heart Rate (HR)– Becomes insufficient to meet metabolic needs of body

• SV – determined by preload, afterload and myocardial contractility

• Ejection Fraction (EF) (need to understand)

• Classifications HFClassifications HF– Systolic failure – decrease contractility

– Diastolic failure – decrease filling

– Mixed

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PreloadPreload

• Volume of blood in ventricles

at end diastole

• Depends on venous return

• Depends on compliance

AfterloadAfterload• Force needed to eject blood into

circulation

• Depends upon arterial BP,

pulmonary artery pressure

• Valvular disease increases

afterload

Factors Effecting Heart Pump Factors Effecting Heart Pump Effectiveness Effectiveness

Page 8: Heart failure / cardiac failure

Ejection Fraction (EF)Ejection Fraction (EF)

• One of the measurements used by physicians to assess how well a patient’s heart is functioning

• “Ejection” refers to the amount of blood that is pumped out of the heart’s main pumping chamber during each heartbeat

• “Fraction” refers to the fact that, even in a healthy heart, some blood always remains within this chamber after each heartbeat

• An ejection fraction is a percentage of the blood within the chamber that is pumped out with every heartbeat

• Normal EF = 55 to 75 percent

Page 9: Heart failure / cardiac failure

90ml/140ml = 64% (EF 55-65% normal)

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Keys To Understanding HFKeys To Understanding HF

• All organs (liver, lungs, legs, etc.) return blood to heart

• When heart begins to fail/ weaken unable to pump blood forwardfluid backs up Increase pressure within all organs

• Organ responseOrgan response– LUNGS:LUNGS: congested increase effort to breathe fluid starts to escape

into alveoli (pulmonary edema) fluid interferes with O2 exchange (hypoxia) aggravates shortness of breath

– Shortness of breath during exertion may be early symptoms progresses later require extra pillows at night to breathe (orthopnea) and experience "P.N.D." or paroxysmal nocturnal dyspnea

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• LEGS, ANKLES, FEET: LEGS, ANKLES, FEET: blood from feet and legs back-up of fluid and pressure in these areas, as heart unable to pump blood as promptly as received increase fluid within feet and legs (pedal/dependent edema) and increase in weight

Keys To Understanding HFKeys To Understanding HF

Page 12: Heart failure / cardiac failure

Heart FailureHeart Failure

Page 13: Heart failure / cardiac failure

Heart FailureHeart Failure EtiologyEtiology

• Systolic Failure Systolic Failure - most common – Hallmark finding: Decrease in left ventricular ejection

fraction <40% (EF)• Due to

– Impaired contractile function (e.g., MI)– Increased afterload (e.g., hypertension)– Cardiomyopathy– Mechanical abnormalities (e.g., valve disease)

Page 14: Heart failure / cardiac failure

Heart FailureHeart Failure EtiologyEtiology

Diastolic failureDiastolic failure– Impaired ability of ventricles to relax and fill during diastole

decrease stroke volume and CO

– Diagnosis based on presence of pulmonary congestion, pulmonary hypertension, ventricular hypertrophy

– Normal ejection fraction (EF)- Know why!

Not have much blood to ejectNot have much blood to eject

Page 15: Heart failure / cardiac failure

Heart FailureHeart Failure EtiologyEtiology

• Mixed systolic and diastolic failureMixed systolic and diastolic failure– Seen in disease states such as dilated cardiomyopathy (DCM)

– Poor EFs (<35%)

– High pulmonary pressures

• Biventricular failure Biventricular failure – Both ventricles may be dilated and have poor filling and

emptying capacity

Page 16: Heart failure / cardiac failure
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Heart Failure Heart Failure PathophysiologyPathophysiology

A.A.Cardiac compensatory mechanismsCardiac compensatory mechanisms

1. Tachycardia

2. Ventricular dilation - Frank Starling’s law

3. Myocardial hypertrophy

Page 18: Heart failure / cardiac failure

B.B. Homeostatic Compensatory MechanismsHomeostatic Compensatory MechanismsActivation of Sympathetic Nervous System (First line)1. In vascular system resulting in vasoconstriction

(What effect on afterload?)2. Kidneys

i. Decrease renal perfusion Renin angiotensin release

ii. Aldosterone release Na and H2O retention3. Liver

i. Stores venous volume causing ascites, hepatomegaly

Heart Failure Heart Failure PathophysiologyPathophysiology

Page 19: Heart failure / cardiac failure

• Increase Na release of Anti diuretic hormone

(ADH)

• Release of atrial natriuretic factor (ANP) and BNP

Na and H20 excretion

– Thus PreventsPrevents severe cardiac decompensation

Heart Failure Heart Failure PathophysiologyPathophysiology

Counter Regulatory ResponseCounter Regulatory Response

Page 20: Heart failure / cardiac failure

Heart FailureHeart FailurePathophysiologyPathophysiology

– Neurohormonal responses:Neurohormonal responses: Endothelin - stimulated by

ADH, catecholamines, and angiotensin II

• Arterial vasoconstriction

• Increase in cardiac contractility

• Hypertrophy

Counter Regulatory ResponseCounter Regulatory Response

Page 21: Heart failure / cardiac failure

Heart FailureHeart Failure PathophysiologyPathophysiology

– Neurohormonal responsesNeurohormonal responses: Proinflammatory cytokines (e.g., tumor necrosis factor)

• Released by cardiac myocytes in response to cardiac injury

• Depress cardiac function cardiac hypertrophy, contractile dysfunction, and myocyte cell death

Counter Regulatory ResponseCounter Regulatory Response

Page 22: Heart failure / cardiac failure

Heart FailureHeart Failure PathophysiologyPathophysiology

– Neurohormonal responses: Neurohormonal responses: Over time systemic

inflammatory response results

• Cardiac wasting

• Muscle myopathy

• Fatigue

Page 23: Heart failure / cardiac failure

Heart FailureHeart Failure PathophysiologyPathophysiology

– Natriuretic peptides: atrial natriuretic peptide (ANP) and b-type natriuretic peptide (BNP)

• Released in response to increase in atrial volume and ventricular pressure

• Promote venous and arterial vasodilation, reduce preload and afterload

• Prolonged HF depletion of these factors

Counter Regulatory ResponseCounter Regulatory Response

Page 24: Heart failure / cardiac failure

• Consequences of compensatory mechanismsConsequences of compensatory mechanisms• Ventricular dilation: Ventricular dilation: Enlargement of heart chambers elevated left

ventricular pressure initially effective adaptive mechanism then mechanism inadequate cardiac output decrease

• Frank-Starling law: Frank-Starling law: Initially increase venous return results in increase in force of contraction later increase ventricular filling and myocardial stretch eventually results in ineffective contraction

• Hypertrophy: Hypertrophy: Increase in muscle mass and cardiac wall thickness in response to chronic dilation heart muscle poor contractility, increase in oxygen needs, poor coronary artery circulation, prone to ventricular dysrhythmias (sudden cardiac death)

Heart FailureHeart Failure PathophysiologyPathophysiology

Page 25: Heart failure / cardiac failure

Heart FailureHeart Failure PathophysiologyPathophysiology

• Ventricular remodeling/ cardiac remodelingVentricular remodeling/ cardiac remodeling– Refers to the changes in size, shape, structure and physiology of

the heart after injury to the myocardium

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Ventricular Remodeling

Page 28: Heart failure / cardiac failure

End ResultEnd Result

FLUID OVERLOAD Acute Decompensated Heart Failure /Pulmonary Edema

Medical Emergency!!Medical Emergency!!

Page 29: Heart failure / cardiac failure

Heart FailureHeart FailureClassification SystemsClassification Systems

• New York Heart Association (NYHA) Functional

Classification of HF

– Classes I to IV

• ACC/AHA Stages of HF (newer)

– Stages A to D

Page 30: Heart failure / cardiac failure

Heart FailureHeart FailureClassification SystemsClassification Systems

Page 31: Heart failure / cardiac failure

Heart FailureHeart FailureClassification SystemsClassification Systems

Page 32: Heart failure / cardiac failure

NY ASSN Funct Class

ACC/AHA Stages

Page 33: Heart failure / cardiac failure

Heart FailureRisk FactorsRisk Factors

• Primary risk factorsPrimary risk factors– Coronary artery disease (CAD)– Advancing age

• Contributing risk factors Contributing risk factors – Hypertension– Diabetes– Tobacco use– Obesity– High serum cholesterol– African American descent– Valvular heart disease– Hypervolemia

Page 34: Heart failure / cardiac failure

1.1. Impaired cardiac functionImpaired cardiac function• Coronary heart disease

• Cardiomyopathies

• Rheumatic fever

• Endocarditis

2.2. Increased cardiac workloadIncreased cardiac workload• Hypertension

• Valvular disorders

• Anemias

• Congenital heart defects

3.3. Acute non-cardiac conditionsAcute non-cardiac conditions• Volume overload

• Hyperthyroid, Fever,infection

Heart FailureHeart FailureCausesCauses

Page 35: Heart failure / cardiac failure

1.1. Systolic versus DiastolicSystolic versus Diastolic– Systolic - loss of contractility get decease CO

– Diastolic - decreased filling or preload

2.2. Left sided versus Right sidedLeft sided versus Right sided– Left ventricle - lungs

– Right ventricle - peripheral

3.3. High output vs Low outputHigh output vs Low output– Hypermetabolic state

4.4. Acute versus ChronicAcute versus Chronic– Acute MI

– Chronic Cardiomyopathy

Heart FailureHeart FailureCausesCauses

Page 36: Heart failure / cardiac failure

SymptomsSymptoms

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• Signs and symptoms– Dyspnea

– Orthopnea & PND ??

– Cheyne Stokes

– Fatigue

– Anxiety

– Rales

• Orthopnea: dyspnea on lying flat - due to increased distribution of blood to the pulmonary circulation while recumbent

Heart FailureHeart FailureSymptomsSymptoms

Page 38: Heart failure / cardiac failure

Paroxysmal Nocturnal DyspnoeaParoxysmal Nocturnal Dyspnoea

• Attacks of severe shortness of breath and coughing that generally occur at night

• It usually awakens the person from sleep, and may be quite frightening

• Cause: Cause: – Caused in part by the depression of the respiratory center during sleep,

which may reduce arterial oxygen tension, particularly in patients with reduced pulmonary compliance

– Also, in the horizontal position there is redistribution of blood volume from the lower extremities and splanchnic beds to the lungs

• Little effect in normal individuals, but in patients with failing left ventricle, there is a significant reduction in vital capacity and pulmonary compliance with resultant shortness of breath

Page 39: Heart failure / cardiac failure

Heart FailureHeart FailureClinical ManifestationsClinical Manifestations

• Acute decompensated heart failure (ADHF) Pulmonary edemaPulmonary edema, often life-threatening

• Early – Increase in the respiratory rate – Decrease in PaO2 (hypoxia)

• Later – Tachypnea – Respiratory acidosis

Page 40: Heart failure / cardiac failure

Acute Decompensated Heart Failure Acute Decompensated Heart Failure (ADHF)(ADHF)

Clinical ManifestationsClinical Manifestations

Physical findings

• Orthopnea

• Dyspnea, Tachypnea

• Use of accessory muscles of respiration

• Cyanosis

• Cool and clammy skin

• S3 gallop rhythm

Physical findings

• Cough with frothy, blood-tinged sputum

• Breath sounds: Crackles, wheezes, rhonchi

• Tachycardia

• Hypotension or hypertension

Page 41: Heart failure / cardiac failure

Person Literally Drowning In Person Literally Drowning In SecretionsSecretions

Immediate Action Needed

Page 42: Heart failure / cardiac failure

Right Heart FailureRight Heart Failure

• Signs and SymptomsSigns and Symptoms

– Fatigue, weakness, lethargy

– weight gain

– Increase abdominal girth

– Anorexia

– Right upper quadrant pain

– elevated neck veins

– Hepatomegaly

– May not see signs of LVF

Page 43: Heart failure / cardiac failure

What does this show?

Page 44: Heart failure / cardiac failure

What is present in this extremity, common to right sided HF?

Page 45: Heart failure / cardiac failure

Can You Have RVF Without LVF?Can You Have RVF Without LVF?

• What is this called?

COR PULMONALECOR PULMONALE

Page 46: Heart failure / cardiac failure

Heart FailureHeart FailureComplicationsComplications

• Pleural effusion• Atrial fibrillation (most common dysrhythmia)

– Loss of atrial contraction (kick) – necessary for 20-25% of cardiac output

• Reduce CO by 20% to 25%

– Promotes thrombus/embolus formation• Increase risk for stroke

Page 47: Heart failure / cardiac failure

Heart FailureHeart FailureComplicationsComplications

• High risk of fatal dysrhythmias fatal dysrhythmias (e.g., sudden cardiac death, ventricular tachycardia) with HF and an EF <35%

• HF lead to severe hepatomegaly, especially with RV failure – Fibrosis and cirrhosis (cardiac cirrhosis) - develop over time

• Renal insufficiency or failure (cardiorenal syndromecardiorenal syndrome)

Page 48: Heart failure / cardiac failure

Heart FailureHeart FailureInitial EvaluationInitial Evaluation

Primary goal - Primary goal - Determine underlying cause• Thorough history and physical examination – to identify cardiac

and noncardiac disorders or behaviors that might cause or accelerate the development or progression of HF

• Volume status and vital signs should be assessed

Page 49: Heart failure / cardiac failure

Heart FailureHeart FailureDiagnostic TestsDiagnostic Tests

Initial Lab workup includesInitial Lab workup includes

1. ECG

2. Chest X ray

3. Complete blood count (CBC)

4. Urinalysis

5. Serum electrolytes (including calcium and magnesium)

6. Blood urea nitrogen (BUN) and serum creatinine (Cr)

7. Glucose

8. Fasting lipid profile (FLP)

9. liver function tests (LFT)

10. Thyroid-stimulating hormone (TSH)

11. Cardiac Troponins

12. Beta naturetic peptide (BNP)

13. Arterial Blood gas (ABG)

Page 50: Heart failure / cardiac failure

Chest xrayChest xray

NormalNormal Pulmonary edemaPulmonary edema

Page 51: Heart failure / cardiac failure

• 2-dimensional echocardiogram (2-D echo) with Doppler should be performed during initial evaluation of patients presenting with HF to assess ventricular function, size, wall thickness, wall motion, and valve function

Heart FailureHeart FailureDiagnostic TestsDiagnostic Tests

Page 52: Heart failure / cardiac failure

But

Page 53: Heart failure / cardiac failure

Heart FailureHeart FailureDiagnostic StudiesDiagnostic Studies

• Invasive hemodynamic monitoringInvasive hemodynamic monitoring– Can be useful for carefully selected patients with acute HF who have

persistent symptoms despite empiric adjustment of standard therapies and

a. Whose fluid status, perfusion, or systemic or pulmonary vascular resistance is uncertain

b. Whose systolic pressure remains low, or is associated with symptoms, despite initial therapy

c. Whose renal function is worsening with therapy

d. Who require parenteral vasoactive agents

• Coronary angiography Coronary angiography if ischemia is likely cause of heart failure

Page 54: Heart failure / cardiac failure

Heart FailureHeart FailureEmergency ManagementEmergency Management

U Upright Position

N Nitrates

L Lasix

O Oxygen

A ACE, ARBs, Aldactone, Amiodarone

D Digoxin, Dobutamine, Dopamine

M Morphine Sulfate

E Extremities Down

Page 55: Heart failure / cardiac failure

Heart FailureHeart FailureStage Stage A

At Risk Of Developing Heart Failure but no structural heart At Risk Of Developing Heart Failure but no structural heart disease yet:disease yet:

– Adequate BP control

– Adequate Diabetes control

– Weight reduction

– Quit smoking

– Avoid cardiotoxins

– Lipid management

– Atrial fibrillation management

Page 56: Heart failure / cardiac failure

Heart FailureHeart FailureStage BStage B

Structural Heart Disease Without Overt SymptomsStructural Heart Disease Without Overt Symptoms

• Care measures as in Stage A along with:– Should be on ACE-I

– Add beta blockers

– Spironolactone – if LVEF <40%

• Surgical consultation for coronary artery revascularization and valve repair/replacement (as appropriate)

Page 57: Heart failure / cardiac failure

Structural Heart Disease With Overt SymptomsStructural Heart Disease With Overt SymptomsNonpharmacological InterventionsNonpharmacological Interventions

• Therapeutic life style changes:Therapeutic life style changes: DietDiet low salt, low fat, rich in fruit and veggie, increase fiber, water intake limited to 1.5 liters

• Smoking cessationSmoking cessation

• Activity & exerciseActivity & exercise

– Duration of activity:Duration of activity: Exercise training and rehab atleast 30 min aerobic exercise/brisk walking with 5 days and ideally 7 days a week

– Benefits: Benefits: improve HRQOL, increase in functional status, improve exercise capacity and reduce hospitalization and mortality, improve endothelial function and improve O2 extraction from peripheral tissue

Heart FailureHeart FailureStage CStage C

HRQOL – Health related quality of life

Page 58: Heart failure / cardiac failure

Nonpharmacological InterventionsNonpharmacological Interventions

• SaltSalt :1.5gm for stage A&B and <3gm for stage C&D

• BMI:BMI: 30-34.9kg/m2 (grade 1 obesity) lowest mortality – weight U-shaped mortality curve (cardiac cachexiacardiac cachexia)– daily weight monitoring – same time with same clothing

– Weight gainWeight gain of 3 lb (1.5 kg) over 2 days or a 3- to 5-lb (2.5 kg) gain over a week – report to health care provider

Heart FailureHeart FailureStage BStage B

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• Pharmacological InterventionsPharmacological Interventions– All measures of stage A and B

DiureticsDiuretics

– FurosimideFurosimide (20-40mg once or twice)

– Hydroclorothiazide Hydroclorothiazide (25mg once or twice)

– MetolazoneMetolazone (2.5-5mg OD )

– Spironolactone Spironolactone (12.5-25 once or twice)

• Aim of diuretic therapy on outpatient is to decrease weight 0.5-1kg daily with adequate diuresis and adjust the dose accordingly until evidence of fluid retention resolved– Then daily wt and adjust the dose accordingly

Heart FailureHeart FailureStage CStage C

Page 60: Heart failure / cardiac failure

Heart FailureHeart FailureStage CStage C

Pharmacological InterventionsPharmacological Interventions

ACE InhibitorsACE Inhibitors

• Capotopril:Capotopril: 6.25mg thrice till 50mg thrice a day

• Enalapril :Enalapril : 2.5mg twice to 10-20mg twice a day

• Lisinopril: Lisinopril: 2.5-5mg once to 20-40mg once a day

• Ramipril: Ramipril: 1.25-2.5mg once till 10mg once a day

• C/I C/I – Cr >3mg/dl, angioedema, pregnant, hypotension (SBP<80mmHg), B/L RAS, inc. K(>5mg/dl)

• Initiation:Initiation: start low dose – if tolerated then gradual increase in few days to weeks to target dose or max tolerable dose.

– Renal function monitoring before starting, 1-2weeks after and periodically thereafter and after changing dose

• ACE induced cough – 20%

Page 61: Heart failure / cardiac failure

• When ACEI intolerant or alternative to ACEI

• AT 1 receptor blocker

• Can be substituted to ACEI with angioedema history but with caution (pt can develop angioedema with ARB as well)

• Losartan: Losartan: 25-50mg once till 50-150mg once a day

• Valsartan:Valsartan: 20-40mg twice till 160mg twice

• Same initiation and monitoring as ACEI

• Titration by doubling the dose

Heart FailureHeart FailureStage CStage C

Pharmacological InterventionsPharmacological Interventions

Angiotensin Receptor BlockersAngiotensin Receptor Blockers

Page 62: Heart failure / cardiac failure

• To all pt with LV dysfunction

• Start earlyearly when Symptoms improved

• Caution:Caution: Can worsen heart failure

• START LOW AND GO SLOW START LOW AND GO SLOW

• Start in low dose even during hospitalization (careful in pt require inotropic support) gradually increase dose in weeks duration and try to reach target dose

• Bisoprolol:Bisoprolol: 1.25-2.5mg once till 10mg once

• Carvedilol: Carvedilol: 3.125 twice till 50mg twice

• Metoprolol Succinate: Metoprolol Succinate: 12.5 once till 200mg once

• Continue even Sx not improved

• Abrupt withdrawal avoided

• S/E: S/E: fluid retention and worsening HF, slow heart rate, fatigue, blocks, hypotension (minimize by different dosing timings of BB and ACEI)

Heart FailureHeart FailureStage CStage C

Pharmacological InterventionsPharmacological Interventions

Beta BlockersBeta Blockers

Page 63: Heart failure / cardiac failure

• Indications: Indications: NYHA II-IV, EF ≤35%, no C/I (GFR >30, Cr: 2.5mg/dl male and 2.0mg/dl female, K<5mg/dl

• Dosing: SpironolactoneDosing: Spironolactone 12.5-25mg once till 50mg daily

• Monitoring:Monitoring:– stop all K supplements, check K+ and

Cr 2-3 days after starting then one week and every month for 3 months and every 3 month & when clinically indicated .

– Cycle restarted after changing dose of ARA or ACEI

• High K containing food: Prunes, banana, salmon fish, dark green leafy vegetables, mushrooms, yogurt, white beans and dried apricot

• S/E: S/E: Increase K+ (10-15%), gynecomastia

Heart FailureHeart FailureStage CStage C

Pharmacological InterventionsPharmacological Interventions

Aldosterone Receptor AntagonistsAldosterone Receptor Antagonists

Page 64: Heart failure / cardiac failure

• No mortality benefit

• Only decrease frequency of hospitalizations, Symptoms and HRQOL

• Don’t stop digoxin if patient is not on ACEI or BB, but try to initiate them

• No loading required – usual dose 0.125-0.25mg daily (low dose 0.125mg alternate day if >70yrs, CKD, Low lean body mass

• 0.5-0.9 ng/dl plasma conc. (narrow therapeutic range)• S/E: Nausea, vomiting and diarrhea, visual disturbances (yellow-green

halos and problems with color perception), supraventricular and ventricular arrhythmias

Heart FailureHeart FailureStage CStage C

Pharmacological InterventionsPharmacological Interventions

DigoxinDigoxin

Page 65: Heart failure / cardiac failure

• Indication: Indication: African-American origin, NYHA III-IV, HFrEF on ACEI and BB

• Bildil (37.5mg hydralazine and 20mg ISDN) start one tab TID to increase till 2tab TID

• If given separately then both at least TID

Heart FailureHeart FailureStage CStage C

Pharmacological InterventionsPharmacological Interventions

Hydralazine Nitrate CombinationHydralazine Nitrate Combination

Page 66: Heart failure / cardiac failure

• Drugs not to be used:Drugs not to be used:– Statins (no benefit – unless there is ischemic etiology)

– CCB (except Amlodipine)

– NSAIDS

– Thiozolidinidinones

– Most anti arrhythmics drugs (except Amiodarone, dofelitide)

– Nutritional Supplements

– Hormonal therapy

Heart FailureHeart FailureStage CStage C

Pharmacological InterventionsPharmacological Interventions

Page 67: Heart failure / cardiac failure

Pharmacologic Treatment for Stage CPharmacologic Treatment for Stage CHeart Failure Stage C

NYHA Class I – IVTreatment:

For NYHA class II - IV patients . Provided estimated creatinine

>30 mL/ min and K + <5.0 mEq/dL

For persistently symptomatic African Americans ,NYHA class III -IV

Class I , LOE AACEI or ARB AND

Beta Blocker

Class I , LOE CLoop Diuretics

Class I , LOE AHydral - Nitrates

Class I , LOE AAldosterone Antagonist

AddAdd Add

For all volume overload , NYHA class II - IV patients

Page 68: Heart failure / cardiac failure

• Implantable Cardioverter Defibrillator (ICD)Implantable Cardioverter Defibrillator (ICD)– Nonischemic or ischemic heart disease (at least 40 days post-MI)

with LVEF of ≤35% with NYHA class II or III symptoms or NYHA 1 with EF ≤30% on chronic medical therapy, who have reasonable expectation of meaningful survival for more than 1 year

• Cardiac Resynchronization Therapy (CRT)Cardiac Resynchronization Therapy (CRT)– Indicated for patients who have LVEF of 35% or less, sinus

rhythm, left bundle-branch block (LBBB) with a QRS duration of 150 ms or greater, and NYHA class II, III, or ambulatory IV symptoms on GDMT

Heart FailureHeart FailureStage CStage C

Device TherapyDevice Therapy

Page 69: Heart failure / cardiac failure

1. Repeated (≥2) hospitalizations or ED visits for HF in the past year

2. Progressive deterioration in renal function (e.g., rise in BUN and creatinine)

3. Weight loss without other cause (e.g., cardiac cachexia)

4. Intolerance to ACE inhibitors due to hypotension and/or worsening renal function

5. Intolerance to beta blockers due to worsening HF or hypotension6. Frequent systolic blood pressure <90 mm Hg

7. Persistent dyspnea with dressing or bathing requiring rest

8. Inability to walk 1 block on the level ground due to dyspnea or fatigue9. Recent need to escalate diuretics to maintain volume status, often reaching daily

furosemide equivalent dose >160 mg/d and/or use of supplemental metolazone therapy

10. Progressive decline in serum sodium, usually to <133 mEq/L

11. Frequent ICD shocks

Heart FailureHeart FailureStage DStage D

Clinical Events and Findings Useful for Identifying Patients Clinical Events and Findings Useful for Identifying Patients With Advanced HFWith Advanced HF

Page 70: Heart failure / cardiac failure

• All the measures of Stage A, B & C

• Until definitive therapy [e.g., coronary revascularization, Mechanical circulatory support, heart transplantation or resolution of the acute precipitating problem], patients with cardiogenic shock should receive temporary intravenous inotropic support to maintain systemic perfusion and preserve end-organ performance.

Heart FailureHeart FailureStage DStage D

Page 71: Heart failure / cardiac failure

Heart FailureHeart FailureStage DStage D

Mechanical Circulatory SupportMechanical Circulatory Support• Intraaortic balloon pump Intraaortic balloon pump (IABP) therapy

– Used for cardiogenic shock

– Allows heart to rest

• Ventricular assist devices Ventricular assist devices (VADs)– Takes over pumping for the ventricles

– Used as a bridge to transplant

• Destination therapy-permanentDestination therapy-permanent, implantable VAD

• CardiomyoplastyCardiomyoplasty- - wrap latissimus dorsi around heart

• Ventricular reductionVentricular reduction - -ventricular wall resected

• Transplant/Artificial HeartTransplant/Artificial Heart

Page 72: Heart failure / cardiac failure

Stage AStage A

At high risk for developing heart failure. Includes people with:

•Hypertension

•Diabetes mellitus

•CAD (including heart attack)

•History of cardiotoxic drug therapy

•History of alcohol abuse

•History of rheumatic fever

•Family history of CMP

•Exercise regularly

•Quit smoking

•Treat hypertension

•Treat lipid disorders

•Discourage alcohol or illicit drug use

•If previous heart attack/ current diabetes mellitus or HTN, use ACE-I

Stage BStage B

•Those diagnosed with “systolic” heart failure- have never had symptoms of heart failure (usually by finding an ejection fraction of less than 40% on echocardiogram

•Care measures in Stage A +

•Should be on ACE-I

•Add beta -blockers

•Surgical consultation for coronary artery revascularization and valve repair/replacement (as appropriate

Heart FailureHeart FailureTherapiesTherapies

Page 73: Heart failure / cardiac failure

Stage CStage C

Patients with known heart failure with current or prior symptoms.

Symptoms include: SOB, fatigue, Reduced exercise intolerance

All care measures from Stage A apply, ACE-I and beta-blockers should be used + Diuretics, Digoxin,

Dietary sodium restriction

Weight monitoring, Fluid restriction Withdrawal drugs that worsen condition

Maybe Spironolactone therapy

Heart FailureHeart FailureTherapiesTherapies

Page 74: Heart failure / cardiac failure

Stage DStage D

Presence of advanced symptoms, after assuring optimized medical care

All therapies -Stages A, B and C + evaluation for:Cardiac transplantation, VADs, surgical options, research therapies, Continuous intravenous inotropic infusions/ End-of-life care

Heart FailureHeart FailureTherapiesTherapies

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Heart FailureHeart FailurePrognosisPrognosis

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SBPSBPAdmission and early post-discharge SBP inversely correlates

with post-discharge mortality

Coronary artery disease Coronary artery disease (CAD)(CAD)

Extent and severity of CAD appears to be a predictor of poor prognosis

Troponin releaseTroponin releaseResults in a 3-fold increase in in-hospital mortality and

rehospitalization rate, a 2-fold increase in post-discharge mortality

Ventricular dyssynchronyVentricular dyssynchronyIncrease in QRS duration occurs in approximately 40% of

patients with reduced systolic function and is a strong predictor of early and late post-discharge mortality and rehospitalization

Renal impairmentRenal impairmentWorsening renal function during hospitalization or soon after

discharge is associated with an increase in in-hospital and post-discharge mortality

Heart FailureHeart FailurePrognostic FactorsPrognostic Factors

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HyponatremiaHyponatremiaDefined as serum sodium < 135 mmol/l, occurs in approximately 25% of patients, and is associated with a 2- to 3-fold increase in

post-discharge mortality

Clinical congestion at time Clinical congestion at time of dischargeof discharge

An important predictor of post-discharge mortality and morbidity

EFEFSimilar early post-discharge event rates and mortality between

reduced and preserved EF

BNP/NT-proBNPBNP/NT-proBNPElevated natriuretic peptides associated with increased resource

utilization and mortality

Functional capacity at Functional capacity at time of dischargetime of discharge

Pre-discharge functional capacity, defined by the 6-min walk test, is emerging as an important predictor of post-discharge outcomes

Heart FailurePrognostic Factors

Page 78: Heart failure / cardiac failure

Take Home MessageTake Home Message

• Heart failure is common problem in elderly and having prognosis worse then Carcinoma Lung

• It is clinical diagnosis supplemented by lab test and echo

• Echo can suggest the etiology of heart failure

• Diuretics are for acute relief and also for chronic management of fluid overload

• Look for the precipitating event for acute decompensation

• ACE inhibitors/ARB, Beta blockers, Spironolactone improve prognosis in patient with reduced ejection fraction

Page 79: Heart failure / cardiac failure

• Maintain patient on 2- to 3-g sodium diet. Follow daily weight and determine target/ideal weight, which is not the dry weight - In order to prevent worsening azotemia and adjust the dose of diuretic accordingly

• Use Digoxin in most symptomatic heart failure

• Encourage exercise training

• Consider a cardiology consultation in patients who fail to improve

• Heart transplantation is for end stage heart failure

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Page 80: Heart failure / cardiac failure