healthy lifestyles to promote mental health kathi j. kemper, md, faap caryl j guth chair for...
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Healthy Lifestyles to Promote Mental Health
Kathi J. Kemper, MD, FAAP
Caryl J Guth Chair for Complementary and Integrative Medicine
Wake Forest University School of Medicine
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“The part cannot be well unless the whole is well.”
Plato
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Faculty Disclosure
In the past 12 months, I have had no relevant financial relationships with the
manufacturers of any commercial products and/or providers of commercial services discussed in this CME activity. I do not
intend to discuss an unapproved or investigative use of a commercial product
or device in my presentation.
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Objectives (by the end of this session, you will be able to…):
1. Compare and contrast mental, physical and spiritual health
2. Describe the role of a healthy lifestyle in promoting mental health
3. Advise patients to make healthy lifestyle changes using effective communication skills
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Objective 4: Resources
http://www1.wfubmc.edu/phim/MHN.htm
1. Are Mental Health Problems Really a Problem?
2. What is Mental Health? 3. Exercise 4. Sleep 5. Nutrition 6. Dietary Supplements Overview 7. Vitamins 8. Minerals9. Essential Fatty Acids10. Amino Acids11. Hormones12. Probiotics
13. Environment: Promoting Positive Aspects
14. Environment: Protecting Against Negative Aspects
Stress Management Overview 15.
Stress Management: Emotional Practices
16. Managing Stress: Mental Practices
17. Managing Stress: Spiritual Practices
Intro to Communication Skills & Community Building
18. Communication Skills: Talking with Yourself
19. Communication Skills: Talking with Others
20. Building Community to Promote Mental Health
More to follow……
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Depression Case
A 16 year old girl who is sad, has had a drop in grades and been irritable with her family; recently broke up with her boyfriend; less interested in tennis, has stopped taking her SSRI after hearing about black box warnings.
How can her lifestyle choices support her mental health?
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Definitions: Mental Health
• Most medical literature on mental health focuses on mental illness, eg. Depression, anxiety, Bipolar, schizophrenia, ADHD, cognition/memory problems, adjustment disorders, personality disorders, etc.
• Mental health "First say to yourself what you would be; and then do what
you have to do." Epitectus
“You got to be careful if you don't know where you're going, because you might not get there.”
Yogi Berra
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Optimal Physical health: Example
• Strength• Flexibility• Stamina/Endurance• Focus• Coordination• Resilience, and• Effective teamwork
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Optimal Spiritual Health
• Faith• Forgiveness• Hope• Love• Kindness• Charity/generosity, and• Transcendence – connection
with something greater than our individual self
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Mental Health: elements
• Confidence and courage• Adaptability• Cheerfulness• Attention / Concentration• Harmony• Hardiness in face of stress• Social Network/
communication skills/ connection to community
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Mental Health - strategies
• Healthy lifestyle – as for promoting heart health, reproductive health, immune function, etc.
• #1 Lifestyle: Exercise/Rest, Nutrition, Environment(+/-), Stress management practices (EMS), Communication and community
• #2: Supplements/Meds, Professionals (psychologists, massage, acupuncture, etc)
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Content: Conventional
• Psychotherapy• Medications
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Cognitive Behavioral Therapy“From an evidence-based
perspective, cognitive-behavioral therapy is currently the treatment of choice for anxiety and depressive disorders.”
Compton SN. JAm Acad Child Adolesc
Psychiatry. 2004
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SSRI Side effects 1
• GI upset• Headache; sleep
disorders• Sexual side effects
Dizziness, Fatigue, Sweating
• Neonatal withdrawal syndrome
• Drug interactions
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SSRI Side effects 2• Serotonergic syndrome (HTN,
tachycardia, mania)• Agitation and hostility• Suicidal ideation, esp in those with
agitation/hostility
• Drug co. assertion: our way or deprive patients of treatment. FALSE!Mosholder AD. J Child Adolesc Psychopharmacol. 2006
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Natural: used commonly • Depression is one of the top 10
diagnoses for which patients seek natural therapies
• Commonly used by women• Fewer than 30% of patients tell
docs they are using natural therapies or strategies
• Clinicians need to ask!• Clinicians need to emphasize
the importance of healthy lifestyles for overall physical and mental health
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Lifestyle - overview• Environment: More Sunshine and music,
Less TV and toxins• Exercise/Sleep (more of both)• Nutrition (Essential nutrients for optimal
brain function, EFA, amino acids, vitamins, minerals)
• Manage stress – emotional, mental, spiritual practices
• Communication/Community
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Sunshine, circadian rhythms and sleep
Desynchronization of internal rhythms plays an important role in the pathophysiology of depression.
Resetting normal circadian rhythms can have antidepressant effects.
“Winter depression was first modeled on regulation of animal behavior by seasonal changes in day length, and led to application of light as the first successful chronobiological treatment in psychiatry.”
Fuchs E. Int Clin Psychopharmacol, 2006
Wirz-Justice A. Int Clin Psychopharmacol. 2006
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Bright light exposure therapy
• Cochrane systematic review—all published studies on bright light exposure for non-seasonal depression found “modest though promising anti-depressive efficacy, especially when administered during the first week of treatment, in the morning, and as an adjunctive treatment to sleep deprivation responders (Tuuainen et al., 2004).”
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Light Therapy for Depression
Plus 3 studies not included in this review, comparing dim light to bright light. Golden R. Am J Psychiatry. 2005
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Light therapy
• Proven effective for SAD (Terman M Evid Based Ment Health, 2006)
• Meta-analysis of studies from 1987-2001: (effect size=0.53, 95% CI=0.18 to 0.89, similar to medications) for non-SAD
• RCT of 29 women with non-seasonal depression; light therapy for 28 days significantly better than control, (McEnany GW, 2005)
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Light Therapy 2
• Benefits onset within 2 days; effective in institutionalized elderly and community; effective in summer and winter
• Side effects: hypomania, autonomic hyperactivation
(Terman M, 2005)
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Vitamin D and depression
• Vitamin D receptors in brain• Low level of serum 25-hydroxyvitamin
D and high PTH are significantly associated with depression (Jorde, 2005)
• 25-hydroxyvitamin D3 and 1,25-dihydroxvitamin D3 levels are significantly lower in psychiatric patients than in normal controls (Schneider, 2000)
• RCT of 44 Australian patients (none, 400 IU versus 800 IU vitamin D) vitamin D3 significantly enhanced mood (Landsdowne, 1998)
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More positive environment
• Music (avoid ear damage from loud noises)
• Nature (Last Child in the Woods)• Aromas (mint, citrus, lavender, vanilla)• More organization; less clutter• Implications for clinic/hospital design;
school design; workplace design
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Turn off Depressing TV
• 9/11. Respondents who repeatedly saw "people falling or jumping from the towers of the World Trade Center" had higher prevalence of PTSD (17.4%) and depression (14.7%) than those who did not (6.2% and 5.3%, respectively).
• Depressive symptoms after the hurricane were predicted by watching television coverage of the looting that occurred in New Orleans
• People who watch more TV socialize less
Ahern, Psychiatry, 2002McLeish. Depress Anx, 2008
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Other Environmental Toxins to Minimize
• Environmental Tobacco Smoke• Pesticides (neurotoxins)• BPA (behavioral as well as endocrine
effects)• Lead, mercury, etc. • Perc (dry cleaning)• Air pollution
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Exercise
• Depressed mood / fatigue are common in those deprived of usual exercise.
• Mood changes noted in patients with injuries and mono.
• Exercise benefits depression *• Common sense precautions
Berlin AA. Psychosomatic Med, 2006
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Exercise as Therapy – Yes
Lawlor DA. BMJ 2001
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Yoga for depression
• Five RCTs --each used different forms of yoga.
• All trials reported positive findings
• No adverse effects except fatigue and breathlessness
Pilkington K. J Affective Disord, 2005
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Sleep
• Poor sleep is barometer of depression
• Reduced sleep equals impaired focus and labile mood (ADHD, Learning problems)
• Sleep quality is a good screen for good mental health
• We sleep 20% less than we did 100 yrs ago
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Sleep Hygiene
• Regular time; Routine• Hot bath; cool room; dark room• Massage before bed• Lavender, chamomile, melatonin?• No caffeine within 8 hours of bedtime• Music, calm, orderly, quiet• NO TV IN BEDROOM• NO vigorous exercise right before bed• GET MORE versus intentional sleep
reduction/deprivation
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Nutrition – essential nutrients for optimal brain function
• Omega-3 fatty acids• Amino acids (SAM-E,
Trp, 5-HTP)• Vitamins (B vitamins,
Vitamin D)• Minerals (Iron,
Calcium, Magnesium, Zinc)
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Top Foods (scores > 90/100)
Broccoli Green cabbageOranges TomatoGreen Beans ClementinePineapple WatermelonRadish MangoSummer Squash NF MilkApple FigsGrapes Bananas
Yale’s Griffin Prevention Research Center, 2008
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Omega-6 Fatty Acids Omega-3 Fatty Acids
Linoleic Acid (18:2n-6) a-Linolenic Acid (18:3n-3)
(GLA)γ -Linolenic Acid (18:3n-6)
(DHGLA) Dihomo-γ-Linolenic Acid (20:3n-6)
(AA)Arachidonic Acid (20:4n-6)
EicosanoidsLeukotriene 4-series
Prostaglandins E2
Thromboxanes A2
Eicosanoids
Stearidonic Acid (18:4n-3)
Eicosatetraenoic Acid (20:4n-3)
(EPA) Eicosapentaenoic Acid (20:5n-3)
24:5n-3
24:6n-3
(DHA) Docosahexaenoic Acid (22:6n-3)
EicosanoidsLeukotriene 5-seriesProstaglandins E3
Thromboxanes A3
∆-6 Desaturase
Elongase
∆-5 Desaturase
Elongase
∆-6 Desaturase
β-Oxidation
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Omega 3 EFA’s: mechanism
• Neuronal membrane structure and function
• Brain development• Second messenger inside cells
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Mood and Omega-3’s• Inverse correlation between fish intake
and depression (Hibbeln: Lancet 1998; 351:1213; Crowe: Am J Clin Nutr, 2007)
• Effective for bipolar patients (Stoll: Arch. of Gen. Psych. 1999; 56: 407-12)
• Effective for major depression (Nemets: Am. J. Psych. 2002: 159 (3) 477-9)
• Effective for depression in children (Am J Psychiatry 2006;163:1098-0)
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Fish Oil –Doses, Safety, Brands• Dose: 1 gram daily of EPA probably
enough.(Peet M, 2002); Frangou S. Br J Psychiatry, 2006)
• Safety: fish allergies, taste, belching; very high doses, increased risk of bleeding, nosebleeds? Little risk of mercury, dioxin, PCB’s;
• Brands: Compare brands at www.consumerlabs.com
• My family takes Coromega, Carlson’s or Nordic Natural
• Read labels: Omega 3 does NOT necessarily all equal EPA/DHA
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Amino Acids: real protein
• SAM-E Produced from ATP and methionine • Meta-analysis: SAMe significantly improves depression,
comparable to antidepressant medications (http://www.ahrq.gov/clinic/epcsums/samesum.htm)
• Acute tryp depletion leads to depression• Dietary L-tryp -> 5-HTP -> serotonin • Meta-analysis: 5-HTP and L-trp better than placebo for
depression (Shaw K, Cochrane. 2002)
• Food sources – dairy, eggs, poultry, meat, soy, tofu, nuts; WHEY protein
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Vitamin B6 - pyridoxine
• Low levels of pyridoxal phosphate (PLP) are associated with depressive symptoms (Hvas AM 2004)
• Dose: 100 – 200 mg daily benefits PMS- depression; Odds ratio ~2.(Wyatt KM. BMJ, 1999)
• Side effects: nausea, vomiting, abd. pain, anorexia, headache, somnolence, lower B12 levels, sensory neuropathy (typically with doses over 1000 mg daily, can occur lower)
• Food: Beans, nuts, legumes, fish, meat
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Folate• Folate (Essential co-factor for synthesis of S-adenosyl-methionine).
– Lower levels of folate in depressed persons– Low folate associated with poorer response to antidepressant meds
• Methylfolate in depressed pts (elderly, EtOH dependent, dementia) show significant improvement (Guaraldi et al., 1993; Di Palma et al., 1994; Glória et al., 1997; Passeri et al., 1993)
• RPCT: folate as adjunctive Rx in folate deficient MDD pts showed signif improvement over placebo (Godfrey et al., 1990)
• RPCT MDD pts randomized to fluoxetine + folate (0.5mg) improved more than fluox. + placebo; differences esp striking in WOMEN (Coppen & Bailey 2000)
• Studies on supplements in non-folate deficient MDD pts on SSRIs found significant reduction in sx severity and 19% remission (Alpert et al., 2002)
• Folate augmentation may enhance response to lithium in folate deficient bipolar and unipolar depression (Coppen and Chaudhry, 1986)
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Bottom line on Amino acids and B vitamins
• Healthy diet rich in green vegetables and nutritious protein sources
• Consider B-complex supplement
• Consider whey powder (high in tryptophan), SAM-E, Tryp/5-HTP
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Mood and Minerals: Iron
• Iron deficiency associated with depression
• Iron deficiency common in women
• Correcting iron deficiency helps with mood and attention
Beard JL. J Nutr, 2005
LE Murray-Kolb. Am J Clin Nutr, 2007
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Mood and Minerals: Calcium
• Lower levels of calcium in depressed persons
• Higher PTH in depressed persons
• Estrogen regulates calcium and PTH metabolism; sometimes dysregulates? (Thys-Jacobs S. J Am Coll Nutr, 2000)
• Supplementation may benefit women with PMS-related depression (Dickerson LM. Am Fam Physician, 2003)
• 1000 – 1200 mg daily
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Non-dairy sources of calcium
• Soy beans, tofu
• Calcium fortified OJ
• Green leafy vegetables (broccoli)
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Magnesium
• Needed to convert tryp to serotonin• Regulates NMDA (N-methyl-D-aspartic acid)
receptors• Alters activity of glutamate, an amino acid
involved in learning and memory• Deficiency symptoms incl: constipation,
irritability, fatigue, mental confusion, insomnia, anxiety and easily feeling stressed.
• 2 + trials on Mg suppls for PMS- related anxiety• 3+ studies on Mg for bipolar/mania – stabilizes• Spinach, beans, seeds, nuts, whole grains
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Iodine
• Needed to convert T4 to T3• Can be deficient if little iodized salt or
fish intake• World Health Organization (WHO)
statistics indicate that iodine deficiency disorders affect 740 million people throughout the world, and nearly 50 million people suffer from some degree of iodine-deficiency related brain damage (cretinism/MR/low IQ), plus increased risk of anxiety and depression
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Nutrition Summary
• Healthy fat (omega 3, eg fish, nuts, flax); not fried foods, saturated fats
• Healthy protein (essential amino acids)• Foods rich in minerals and vitamins (organic,
locally grown vegetables, beans, grains)• Iodized salt• Multivitamin-mineral supplement (extra D)• Fish oil supplement• Consider B vitamins, Calcium, Mg, Iron if
deficient
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Lifestyle: Stress management
• Stress is common• Stress commonly triggers mood problems• Managing stress: exercise, sleep, nutrition,
mind/emotion/body/spirit– Meditation– Biofeedback
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Meditation
• Meditation training ↑ left-sided anterior activation, a pattern associated with positive affect, in meditators compared with the nonmeditators
• Positive effects on anxiety and improves concentration/clarity
• Few side effects; can combine mindfulness with CBT
Davidson RJ Psychosom Med, 2003
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Stress, Emotion, and Physiological Activation
High Arousal/High Energy
SYMPATHETIC
PARASYMPATHETIC
Low Arousal/Low Energy
Institute of HeartMath
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Stress, Emotion, and Physiological Activation
High Arousal/High Energy
SYMPATHETIC
PARASYMPATHETIC
Low Arousal/Low Energy
Negative
Emotion
Positive
Emotion
“Fight-or-Flight”
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Stress, Emotion, and Physiological Activation
High Arousal/High Energy
SYMPATHETIC
PARASYMPATHETICLow Arousal/Low Energy
Negative
Emotion
Positive
Emotion
“Fight-or-Flight”Frustration, Anger, Hostility,
Fear, Worry Anxiety
Judgment, Resentment,
Feeling Overwhelmed, Anguish
Hopelessness, Submission,
Despair, Depression
Burnout, Withdrawal,
Boredom, Apathy
Exhilaration, Passion,
Love, Care,
Joy, Happiness
Kindness, Appreciation
Compassion, Tolerance,
Acceptance, Forgiveness
Serenity, Inner Balance,
Reflection, Contentment
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The Heart Brain Relationship
The heart has its own complex nervous system -the “Heart Brain”
The heart sends far more information to the brain than the brain sends to the heart
The heart signals especially affect the brain centers involved in decision making, creativity and emotional experience
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Stress management: biofeedback
• HRV biofeedback appears to be a useful adjunctive treatment for the treatment of MDD
• Significant improvements in – Hamilton Depression Scale (HAM-D) – Beck Depression Inventory (BDI-II) by week 4,
Karavidas, et al. Appl Psychophysiol Biofeedback. 2007
Nolan RP. Am Heart J, 2005
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Promote Social Support
• Religiosity (participation) helps protect against depression
• Participation in organized athletics, civic groups, etc. is protective
• Ongoing volunteer work is protective
• Connected people are happier people
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SUMMARY: LIFESTYLE
• Sunshine, sleep, exercise, nutrition (supplement when necessary), stress management and social support (fellowship/ community)
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How: Behavioral Medicine
• Identify the goal• Consider various strategies• Pick a strategy• Identify a small, achievable step that the patient
and family can support• Explore pros and cons of change• Anticipate barriers; identify resources• Plan rewards/celebrations!• Re-evaluate; take the next step
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Goal-setting
• Pick a POSITIVE goal– E.g., healthier lifestyle
– NOT stop eating junk food– DEPRIVATION IS
UNATTRACTIVE
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Example: Healthier lifestyle
To promote Better moodBetter focus or concentrationGreater calm More resilienceMore cheerfulness Greater adaptabilityMore confidence More creativeMore clarityBetter memoryMore harmonious relationshipsHigher self esteemMore consistent with personal valuesother?
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Pick a specific strategy
• More exercise• Better nutrition• Judicious use of supplements• Better sleep• Healthier environment• Stress management; biofeedback; journal;
meditation• Use medication• Massage, psychotherapy, acupuncture or other
professional help
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Identify a small, achievable step
• Rome was not built in a day; habits are not changed overnight: BABY STEPS.
• For exercise, go from sedentary, to 5 minute walks with the dog 5 days a week.
• Be specific (with or without an MP3 player; with or without a friend; regardless of weather?; distance vs. time)
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How important is this to you?
0 1 2 3 4 5 6 7 8 9 10Not Very
Why did you pick that number and not a lower number? (e.g. a 7 instead of a 5)
Asking this question helps the patient/family provide their own rationale for why this is important. They talk themselves into it!
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How confident are you that you can do this for one month?
0 1 2 3 4 5 6 7 8 9 10Not Very
If they pick an 8 or higher (pretty confident), proceed with next step of making a chart and planning rewards and
follow-up.
If they pick a number less than 8, “What would it take for you to go from the number you
picked to a higher number?” Begin to explore their ambivalence…. It’s OK to be ambivalent about change!
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Identify Pros and Cons
PRO CON
Change More cheerful Change routine
More fit and cool Brother might tease
Clothes fit better Yucky dog clean up
Better sleep
Better self-esteem
No Change Easy Continued mood probs
Mom does yucky job Get fat
Feel ugly
Sleep badly
Unhappy with myself
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Identify Barriers and Resources
• In addition to (cons listed above), what other barriers or challenges might you anticipate as you try to make this change? Need new tennis shoes; need leash; need pooper-scooper
• What resources do you have/need to help you make this change? Will Mom commit to getting new shoes, leash, etc. ? Will the child want/need a reminder? Is it helpful for Dad to do that? Do they need a chore chart? A calendar?
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Plan celebrations/rewards
• Pick a tangible reward and timing (will it be offered after week 1, 2, 3, 4?)
• Samples: new walking shoes; Support the patient’s choices.
• Emphasize the importance of the reward/celebration. If the patient says they expect “good” behavior, suggest they consider celebrating it (instead of rewarding it).
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Sample behavior diary (OK to copy)
Goal
Sample: M T W Th Fri Sa Su Total
Walk dog 5 minutes 5 days a week √ √ √ √ √ 5
Week 1
Week 2
Week 3
Week 4
Re-evaluate.Celebrate.Next steps?
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Follow Up
• Follow- up in 4-6 weeks.• Ask patient to bring chart and say you
plan to be proud of them (build expectation of success) and will ask them what they’d like to do for next step (involve them in problem solving).
• Do it!
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Behavioral Medicine
• Identify the goal• Consider various strategies• Pick a strategy• Identify a small, achievable step that the patient
can embrace• Explore pros and cons of change• Anticipate barriers; identify resources• Plan rewards/celebrations!• Re-evaluate; take the next step
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Resources
• Kemper KJ, Shannon S. Complementary and alternative medicine therapies to promote healthy moods.Pediatr Clin North Am. 2007 Dec;54(6):901-26
• Natural Medicines Comprehensive Database• Natural Standards
• http://www.besthealth.com/Integrated+Medicine/
• http://www1.wfubmc.edu/phim/MHN.htm