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Healing the brain with Light Energy By: Dr Lew Lim November 2014 Slide 2 Click here to view Featured on Slide 3 One year ago, Rudy was not allowed out on his own. Today, he drives on his own Slide 4 Rudys MMSE Scores (Alzheimers) Slide 5 Our cells desire light Click here to view Slide 6 Source: Giuliani et al. Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress. BMC Com Alt Med 2009, 9:8. In vitro post-oxidative stress. 670nm, 3 mW, 20 sec/day, 5 days Healing of Neurons with Light Slide 7 Over 1 million results as well as many research studies if you google: low level light therapylow level light therapy low level laser therapylow level laser therapy Slide 8 Alternative transcranial light therapy devices They cannot reach the hippocampus key for memory function Expensive and very hard to use Slide 9 Picture source: OpimMeadow. Flickr Intranasal: Path of low resistance to mid-brain Key regions Transcranial Slide 10 Source of picture: Atlas of human anatomy: http://www.anatomyatlases.org/atlasofanatomy/plate24/03sagmedialr.shtml Key memory and regulatory areas are inaccessible from the skull Slide 11 Barriers at transcranial areas Slide 12 Intranasal device to reach the brain Vielight 810 Infrared Slide 13 The Default Mode Network is Important Source: Sandrone S, and Catani M Neurology 2013;81:e172-e175 Slide 14 Problem locations of Alzheimers Source: Buckner et al, Journal of Neuroscience 2005 Slide 15 Parkinsons is affected Normal With Parkinsons Source: Elemeren T. et al. Dysfunction of the Default Mode Network in Parkinson Disease. Arch Neurol. Jul 2009; 66(7): 877883. Slide 16 Key Target Locations Source of illustration: http://www.showboatentertainment.com/illustrations/medical-illustrations.html Slide 17 Source: Barolet D. Light-emitting Diodes (LED) in Dermatology. 2008 810nm 630nm 660nm 810 nm Optical Penetration Depth Slide 18 810nm: Highest nerve absorption and regeneration Source: Prof. Juanita Anders Uniformed Services University of the Health Sciences 810 nm seems to bypass the shallower nerves and deposits deeper in (5 inches) Slide 19 810 nm: Minimal blood and water absorption Source: Prof. Juanita Anders Uniformed Services University of the Health Sciences 810 nm mainly passes right through blood serum to reach the brain Slide 20 Source: Sagittal magnetic resonance imaging (MRI) image of a human head (Courtesy of the Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, UK) Penetration Achievable Slide 21 Ando et al. Comparison of Therapeutic Effects between Pulsed and Continuous Wave 810-nm Wavelength Laser Irradiation for Traumatic Brain Injury in Mice. Plos One. Oct 2011 Neurological Severity Score Area under curve Effect of 10 Hz Alpha wave Pulse Mode Slide 22 Literature on Alpha Brainwaves (8 12 Hz) Concentration Clarity Calms Imagination Higher awareness Better sleep De-stress Immune system Learning Memory Slide 23 Vielight Neuro Cranial-nasal light therapy using 810 nm, pulsed at 10 Hz, for 25 minutes Slide 24 New Vielight Neuro Light, portable and easy to use Comprehensive phototherapy Scientifically superior and more affordable than the alternatives. Slide 25 Vielight science advisors and clinical research team leaders Prof. Francisco Gonzalez- Lima, University of Texas, Austin (for Alzheimers research) Assoc. Prof. Michael Hamblin, Harvard University Prof. Juanita Anders, US Uniformed Services University All are recognized worldwide as thought leaders in light therapy for neurologic conditions, backed by numerous published works. Prof. Timon CY Liu South China Normal University Slide 26 Independent controlled studies Boston University Vielight 810 Infrared Ongoing studies PTSD Slide 27 Differentiating 810 Infrared and Neuro Vielight 810 InfraredVielight Neuro Treats key regions Everyday use as prophylaxis Very convenient Safely used for all brain conditions Some risk of temporary headache Low cost at $499 Comprehensive treatment Use once every 2 days only Not as convenient Designed for difficult conditions More tendency for headache Higher cost at $999 Available since 2012 Available in early 2014 Slide 28 Other Vielight intranasal light therapy devices 655 Prime uses Laser $399633 Red uses LED $299 Mainly for the body in general: Immune system Vascular system Systemic pain Slide 29 END Lew Lim, Vielight Inc.