hdrs – colipa-tf sun protection 1994 / venice hdrs – the future of spf · 2019. 12. 29. ·...
TRANSCRIPT
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HDRSHybrid Diffuse Reflectance Spectroscopy
The first real change in SPF-testing since COLIPA 1994
Mathias Rohr
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HDRS – COLIPA-TF Sun Protection 1994 / Venice
Published May 1994
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HDRS – The Future of SPF
Albert Einstein (1879-1955)
Die Probleme dieser Welt lassen sich nicht mit den gleichen Denkweisen lösen, die sie erzeugt haben!
A whole new way of thinking is required forsolving the problems we have created through our old way of thinking!
Let’s Start and
Let’s talk about Hybrid Diffuse Reflectance Spectroscopy or ISO 23698
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ISO 24444 – SPF Measurement
Application
Test ProductIrradiation
of Test Product
SPFof
Test Product
Expected SPF Range
Volunteer recruitment
Definition of spectrum
Range finding
Definition of MED
Reading of MED
Waiting Time 16-24h
Energy - Homogeneity
Certificates
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ISO 24444 – UVB Erythema / MED
UVB-Erythema
156%
125%
MED = 100%
80%
64%
51%
MED
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ISO 24444 – UVB Erythema?
UVB-Erythema?
Beside any Ethical Concernssometimes even the simple definition of
the correct MED might be a challenge
In order to get rid of all these points
Future SPF-Testing should be „free off“
any Erythemal Testing
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Basic Ideas of HDRS
Basic Ideas of HDRS
Technique
Results / SPF / Photostability
Results / UVA-PF
Results / Water-Resistance
Ongoing Statistics - ISO
Summary
-
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SPFHDRS – A combination of in vivo and in vitro calculations
SPFcalculated =
E( ) I( ) 10 –A( ) d=290
=400
E( ) I( ) d=290
=400
E( ) = Erythemal Action SpectrumI( ) = Spectral IrradianceA( ) = Absorbance
SPF-Calculation
Experimental Design HDRS: Combination of ISO 24443 (in vitro) and Diffuse Reflectance Spectroscopy (DRS in vivo)
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300 320 340 360 380 4000.0
0.5
1.0
1.5
2.0
2.5 DRS in vivo (Skin)
Wavelength [nm]
Abso
rptio
n [O
D]
HDRS – DRS-Signal
No Signal
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300 320 340 360 380 4000.0
0.5
1.0
1.5
2.0
2.5 DRS in vivo (Skin)
Wavelength [nm]
Abso
rptio
n [O
D]
SPFHDRS – Hybrid-Signals
HDRS-Signal
300 320 340 360 380 4000.0
0.5
1.0
1.5
2.0
2.5 DRS in vivo (Skin) UV in vitro (PMMA)
Wavelength [nm]
Abso
rptio
n [O
D]
AdjustmentHybridisation Wavelength
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SPFHDRS – A combination of in vivo and in vitro calculations
SPFcalculated =
E( ) I( ) 10 –A( ) d=290
=400
E( ) I( ) d=290
=400
E( ) = Erythemal Action SpectrumI( ) = Spectral IrradianceA( ) = Absorbance
SPF-Calculation HDRS
SPF-Calculation based on A( ) from HDRS-Data
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Technique
Basic Ideas of HDRS
Technique
Results / SPF / Photostability
Results / UVA-PF
Results / Water-Resistance
Ongoing Statistics - ISO
Summary
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SPFHDRS – Technique
Light
Sou
rce
Diffuse Reflectance DRS / in vivo
Signal analysis
Excitationmonochromator
Emissionmonochromator
UVB / UVADetection
Hardware configuration
ISO 24443UVB / in vitro
Ligh
LighghghhhhghghgLiLiLLLLLLLLL
SoSoSoSot So
tSo
tSoSotSoSot SoSotSo
tSo
t SoSoootSooooSoooSoSoSoooooSooSooSot SooSSSSSSSSSSStSSSSSSSSt SSSSSSSSS
urce
urc
urccrcccrcurcc
urccccccccccc
urccc
urcccrcrcccurc
urc
urc
urcc
urc
urcc
urccrrrrruuuuuuuuuuuuu
Diffuse ReflectannnccccccccceDRS / / in vivo
ExExcitExExExcitExcitExcitExcittEExcitEE ititatatioatatioationationttiontiontitionoonationatiattitittiotionataati nnatiaatttiottttiioonooooonnnnnatationatioonnamonocmonocmonocmonocmonomonooonnnmonononmononomonoonomonomonocmonoccmonocmonocnocmonocmonooonocmonomomooonoo oonoocccccmonommono ooomonomonocmonococmonocmonmmmmmm nnnomonocmmmmmonocmmmmoooommmmmmmm nmm hhhhhhhhhhhromhromromromromahromahromahromahromromhromhromhhhhhromhromhhhhhhrohrohrohrhrhroohrhrohrh torrrorrrrrrrrrorrrrrroorrrrrrooorrrrr
g
ISOISOISOISOISISOSOISOISSOISOSOSOOOISOISOISOSSOIIISSSSISOSISISSSSSSOSOSSSOSSSSOOSOOISOISOSSOSOSOSOOOOSOOSOOSOISOOISOSOSSSOOOOOOOOOOISSOSOOOOIS 242424242422242424422224244222222222244444242242244444444443443433333333443333333333333443443444333334444444 33UVBUVBUVUVBUVBUUVBUVBUVBBUVBUUVUUUUUVBUVUUUUUUUUUUUUUUUUVBUVBUVBVBUUUUUUUUUUVBVVVBUUUUUUUUUVBVBUUUUUUVBUVBVVUVBUUUUUVVUUUUUVVBUUUUUUVB // / / //////// inin iniiniininnnnin vvvvvvvviiiiiittvvvvivviivivvvvvvvvvvvvvviiiv
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SPFHDRS – Technique
Bentham 2 Monochromator System
Bi-Alkali PMT - cooled
Measurement range 200 – 650 nm
450 Xenon Lamp
Y-Quartz-Fiber with optically separated excitation and detectionfixed on a specially designed stand
Dynamic Range up to 6 OD
Bentham 2 Monochromator Sysssssssttt
Bi-Alkali PMT - cooleedddddddd
Measurement range 200 – 650 nm
450 Xenon Lamp
Y-Quartz-Fiber with oppppppppseparated excitation aaaannnnfixed on a specially deeessssss
Dynamic Range up to 666
tittitiititiittitiittiiit tttuteuteuteuteute dddddedededede
TeTeTeTeechchchchc ninininiquququququqqq eeeee
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Results / SPF / Photostability
Basic Ideas of HDRS
Technique
Results / SPF / Photostability
Results / UVA-PF
Results / Water-Resistance
Ongoing Statistics - ISO
Summary
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HDRS – Test-Design
Study Objective: Quantification of SPF
Experimental Design: Combination of ISO 24443 (in vitro) and Diffuse Reflectance Spectroscopy (DRS in vivo)
Test Products : 250 Products (marked and specially designed)
SPF-Range : SPF 4 - SPF 120
Subjects: SPF24444 (n=10) / SPFHDRS (n=10-15)
Statistical Analysis: SPF24444 and SPFHDRS / Regression Analysis…….
ISO 24444 (SPF in vivo)
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HDRS – Test-Products
Test Products: O/W-Lotion and CreamW/O-Lotion and CreamCream GelO/W-SprayOil-Spray (with and without Alcohol)StickAerosol-SprayPowderFoam
UV-Filter: A wide range of organic and inorganic UV-FilterWith and without TiO2 (Nano and Non-Nano)With and without ZnO
Photostability: Photo-stablePhoto-unstable (UVB and/or UVA)
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HDRS – Results SPF24444 / SPFHDRS / n=250
0 20 40 60 80 100 1200
20
40
60
80
100
120
SPF
[HDR
S]
SPF [ISO 24444]
n=250
Linear Fit: m = 0.983 / R2 = 0.974
SPFHDRS approved
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SPFHDRS – approved
Photo-Stability adjusted
No limits concerning the type of formulation
Excellent Correlation of SPF24444 and SPFHDRS up to SPF 120
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0 20 40 60 80 100 1200
100
200
300
400
SPF
[HDR
S] [N
ot a
djus
ted]
SPF [ISO 24444]
n=250
0 20 40 60 80 100 1200
100
200
300
400
SPF
[HDR
S] [N
ot a
djus
ted]
SPF [ISO 24444]
n=250
HDRS – Results SPF24444 / SPFHDRS / n=250
Expected Correlation
Calculated
How to include Photo-Stability?
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HDRS – Photo-Stability / Limits of pre-Irradiation Dose
Using ISO 24443
How to include Photo-Stability
Pre-Irradiation Dose according to ISO 24443 (1.2 x UVA-PF0 [J/cm2])
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280 300 320 340 360 380 4000.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
1.8
in vitro UV-Absorption - Before pre-irradiation in vitro UV-Absorption - After pre-irradiation
Wavelength [nm]
Abso
rptio
n [O
D]
280 300 320 340 360 380 4000.00.20.40.60.81.01.21.41.61.82.02.2
in vitro UV-Absorption - Before pre-irradiation in vitro UV-Absorption - After pre-irradiation
Wavelength [nm]
Abso
rptio
n [O
D]
280 300 320 340 360 380 4000.00.20.40.60.81.01.21.41.61.82.02.2
in vitro UV-Absorption - Before pre-irradiation in vitro UV-Absorption - After pre-irradiation
Wavelength [nm]
Abso
rptio
n [O
D]
Absorption – Variation of UV-Stability (PMMA)
Stable UVA-Unstable
UVB-Unstable
SPFcalculated =
E( ) I( ) 10 –A( ) d=290
=400
E( ) I( ) d=290
=400
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280 300 320 340 360 380 4000.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
1.8
in vitro UV-Absorption - Before pre-irradiation in vitro UV-Absorption - After pre-irradiation
Wavelength [nm]
Abso
rptio
n [O
D]
280 300 320 340 360 380 400
0
5
10
15
20
25
30
35
Before pre-irradiation After pre-irradiation
Wavelength [nm]
10Ab
sorp
tion
[OD]
280 300 320 340 360 380 4000.00.20.40.60.81.01.21.41.61.82.02.2
in vitro UV-Absorption - Before pre-irradiation in vitro UV-Absorption - After pre-irradiation
Wavelength [nm]
Abso
rptio
n [O
D]
280 300 320 340 360 380 4000
10
20
30
40
50
60
70
80
Before pre-irradiation After pre-irradiation
Wavelength [nm]
10Ab
sorp
tion
[OD]
SRPD – Spectral Ratio of Photo Degradation
UVA-UnstableUVB-Unstable
= 1111 10 ( )10 ( )Photostability: Multiplication of AHDRS with the defined SRPD wavelength by wavelength
Calculation of SPFHDRS300 320 340 360 380 4000.5
0.6
0.7
0.8
0.9
1.0
1.1
mainly UVB mainly UVA
Wavelength [nm]
SRPD
[a.u.
]
SRPD
Ratio of Absorption Curves
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HDRS – Results SPF24444 / SPFHDRS / n=250
No PhotostabilityPhotostabilityadjusted
0 20 40 60 80 100 1200
100
200
300
400
SPF
[HDR
S] [N
ot a
djus
ted]
SPF [ISO 24444]
n=250
0 20 40 60 80 100 1200
20
40
60
80
100
120
SPF
[HDR
S]
SPF [ISO 24444]
n=250
Linear Fit: m = 0.983 / R2 = 0.974
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HDRS – Photo-Stability / Limits of pre-Irradiation Dose
Using ISO 24443
How to include Photo-Stability
Pre-Irradiation Dose according to ISO 24443 (1.2 x UVA-PF0 [J/cm2])
Is there a reason to define a maximum pre-Irradiation Dose?
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0 2 4 6 8 10 12 14 160
1000
2000
3000
4000
5000
6000
7000
8000
Dose
per
Day
[J/m
2 d]
UV-Index
HDRS – Limits of pre-Irradiation Dose
0 2 4 6 8 10 12 14 160
1000
2000
3000
4000
5000
6000
7000
8000 Dose per Day
Dose
per
Day
[J/m
2 d]
UV-Index
0 2 4 6 8 10 12 14 160
1000
2000
3000
4000
5000
6000
7000
8000 Dose per Day Linear Fit : m = 522.0 / b = -106.4 / R2 = 0.993
Dose
per
Day
[J/m
2 d]
UV-Index
0 2 4 6 8 10 12 14 160
5
10
15
20
25
30 SED Skin Type II (250 J/m2)
Linear Fit : m = 2.09 / b = -0.43 / R2 = 0.993
MED
per
Day
[250
J/m
2 d]
UV-Index(Data from: Knuscke et. all, Bundesamt für Arbeitsschutz und Arbeitsmedizin, Schutzkomponenten bei solarer UV-Exposition – Forschungr Projekt F2036, 2015)
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HDRS – Limits of pre-Irradiation Dose
0 2 4 6 8 10 12 14 160
5
10
15
20
25
30 SED Skin Type II (250 J/m2)
Linear Fit : m = 2.09 / b = -0.43 / R2 = 0.993
MED
per
Day
[250
J/m
2 d]
UV-Index
Berlin 14 MED/d
Majorca 18 MED/d
Berlin Majorca Sydney
Sydney 23 MED/d
Equator 27 MED/d
Equator
SPF 30 Defines a relevant
Maximum of apre-Irradiation-Dose
on Earthfor
Photo-Stability-Testing
UVA-PF0 30 is more than enough
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HDRS – Photo-Stability / Limits of pre-Irradiation Dose
Using ISO 24443
How to include Photo-Stability
Pre-Irradiation Dose according to ISO 24443 (1.2 x UVA-PF0 [J/cm2])
Is there a reason to define a maximum pre-Irradiation Dose?
Proposal: If the calculated UVA-PF0-HDRS > 30
This value should be limited to UVA-PF0 = 30to calculate the pre-Irradiation Dose according to ISO 24443 (1.2 x UVA-PF0 [J/cm2])
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SPFHDRS – approved
Photo-Stability adjusted
No Irradiation of Skin
No limits concerning the type of formulation
Excellent Correlation of SPF24444 and SPFHDRS up to SPF 120
(and should be limited, correlated to UVA-PF0 30)
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HDRS – Really non-invasive?
Is there a relevant irradiation dose during the measurement process?
Irradiation during measurement
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HDRS – Erythemal weighted Irradiation Dose
UV-Range
[nm]
Mean Irradiation Dose(n=10)
[mJ/cm2]
Relative to Reference MEDu(Skin Type II, 21 J/cm2)
[%]
280 – 405
290 – 405
300 – 405
310 - 405
0.377 ± 0.029
0.336 ± 0.011
0.155 ± 0.009
0.036 ± 0.002
1.79
1.60
0.74
0.17
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SPFHDRS – approved
Photo-Stability adjusted
No Irradiation of Skin
No limits concerning the type of formulation
Excellent Correlation of SPF24444 and SPFHDRS up to SPF 120
(and should be limited, correlated to UVA-PF0 30)
(Absolute no relevant UV-Irradiation of Skin)
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Results / UVA-PF
Basic Ideas of HDRS
Technique
Results / SPF / Photostability
Results / UVA-PF
Results / Water-Resistance
Ongoing Statistics - ISO
Summary
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HDRS – Test-Design / UVA-PF
Experimental Design : Diffuse Reflectance Spectroscopy (DRS in vivo)
42 Products
UVA-PF 2 - UVA-PF 30
ISO 24442 (UVA-PF in vivo) ISO 24443 (UVA-PF in vitro)
210 Products
UVA-PF 2 - UVA-PF 50
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HDRS – UVA-PF
Study Objective: Quantification of UVA-PF
UVA-PF =
P( ) I( ) 10 –A( ) d=320
=400
P( ) I( ) d=320
=400
P( ) = PPD Action SpectrumI( ) = Spectral Irradiance (UVA)A( ) = Absorbance
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HDRS – Spectrum of UVA-PFHDRS
300 320 340 360 380 4000.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
1.8
2.0
DRS-Absorption
Wavelength [nm]
Abso
rptio
n [O
D]
Wavelength Range used for UVA-PFHDRS calculation
UVA-PF =
P( ) I( ) 10 –A( ) d=320
=400
P( ) I( ) d=320
=400
Direct calculation based on
in vivo DRS-Absorbance A( )
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HDRS – Results UVA-PF24442 / UVA-PFHDRS
0 5 10 15 20 25 300
5
10
15
20
25
30
UVA-
PF [H
DRS]
UVA-PF [ISO 24442]
n=42
0 5 10 15 20 25 300
5
10
15
20
25
30
UVA-
PF [H
DRS]
UVA-PF [ISO 24442]
n=42
Linear Fit: m = 0.978 / R2 = 0.970
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SPFHDRS – approved / UVA-PFHDRS – approved
Photo-Stability adjusted
No Irradiation of Skin
No limits concerning the type of formulation
Excellent Correlation of SPF24444 and SPFHDRS up to SPF 120
(Absolute no relevant UV-Irradiation of Skin)
(and should be limited, correlated to UVA-PF0 30)
SPF
All comments can be adapted to UVA-PF
UVA-PF
Does it work in correlation to ISO 24443 UVA in vitro?
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HDRS – Results UVA-PF24443 / UVA-PFHDRS
0 10 20 30 40 50 600
10
20
30
40
50
60
UVA-
PF [H
DRS]
UVA-PF [ISO 24443]
0 10 20 30 40 50 600
10
20
30
40
50
60
UVA-
PF [H
DRS]
UVA-PF [ISO 24443]
n=210
0 10 20 30 40 50 600
10
20
30
40
50
60
Linear Fit: m = 1.04 / R2 = 0.967
UVA-
PF [H
DRS]
UVA-PF [ISO 24443]
n=210
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SPFHDRS – approved / UVA-PFHDRS – approved
No limits concerning the type of formulation
Excellent Correlation of SPF24444 and SPFHDRS up to SPF 120
SPF
All comments can be adapted to UVA-PF
UVA-PF
Correlation of UVA-PFHDRS to ISO 24442 (in vivo) and ISO 24443 (in vitro)
Photo-Stability adjusted
No Irradiation of Skin (Absolute no relevant UV-Irradiation of Skin)
(and should be limited, correlated to UVA-PF0 30)
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Results / Water-Resistance
Basic Ideas of HDRS
Technique
Results / SPF / Photostability
Results / UVA-PF
Results / Water-Resistance
Ongoing Statistics - ISO
Summary
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Are there any experimental differences for HDRS?
The actual method in Europe is still the COLIPA method from 2005(2x20min Spa Pool, static and wet SPF, calculation of WR)
HDRS – Water-Resistance-Testing
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Water-Resistance-Testing
Product application 2.0 0.05 mg/cm2 Movement of water by jet impact, no air bubbles
Waiting Time 15 min Test area has to be totally covered with water / no contact to pool
1. Spa Pool Time 20 min Controlled water qualityEC Council Directive 98/83 EC
Drying Time at air 15 min Mg and Ca50 mg/ml - 500 mg/ml
1. Spa Pool Time 20 min Hygienic control by Cl
Drying Time at air 15 min / or until the test area is totally dryWater Temperature
29 2 °C.
Test of SPF on static and wet test areas
HDRS – Water-Resistance-Testing
-
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HDRS – Water-Resistance-Testing / Spa Pool
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Are there any experimental differences for HDRS?
The actual method in Europe is still the COLIPA method from 2005(2x20min Spa Pool, static and wet SPF, calculation of WR)
Are there any calculation differences for HDRS?
HDRS – Water-Resistance-Testing
No!
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SPFsi = individual SPF-staticSPFwi = individual SPF-wet%WRi = individual Water-Resistance in %mean %WR = Mean Water-Resistance in %d = 90% CI
%WRi = SPFwi - 1
SPFsi - 1 x 100
mean %WR = %WRi
n
n
i=1
HDRS – Water-Resistance-Testing / Calculation
mean %WR = mean SPFw - 1
mean SPFs - 1 x 100
mean SPFs = mean SPF-staticmean SPFw = mean SPF-wetmean %WR = Mean Water-Resistance in %
WR-Classic: WR-HDRS:
WRR = mean %WR – d
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Are there any experimental differences for HDRS?
The actual method in Europe is still the COLIPA method from 2005(2x20min Spa Pool, static and wet SPF, calculation of WR)
Are there any calculation differences for HDRS?
HDRS – Water-Resistance-Testing
No!
Yes!
Are there any differences in the resulting WR for HDRS?
-
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HDRS – Test-Design / Water-Resistance
Study Objective: Quantification of Water Resistance (WR)
Experimental Design: WR-Classic and WR-HDRS
Water Resistance: 2x20 min Spa Pool / WR: 30%-90% (classic)
Test Products : 15 Products
Measurements: DRS-static and DRS-wet
Analysis: Calculation of SPFHDRS / Calculation of WRHDRS
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HDRS – Water-Resistance / Static Results
0 20 40 60 80 100 1200
20
40
60
80
100
120
SPFs
tatic
[HD
RS]
SPFstatic [ISO24444]
0 20 40 60 80 100 1200
20
40
60
80
100
120
SPFs
tatic
[HD
RS]
SPFstatic [ISO24444]
Linear Fit: m = 0.99 / R2 = 0.971
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HDRS – Water-Resistance / Wet Results
0 20 40 60 80 100 1200
20
40
60
80
100
120
SPFw
et [
HDRS
]
SPFwet [ISO24444]
0 20 40 60 80 100 1200
20
40
60
80
100
120
SPFw
et [
HDRS
]
SPFwet [ISO24444]
Linear Fit: m = 1.11 / R2 = 0.951
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HDRS – Water-Resistance / %-Results
0 20 40 60 80 100 1200
20
40
60
80
100
120
WR-
HDRS
[%
]
WR-classic [% ]
0 20 40 60 80 100 1200
20
40
60
80
100
120
WR-
HDRS
[%
]
WR-classic [% ]
Linear Fit: m = 1.07 / R2 = 0.942
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Are there any experimental differences for HDRS?
The actual method in Europe is still the COLIPA method from 2005(2x20min Spa Pool, static and wet SPF, calculation of WR)
Are there any calculation differences for HDRS?
HDRS – Water-Resistance-Testing
No!
Yes!
Are there any differences in the resulting WR for HDRS? No!
Again -For the first time we have an alternative method which can handle WR-Testing!
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Ongoing Statistics - ISO
Basic Ideas of HDRS
Technique
Results / SPF / Photostability
Results / UVA-PF
Results / Water-Resistance
Ongoing Statistics - ISO
Summary
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HDRS – Ring-Test / 3 Countries
1. Ringtest (2017): 1 Lab SPFISO 24444 3 Labs SPFHDRS7 Products SPF 5 – 30
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5 10 15 20 25 30 35 40
5
10
15
20
25
30
35
40
Hybrid SPF = 1.00778 * (in vivo SPF)r2=0.96
Hybr
id SP
F
in vivo SPF
• Clinical Research Labs-CRL - Piscataway, US – SkinSkan (Horiba, USA)• Medcin Instituto da Pele - Guarulhos, BR – Fluorolog 3-22 (Horiba, USA) • Institut Dr. Schrader - Holzminden, GE – Bentham Instruments
HDRS – Ring-Test Results of 3 Labs / 7 Products (2017)
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HDRS – Ring-Test / 3 Countries
1. Ringtest (2017): 1 Lab SPFISO 24444 3 Labs SPFHDRS7 Products SPF 5 – 30
2. Ringtest (2018): 3 Labs SPFISO 24444 3 Labs SPFHDRS12 Products SPF 5 – 60
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y = 1.0614xR² = 0.9917
0.0
10.0
20.0
30.0
40.0
50.0
60.0
70.0
80.0
0 10 20 30 40 50 60 70 80
HDRS
SPF
in vivo SPF
HDRS – Ring-Test Results of 3 Labs / 12 Products (2018)
12 Products
3 Labs / in vivo and HDRS
3 different Countries
Excellent Correlation
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HDRS – Ring-Test / 3 Countries
1. Ringtest (2017): 1 Lab SPFISO 24444 3 Labs SPFHDRS7 Products SPF 5 – 30
2. Ringtest (2018): 3 Labs SPFISO 24444 3 Labs SPFHDRS12 Products SPF 5 – 60
3. Ringtest (2019): 3 Labs SPFISO 24444 3 Labs SPFHDRS25 Products SPF 5 – 60 ISO Acceptance Criteria
Results ready for presentation on the next ISO-Meeting / June 2019
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Basic Ideas of HDRS
Technique
Results / SPF / Photostability
Results / UVA-PF
Results / Water-Resistance
Ongoing Statistics - ISO
Summary
Summary
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ISO 24444 on its way to ISO 23698 (NWI)
Application
Test ProductIrradiation
of Test Product
SPFof
Test Product
Expected SPF Range
Volunteer recruitment
Definition of spectrum
Range finding
Definition of MED
Reading of MED
Waiting Time 16-24h
Energy - Homogeneity
Certificates
HDRSNon invasive
Measurement
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SPFHDRS – The alternative non erythemal SPF – in vivo
No Ethical Concerns
Irradiation of Skin
Photostability linked to ISO 24443
SPF-Range covered up to SPF 120
Correlation of UVA-PF24442 / 3 and UVA-PFHDRS
Definition of MED
Training of MED reading
UVA-PF-Range covered up to UVA-PF 30
Not needed:
Information of expected SPF
Irradiation Spectrum
Excellent:
No limits concerning the type of formulation
Let’s start and go this new way in SPF testing
Separate testing of SPF and UVA-PF
Correlation of SPF24444 and SPFHDRS
Water-Resistance Testing included
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HDRS – ISO 23698
COLIPA-TF Sun Protection 1994 / Venice
ISO/TC217/WG7 Sun Protection test methods 2018 / Monaco
ISO 23698 / HDRSComing soon!
HDRS the first real changein SPF in vivo since 25 years!
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Thank you for your attention
Merci de votre attention
Gracias por su atención
Vielen Dank für Ihre Aufmerksamkeit
Obrigado para sua atençãoo
Thank you for your attention
Merci de votre attention
Gracias por su atención
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