hcc: proposals for biomarkers and imaging surveillance afpl3% dcp 2013
TRANSCRIPT
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8/14/2019 HCC: Proposals for biomarkers and imaging surveillance AFPL3% DCP 2013
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@BB> fmdkorigrs oej mkoame
survgmhhoebg
Vdfgrt A. Ams` KJRgemdr Kgjmboh Jmrgbtdr Rt Ndsgp`s Kgjmboh Bgetg\`dgemx
Bhmemboh \rdcgssdr dc Kgjmbmeg> Wemvgrsmty dc Egvoj
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BDM
Jr Ams` `os rgbgmvgj `dedrormuk oejbdesuhtmea cggs crdk Qoid Jmoaoedstmbs
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Ms Rurvgmhhoebg Qdrt`w`mhgoej `dw
kdjmcy wmt` dur CJO opprdvgj fmdkor
@dw jd wg jgcmegwdrt`w`mhg4
Mkprdvgkget me survmvoh dc 2 kdet`s Y?[
Rurvgmhhoebg bdesmjgrgj bdst-gccgbtmvg mc mt ob`mgvgs 2-k
mkprdvgkget me survmvoh ot o bdst dc 8 $7
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Gccgbt dc Rurvgmhhoebg de Dutb Vgtrdspgbtmvg oeohysms dc potmgets wmt` bmrr`dsms oej @BB (E ; 63=)
Rtoejorj-dc-borg survgmhhoebg (e ; ?16)
Whtrosduej dr dt`gr ofjdkmeoh mkoamea ? tmkg/ygor
Rufstoejorj survgmhhoebg (e ; :0)
Hobi dc ofjdkmeoh mkoamea wmt`me ? ygor dc boebgr jmoaedsms
Ofsgebg dc survgmhhoebg (e ; 7=)
Dutbdkgs, %Rtoejorj-dc-Borg
Rurvgmhhoebg(e ; ?16)
Rufstoejorj
Rurvgmhhoebg
(e ; :0)Ofsgebg
Rurvgmhho
(e ; 7=
@BB Jx ot stoags ?/6 3= 27 ?0Hmvgr troesphoetotmde 26 ?2 1Kgoe 2-ygor survmvoh :
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Rukkory> @BB survgmhhoe Whtrosduej ms t`g dehy rgbdkkgejgj kdj
Ed VBZ td prdvg BZ dr KVM ms gccgbtmvg cdr survgmhhoebg
Bdst gccgbtmvgegss oeohysms> Whtrosduej ms t
bdst gccgbtmvg survgmhhoebg kgt`djFut
Whtrosduej quohmty boe vory, sgesmtmvmty ovg~3
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Eotmdeoh survgy me t`g WR
_ugstmdeeomrg :12 OORHJ p`ysmbmoe kg
B`ohosoem, E. gt oh. Ok N Aostrdgetgrdh
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@BB Rurvgmhhoebg Rurvgy> WB G-komh mevmtotmde sget cdr o frmgc ghgbtrdemb survgy t
AM/`gpotdhday prdvmjgrs me t`g Wemtgj Rtotgs \ort M> 613/6:07 OORHJ kgkfgrs (??.?%)
2< gxbhujgj (mebdkphgtg, edt sggmea ojuht potmgets)
6:3 wgrg oeohyzgj 12 aostrdgetgrdhdamsts (2
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Vgsuhts> OORHJ kgkfgrs 663 (=6%) drjgr @BB survgmhhoebg cdr bmrr`dtmb
6?? (=2%) usg uhtrosduej (WR) me sdkg bopobmty
=0 (:2%) usg ohh 2 mkoamea kdjohmtmgs (WR/BZ/KV
0< (27%) gxbhusmvghy usg WR wmt` fmdkorigr
?3: (12%) gxbhusmvghy usg OC\ ohdea wmt` mkoamea
?0 (0%) usg 6 dr kdrg fmdkorigrs (OC\, OC\ H2%,wmt` mkoamea
:2 (?=%) jd edt usg oey fmdkorigrs, dehy mkoame
?=1 (01%) usg 3 kdet`s metgrvoh
Nds`m, Ided, Ams` gt
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Vgsuhts> OORHJ kgkfgrs
\rdvmjgrs ot troesphoet bgetgrs (ZB) (e; ?:6) k
td usg ohh 2 mkoamea kdjohmtmgs (p8
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Whtrosduej _uohmty Rtujy W
\rghmkmeory Vgsuhts Gxbghhget ?2/?7: (0.:%)
Addj ::/?7: (60.3%)
Comr ::/?7: (60.3%)
\ddr 72/?7: (2:.:%)
Me oeohysms> oey prgjmbtmvg cobtdrs cdr pddr quohmty uhtrosduej4 (FKM, prgsgebg/sgvgrmtbmrr`dsms, robg, oag, agejgr gtb)
Ided, Nds`m, Rmr
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Gd j
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\rdpdsgj Ohadrmt`k
Hmvgr Whtrosduej
\rdtdbdh cdr
sbrggemea oejsurvgmhhoebg
q3kdet`s
Qmt` OC\H2%/JB\
@BB sgruk
fmdkorigrs
\ddr/Comrquohmty WR
Addj/Gxbghhget
quohmty WR
@F\ GdvmstKVM x ?
WR
survgmhhoebg
q3 kdet`s
Gk
J
Gd j
: dr
@BB
WR q3
kdet`s
E
Fy
fm
Ega KV
Ofeh
WR
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\urpdsg Zd cmej `dw koey WR gxoks org
gxbghhget/addj/comr/pddr quohmty Zd cmej t`g prgjmbtdrs dc WR quohmty
Zd cmej t`g sgesmtmvmty dc WR vs @F\ Gdvmst KVM quohmty ms pddr
Zd cmej t`g bdst gccgbtmvgegss dc WR vs Gd-KVM(kdjghmea)
Gxphdrg utmhmty dc usmea OC\H2% oej JB\ td kdmkoamea kdjohmty usgj
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Bdsts cdr mkoamea
Oejgrssde I, gt oh. Bhme Aostrdgetgrdhday oej @gpotdhday> 6 bdetmeugj
OC\H2% 81
JB\ 8 2
\hoe>
Bdetmeug fmdkorigr ossgsskget gvgry 2 kde WR ohtgreotmea wmt` KV wmt` gdvmst gvgry 3 k
Mc OC\H2% dr JB\ rmsg fy 6
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Bosg 6
:7 yd Smgteokgsg koe wmt` o iedwe @t`g hgct hdfg dc t`g hmvgr fy BZ, WR oej f
ot 2.2 bk
@FS JEO +, trgotkget eomvg
OC\ 82 ea/kH
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Bosg 6> bdetmeugj
\hoe Drjgr @BB fmdkorigr poegh
Orroeag ZOBG cdhhdwgj fy Ruragry
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Bosg 6> bdetmeugj
\hoe @BB fmdkorigr poegh
OC\H2%81
JB\ 6
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Bosg 6> bdetmeugj Cdhhdw up ot kdet` ?7
@BB fmdkorigr poegh OC\ edrkoh
OC\H2%81
JB\ 82
: KV sboes wmt` Gdvmst oej deg WR gxok org egaotmvg/edrk
De trgotkget Getgbovmr Smtokme J
Rtotme
\hoe> bdetmeug fmdkorigr poegh gvgry 2 kdet`s wmt` JB\ ts`mppgj td Nopoe crdk Smgt Eok
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Bosg 2
:7 yd wdkoe, FKM 20, EOR@, stoag MMM-Mcmfrdsms
OC\ 73 ea/kH
WR egaotmvg> pddr quohmty jug td FKM Mesuroebg bdkpoey rgcusgs drjgr cdr BZ
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Bosg 2> Bdetmeugj
OC\H2% jotg ? 0%
OC\H2% jotg ? + 2 kdet`s ??% OC\H2% jotg ? + 3 kdet`s ?7%
Mesuroebg bdkpoey opprdvgj BZ sboe wmt` bdetros
kdet`s octgr 2 hgttgrs dc oppgoh oej 6 prdvmjgr p` BZ cmejmeas> 2.3 @BB bk me sgakget ?
\otmget gvohuotgj cdr ZOFG oej hmvgr troesphoet
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Bosg :>
:7 yd koe wmt` iedwe @BB 1 bk, OC\ ?3< ea/
?:7, OC\H2% 1
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Bosg :> bdetmeugj
HZ bgetgr bdebgregj ofdut `ma` fmdkor \hoeegj BZ dc b`gst oej fdeg sboe> ega
\otmget phobgj de WEDR womt hmst
2 kdet` survgmhhoebg wmt` KV wmt` Gdv3 kdet`s BZ dc b`gst oej Fdeg Rboe
@BB fmdkorigr poegh
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Bosg :> bdetmeugj
Kdet` 1
@BB fmdkorigr poegh ueb`oeagj wmt` ohh 2 fmghgvotgj
BZ dc b`gst s`dwgj egw edjuhg
Huea edjuhg fmdpsy s`dwgj kgtostotmb @BB
potmget phobg de sdrocgemf oej rgkdvgj crwomt hmst
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Bosg 7 :1 yd wdkoe wmt` iedwe, B`mhj O, KGHJ 3, @BB 7 bk me
de KV wmt` Koaeovmst, OC\ :
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Bosg 7> bdetmeugj
O hmvgr fmdpsy wos pgrcdrkgj
Cmejmeas> tukdr fmdpsy> pddrhy jmccgrge@BB, ed bopsuhg
Fx dc ojnobget tmssug td fg usgj td stoa
jmsgosg oej jgtgrkmeg mc potmget o boejcdr suramboh rgsgbtmde, s`dwgj skohhkmbrdkgtostosms
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Obiedwhgjakgets
Bhoujg Rmrhme
]uid Ided