gut-brain regeneration: the microbiome as a new avenue for therapeutic management zach bush, md...
TRANSCRIPT
![Page 1: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/1.jpg)
Gut-Brain Regeneration:The microbiome as a new avenue for
therapeutic management
Zach Bush, MDInternal Medicine, Endocrinology and Metabolism
Founder, Director of Clinical AffairsRevolution Health Center
Scottsville, VA
Founder, CEOBiomic Sciences
![Page 2: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/2.jpg)
Disclosure• I discovered carbon-based bacterial metabolites that
have the potential to function as Redox signaling molecules
• I am founder and CEO of Biomic Sciences that has brought to market RESTORE, the first Carbon-based redox molecule supplement, and my team has created a new paradigm of cell signaling science
• I am the founder and President of Revolution Health Center
• My clinical and basic science operations and experience that I share with you today produce all of my income
![Page 3: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/3.jpg)
![Page 4: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/4.jpg)
USA Ranks 49th in health outcomes
![Page 5: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/5.jpg)
1st World Epidemics• Autism 1:68• Attention Deficit 1:10 (70% medicated)• Asthma 1:10• Allergy 1:4• Diabetes 1:4• Obesity 1:3• Major Depression 1:2• Cancer 1:2• Dementia 1:1
![Page 6: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/6.jpg)
1st World Epidemics• Autism 1:68• Attention Deficit 1:10 (70% medicated)• Asthma 1:10• Allergy 1:4• Diabetes 1:4• Obesity 1:3• Major Depression 1:2• Cancer 1:2• Dementia 1:1
![Page 7: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/7.jpg)
1st World Epidemics• Autism 1:68• Attention Deficit 1:10 (70% medicated)• Asthma 1:10• Allergy 1:4• Diabetes 1:4• Obesity 1:3• Major Depression 1:2• Cancer 1:2• Dementia 1:1
![Page 8: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/8.jpg)
Root Cause of disease?
Root Cause of Aging and Disease
![Page 9: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/9.jpg)
Inflammation is the root of all chronic disorder and disease
Autism
![Page 10: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/10.jpg)
Oxidative Stress
• Acute inflammation can save our lives – Injury Repair– Infection control
• Chronic inflammation– oxidative stress = positive charge/acid– Shutdown/overwhelm of the antioxidant system
chronic inflammation = loss of communication
![Page 11: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/11.jpg)
What is theRoot Cause of Inflammation?
Root Cause of Aging and Disease
![Page 12: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/12.jpg)
Ecosystem News
• Bacterial population patterns in the human gut predict occurrence of chronic inflammatory disease
– Obesity/Diabetes– Asthma– Autoimmunity– Cancers– Dementia– Autism
![Page 13: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/13.jpg)
The GALT
• Gastrointesinal Associated Lymphatic Tissue
GALT: 80% of the antibodies in your body are made here
Gut InflammationFood SensitivityAsthma/EczemaAllergyAutoimmune
![Page 14: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/14.jpg)
Intercellular Tight JunctionsFirewalls of Defense
![Page 15: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/15.jpg)
Gut/Brain Axis
• Gut injury: Gluten, Glyphosate, Lipopolysaccharides
• Zonulin goes systemic• Tight junction injury
– Gut– Blood/brain barrier– Vascular system– Kidney tubules
![Page 16: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/16.jpg)
Gut/Brain Axis
• Leaky Brain– Interleukin inflammatory cytokines– Neuro transmitter dysregulation– Neuro-hormonal stress
![Page 17: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/17.jpg)
A catastrophic vulnerability
Bacteria
UnprotectedMembranes
![Page 18: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/18.jpg)
Tight Junction Toxins
Bacteria
![Page 19: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/19.jpg)
Bacterial metabolites:Carbon-based Redox system
• Each bacterial species (30,000 species) creates a unique subset of carbon metabolites during the digestive process
• These function as an interspecies molecular communication network that allows for coordinated cell protection, injury response, and repair
Carbon Redox
www.restore4life.com
![Page 20: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/20.jpg)
What are your bacteria saying?
• Dysbiosis: broken ecosystem– Monoculture Antibiotics, pesticides, chemicals, processed foods
• Weeds grow up: E.Coli, Klebsiela, Psudomonas, Candida
Probiotics – 3 - 24 species, $30 Billion monoculture
Monoculture = limited vocabulary = limited defense
• Optimal bowel ecology = 20,000 species
Biodiversity = fluid communication = strong defenes
![Page 21: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/21.jpg)
GLUTENToxic Peptides
CXCR3
InflammationZONULIN
ENZ
TJ breakdown
Leaky Gut/Brain Leak GutGLYPHOSATE
BACTERIAL/YEASTOVERGROWTH
Enzymes
Chronic Inflammation
Leaky Gut
![Page 22: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/22.jpg)
Vagal Nerve Stimulation and CNS inflammation
![Page 23: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/23.jpg)
Functional Gut Barrier
www.restore4life.com
![Page 24: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/24.jpg)
Leaky Gut in real time
VEH PT-GliadinCONTROL Gluten in 1 slice of pizza
www.restore4life.com
![Page 25: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/25.jpg)
Bacterial Communication Frontlines of Defense
TIGHT JUNCTIONS
![Page 26: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/26.jpg)
Bacterial communication impacts tight junction function
TE
ER
ohm
s/cm
2
www.restore4life.com
![Page 27: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/27.jpg)
From Sieve to FirewallDouble-click to add an object
VEH PT-GliadinCONTROL GLUTEN
GLUTEN and RESTORE RESTORE ww
w.restore4life.com
![Page 28: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/28.jpg)
Bacterial communication induces differential
Mitochondrial ROS ActivityR
OS
pro
duct
ion
www.restore4life.com
ROS assay RT- PCR
1 3 5 10 60
Minutes
DAMAGED
(MCF-7)
HEALTHY
![Page 29: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/29.jpg)
Bacterial communication impacts Stem Cell Activation
Urin
e C
D13
3
www.restore4life.com
Urine CD133
![Page 30: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/30.jpg)
1st and 2nd birth of our children
HUMAN70 Trillion Cells 25,000 Genes
BACTERIA 20,000 Species
1.4 Quadrillion Cells 2 Million Genes
Bacteria
www.restore4life.com
![Page 31: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/31.jpg)
Epigenetics / Micro RNA
• Which genes turn on/off is determined by your environment
• Micro RNA are non-coding sequences in the genome that turn on and off gene pathways at the DNA level
• 15% of the micro RNA that is circulating in your blood stream today are from the bacteria in your gut– Bacterial genome is turning on and off the human
genes
www.restore4life.com
![Page 32: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/32.jpg)
USA Ranks 49th in health outcomes
www.restore4life.com
![Page 33: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/33.jpg)
The natural history of neurologic injury
• Children are being born into an ever more narrow bacterial ecosystem (vulnerability)
• Breast milk and food/drink thereafter is contaminated with glyphosate-based herbicides
• Gluten, polyunsaturated oils, and other refined foods
(leaky gut/leaky brain occurs)• Exposure to antibiotics, NSAIDS, Alcohol, invasive bacteria,
parasites• Leaky Gut/Leaky Gut Brain – Toxins accumulate
(accelerating neurologic injury)• Widespread immune dysfunction (invasive bacteria, chronic
viremia – HPV, HSV, HepC, HIV)• Shutdown of the antioxidant system (chronic inflammation)• System overwhelm (Autism to Alzheimers, CVD to Cancer)
![Page 34: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/34.jpg)
Leaky Gut - Leaky BrainInflammation cascade from birth to
death Colic
Sensory processing defects Attention Deficit Anxiety Disorders Major Depression
Disordered Sleep Insulin resistance Infertility Diabetes Vascular Disease Cancer Dementia
![Page 35: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/35.jpg)
Gut/Brain Injury What can we do about it?• Tight Junction firewall up and running• Direct toxin antidote – glyphosate, gluten• Promote eco-diversity in the gut and beyond• Increase bacterial breakdown of toxins• Increase bio-availabilty of food nutrients
Maximize the Biome: Get out in nature – breathe biodiversity Grow your own food Eat from the bottom of the food chain Stop Dairy (high glyphosate, highly acidic) Fermented foods:
Miso Soup, Sauerkraut, etc
www.restore4life.com
Soil/Gut Communication Supplementation:
![Page 36: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/36.jpg)
What’s in Restore?• Carbon-based redox molecules extracted from fossil soil
in the South West United States• Trace micronutrients – minerals and amino acids with
concentration profiles similar to that of a sweet potato skin
• Unprecedented results in cellular safety studies– Gold-standard Renal Tubule Toxicity studies – No LD50, extends
life of cell lines at every concentration– Even at 100% concentrations
![Page 37: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/37.jpg)
Restore Logistics• 1 tsp to 1 TBL three times daily before or with
meals• For very sensitive kids:
– 2-5 drops by mouth – plain or
with non-chlorinated water/juice– Slowly increase to 1 tsp three times daily
• Once on restore you can stop probiotics and digestive enzymes to speed recovery of natural gut biome diversity and healthy digestive processes
• No drug-drug interactions
![Page 38: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/38.jpg)
References1. Centers for Disease Control and Prevention (CDC), Key Findings: Trends in the
Parent-Report of Health Care Provider-Diagnosis and Medication Treatment for ADHD: United States, 2003-2011 the National Survey of Children's Health (NSCH)
2. Ellwood P, Williams H, Aït-Khaled N, Björkstén B, Robertson C, ISAAC Phase III Study Group. Translation of questions: The International Study of Asthma and Allergies in Childhood (ISAAC) experience. Int J Tuberc Lung Dis. September 2009; 13(9): 1174-1182
3. Massey JT, Moore TF, Parsons VL, Tadros W. Design and estimation for the National Health Interview Survey, 1985–1994. National Center for Health Statistics. Vital Health Stat 1989;2(110)
4. Botman SL, Moore TF, Moriarity CL, Parsons VL. Design and estimation for the National Health Interview Survey, 1995–2004. National Center for Health Statistics. Vital Health Stat 2000;2(130)
5. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014
![Page 39: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/39.jpg)
References6. Janeway, CA Jr.; et al. (2001). "The mucosal immune system". Immunobiology. New
York: Garland Science. 10-13
7. Salminen S, Bouley C, Boutron-Ruault MC, et al. (1998). "Functional food science and gastrointestinal physiology and function". British Journal of Nutrition 80 (S1): S147–S171
8. Moriame G; et al. Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of HIV Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection Journal of Virology, August 2006, p. 8236-8247, Vol. 80, No. 16
9. Abbas A.B.; Lichtman A.H. (2009). "Ch.2 Innate Immunity". In Saunders (Elsevier). Basic Immunology. Functions and disorders of the immune system (3rd ed.)
10. Eming, S. A.; Krieg, T.; Davidson, J. M. (2007). "Inflammation in wound repair: molecular and cellular mechanisms". Journal of Investigative Dermatology 127 (3): 514–525
11. Van Dorpe, S; et al. (2012). "Brainpeps: The blood–brain barrier peptide database". Brain structure & function 217 (3): 687–718
12. Schneider, Stefan W.; et al. (March 2004). "Glioblastoma cells release factors that disrupt blood–brain barrier features". Acta Neuropathologica 107 (3): 272–276
![Page 40: Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder,](https://reader030.vdocuments.us/reader030/viewer/2022033108/56649f535503460f94c78075/html5/thumbnails/40.jpg)
References13. H Chen; EE Konofagou. Journal of Cerebral Blood Flow &
Metabolism (2014) 34, 1197–1204
14. H Matsui ; et al. (2011). The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine J Clin Biochem Nutr. 2011 Mar; 48(2): 107–111
15. Eadon MT; et al. Endotoxemia alters tight junction gene and protein expression in the kidney (2012). Am J Physiol Renal Physiol. 2012 Sep 15; 303(6): F821–F830