guillain-barre-syndrome
TRANSCRIPT
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GUILLAIN –BARRE SYNDROME
Presented by:RABEIYA TAZEEM
B.S.P.T (Final yr)Batch-2007
College of Physiotherapy-JPMC
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PRESENTATION FLOW
IntroductionEpidemiology
Sub-typesPathology
Medical treatmentRehabilitation
Prognosis
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Introduction
Introduction
“It is an acquired ,frequently severe ,monophasic autoimmune illness of Peripheral Nervous System(PNS)”
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Alternative Names
Alternative Names
•Landry-Guillain-Barre-Strohl Syndrome•Post-Infectious Polyneuropathy•Acute Idiopathic Polyneuropathy
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After the advent of OPV ,today GBS is almost the only inflammatory Polyneuropathy and most frequent cause of acute flaccid paralysis in general medical practice
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Approximately 85% patients recover spontaneously while 10% patients need hospitalization
Its prevalence has been reported to vary from region to region
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Epidemiology
According to more recent study ,GBS occurs
throughout the world with a medium incidence of 1.3
cases per 100,000 population
Males are more commonly affected than females
Peaks in young adults and in elderly
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Sub-types of GBS
GBSAIDP
AMANAMSAN
MFS
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Acute Inflammatory Demyelinating Polyneuropathy(AIDP)
Prevalent in western countries (90% of the GBS
cases)
Adults are affected more than the children
First attack appears directed against a component of
Schwann cell
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AIDP cont’d…
Cause of flaccid paralysis & sensory disturbances is
the block of conduction ,whereas axonal connection
remains intact
Recovery is most often rapid as remyelination occurs
In the severe forms of AIDP ,when axonal damage
occurs , the rate of recovery is slower ,& the degree of
residual disability greater
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AIDP cont’d…
Usual Electro diagnostic features;
Prolonged distal latencies
Conduction velocity slowing
Evidence of conduction block
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Primary Acute Motor Axonal Neuropathy (AMAN)
Prevalent in China & Mexico with seasonal prevalence
Children and young subjects are affected more than adults
First attack appears directed against the axolemma & Nodes of Ranvier
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AMAN cont’d…
Axonal damage is the prominent pathological alteration
Recovery takes place when axon regeneration is complete and it is rapid when lesion is localized
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AMAN cont’d…
Usual Electro diagnostic features;In case of primary axonal damage there is reduced amplitude of compound action potential (without conduction slowing or prolongation of distal latencies)
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Acute Motor-Sensory Axonal Neuropathy(AMSAN)
Very rare
Closely related to AMAN
Adults are mostly affected
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AMSAN cont’d..
First attack is directed at motor nodes of Ranvier ,but also affects Sensory nerve and roots
Axonal damage is severe
Recovery is slow and often incomplete
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Miller-Fisher Syndrome
Adults ,young subjects and children are affected
Involves PNS & CNS structures
Pathological features resemble that of AIDP
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MFS cont’d…
Characterized by rapidly evolving of Triad;1) Variable opthalmoplegia (often with
pupillary paralysis)
2) Ataxia
3) Tendon areflexia (without weakness)
Recovery can be rapid
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Etiology (Predisposing or Antecedent events in GBS )
Preceding vaccination
Bacterial infection
Viral infection
Protozoan infection
Surgeries
Blood Transfusion & Transplantation
Anesthesia & Analgesia
Preceding heat stroke
Several drugs
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Pregnancy and GBS
Even though maternal GBS is very rare there may be approximately 6% chances of GBS development during pregnancy
Cause is idiopathic
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Malignancy and GBS
GBS has also been described in association with malignancy ,in these instances GBS may be considered in a secondary event
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Pathogenesis
Classic studies in man and experimental animals and several lines of evidence support on immunological basis for demyelination of peripheral nerves in GBS
patients
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Pathology
DEMYELINATION is the main type of pathophysiological lesion
Characteristics of GBS is the “Segmental Demyelination” with mononuclear cell infiltration in spinal roots ,proximal nerve trunks ,distal nerves and autonomic ganglia
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Pattern of re-myelination
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In GBS primary demyelination of CNS is not found. Other changes such as degeneration of spinal
posterior tract are secondary to pathology in the PNS
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Clinical features
Rapidly evolving areflexic ascending motor paralysis of the extremities ,up to the tetraparesis
Reduced or absent deep tendon reflexes
Mild sensory symptoms
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Clinical features cont’d…
FeverFatiguePainBilateral facial palsyAntecedent symptoms
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Clinical features cont’d…
Involvement of autonomic nervous systema. Taste loss(initial symptom)b. Swallowing dysfunctionc. Sweat gland alterationsd. Urinary retentione. Cardio-respiratory arrestf. Postural hypotension
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Differential Diagnosis
• Poliomyelitis• Botulism• Infantile spinal muscular atrophy• Neurosarcoidosis• Sub-dural spinal granuloma from Candida albicans• Severe anaemia• Diphtheric neuropathy
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Diagnosis
• Observation of the patients symptoms and evaluation of the medical history provide the basis for the diagnosis of GBS ,although no single observation is suitable to make the diagnosis
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Diagnosis cont’d…
1. Past medical history2. Laboratory findingsa. Lumbar puncture an elevated level of protein
without an in the no. of WBC in the CSF is he characteristic of GBS
b. Electromyogram show the loss of individual nerve impulses due to the disease ‘s characteristic slowing of nerve responses
c. NCS these signals are characteristically slowed in GBS
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DISABILITY CRITERIA
In most studies, the primary outcome measureused disability scale, where: 0 = normal 1 = symptoms but able to run 2 = unable to run 3 = unable to walk unaided 4 = bed-bound 5 = needing ventilation 6 = dead
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Management
MANAGEMENT
MEDICAL
REHABILITATION
PHYSIOTHERAPY
SPEECH THERAPY OCCUPATIONAL THERAPY
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MEDICATION
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Medical management
a) IVIg
b) Plasmapheresis
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PLASMAPHERESIS
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a- PainNSAIDAcetaminophen with Hydrocodone
b-Unpleasant sensations such as painful tinglingTricyclic antidepressantsAnti convulsants
Corticosteroids ,which often effectively treat the symptoms of autoimmune disorder actually worsen GBS and should not be used
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“The physiotherapist was a most welcome person ,as
,despite the discomfort endured to have ‘dead’ limbs stretched and repositioned ,this left me comfortable for several hours.”
Clark,1985
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Physiotherapy Management
PT MANAGEMENT
ACUTE PHASE SUBACUTE REHAB PHASE
ONGOING/LONG-TERM REHAB PHASE III
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ACUTE PHASE
It is a phase when patient is admitted in hospital
GOAL: Respiratory care Prevention from Decubitus Ulcer Prevention from Contracture formation Prevention from DVT Maintain peripheral circulation Assist in swallowing (feeding)
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RESPIRATORY MANAGEMENT
If patient is on ventilator , •Suctioning can be done (if required)
• Huffing-coughing
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SYMMETRY OF THE CHEST
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1.Upper lobe expansion
2.Lower lobe expansion
3.Middle lobe expansion
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AUSCULTATION
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PERCUSSION
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Findings;Dull & Flat solid>air Hyper-resonant (tympanic) >air
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EXERCISES
Diaphragmatic breathingIncentive spirometery
Glossophayrengeal breathingChest mobilization ex’s
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Areas which are most affected in different positions
PREVENTION FROM DECUBITUS ULCER
By Repositioning
By Devices (e.g. pneumatic gloves)
Through diet
PREVENTION FROM DECUBITUS ULCER
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PREVENTION FROM DVT
•Begin ambulation as soon as possible
•Anticoagulant as a prophylactic Rx
•Active pumping ex’s
•Keep lower extremities elevated
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FROM CONTRACTURES
• Generalized ROM ex’s• Spinal movements should be included e.g.
a. Double knee-and-hip flexion, b. Knee rolling andc. Neck movements with due care of tracheal
tubes
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Double knee-and-hip flexion
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Knee rolling
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NECK MOVEMENTS
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• Risk of hypotension is reduced by ;Ensuring that turning is gentleAvoiding any intervention if CVP is below5cmH2OAcclimatization to the upright posture with a tilt
tableRisk of bradycardia is reduced by oxygenation
before and after suction
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ASSIST IN SWALLOWING
•By positioningKeep head upright with slight extension (elevated-
45degree)
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PHASE II (when patient maintain his respiration)
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• Pain management-TENS• ACBT’S• Stretching• Strengthening and endurance ex’s • Paced breathing• Aerobic ex’s• Energy conservation• Improve swallowing
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DIPHRAGMATIC BREATHING
THORACIC EXPANSION
(lateral)
PURSED-LIP BREATHING
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TREADMILL
SWIMMING
CYCLING
WALKING
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Interventions for Strengthening may include;
PROM AAROM AROM ARROMBy means of EMG biofeedback
PNF Rhythmic Initiation
Rhythmic StabilizationRepeated contractions
Hold Relax
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EMG BIOFEEDBACK
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position for ex’s: sitting or prone on elbowTo keep the chewed food inside the mouth patient
must be able to hold their lips closed ,can improved by ex’s of facial muscles & tongue movements
Improve Swallowing
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Tongue movements
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As the swallowing continues ,the hyoid bone and larynx moves upward. To stimulate the muscles that elevate the larynx use quick ice and stretch .Give the stretch diagonally down to the right and. then to the
left.
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PHASE III(when patient have good strength of
muscles)
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• Strengthening• Stretching• Improve gripping• Balancing (Tai chi) • Hydrotherapy• Gait training• Prevention from medical complications
and sequlae
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7204/12/2023
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TAI
CHI
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To improve gripping
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SPEECH THERAPY
Stimulation of the laryngeal muscles with quick ice followed by stretch and resistance to the motion of
laryngeal elevation
Promote controlled exhalation during speech with resisted breathing exercises
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HOME PROGRAM
Breathing ex’s
Stretching ex’s
Walking Jogging
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SEQUELAE
•GBS may leave sequelae that are unpredictable
•Most serious residual disability was found distally in the legs
Residual severe neurological deficits
Muscle aches and cramps
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PROGNOSIS The length of time and the amount of effort required to bringabout the best possible recovery varies among individuals and is related primarily to the severity of the symptoms.
About 30% of persons affected with GBS have some degree ofresidual weakness after three years.
3 - 5% may suffer a relapse many years later.
1- 5% of cases are fatal, usually due to respiratory or cardiac complications.
Most people, however, are able to recover completely and leadnormal lives.
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REFRENCES
Guillain-Barre syndrome: pathological, clinical, and therapeutical aspects
By Silvia IannelloPNF in practice –An illustrated guide
Adler ,Beckers ,BuckTherapeutic exercises
Kisnerhttp://neurologychannel.com/guillain
http://en.wikipedia.org/wiki/guillain-barre-syndrome/
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GOLDEN WORDS
“Your main occupation should be — in fairness to yourself, in fairness to your parents, in
fairness to the state – to devote your attention to your studies.”
(Mohammad Ali Jinnah-March 21 ,1948)
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ACKNOWLEDGEMENT
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MAM HINA