group a3 presenters: anastasia christopher, carol rego, sarah mcneil technical experts: bonnie chan,...
TRANSCRIPT
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Receptive Field Dynamics in Adult Primary Visual
CortexGroup A3
Presenters: Anastasia Christopher, Carol Rego, Sarah McNeilTechnical Experts: Bonnie Chan, Herman Gill, Marisa Leung
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Brief overview of Module 3 Background information and important
definitions Anatomy of the brain Lateral Geniculate Nucleus
◦ Method◦ Results
Primary Visual Cortex◦ Method◦ Results
Conclusion
Table of ContentsAnastasia Christopher
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By: Charles Gilbert and Torsten Wiesel
Receptive Field Dynamics in Adult Primary Visual Cortex
Anastasia Christopher
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Important Definitions
Receptive Field Size
Cortical Topography
Binocular Retinal Lesion
Scotoma
Anastasia Christopher
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Is the locus of change in regards to sensory input located at the cortical level (Primary Visual
Cortex) or at a prior stage in the sensory pathway (Lateral
Geniculate Nucleus)?
Anastasia Christopher
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Lateral Geniculate Nucleus (LGN)
Anastasia Christopher
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Primary Visual CortexAnastasia Christopher
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Immediately After Lesion 2 Months After Lesion
LGN
Primary Visual Cortex
Anastasia Christopher
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Studied 2 cats and 1 monkey
Topographical mapping of the LGN
Multiple electrode penetrations across the LGN
Two injections of retrograde tracers in V1
LGN - MethodsCarol Rego
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Large silent area about 1mm in diameter
Shift in RF position
LGN – Electrode Readings Carol Rego
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Immediately After Lesion 2 Months After Lesion
LGN
________________
• Large silent area
• Shift in RF position
• No evidence in plasticity observed
Primary Visual Cortex
________________ ________________
Carol Rego
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Studied 4 cats and 6 monkeys
RF maps were made using vertical electrode penetration
RF maps were made at the same sites before, immediately after, and 2 months after making the lesion
Primary Visual Cortex - Methods
Sarah McNeil
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Immediately after:
◦ Inactivity in original sites
◦ 5X larger sites
◦ Centrifugal shift
Primary Visual Cortex - Results
Sarah McNeil
Before lesion
Immediately after lesion
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2 months after:
◦ RF field size shrunk
◦ 5˚ centrifugal shift in position
◦ Area of activity expanded beyond affected area
Primary Visual Cortex - Results
Sarah McNeil
Before Lesion 2 Months
After Lesion
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Initial shock
Long term consolidation
Sarah McNeil
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Immediately After Lesion 2 Months After Lesion
LGN
________________
• Large silent area
• Shift in RF position
• No evidence in plasticity observed
Primary Visual Cortex
• 5X larger in RF sites
• Centrifugal shift >1˚
• RF field size shrunk to several times the original size
• Area of activity expanded
• Centrifugal shift 5˚
Sarah McNeil
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Anastasia Christopher
Is the locus of change in regards to sensory input located at the cortical level (Primary Visual
Cortex) or at a prior stage in the sensory pathway (Lateral
Geniculate Nucleus)?
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Brain is high in plasticity
Compensation of damaged tissue as a result of binocular retinal lesions does not take place in LGN
Takes place at the cortical level of V1
ConclusionAnastasia Christopher