Gregor Mendel. . . . . .and his pea plants 1860s

The establishment of genetics

Fruitfly: Drosophila melanogaster

Thomas Hunt Morgan

1920’s

Escherichia coli Jacques Monod

Lambda phage virus

Esther Lederberg

Mouse

Arabidopsis thaliana

Friedrich Laibach

Yeast: Saccharomyces cerevisiae

Pub patrons everywhere

Caenorhabditis elegans

Sydney Brenner

Zebrafish George Streisinger

Caenorhabditis elegans

Primary spermatocyte

Secondary spermatocytes

Residual body

Spermatid

Spiky intermediate

Pseudopod formation

Spermatozoon

Spermiogenesis

fertilization

Mutation analysis

spe-46 spe-47

spe-46 spe-47

spe-6

spe-26, spe-4, spe-5

fer-2, fer-6

fer-3, fer-4 fer-15

spe-8, spe-12, spe-19, spe-27, spe-29

fer-1, spe-10, spe-17

fer-14, spe-9, spe-13, spe-16

spe-11

spe-44

1.  How would you create a strain that had both green peas and white flowers?

2.  How could you tell if the genes responsible for pea and flower color are on the same chromosome?

3.  What is causing the phenotypes and how is it affecting the genes?

4.  What could you do to create more phenotypes?

Gene Chromosome Genome Locus Linkage Allele Epistasis Pleiotropy Mutation Segregation Monohybrid cross Dihybrid cross Independent assortment Recombination Homologous chromosome

Gain of function Loss of function Sex linked Map units Genetic map Physical map Complementation test