greenTEG AG offering of Core Body Temperature sensors

Presentation to the “Fytbyt” CPO

Feb. 6th, 2018, Technopark Zurich, Zurich, Switzerland

Description of our client «Fytbyt» and its problem to solve

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Fytbyt brief- US company headquartered in the Silicon Valley- Main product: activity trackers, wireless-enabled wearable

technology devices that measure data such as the number of steps walked, heart rate, quality of sleep, steps climbed, and other personal metrics involved in fitness

- 1.3bn in Revenues in 2017, 10mn devices sold

Problem to solve- Constant measurements gain better

insights

- The more vital signs you measure – thebetter

- Core Body Temperature measurementat wrist not yet available

gSKIN®

«sense how it feels»

greenTEGgreenTEG is the thermal sensing expert with a large growth opportunity in wearables and other applications

greenTEG’s patented and highly scalable sensing platform is able to add value in three different industries

Current business High volume opportunity

Photonics

greenTEG’s Laser power detectors increase the

productivity of Lasers for OEM customers

Building

greenTEG’s U-Value Kit and sole Heat Flux Sensors

enable energy savings in buildings

Wearables

greenTEG’s technology for Core Body Temperature Measurement is able to

improve health monitoring

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gSKIN®: Is our skin measuring temperature?

greenTEG fabricates thermoelectric sensors and generatorswhich transform heat directly into electricity

Sensor

Heat

Voltage

Generator

Heat

Power

Thermoelectric converterAir temp: -10°C

Water temp: 0°C

Solution:

Reactive to preventive Health Care

Motivation

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Market status: Insurances are embracing the concept of vital monitoring via wearables accelerated growth

Problem:

Cost explosion in Health Care

Hypothesis:Onset of health problem is visible in a change of vital parameters

Requirement:Continuous & non-invasive monitoring of relevant vitals

From reactive to preventive health care: paradigm shift & digital revolution in health care

Motivation

Time & machine learning will tell (big data and AI approach) but this is the experts’ (medical doctors) best guess:

5 vital parameters

Respiration

✓

Oxygen saturation

O2

✓

Heart rate

✓

Core body temperature(CBT)

✗

Blood pressure

✗

High invasiveness, low accuracy, difficult to integrate, not continuous

Key problems with current solutions:

greenTEG enables accurate, continuous and non-invasive core body temperature (CBT) measurement for low activity!

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Which are the relevant vitals?

Motivation CBT measurements are an insightful indicator of health

The Circadian rhythm is defined by the core body temperature drop during night.

• Shows insight into health and behavior of each individual

• Current solutions are all invasive (radio pill, rectal probe, ...)

Symptom1 Amplitude shift

Phase shift

Jetlag x

Narcolepsy x

Insomnia x

Sleep quality x

Burnout x

Alzheimer x

Parkinson x

Ovulation x

Sport x

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1 As shown in medical publications (see also Appendix II)

SolutionWe developed a sensor combined with an algorithm for integration into an existing wearable device

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Fitness trackers Smart patches Smartwatches

Accurate

• Precision <0.2°C• User independent

Compact

• Small size PCB• Optional: SMD

package (~3mm x 3 mm)

Non-Invasive

• Placed on skin

Continuous

• Smart Algorithm for μP• Real time measurement

gSKIN Body Temperature Sensor

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Solution – ProofAccuracy of gT CBT Solution

Night and day measurement in Sleep-wake lab• Position: Cheest• Sensor fixation: Patch• Mean deviation to ref. temperature of 5 candidates: 0.2 °C

Night

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Solution – ProofFirst wrist measurements are promising

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Night and day measurement in Sleep-wake lab• Position: Wrist• Sensor fixation: Patch• Mean deviation to ref. temperature of 5 candidates: 0.3 °C

Night

Underlying magicOur smart algorithm uses the heat flux and skin temperature signal to calculate the CBT

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Output

Input

1 Other inputs such as different thermal resistances of the skin during different activities are taken into account for our CBT measurement method

Heat flux

Heat flux sensor

Human body

TCore

TSkin

Other vital signs1

Packaging

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CompetitionOur non-invasive sensor solution sets itself apart with its high accuracy combined with a high integrability in wearables

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Source: Expert interviews

Acc

ura

cyLo

wH

igh

Suitability for wearable integration

Low High

Reference

Heat flux method

Skin temperature method

Other

• Standard skin temperature method can be easily integrated into wearables but also show a low accuracy

• greenTEG’s value is defined in high accuracy with high integrability

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OvulationSports

Application AreasBroad range of Core Body Temperature applications

Sleep

Animal Monitoring

Ovulation

Ovulation

Early Diagnostics

Work SafetyPatient

Monitoring

Saving billions by releasing patients earlier from the hospital

Next generation fitness trackers and smart watches with accurate sleep analysis

Wanted future feature for smart watches and fitness trackers

CBT is most important sensing parameter for ovulation detection

Health and breeding control - CBT measurement through the fur

Are you ready and prepared for best performance?

Big demand from heavy working industry

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Our offering: Test KIT and design in for any device

Evaluation & Testing : gSKIN® BT Demo Kit• Integrated gSKIN® BT sensor (~3mm x 3mm) • Body attachment with very durable medical tape • Portable readout device with LCD display • >70h battery life, 3 channels, 700k datapoints• Sensor placement: Any body location for body-

temperature

Design in • 3mm x 3mm x 0.5 on a PCB by SMD• Thermal integration solution for housing and patch

~5-8mm diameter at the skin and on PCB)• Electrical readout solution • Algorithm for μP • Integration support • Thermal characterization of the customers device• Adaption of the algorithm to the customers device

greenTEG AG

gSKIN® thermal sensing

Dr. Holger Hendrichs,VP Sales / Marketing

greenTEG AG

Technoparkstr. 1 | 8005 Zurich, Switzerland

tel. +41 (0)44 633 0697

Email: hendrichs@greenTEG.com

A flex-PCB based, highly scalable sensor technology for high performance and unique heat flux sensors with the following key advantages:

• High sensitivity & Small form factor

• Robust design

• Low thermal invasiveness and thickness

• Low electrical resistance

• Integration: SMD mounting on PCB

gSKIN® - Converting Heat into Voltage

Package (e.g. Silicone, Al)

Interconnects

Thermopiles

Substrate

Contactscold

hot

Photonics: gRAY® detectors – Overview & USP

Low powers – 10x more sensitive Medium powers – 5x faster

since 2013

Position – 5x higher resolution

since 2015

since 2017 exclusive Re-seller partnershipwith

since 2014

Summary of norm (ISO-9869)

• Heat flux based method leads to reliable, quantitative data

• Non-invasive measurements, starting from a temperature difference of as little as 5°C

• Duration of the measurement has to be 72 hours (to be ISO conform), shorter measurement times also possible

• Moving average leads to stable results

Measurement setup

Building: greenTEG`s U-value measurement is based on heat flux monitoring, described in ISO 9869

Simple installation, real time observation within the web-cloud, easy communication via proprietary IoT based LoRa protocol

Outside

Inside

Appendix

Medical Publications showing relevance of CBT

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Insomnia/Jetlag

Oka T, Oka K, Hori T (2001) Mechanisms and Mediators of Psychological Stress-Induced Rise in Core Temperature. Psychosomatic Medicine 63:476-486

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Fertility

Baker FC, Waner JI, Vieira EF, Taylor SR, Driver HS, Mitchell D (2001) Sleep and 24 hour body temperatures: a comparison in young men, naturally cycling women and women taking hormonal contraceptives.Journal of Physiology 530.3: 565—574

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Parkinson

George Zhoung (2013The Relationship between Thermoregulation and REMSleep Behaviour Disorder in Parkinson’s Disease. PLOSone; e72661

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Sports

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J.P. Rosa et.al (2016) 2016 Rio Olympic Games: Can the schedule of events compromise athletes performance?, Chrmonobiology International, 33, 4, 435

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