GOVERNMENT OF INDIA MINISTRY OF HEALTH & FAMILY WELFARE

DEPARTMENT OF AYUSH PHARMACOPOEIAL LABORATORY FOR INDIAN MEDICINE

Kamla Nehru Nagar

Ghaziabad-201002 Ph-2787016, 2786554, 2786585

TENDER NOTICE Sealed Tenders are invited for the purchase of the following Instruments.

1. Fourier Transform Infra Red Spectrophotometer 2. Gas Chromatograph with ECD, NPD, FID and Head Space Analyser 3. Flash Evaporator with Accessories 4. Fluorescence Microscope 5. Homeopathic Potentiser

The Tender Documents can be obtained from the office of the Director, PLIM/ HPL, in front of M Block, Sanjay Nagar, Ghaziabad-201002 from 10th to 14th Aug, 2007 from 3:00PM to 5:00PM either in cash or in the from of demand draft drawn in the name of SSO (P), payable at Ghaziabad, alternatively, can be downloaded from the laboratory website (www.plimism.nic.in) and a DD of Rs.100/- (Rs.One Hundred only) should be attached to it.Due date of submission of tender is 21st September, 2007.

(Director) PLIM/ HPL

GOVERNMENT OF INDIA MINISTRY OF HEALTH & FAMILY WELFARE DEPARTMENT OF AYUSH

PHARMACOPOEIAL LABORATORY FOR INDIAN MEDICINE

Kamla Nehru Nagar Ghaziabad-201002

Ph-2787016, 2786554, 2786585

CORIGENDUM

With reference to the tender for purchase of Scientific Instruments published in TOI,

dated 07/09/07, tenders may also be submitted for AAS and the date for collection of tender

document may be read as 18th – 25th Sept, 2007. Last date of submission of tender will be

05/10/07. Rest of the conditions will be same.

Director

PLIM/HPL

PURCHASE OF FTIR, GC WITH FID,NPD,ECD AND HEAD SPACE SAMPLER, FLASH EVAPORATOR, FLOROSCENCE MICROSCOPE, HOMEOPATHIC POTENTISER AND AAS at PLIM/HPL, KAMLA NEHRU NAGAR, GHAZIABAD. GENERAL CONDITIONS FOR THE PURCHASE

1. Firms participating in the tender should submit two bids i.e. Technical bid and Price bid

(financial bid).

2. Firms quoting for more than one instrument should quote separate rates for each

instrument and separate tender documents should be purchased for each instrument.

3. Bids should be submitted either by original manufacturer or authorized dealers appointed

by such manufacturers in India, who have after sale service experience in supplying such

instruments for more than 5 years.

4. The rates should be quoted FOB, Ghaziabad and should include transportation and

Commissioning of the instrument (s) at PLIM/HPL, Ghaziabad.

5. The supplier should mention the Warranty/Guarantee period for the instrument.

6. The supplier should provide spares for next 5 years of operation of instrument.

7. The supplier should also quote for AMC after expiry of Warranty/Guarantee period.

8. Each bidder should submit an E.M.D. of Rs. 50,000/- ( Fifty Thousand Only) for each

instrument quoted. The EMD will be returned to the unsuccessful bidder after the bids are

finalised. EMD should be in the form of Demand Draft, drawn in the name SSO (P),

payable at Ghaziabad.

9. The supplier should supply the instrument in one supply only, part supply will not be

entertained.

10. The supplier should not handover execution of order to any other /sister firm (s); it will

amount to the cancellation of order.

11. In case the supplier being unable to supply with in stipulated time or going insolvent the

loss incurred to the Government will be borne by the supplier.

12. The director has every right to reject any bid without assigning any reason.

(DIRECTOR)

Item No. 1.- TeCHNICAL SPECIFICATIONS FOR fOURIER tRANSFORM INFRA RED SPECTROPHOTOMETER General -Sealed and desiccated optical unit. Vibration isolated base plate. Optical Performance: Wavelength range: 7800-350 cm-1, Signal-to-noise 35000:1 RMS 1.2x 10-5 Abs, 7000:1 peak-peak 6.2x10-5. Wave Accuracy: Better than 0.1 cm-1 at 1,600 cm-1 Interferometer- Michelson type interferometer, self-compensating for dynamic alignment changes due to tilt and shear, incorporating high-reflectivity, first-surface aluminum coated optics. Optics - Kinematically mounted, zero alignment optics. Mirrors- High reflectivity, first-surface, aluminum-coated optics with a low-angle off axis design. Detectors - Capabilities for two permanently installed detectors. Single software click to switch active detectors. Electronically, temperature-stabilized fast recovery deuterated triglycine sulfate (FR- DTGS) or DLATGS, Lithium tantalate (LiTaO3) detector or equivalent. Source -Long-life source Quartz/halogen and Tungsten. Beam splitter - Extended range KBr or Germanium coated KBr plate or equivalent. Desiccant – Instrument should accept disposable packs or rechargeable desiccant cartridges with visible desiccant lifetime indicator. Electronics- Signal sampling Over-sampling, delta-sigma converter. Data system- Communication TCP/IP interface to allows direct connection or a Local Area Network (LAN). Should be Windows XP compatible. Calibration transfer - Absolute Virtual Instrument (AVI) – actively standardizes instrument response to improve repeatability and protect data integrity. Atmospheric compensation- To minimizes effect of atmospheric water and CO2 on the sample spectra without the need for reference or calibration spectra. Productivity- Automatic detection of sample when placed into the sample compartment. Data collection should start after sample information is fed. Bench details- Size 520 mm x 600 mm x 300 mm (W x D x H) (Approximate)

Software General - Appropriate user friendly single software platform to control all of the functions required for infrared analyses; instrument control, data manipulation and analysis, and flexible report utilities. Reports - Quick print facility for graphs, spectra and results windows. Processing- Smoothing, peak detection, derivative, baseline correction, data correction, difference, normalization, A, %T, %R, KM, LOG (1/R), ordinate modes, cm-1, nm and micron abscissa modes, +,-,*,/, deconvolution, apex, interpolate, blank, Kramers-Kronig, Kubelka-Munk conversion, ATR correction, peak table, peak height and peak area. Spectral searching against commercially available or customer developed libraries. Quantitative analysis- Single frequency, method development software type or eqivalent. Spectrum should includes Beer’s Law, PLS and PCR quantitative prediction. Compliance : GLP/GMP compliance.

The system should be supplied with all respects with spares and consumables for 5 years trouble for service. After sales service should be given. Service manual and operation manual should be supplied with the instrument. Optional: 1. KBr Dye making set: Complete KBr pellet making set with complete accessories like agate pastel and mortar, plate holder, disc holder etc. Buy BACK: PERKIN ELMER SYSTEM 2000 FTIR

(DIRECTOR)

Item No. 2.- TECHNICAL SPECIFICATIONS FOR GAS CHROMATOGRAPH WITH FID, ECD, TID AND HEAD SPACE SAMPLER

1. GC with One packed and One Capillary Injection Ports with Split / Split less facility 2. Single Flame Ionisation Detector with Amplifier 3. Thermionic Ionisation Detector (NPD) 4. Electron Capture Detector with control module 5. Start up kit 6. Chromatography Software 7. Capillary Column 25 meter length, 8. Packed Columns 9. Head Space Sampler Gas Chromatograph 1. Oven : Stainless Steel size 300x310x220mm (approx.) 2. Temp. Control : 50C above ambient temp. to 5000C adjustable in

step of 10C

3. Temperature Control : Microprocessor temperature control accuracy ±0.050C.

4. Temp. progm. : 0.10C/min to 500C/min. in ramps of

0.10C/min.

5. Time events : 5 events with two ON-OFF status. 6. Files : 35-40 7. Auxiliary Temp. : 2 control zones 8. Auto Diagnostics : Exhaustive checks, corrects operation & status of GC control, CPU, ROM, RA sensor, keyboard etc. 9. Cooling : 7 minutes from 3000C to 700C at 250C room temperature 10. Temp. Upper Limit : Software adjustable from

-1500 C to 5000 C cut-off Independent protection factory preset at +5150 C. 11. Serial :Built in interface compatible with Communication with PC AT VGA for setting of comple te

RS232 interface set of GC control operative parameters.

Single Flame Ionisation Detector (FID) Specification: 1. Type Solid State Linear electrometer amplifier. 2. Electrometer Sensitivity 5 x 10-12 Amps full scale on max. sensitivity. 3. FID Sensitivity 5 x 10-12 gram/sec for C9 hydrocarbon. 4. Range x1, x10, x1000 Software selectable 5. Linear Dynamic Range Better than 107. 6. Max. Temperature 450 deg. 0C 7. Noise Less than 1%. 8. Drift Less than 1%. 9. Backing of x1, x10, two ranges. 10. Auto Zero Facility Should be operated through key board. 10. Output Provision As 1V DC or 10V DC Required Electron Capture Detector (ECD) Specification: 1. Radioactive Source Nickel 63. 2. Ionization Chamber 0.75 ml.

Column 3. Temp. Control Range Ambient to 3500C

Accuracy ± 0.10 C 4. Operation Mode Two modes of operation 1) DC at constant voltage 2) MF – mode 5. Electrometer 10-13 gm/ sec. for Lindane

Sensitivity 6. Linearity Better than 104

7. Output Attenuator Binary steps 1-1024 + shunt 8. Zero potentiometer for adjusting Recorder zero 9. Output To Recorder: 1mV or 10mV To Integrator: 1V DC. To Computer: 10V DC. Nitrogen Phosphorous Detector (NPD) Specification: 1. Detector TID Termionic Ionisation Detector Head selective for Nitrogen Phosphorous compound. 2. Sources Alkaline catalytic source 3. TID Power Supply A separate control unit to control current

and temperature of the source. 4. Temp. Range Up to 4000 C maximum 5. Linear Range Better than 104 6. TID Sensitivity 10-13 gm/sec. for methyl parathion HEAD SPACE SAMPLER 1. Sample Heating Chamber Solid Aluminium with vial depression, cartridge heater,

Platinum resistance Thermometer with proportional temperature controller and safety limit cut. Accommodation for six standard vials with septa.

2. Spares Vials (12 nos), Silicon rubber vial seals (12 nos)

COLUMN Capillary Column attached with the Chromatograph: 1 No Fused Silica Capillary Column 30m length (narrow bore) 1 No SOFTWARE : Operating System : Windows XP compatible Program Type : Multi windows, multi user application Data Acquisition : Independent of other activities proceeding in Windows No. of independent : 1 to 4 Measurements Internal converter : Suitable type System Suitability : Built in module Test Data Import : ASCII and AIA built- in conversion module. Data Export : ASCII, AIA, DBF built- in conversion module. START UP KIT: S.No. Items Qty

1. TUBE S.S. INDIAN 1/8” 10 2. CONNECTOR BULLS EYE INDIAN 4 3. FERRULE AL/BRASS 1.6 MM 10 4. FERRULE FRONT BRASS 1/8” 25 5. FERRULE BACK BRASS 1/8” 25 6. FERRULE BRASS FRONT 1/4” 4 7. FERRULE BRASS BACK1/4” 4 8. NUT 6MB WITH HOLE 10 9. NUT BRASS TOSHLOCK 1/8” 25 10. NUT 6MB WITH BLIND (W/O HOLE) 2 11. SPLITTER FOR SERVO AIR 1 12. FUSE GLASS SMALL 3.5 AMP 5 13. FUSE GLASS SMALL 1 AMP 5 14. FUSE GLASS SMALL 1.5 AMP 5 15. SYRINGE 5ML HYPODERMIC 1 16. SYRINGE 5 UL FN SGE (001000) 1 17. FILTER MLSURE+CRBON+PANEL 1 18. MONOMETER SOAP BUBBLE TYPE 1 19. SEPTUM TEFLON 11.5MM (041827) 25

20. SPANNER NO 18, 19 MM 1 21. SPANNER NO 8,9 1 22. WASHER TEFLON 9.5x6x1 2 23. NUT NIPPLE FLOW MEASURMENT 2 24. O RING VITAN SILICON (325143) 3 25. PLUG AL.DBB 1 26. FERRULE OGF/16-005 P/N 072627 4 27. NUT TOSHLOCK CAPILLARY COLUMN 4 28. SLITTER 4W 1/8” SS316 WTH FIT 1 29. FILTER OXYTRAP 100 CC 1 30. SPANNER HR CAPILLARY INSERT 1 31 JIG BRASS PLATD CAPILLARY COLUMN 1

The system should be supplied with all respects with spares and consumables for 5 years

trouble for service. After sales service should be given. Service manual and operation manual should be supplied with the instrument.

(DIRECTOR)

ITEM NO. 3.-

TECHNICAL SPECIFICATION SPECIFICATIONS FOR FLASH EVAPORATOR Water Bath Heating range : 20- 180 0C. Temperature display : Digital temperature display for both set and actual temperature. Dimensions : 285 x 240 x 300 mm (Appx.) (L x H x D) Power Supply : Wire less contacts on the heating bath both for supply of power (incorporating Kettle

Technology) and communications for better safety. Power : 1300W Capacity : 4 litres Evaporation Flask : Provision of use of Evaporation flask from 50 ml to 4000 ml on the same adaptor without additional conditions.

Infra Red connection between heating bath and evaporator. Jack : Motorized quick action jack, operation by press

button, provision for automatic lifting of flask in case of power failure.

Connections : All connectors (for vacuum, water circulation

and vapour temperature) at the lower end of the condenser.

Glass Assembly :Vertical Sealing System : Glass or PTFE should be chemical resistant. Single

sealing system for all glass assemblies. Clip for easy fixing and removal of vapour duct and evaporation flask.

Glass : All glass components should be made of Borosilicate 3.3 glass.

Modularity : Compatible of up gradation in future to higher

versions. Rotation Speed : 20- 280 rpm. Vacuum Controller

With control knob and graphic display Speed control for vacuum pump. Measuring range : 1400-0 mbar Control range : 1100-1 mbar Integral aeration value and precision pressure sensor. Timer function for termination after prescribed time.

(DIRECTOR)

Item No. 4.-

TECHNICAL SPECIFICATION FOR FLORESCENCE MICROSCOPE

The Microscope should provide expanded range of infinity corrected optical systems (UIS - universal infinity system) and advanced fluorescence or differential interference contrast (Nomarski) technology. Based around an enhanced Y-shaped frame, an extended range of accessories and objectives can be used. The microscope should be exhibit rigidity coup led with easy-to-operate front controls on a compact space-efficient frame.

Optical system UIS (universal infinity system )optical system or equivalent Focus Vertical stage movement: 25mm stage stroke with coarse

adjustment limit stop Torque adjustment for coarse adjustment knobs Stage mounting position variable High-sensitivity fine focusing knob (adjustment gradations: 1µ m)

Illuminator Built- in Koehler illumination or equivalent for transmitted light12V100W halogen bulb (pre-centered).Light preset switch. Light intensity LED indicator. The frame should have two built- in neutral density filters, one daylight balancing filter, and one empty slot for an optional filter- fluorescence illuminator optional

Revolving nosepiece Interchangeable reversed quintuple/sextuple/septuple nosepiece Observation tube Widefield binocular, inclined 30° . Widefield (F.N. 22) Widefield tilting binocular, inclined 5º - 35º

Widefield trinocular, inclined 30º .Widefield ergo binocular, inclined 0° -25°

Super widefield (F.N. 26.5) Super widefield trinocular, inclined 24º Stage Ceramic-coated coaxial stage with left or right hand low drive

control; with rotating mechanism and torque adjustment mechanism, optional rubber grips available (non-stick grooved coaxial, plain, rotatable stages should be available)

Condenser Abbe (N.A. 1.1), 4x-100x Swing out Achromatic (N.A. 0.9), 1.25x-100x (swing out: 1.25x-4x) Achromatic Aplanatic (N.A. 1.4) 10x-100x

Universal (N.A. 1.4/0.9), 2x-100x (swing-out: 2x-4x, with oil top lens: 20x-100x).

Digital Camera Provision for attachment of Digital camera with image capture of

the slide. Software Appropriate software for the image transfer and processing.

(DIRECTOR)

Item No. 5.-

TECHNICAL SPECIFICATION FOR ATOMIC ABSORPTION SPECTROPHOTOMETER

Automated fully PC Controlled double beam AAS System having Zeeman background correction with Graphite furnace, Hydride generator with the following technical specifications.

Optics Real-Time dual beam optical system (single-beam for Zeeman furnace operation), Automated wavelength and slit selection with automatic peaking. Monochromator

Focal length 250-300 mm, diffraction grating 1800 lines/mm holographic grating, motorized slits with 0.2 to 2 nm spectral bandwidth. Wavelength –190 –900 nm. Detector – Segmented solid – state wide-range including a built in low-noise CMOS charge amplifier array or equivalent. Automatic Lamp Selection – 6-8 lamp holders with dedicated power supply for hollow cathode motorized turret with automatic lamp selection and individual lamp selection via software. Lamps should be GCP Compliant. Background Correction – AC Zeeman – effect electromagnet background correction with peak filed on strength of 0.8 Tesla during read period. Correction up to 2.5 Abs at 2 ms response time with electronic modulation and automatic attenuation. Safety features – Safety interlocks for burner, liquid trap, pressure relief bung, flame shield, mains, power, gas and oxidant pressure. Sensitivity – Better than 0.75 Abs with 0.5% RSD for 5 ppm Cu Solution. Graphite furnance – Fully Automated, built- in computer controlled. Maximum temp. 3000°C. Temperature programmable from 40-3000°C. Autosampler-Capacity for 50 samples in 20 µl vials with five central 25 ml vessels for bulk solutions. Automatic 10-point concentration or standard additions, calibration from one bulk standard.

Hydride Generator– Modular continuous flow vapour generation for hydride forming elements at ppb levels. Precision 1-2% RSD with sample throughput of 60-70 samples/hr determined in triplicate. The system should have a built in Atomizer for both flame and graphite furnaces and should be selectable by user through software by mechanical movement in one chamber. Software - Windows based software to control all operations of analysis, archiving, results, calculations, summary reports etc. Computer – Pentium IV, 3.0 GHz, 512 DDR RAM, DVD Reader drive, 80 GB HDD, 17” flat colour monitor, 104 keys key board, optical mouse, Windows XP, serial and parallel ports and Desk jet colour printer. Other fittings – Fume hood with exhaust facility supply and erection. Lamps – Hg, Cd, As, Pb, Cu, Au, Ag, Fe, Ca, Na, K, Mg, Sn, Si, Mn, Zn.

The system should be supplied with all respects with spares and consumables for 5 years trouble for service. After sales service should be given. Service manual and operation manual should be supplied with the instrument. Buy-back of old AAS, Perkin Elmer make model No. 2380

(DIRECTOR)

Item No. 6.- TECHNICAL SPECIFICATION FOR Homeopathic Potentiser Mechanical Homoeopathic Potentiser. It should have following specifications:

1. The mechanical lever 24” length having motion up and down up to 15” high, motor operated with 1 hp single phase electric motor.

2. The lever should have provision for fixing a glass bottle of 5ml to 100ml size at various distances at 7 stations at a distance of 1 inch each from 12” onwards.

3. The bottle should strike on a rubber pad and where a facility should be there to measure the force by which the lever or bottle striking. A pressure gauge facility for measuring pressure may be provided. There should be a provision to automatic drainage of measured quantity of liquid (9 to 90 ml) from the bottle and refilling the same quantity of liquid from another container automatically after each stroke.

4. A graduated scale up to 15” for measuring the height of lever with a provision to measure the maximum height taken by the lever.

5. A counter for counting the movement of lever / minute and auto stop after a fixed number of movements.

All as per figure attached. DOUBLE HEADED AUTOMATIC HOMOEOPATHIC POTENTISER :

This machine is basically for preparation of liquid homoeopathic potencies from 000 to 999 and higher. Double headed. Two sets can work independently for raising homeopathic potencies. Mounted on heavy rust proof material of Aluminium / Stainless Steel and vibration free.

It should have the following features: Made up of stainless steel. All parts coming directly in to the contact of drug Solution made of SS 316. Dosing pipe material- Silicon / Teflon.

Cycle Time : For a complete of Dosing / Dynamization / Evacuation, machine will take 4-6 seconds. It gives a speed of around 15 cycles per minute.

Dosing : 1. Solvent will be fed in to 10 ml bottle through injection made of SS 316. Dosing accuracy will be closed to ± 3%.

2. Dose volume can be adjusted from 5ml to 10 ml as per the requirement.

3. Dosing time: 1.5 sec to 2 sec per cycle. Dymanization : 1. For Dynamization-vertical vibration (up-down).

2. Vibration speed 3000 RPM. Dilution is shaken for fifty times per seconds.

3. Vibration time is 1.5 sec per cycle. Evacuation : 1. Evacuation of the bottle will be through air

compressor with dry filtered air. 2. Evacuation time- 0.5 sec per cycle. 3. Amount of drug solution to be left inside the bottle

can be adjusted as desired. General Features : 1. The machine can be sent to manual operation

of programme to automatic mode. 2. Machine will have electronic counters for indicating

numbers of cycles completed. 3. Machine will completely stop automatically at the

prefixed cycles number after dynamization. 4. The machine accurately shuts down at preset

numbers of performance / dilution. In case of powder failure it retains the data in memory and restarts the dilution from the stage it was shut off and continue to further stage.

Power Input : 230 Volts. Single Phase.

Interested parties who have experience of manufacture and supplied such machine

may applied with complete details of machine, cost. List of users and past experience in the field to the Director, Homoeopathic Pharmacopoeia Laboratory, Kamla Nehru Nagar, Ghaziabad-201002 in a sealed cover marked with “Tender for Potentiser”.

(DIRECTOR)

(DIRECTOR)