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Gordon Research Conferences

Bones & Teeth

Evolutionary and Developmental Mechanisms of Skeletal and Tooth Biology and Disease

June 19-24, 2011

Les Diablerets Conference Center

Les Diablerets, Switzerland

Chair:Bjorn R. Olsen

Vice Chair:

Brendan Lee

Application Deadline

The application deadline for this meeting was May 22, 2011. You may still submit an application. However, it will only beconsidered by the Conference Chair if more seats become available due to cancellations.

Related Meeting Information

The Bones & Teeth Gordon Research Conference will be held in conjunction with the Bones & T eeth Gordon Research

Seminar. Those interested in attending both meetings must submit an application for the GRS in addition to an application for

the GRC. Please refer to the Bones & Teeth GRS web page for more information.

The 2011 Gordon Research Conference (GRC) on “Bones & Teeth” will be focused on cellular and molecular aspects of

skeletal biology and pathology in the context of evolutionary and developmental principles and mechanisms. The Program will

include sessions on Evolution of Bones and Teeth, Developmental and Genetic Mechanisms, Postnatal Homeostasis, Stem

Cells and Regenerative Medicine/Dentistry, Osteoporosis, Cancer, as well as Joints and Soft Tissue Connections of Bones and

Teeth. The meeting will conclude with a keynote session on Evolutionary Gain and Loss of Skeletal Elements. The sessions,

chaired by leaders in the field, will foster discussion among invited speakers and other senior and junior investigators, students

and post-docs in a collegiate atmosphere. Some poster presentations will be selected for short talks. The programmed talks,

discussions, poster presentations and more informal gatherings in the afternoon and evenings will provide avenues for scientists

from different disciplines to brainstorm about skeletal structure and function in health and disease, stimulate ideas aboutdevelopment of new therapeutic strategies for diseases of bones and teeth, and promote cross-disciplinary collaborations in the

various research areas represented.

The GRC will be preceded by a two-day Gordon Research Seminar (GRS) on “Cell Niche Microenvironments in Bone and

Tooth Development and Regeneration”. This is a unique forum for graduate students, post-docs and other scientists with

comparable levels of experience and education to present and exchange new data and cutting edge ideas. The Seminar will

Gordon Research Conferences - 2011 Program - Bones & Teeth http:/ /www.grc.org/programs.aspx?year=2011&program=bones



Contributors

SUNDAY

4:00 pm - 8:00 pm Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)

6:00 pm Dinner

7:30 pm - 7:40 pm Welcome / Introductory Comments by Conference Chairs and GRC Site Staff

7:40 pm - 9:30 pm EVOLUTION OF BONES AND TEETH

Discussion Leader: David Kingsley (Stanford University School of Medicine, Stanford, CA, USA)

7:40 pm - 7:50 pm David Kingsley (Stanford University School of Medicine, Stanford, CA, USA)

"Introduction"

7:50 pm - 8:15 pm Tanya Smith (Harvard University, Boston, MA, USA)

"A Primate Perspective on Dental Evolution"

8:15 pm - 8:30 pm Discussion

8:30 pm - 8:40 pm Short Presentation: Elodie Renvoise (Institute of Biotechnology, Helsinki, Finland)

"Developmental Mechanisms in the Evolution Of Morphological Innovation in Small Mammals"


8:50 pm - 9:15 pm Robert Cerny (Charles University, Prague, Czech Republic)

"Jaw Evolution (prepattern/cooption model): Understanding Evolution of New Skeletal Tissues and Joint

Formation Based on Studies of an Agnathan Vertebrate"


Gordon Research Conferences - 2011 Program - Bones & Teeth http://www.grc.org/programs.aspx?year=2011&program=bones

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9:40 am - 9:50 am Short Presentation: Nik Kantaputra (Chiang Mai University, Thailand)

"The Smallest Teeth in the World are Caused by Mutations in PCNT Gene"

9:50 am - 10:00 am Discussion

10:00 am Coffee Break / Group Photo

10:30 am - 10:55 am Elazar Zelzer (Weizmann Institute of Science, Israel)"The Mechanisms that Sculpt our Bones"


11:10 am - 11:20 am Short Presentation: Florence Lorget (Biomarin Pharmaceutical Inc., Novato, CA)

"BMN 111, a CNP Analogue, Promotes Skeletal Growth and Rescues Dwarfism in two Transgenic Mouse

Models of Fgfr3-related Chondrodysplasia"


11:30 am - 11:40 am Short Presentation: Jerry Feng (Baylor College of Dentistry, TX A&M Health Science Center, Dallas, TX,

USA)"Dentinogenesis: A Key Role of ALK3-Osx Signal Pathway"


11:50 am - 12:15 pm Shigeaki Kato (University of Tokyo, Japan)

"Epigenetic Regulators in Osteoclast Development"


12:30 pm Lunch

1:30 pm - 4:00 pm Free Time4:00 pm - 5:30 pm Poster Session

5:30 pm - 7:30 pm GENETIC MECHANISMS

Discussion Leader: Daniel H. Cohn (University of California, Los Angeles, CA, USA)

5:30 pm - 5:55 pm Deborah Krakow (University of California, Los Angeles, CA, USA)

"Mutations in FKBP65, an ER Localized Protein, Produces OI"


6:10 pm - 6:35 pm André G. Uitterlinden (Erasmus University Medical Center, Rotterdam, The Netherlands)"Genome - Wide Screens for Skeletal Disease-Genes"


6:50 pm - 7:15 pm Stefan Mundlos (Max Planck Institute for Molecular Genetics, Berlin, Germany)

"Far Far away - Long Range Regulation in Skeletal Development and Disease"


8:00 pm Dinner

TUESDAY7:30 am - 8:30 am Breakfast

9:00 am - 12:30 pm POSTNATAL HOMEOSTASIS

Discussion Leader: Thomas L. Clemens (John Hopkins University, Baltimore, MD, USA)

9:00 am - 9:25 am Eileen Shore (University of Pennsylvania, Philadelphia, PA, USA)

"Molecular and Cellular Mechanisms of Ectopic Bone Formation"


Gordon Research Conferences 2011 Program Bones & Teeth http://www grc org/programs aspx?year=2011&program=bones



11:10 am - 11:20 am Short Presentation: Matthew Grol (The University Of Western Ontario, London, Canada)

"Persistence of ATP-Induced Calcium-NFATc1 Signaling in Osteoblasts is Determined by Distinct

Nucleotide Receptor Subtypes: A Novel Mechanism for Coupling Agonist Concentration to Signal

Duration"


11:30 am - 11:40 am Short Presentation: Stavroula Kousteni (Columbia University, New York, NY, USA)

"FoxO1 in Skeletal Physiology"


11:50 am - 12:15 pm Beate Lanske (Harvard School of Dental Medicine, Boston, MA, USA)

"The Effects of Bone on Kidney and Parathyroid Glands"


12:30 pm Lunch

1:30 pm - 4:00 pm Free Time

4:00 pm - 5:30 pm Poster Session

5:30 pm - 7:30 pm STEM CELLS AND REGENERATIVE MEDICINE/DENTISTRY

Discussion Leader: Jeremy Mao (Columbia University, New York, NY, USA)

5:30 pm - 5:55 pm Pamela G. Robey (NIH/NIDCR, Bethesda, MD, USA)

"Musculoskeletal Stem Cell Biology"


6:10 pm - 6:20 pm Short Presentation: Nick Van Gastel (Katholieke Universiteit, Leuven, Belgium)

"Engineering Vascularized Bone: Osteogenic and Pro-Angiogenic Potential of Murine Periosteal Cells"


6:30 pm - 6:40 pm Short Presentation: Nicolai Miosge (Tissue Regeneration Work Group, University of Gottingen,

Gottingen, Germany)

"Chondrogenic Progenitor Cells in Osteoarthritis are Regulated by Runx2, Sox9 and Sex Hormones"


6:50 pm - 7:15 pm Kristi S. Anseth (University of Colorado, CO, USA)"Programmable Hydrogel Niches for MSC Culture and Differentiation"


8:00 pm Dinner

WEDNESDAY

7:30 am - 8:30 am Breakfast

9:00 am - 12:30 pm OSTEOPOROSIS

Discussion Leader: Roland Baron (Harvard School of Dental Medicine, Boston, MA, USA)9:00 am - 9:25 am Chris Paszty (Amgen Inc., Thousand Oaks, CA, USA)

"Sclerostin: From Gene Discovery to Bone Building Antibodies"


9:40 am - 9:50 am Short Presentation: Rao V. Papineni (Carestream Health Inc, Woodbridge, CT, USA)

"Bisphosphonates: A Targetable Theragnostic Agent with no Bone of Contention"


Gordon Research Conferences - 2011 Program - Bones & Teeth http:/ /www grc org/programs aspx?year=2011&program=bones



11:30 am - 11:40 am Short Presentation: Leonie Huitema (Hubrecht Institute, Utrecht, Netherlands)

"A Novel Ectonucleotidase Essential for Bone Formation in Fish"

11:40 pm - 11:50 am Discussion

11:50 am - 12:15 pm Alexander G. Robling (Indiana University School of Medicine, Indianapolis, IN, USA)

"Lrp5 Signaling in Bone: Local Regulation of Bone Metabolism and Mechanotransduction"


12:30 pm Lunch

1:30 pm - 4:00 pm Free Time

4:00 pm - 5:30 pm Poster Session

5:30 pm - 6:50 pm CANCER

Discussion Leader: Theresa A. Guise (Indiana University School of Medicine, Indianapolis, IN, USA)

5:30 pm - 5:55 pm Yibin Kang (Princeton University, Princeton, NJ, USA)"Novel Mediators of Tumor-Stromal Interactions in Bone Metastasis"


6:10 pm - 6:35 pm David M. Thomas (Peter MacCallum Cancer Centre, East Melbourne, Australia)

"Basic and Clinical Studies in Benign and Malignant Bone Tumors"


6:50 pm - 8:00 pm Business Meeting

Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site &Scheduling preferences; Election of the next Vice Chair

8:00 pm Dinner

THURSDAY

7:30 am - 8:30 am Breakfast

9:00 am - 12:30 pm BONES AND TEETH: JOINTS AND SOFT TISSUE CONNECTIONS

Discussion Leader: Yingzi Yang (National Human Genome Research Institute, Bethesda, MD, USA)

9:00 am - 9:25 am Malcolm Logan (National Institute for Medical Research, London, UK)"Mechanisms Controlling Morphogenesis of Limb Tissues"


9:40 am - 9:50 am Short Presentation: April Craft (University Health Network, Toronto, ON, Canada)

"Regulation of Articular and Growth Plate Chondrocytes from Pluripotent Stem Cells"


10:00 am Coffee Break

10:30 am - 10:55 am Ronen Schweitzer (Shriners Hospital for Children, Portland, OR, USA)"From Salamander to Mouse - Generation of Long Tendons by Scleraxis Dependent Elongation of

Sox9-Lineage Derived Tendon Precursors"


11:10 am - 11:20 am Short Presentation: George Yang (Stanford University, CT, USA)

"Cartilage-related Phenotype in DEL1 Knockout Mice"

Gordon Research Conferences - 2011 Program - Bones & Teeth http:/ /www.grc.org/programs.aspx?year=2011&program=bones

gordon conference- bones- dr.papineni

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