good research for comparative effectiveness (grace) checklist: an infographic

ASSESSING OBSERVATIONAL STUDIES Observational studies follow patients over time and can evaluate the of interventions on health outcomes STRENGTHS OF OBSERVATIONAL STUDIES D I V E R S E P O P U L A T I O N S P r o v i d e i n f o r m a t i o n a b o u t P A T I E N T - C E N T E R E D O U T C O M E S I m p r o v e u n d e r s t a n d i n g o f R E A L W O R L D S E T T I N G S T e ll u s h o w t r e a t m e n t s w o r k i n - T I M E L Y R E S U L T S C a n b e c o n d u c t e d m o r e q u i c k l y f o r There is growing demand for comparative ectiveness research (CER) and how interventions work in the real world. Yet there is debate about whether and when observational studies are good enough to support decision-making. LIMITATIONS OF OBSERVATIONAL STUDIES M a n y f a c t o r s d r i v e T R E A T M E N T D E C I S I O N S R e a l - w o r l d p a t i e n t s c a n h a v e C O M P L E X C L I N IC A L C O N D I T I O N S S o m e s t u d i e s m u s t a d d r es s U N B A L A N C E D G R O U P S , D I F F E R E N T I A L F O L L O W - U P A N D M IS SI N G D A T A A HELPFUL TOOL When done correctly, observational studies can provide meaningful information; when done poorly, misinterpretations are possible. The Good ReseArch for Comparative (GRACE) Checklist was developed as a guide to assess the quality of observational studies and to help ensure that the information used is credible and reliable. GRACE CHECKLIST* *This is an abridged version of questions in the GRACE checklist. For more information, check out the March 2014 Journal of Managed Care Pharmacy. DATA METHODS Source: Dreyer NA, Velentgas P, Westrich K, Dubois RW. The GRACE Checklist for Rating the Quality of Observational Studies of Comparative J Manag Care Pharm. 2014;20(3):1-12.

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With the growing demand for information about comparative effectiveness and questions about the quality of research that will support future health care decision-making, a group of researchers led by Quintiles and the National Pharmaceutical Council have developed and tested a checklist to evaluate the quality and usefulness of observational research studies. The Good ReseArch for Comparative Effectiveness (GRACE) checklist was published as part of a peer-reviewed study, "The GRACE Checklist for Rating the Quality of Observational Studies of Comparative Effectiveness: A Tale of Hope and Caution," that was published in the March 2014 issue of Journal of Managed Care & Specialty Pharmacy.We've summarized the research in this handy infographic.

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Page 1: Good ReseArch for Comparative Effectiveness (GRACE) Checklist: An Infographic

ASSESSING OBSERVATIONAL STUDIESObservational studies follow patients over time and can evaluate the of interventions on health outcomes

STRENGTHS OF OBSERVATIONAL STUDIES

DIVERSE POPULATIO

Pro

de information about

PATIENT-CENTERED OUTCO

Impr

ove understanding of

REAL WORLD SETTIN

Tell

how treatments work in

- TIMELY RESULTS

Can

conducted more quickly for

There is growing demand for comparative ectiveness research (CER) and how interventions work in the real world. Yet there is debate about whether and when observational studies are good enough to support decision-making.

LIMITATIONS OF OBSERVATIONAL STUDIES

Many factors drive

TREATMENT DECISIO

Rea

l-world patients can have

MPLEX CLINICAL CONDIT

ION

Som

e studies must address

UNBALANCED GROUPS, DIFFERENTIAL FOLLOW-U

AND MISSING DATA

A HELPFUL TOOLWhen done correctly, observational studies can provide meaningful information; when done poorly, misinterpretations are possible. The Good ReseArch for Comparative (GRACE) Checklist was developed as a guide to assess the quality of observational studies and to help ensure that the information used is credible and reliable.

GRACE CHECKLIST*

*This is an abridged version of questions in the GRACE checklist.For more information, check out the March 2014 Journal of Managed Care Pharmacy.

DATA METHODS

Source: Dreyer NA, Velentgas P, Westrich K, Dubois RW. The GRACE Checklist for Rating the Quality of Observational Studies of Comparative J Manag Care Pharm. 2014;20(3):1-12.

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