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“GOOD , B ETTER , B EST HOW  DO I K NOW  W HICH PROGESTERONE CREAM T O BUY ? B  Y  J OHN T ICE

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“Good, Better , Best ”

How do I K now  w HIcH 

ProGesterone cream t o Buy ?

B y  JoHn t Ice

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C © 2003-2009, , C. A .N b x .

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Contents

Acknowledgements iii

 Addendum: iii 

Revisions iv

Background iv

Update History iv

Introduction v

Who Needs This Book? v

Background v

Chapter One: Choosing a Cream 1

 Medical Claims 1

Which Company Should I Trust? 1

“Dr Lee’s Cream” 1

Chapter Two: How Much Progesterone Should Be In My Cream? 3

Determining Progesterone Levels 3

Table 1: Progesterone Levels Reference Chart 4

Chapter Three: Are All Creams

Created Equally? 5

“Dr Lee says wild yam is a scam” What gives? 5

Outlined below are a number of references on this topic 6 

Why do you list “wild yam extract” as an ingredient? 6  

So are you a real progesterone cream with just the words wild yam extract on the

label? 7  

Chapter Four: Ingredients 8

Chemicals in My Cream and Long Chemical Names 8

“No Synthetic Chemicals” 8

Besides progesterone, are there ingredients to look for, or to avoid? 8

Other Ingredients to Watch 9

Is yam- or soy-based progesterone better? 9

Phytoestrogens and Pixie Dust 9

Table 2: Herbal Ingredients Chart 10

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ii

Conflicting Ingredients 11

 Miscellaneous Ingredient Questions 11

Chapter Five: Filter The Nonsense 12

“Contains a combination of ingredients 12

“One full press of this 4 oz ‘pump dispenser’ 12

“Their GMP laboratory uses only the highest quality 12

“Progesterone: (USP 2%) Pharmaceutical Grade 12

“Lecithin, Evening Primrose Oil and Sesame Oil: 12

“Silver Chloride: A full spectrum natural preservative 12

“Vitamin A Palmitate, Allantoin, Xanthan Gum, 13

 And one of the biggest offenders of all: 13

Food Grade Progesterone?! 13

Chapter Six: Packaging 14

Should I buy progesterone cream in a jar, tube, or a pump? 14

 Jars 14

Tubes 14

Pumps 14

Chapter Seven: General Usage

& Common Questions 15

Do all women experience the same results? 15

If some is good, is more better? 15

How much cream is applied? 15

Premenopausal women: 15

 Menopausal women not receiving estrogen: 15

 Menopausal women taking an estrogen supplement: 15

Does progesterone play a role in osteoporosis? 16  

Patience 16  

Chapter Eight: Legislation, Etc 17Drug, Supplement, or Cosmetic? 17  

Proposition 65 17  

Is progesterone as dangerous as “Prop 65” would lead you to believe? 17 

Chapter Nine: Conclusion 18

Chapter Ten: Reading List 19

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iii

 Acknowledgements

N . T K, LLC x.

V I J R. L, MD b  , P. I’ D. L, b .

M Lx, ND,   Natural Woman, Natural Menopause , b  K W’ B C.

R M J G, DC,  Te Estrogen Alternative: Natural Hormone Terapy With Botanical Progesterone , K- ’ .

C S, D Gb, Db A, R R, W Cb, N F, DbS, M S b .

I “ ” .

John Tice

Santa Ana, California

May 2003

 Addendum:

S b, , J L, Ob 2003. D. Lb b A ’ ( ’) .

D-- , I b b b . I J 1998, D. L

Cb, G b . H , , - b b -. H 70, “ .” J, ’ x . W’ .

 J S A, C

 A 2004

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Revisions

B

L , b bj . O b b . I I b   -. I , . L b :

U H 

 J 19, 2003

C O: : “We know o sellers who will not stand behind the products they sell…” 

C F: : “We know o one site, owned and run by a nurse…” 

C Sx: : “We know o one web site that states…” 

 J 18, 2003

C F: : “Food Grade Progesterone?!” 

C F: : “M I Q”

 A 4, 2003

C T: : “ W Y...” “ W Y...”

 A 18, 2004

N C 8 .

O C 8 9 b.

 A 21, 2005

B: : “ ....” “ ....”

C : : “56,600” “60,000” x.

C Sx: : M : ’ , I ? J ’ b b .

Fb 7, 2008

F, , .

Fb 10, 2009

I: : “ ....” “ ....”

C F: : M D

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Introduction 

W N B

 I you are conused about which company is “best”—you need this inormation.

 I you don’t know whether yam derived progesterone is “better” than soy derived progesterone—you need this inormation.

 I you’ve heard that “USP 2% Progesterone” is recommended by experts”—you need this inormation.

 I you are looking or “Dr. Lee’s cream”—you need this inormation.

 I you want a cream with no chemicals”—you need this inormation.

 I you want a cream with only organic ingredients”—you need this inormation.

 In short”—you need this inormation.

BO b b b , ,, . T b . I -.

 W b , – ’ b b .

I “ ,” ’ -—’ b b .F b b : b , , .

 W b — !

 A b, b b : I I

. I’ —b . I’ b 1,000. I’ . I j . I ’ —I ’ !

 T b ( ) b , , , . W b j – .

M ’ b .

This inormation is not intended to diagnose any medical condition and is not intended

to replace competent advice rom your health care proessional. None o the inormation

contained in this report has been evaluated by any regulatory agency. While we have taken

every step to ensure that we are ofering accurate inormation some errors may occur, we

urge you to seek additional inormation i you have any questions on our inormation.

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1

Chapter One: Choosing a Cream

With dozens o natural progesterone creams ,

  “b.” A b . (I ’ b , b

b.) M b , “D. L’ ,” “D. L’ ,” “ O!,” b .

 Medical Claims M b b b ( ). B , — . A  b “” b “” U.S. ; b .

R b ,   ( ) . A b .

Which Company Should I rust?  W K, LLC b 1996, x 18 b, b , b , x 50! T   , , “ b, ---” .

 W b , “N b x.” T ’. P, I ’ b ’ b  . C 100% b , .

M J R. L, MD, M Lx, ND, R M, J G, DC, S S, U R, MD, b . , .N . W b . W .

“Dr. Lee’s Cream” I , “D. L’ F” “A A b D. L” “A b O W.” W ’ O,

D. L : NO , ( ), “ .” C b D. L D. L’ . H NO .

I O , x b U.S.? O . I , b (!) .

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2

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3

Chapter Two: How Much ProgesteroneShould Be In My Cream?

J

ohn R. Lee, MD, x 20 .20 x 480-500 . CN, MD, 2% O W S.

 T x 600 . H b   “ (USP 2%)” “USP 2% ” . T “” b “M (FDA G: 2 G).” M b.

 T . I - j , b b .

• First,decidewhetheryourusageplanhasaphysiologicalorapharmacologicalgoal . P

b b. T b 20 30 .1 

• Pharmacological,ordrug,dosagesaresignicantlyhigherthanphysiological. Ex b . D. L . Fx, x x .2

D. L b 400 500 USP .3 W b

, . O b .4

Determining Progesterone Levels I , b b b j b . F x, ’ b “1.8% USP” j. Y

  : b 60,000 ( x b   ). I b x, 1.8% 60,000 1,080 .

  b ¼ , - j b 48 ( b ¼ - j). U b x, 22.50 (1,080 b 48). T b x 21   ¼ . ½ , b j .5

 T b b j ¼ ½ .

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4

 W b ? S : I b 1.8% USP,  x 510 - 1,019 -. Y 21 ¼ .

O , “ ( ) b ?” U b b

.I b x, b .

Table 1: Progesterone Levels Reference Chart 

P P 2-z

P 1/4 T

P 1/2 T

1.0% 600 12.5 25

1.2% 720 15.0 30

1.4% 840 17.5 35

1.6% 960 20.0 40

1.8% 1,080 22.5 45

2.0% 1,200 25.0 50

2.4% 1,440 30.0 60

3.0% 1,800 37.5 75

(F)1 L, J R., W Y D M N Y Ab M, W B, N Y, . 69.2 L, . 78.3 L, . 271 D. L, Db 1997.4 L, . 271.5 C x bb b b.

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5

Chapter Three: Are All CreamsCreated Equally?

C

ertainly every manuacturer . W x. T x . W x

b . W b .

 W ? O b . W b-. I USP, x. I x x b x. T b x b .1

 W ? I b , b . E b .

“Dr. Lee says wild yam is a scam.” What gives? O x K W’ BC. F , B C USP b D. J R. L . I ,B C b D. L’ x ( ).

 W D. L b

b, b b . U, ,  , b .

O b b .H, B C b . O b.

P x B C b  . K . I ! Mb b. I b . I . O , b jb. I 

  B C, . I b   , :

• Wildyamhasbeenusedinfemale-relatedherbalformulationsforyears.Arecent b b ’   , , , - .

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6

• Whiletherearesomequestionsonwhetherpregnantwomenshouldusewildyam,  b . F, x K W’ B C ,, .

Outlined below are a number o reerences on this topic.

 A W’ B Hb, T H P N R, S, Db, C PbG, 1995. W - .

 T L Hb E, T Hb N R H L, R, J, ND, PD, M Hb. W H B, 1995, 248-9, 369. T . “T b b ….” ( 249) “W b b . … W Y: , .” ( 369).

 T S V Hb M, M, D B., PD, K Pb, 1986, .111-112. R : , , .

 ’ Hb H, T E, , L, MH, W B, 1992, 145-6.R : , , .

I D L’ b ,   b. F x, b W Y D M N Y Ab P (WPM), D. L , “T ‘x ’ D ( L Mx ) AND CLAIM HA I HAS HE SAME EFFEC AS PROGESERONE

 ARE NO SPEAKING HE RUH.” (WPM, 38-39) [E ]. T W Y D M N Y Ab M (WYD), 269-272, .

 T x;

x . O x : I WILL NO URN INO ANY HORMONE IN YOUR BODY. T . W b b b b x b .

Why do you list “wild yam extract” as an ingredient? S. T . W . I , USP .

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7

So are you a real progesterone cream with just the words wild yam extract on the label?  A “ ?” N , “Y,” b x . W b 1996. S :

• WhatYouDoctorMayNotTellYouAboutMenopause,JohnR.Lee, MD

• WhatYouDoctorMayNotTellYouAboutPremenopause,JohnR.Lee, MD• WhatYouDoctorMayNotTellYouAboutBreastCancer,JohnR.Lee, MD

• eJohnRLee, MD, N, J R. L, MD

• NaturalWoman,NaturalMenopause,MarcusLaux, ND

• eEstrogenAlternative,NaturalHormoneerapywithBotanicalProgesterone,R M J G, DC

• HormoneHeresy,SherrillSellman

 T . T : x “ ” .

(F)1 S “

x” -, x.

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8

Chapter Four: Ingredients

Chemicals in My Cream and Long Chemical Names O ( ) .

S , NO b – 90% !M , bj , b. W ’ .

 T b – . M b b . I ( ) , . I’ .

“No Synthetic Chemicals” U “-,” “bbb,” x . U, , b b.

 W , “S ” . C : 1 E ( x, V B-5 “x-”— “ , ’ ?). U   , NOR (, bb  LESS ) ’ .

F x, S L S (SLS) “” , “ .” SLS b   . A —I ’ . J b’ ’ ’ j b ’ , “ ” ’ ’b.

Besides progesterone, are there ingredients to look or, or to avoid?  W x b W’ B C,   b b ,, .

 T S S’ Bb, A C’ G Nx H, P, C, F (S, D & E, S S., MD) . F x, b 1,4-x -, b : , x, b PEG,P, P G, Px, ( ), x.1

B Pb 60 Pb 80 b 1,4-x.S , , b . T : D , DMDM H, I . T b b.

 T b (b, , , ) b . O b-

 x ( b).

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9

 T b : G x,Px, P b, Sb A, (V E), R (V A), Ab

 A (V C) S C.

Other Ingredients to Watch

 W , b , : “… , … …”I :

S K C

S C Q A C (“QAC”). QAC . A QAC’ “ b x…” (S: Consumer’s Ingredients o Cosmetic 

 Ingredients , F E.)

(T b.)

 Is yam- or soy-based progesterone better? R M, PD, ( M D) 1943

  b ( $80,000 (!) $800 10 ).

I 1941, , . M b Mx W Y b. , .

 T USP, b . T . W b ( ), ’ ’ b.

 W , “I b I’ [

b].” W b —’ ’ b“USP.”

Phytoestrogens and Pixie Dust M , - b. M x, , , , . W b , b :

1. M b b . D b 

  -b b? W .

2. L b b b. M , () , , “W!I’ b!”

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10

Hb U/F

B C C D LHI b

B C E/ b

B R P

C I LH

D H S H

D Q B S S

I M V

 W L B H

N R  

P F H H

R Rb A G  S

Sb G Ex H bS

S V M bS U

S. J’ W O C MU C

  C

U U Causes uterine contractions 

G  Y D A

(Source: Te Little Herb Encyclopedia, Tird Edition, Jack Ritchason, N.D., Woodland Health Books, 1995; and, Natural Hormone Replacement For Women Over 45, Jonathan V. Wright, M.D. & John Morgenthaler, Smart Publications, 1997.)

Table 2: Herbal Ingredients Chart 

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11

3. F x, : 400 ( ) B C,“….Ex R Rb, N, C , D Q, B C,D, I M, Sb G, B R, U U, P F,L B, S V, Y D, ; S. J’ W O;….” Tb b .

4. A b b , , . S , “-” b ?

5. I ( ) ? J b b b , .. , , bb b ( b -).

“Px D” I , — j . I , b  b b j b

b b. W ’ 1/10 1% b   b. B b b . T .

  b. I f,  b , b b x b.

Conicting Ingredients  Y b b () . A, . N : x. W , b , ? I / xb “ ”, b ?

 Miscellaneous Ingredient Questions O b b b-.

“[ ] . I b b b b .”

E ( ) — , . P b; b, . W

 J L, MD, x b -b   b b b b . B x, b . O , , b .

(F)1 S, D & E, S, S., M.D., T S S’ Bb, MM, 1995, . 189-95.

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12

Chapter Five: Filter The Nonsense

We requently see nonsense b b “,” b . V ( !). b b . A 

  . W b, .H “” ’ :

“Contains a combination o ingredients...

b , , b , 20 (2%) P USP.“ — “20 (2%) P USP” . 20 ... , 1/4 , ? T (2%) P USP. F, b . W ? “… , b ,…” b – .

“One ull press o this 4 oz ‘pump dispenser’  20 (2%) . “ — H , , ? A 20 (2%) b . 20 1/4 x 1.6% b . 20 0.02% . T b.

“Teir GMP laboratory uses only the highest quality 

b .” — T “b ” b. D b ? F x, :

“Progesterone: (USP 2%) Pharmaceutical Grade 

(550 . . 1650 b).” — A I , “P USP2%.

“Lecithin, Evening Primrose Oil and Sesame Oil:

Tese special oils are very high in Omega 3 and Omega 6 actors which are necessary or transdermal liposome delivery. “  — T “” . B , b ? I , W’ B C.

“Silver Chloride: A ull spectrum natural preservative 

which eliminates the need or any o the paran waxes that are used in many other products, which can hinder delivery o progesterone.” — S f x. T . W S C. T b , .

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13

“Vitamin A Palmitate, Allantoin, Xanthan Gum,

 Arnica and Panthenol (Vitamin B-5): Aid in the delivery and stabilization o our cream. Te special VitaminB-5 is used to open the capillaries or quick absorption into the skin.” — P, x-P, . I , b? A, W’ B C , “-”

.

 And one o the biggest oenders o all:

“All our ingredients are organic ....” — W j . H , “ ”? N , .

S b . F, — ’ . I “.” W ; . W .

Food Grade Progesterone?! 

 J ’ ’ , b, , j : [N ] “ F G P .” I!N ’ b , ! T “ .”

 W’ b b . T (-) b .

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14

Chapter Six: Packaging

Should I buy progesterone cream in a jar, tube, or a pump? 

 Jars 

 T . I b, D. L b. I , j. T x . I , b b. B  , 2 , bb .

 W : “J .” T . O x . O b.

 W b “ j” b,  , “ bb . … .” T - . A “ ” .

ubes 

 b . T : “I ”– .B b: b 3–5% . W j b “ .”

Pumps 

 W : “E x 20 – x   .”

 W b :

•  W ’ , , “ 20  .”

• I , , , b , . O-- — .

•  T “ b”

  x . W j .

 T :

• C— ?

•  Y ’ j . , b ’ b .

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15

Chapter Seven: General Usage& Common Questions

A

t this point we want to make a comment b : i youchoose to use progesterone creams, be committed and be consistent.

Do all women experience the same results? 

 A x , b . B , ’ , , . Y .

 I some is good, is more better? 

 A . O, b b. T . Y b b 

, b .F, .

How much cream is applied? 

N b 1/8 1/4 , , b   , , , b, , .

Premenopausal women:

I b 1, 12 26.I , 28. I b b 26, b

, b 12 .

 Menopausal women not receiving estrogen:

 Y . Y b , x . I ,  .

 Menopausal women taking an estrogen supplement:

D. L b b - . H , x

. Y b  . I b, x / .

 T b b .

 W b . D. L x .

I , P, . W

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16

b b .

Does progesterone play a role in osteoporosis? 

D. L “ b b b [ ] progesterone defciency [ ] j ...

.” S D. L’ b b 35% . W x x- .

Patience 

B . E ’ b . I j b. M , b .

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17

Chapter Eight: Legislation, Etc

Drug, Supplement, or Cosmetic? M b b (1) , (2) --

, (3) , (4) . S, ? T , , . I b b, . W , “W ’ ?” A: b , -- .

 W - . T b , , . T ( ) (b ’ b, ). O : b   .

Proposition 65 C b, S D W x E A 1986, “P 65.” P 65 b “ C , b , , bx .”

P 700 b . A   (A 2004), ( ) bb b Nb 2004 bb b“ .” T : http://www.oehha.ca.gov/

prop65/hazard_ident/pdf_zip/progeshid5.pdf.

C b “P 65” b : “T C , b , .”

 Is progesterone as dangerous as “Prop 65” would lead you to believe?  T’ b . W b b , x P 65 b (1) b b  , (2) b FDA. (H FDA ?)

O , , . I , b

b b .

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18

Chapter Nine: Conclusion 

 At this point b :

• isbookisnotall-inclusive.Weexpectyoutoreadandstudy.

• isbookisnotunbiased.Weareinthebusinessofsellingprogesteronecream. W b b. I  b, ; b . I ’ , ’ — .

• Ifyouarenotusingprogesterone,wethinkyoushould.Youoweittoyourselfand  b .

• WhilewewouldlikeyoutotryKokoro®Women’sBalanceCreme,itismore .

M . W b b I A

. I b I . S , b —I . W - . W I . I’ b. W K b . W

  j .

I , : [email protected] http://www.kokorohealth.com.

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Chapter Ten: Reading List 

H b b b :

 Estrogen Alternative, Te, 3rd 

Edition, Natural Hormone Terapy with Botanical Progesterone , R M J G, DC

Hormone Heresy , S S

 John R Lee, MD, Newsletter, Te , L, J R, MD H, V.

Little Herb Encyclopedia, Te Handbook o Natures Remedies or a Healthier Lie, Te , R, J, ND,PD, M Hb. W H B, 1995.

 Natural Hormone Balance or Women, R, U, MD, P B.

 Natural Woman, Natural Menopause , M Lx, ND, H C.

Sae Shopper’s Bible, Te, A Consumer’s Guide to Nontoxic Household, Products, Cosmetics, and Food , S,

D & E, S S., MD, MM P.Scientifc Validation o Herbal Medicine , Te, M, D B., PD, K Pb, 1986.

oday’s Herbal Health, Tird Edition, , L, MH, W B, 1992.

What Your Doctor May Not ell You About Breast Cancer , L, J R, MD, Z, D, PD, H, V, W B.

What Your Doctor May Not ell You About Menopause , L, J R, MD H, V, WB.

What Your Doctor May Not ell You About Premenopause , L, J R, MD H, V, WB.

 W’ B Hb, T H P N R, A, S, Db, C PbG, 1995.