gold nanoparticles in treatment of cancer

8/12/2019 gold nanoparticles in treatment of cancer

1/14


2/14


3/14

MAHARAJA SURAJMAL

INSTITUTE OF PHARMACYC-4 JANAKPURI NEW DELHI

INDIA


4/14


5/14

ABSTRACT

Cancer is a class of disease in which a cell or a group of celldisplays uncontrolled growth, invasion and sometimesmetastasis. According to the WHO cancer is a leading cause ofdeath worldwide: it accounted for 7.9 million deaths in 2007.Recent years have seen advancement in field ofnanotechnology for diagnosis, treatment and prevention of

cancer. One such application of nanotechnology employs useof Gold Nanoparticles.

As per the recent research, the gold nanoparticles employ its usein tumor targeting technology which uses golds inherentbiocompatibility to develop drugs which can be delivereddirectly into cancerous cells. They strongly absorb and scatter

visible and infrared light. This provides the potential fordesigning novel, optically active reagent for simultaneousmolecular imaging and photothermal cancer therapy. Theadditional advantage provided by this technique is that it iscost effective, simple and sensitive diagnostic test for cancer.


6/14

GOLD NANOPATICLES

Gold nanoparticles are basically colloidal gold which is suspension ofsub-micrometer-sized particles of gold in fluid. Due to the uniqueoptical, electronic and molecular recoganition properties of goldnanoparticles, they are subject of substantial research, withapplication in a wide variety of areas including electron microscopy,electronics, nanotechnology, and material sciences. Properties andapplications of colloidal gold nanoparticles depends upon shape.

Gold nanoparticles are generally produced in a liquid (liquid chemicalmethods) by reduction of chloroauric acid. Other methods forproduction are:

1. Turkevich Method

2. Brust Method

3. Perrault Method

4. Martin Method5. Sonolysis


7/14


8/14

GOLD NANOPARTICLES AS A

DIAGNOSTIC TOOL IN CANCER

Researchers claim that the antibody covered

with gold nanoparticle have 600% better

chance of accumulating than healthy cells.

They produce images using surface plasmonresonance imaging technique. This method

allows clear distinction between the

cancerous and non cancerous cells thus,

improvement cancer detection techniques.Reports of this discovery suggest that all

types of cancer can be detected.


9/14


10/14

GOLD NANOPARTICLES IN

TREATMENT OF CANCEROne of the most promising applications in the emerging field of

nanotechnology is cancer treatment. The ability to targetindividual cells provides safer and more effective treatmentthan current approaches like chemotherapy in which healthycells become collateral damage in the effort to knock outcancerous tumors. This potential has again been demonstrated

by scientists at Rice University who have developed a way toblow up individual diseased cells using lasers and goldnanoparticles. As per the research the single-cell targeting isone of the most touted advantages of nanomedicine, and theapproach delivers on that promise with a localized effect insidean individual cell. The idea is to spot and treat unhealthy cellsearly, before a disease progresses to the point of makingpeople extremely ill. This technique involves producingnanobubbles by zapping gold nanoparticles inside cells withlasers.


11/14


12/14

CONCLUSION

Nanotechnology is one of the major tool in the battleagainst cancer. Nanotechnology has helped invarious ways, it has enabled researchers to preparethis treatment using self-assembly and by working at

the molecular level it has combined bioscience withthe unique optical properties of the nanoscale into amore efficient product.

The use of gold nanoparticles is one of the majorbreakthrough in this field. The researchers insist that

this technique will be one of the major technique indiagnosis and treatment of cancer within the nextten year.


13/14


14/14

BIBLIOGRAPHY

Nanoparticles as applying agent for biopolymers, INRA.

Suresh Munuswamy; Destroying cancer cells withexploding gold nanoparticles; gizmag.com

Using gold nanoparticles to detect and treat cancer;

azonano.com Nanoparticles shine light or cancer diagnosis;

nanopedia, the web course of nanotechnology

Verlag &co., weinheim; Cancer treatment with gold

nanoparticles; Small/Wiley Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki Minakawa;

Gold Supported on Hydroxyapatite as a TandemCatalyst; Theime eJournals

gold nanoparticles in treatment of cancer

Documents