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GOAL:KeepourDietandEnvironmentasToxin-Freeaspossible,inordertoPromotetheQualityofLifeandPREVENTDisease

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How to Recognize and Reduce Environmental Effects, and

Inflammation seen in ASD with Safe Therapies

National Autism Association May18, 2019

David Dornfeld, D.O. Family Wellness Center

www.familywellnesscenternj.com drdavedornfeld@gmail.com

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HOLISTIC APPROACHES AIM TOWARDS PREVENTION OF DISEASES - (from Autism - Aging)

•  Many disorders benefit immensely when you incorporate holistic approaches to the care and balance of the human frame, improve one’s Microbiome, and avoid many food allergens, GMOs and Toxins.

•  These include but are not limited to; cardiovascular, pulmonary, neurological, sex drive, gastrointestinal disorders , and thyroid imbalance (i.e.T3). Very needed especially with AUTISM, ADD, ADHD etc.

•  Enhancement of circulation and reduction of nerve inflammation aids greatly to healing the tissues, brain processing, speech improvement, ADHD reduction.

•  Diet, Detoxification, (ie Chelation therapy) and Hyperbaric oxygenation greatly enhance the immune system’s ability to fight off these issues.

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BodyBurden

•  EWGstudied10newborns.(8-9/2004)

•  Thecordbloodcontained(avg.)200chemicalpollutantsincluding;PCBs,dioxins,flameretardants,DDT,pesticides,andmercury.

•  Total287differentchemicals.

•  Toxiceffectsinclude;•  Carcinogenic•  Toxictobrainandnervoussystem

•  Birthdefects•  Abnormaldevelopment(EnvironmentalWorkingGroup14July

2005)

•  NHANESstudied2,540individuals.Theyfoundwidespreadphthalatemetabolitesfromplasticsin75%ofparticipants.

•  CDCstudied400adults,95%hadbisphenolA(BPA)achemicalfromplastics2008-2009AnnualReportPresidentsCancerPanel

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BodyBurden

•  EachyearchemicalcompaniesintheUSmanufactureover6.5trillionpoundsof9,000differentchemicalsandrelease7.1billionpoundsofover650chemicalpollutantsintotheatmosphereandwater.

•  Inaddition,heavymetalsarereleasedfrommanufacturingandcoalcombustion,including48tonsofmercury/year.

•  EWGstudied9healthyindividualswithnoexposures.167chemicals,76carcinogens,94chemicalswithknowntoxicitytobrainandnervoussystemwerefound.

2008-2009AnnualReportPresidentsCancerPanel

"The doctors of the future will give no medicine, but will interest his patients in; the care of the human frame, in diet and the cause, and prevention of disease”

-Thomas Edison

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Our environment must be as clean as possible in order to maintain optimal health

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Environmental Load Air Contamination Outdoor

sulfur compounds nitrous compounds ozone carbon monoxide particulates EMF – fields lead, cadmium, mercury, pesticides, molds algae, etc.

Indoor natural gas, oil, coal pesticides formaldehyde solvents fumes carpets + glues, etc.

Physical EMF radar radon microwave sun spots heat cold postive ions

Food – Man Made pesticide coloring dyes presevatives cooking transportation

Food – Natural botulism – bacteria parasites virus solinin night shades glycosides, etc. mold

Biological pollen molds foods parasites virus bacteria

Water pesticides – herbicides solvents chlorine gasoline + additives

Specific Environmental Load Ie., Streptococcus hemolyticus, Chlorodane, ionizing radiation

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•  Heavy metals leading to toxic build-up and progression •  Pregnancy and childhood exposures --Avoid BPA exposures ( Hormone Disruptor) •  Mercury - vaccines, dental amalgams, fish, HFCS, forest fires

•  Lead - water, air pollution, paint, chocolate, crystal, aryuvedic herbs, pewter •  Aluminium - cooking materials, foil, antacids, Teflon, deodorants, processed cheeses

•  Cadmium - water, smoke(2nd hand) air, paint ,soil, China costume jewelry, Rubber Mats •  Arsenic - water, shellfish, chicken, eggs, apples, organic brown rice, almonds

(www.EWG.org-----------Dirty Dozen & Healthy Living apps) •  Antimony - flame retardant clothing, cloudy plastics, dust, gun powder •  Tin, titanium, nickel, silver - canned goods, some fillers in poor quality vitamins

ENVIRONMENTAL EXPOSURES

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Autism

Socialization Behavior

Communication

Oxidative Stress Inflammation

Detoxification

Glutithione

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Inflammation Detoxification Oxidative Stress

•  Heart Disease •  Alzheimer’s DX •  Allergies •  Arthritis •  MS/Parkinson’s •  Crohns / Colitis •  Chronic Fatigue •  Neuropathy

•  Autism / ASD •  Cancer •  Auto-Immune DX •  Memory Loss •  Diabetes •  Lyme Disease •  Vasculitis •  Traumatic brain Injury

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The Tacks Laws

•  If you are sitting on a tack, it takes a lot of Respiridol (or narcotics) to make it feel good

•  The appropriate treatment for tack sitting is tack removal

•  If you are sitting on two tacks, removing one does NOT produce 50% improvement

•  Chronic illness - is, or becomes multifactorial Sidney Baker MD(DAN! MENTOR)

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LYME - AUTISM CONNECTION

•  The group suffering most is the newborn babies and young children, who rarely are diagnosed correctly and therefore not treated appropriately.

•  Traditional Lab tests are less than accurate in general. •  Young Lyme patients are labeled ADHD, ASD, or seizure disorder. •  Both have Methylation and Sulfation defects. •  Both extremely sensitive to heavy metals, pesticides, food allergies, EMF,

GMO (www.EWG.org). •  Both can improve dramatically - only after you rid the body of toxic metals

and, if needed, administer Hyperbaric Therapy.

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HOW CAN WE GET OUR AUTISTIC CHILDREN BACK ???

Break the gridlock, interrupt the vicious cycles, restore normal function: • Remove dietary and environmental stressors • Bolster Nutrition • Treat for chronic infections, ie. Lyme / Babesia / Bartonella / Tick Borne Dx • Relieve inflammation • Improve broken biochemistry • Improve immune function • Detoxification, including Chelation Therapy • Hyperbaric oxygen therapy • ABA throughout- Speech/occupational/physical therapies

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THINKING OUTSIDE OF “THE BOX” Can Help Reverse many conditions

•  Comprehensive digestive stool analysis - GI.- control normal and abnormal gut flora

•  Hair analysis for heavy metal exposure and vitamin deficiencies

•  Urine Chelation challenges for toxic metals

•  Hyperbaric oxygen to reduce inflammation and increase tissue oxygenation for repair

The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study. Rossignol DA1, Rossignol LW, James SJ, Melnyk S, Mumper E. Abstract Nov. 2007 BMC Pediatic BACKGROUND: Recently, hyperbaric oxygen therapy (HBOT) has increased in popularity as a treatment for autism. Numerous studies document oxidative stress and inflammation in individuals with autism; both of these conditions have demonstrated improvement with HBOT, along with enhancement of neurological function and cognitive performance. In this study, children with autism were treated with HBOT at atmospheric pressures and oxygen concentrations in current use for this condition. Changes in markers of oxidative stress and inflammation were measured. The children were evaluated to determine clinical effects and safety. METHODS: Eighteen children with autism, ages 3-16 years, underwent 40 hyperbaric sessions of 45 minutes duration each at either 1.5 atmospheres (atm) and 100% oxygen, or at 1.3 atm and 24% oxygen. Measurements of C-reactive protein (CRP) and markers of oxidative stress, including plasma oxidized glutathione (GSSG), were assessed by fasting blood draws collected before and after the 40 treatments. Changes in clinical symptoms, as rated by parents, were also assessed. The children were closely monitored for potential adverse effects. RESULTS: At the endpoint of 40 hyperbaric sessions, neither group demonstrated statistically significant changes in mean plasma GSSG levels, indicating intracellular oxidative stress appears unaffected by either regimen. A trend towards improvement in mean CRP was present in both groups; the largest improvements were observed in children with initially higher elevations in CRP. When all 18 children were pooled, a significant improvement in CRP was found (p = 0.021). Pre- and post-parental observations indicated statistically significant improvements in both groups, including motivation, speech, and cognitive awareness (p < 0.05). No major adverse events were observed. CONCLUSION: In this prospective pilot study of children with autism, HBOT at a maximum pressure of 1.5 atm with up to 100% oxygen was safe and well tolerated. HBOT did not appreciably worsen oxidative stress and significantly decreased inflammation as measured by CRP levels. Parental observations support anecdotal accounts of improvement in several domains of autism. However, since this was an open-label study, definitive statements regarding the efficacy of HBOT for the treatment of individuals with autism must await results from double-blind, controlled trials.

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Lymphonodular hyperplasia

Ulcers in GI tract

Commonly seen in IBD and in autistic kids

Hyperbaric Oxygen as Adjunct for Crohn’s Interactable Enteric

Takeshima et al., 1999 Am J Gastroenterol 94(11):3374-5

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PLAN----RemovalofoffendingagentsAl,Sb,As,Cd,Pb,Ni,Sn,Titoreduceexposure

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Avoid Fish High On The Food Chain - MERCURY!

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Dental Amalgam Product Label from Manufacturer

•  To Chelate means “to grab onto and remove”

•  As we know, environmental exposures become toxic more readily in ASD kids and others with altered detoxification pathways, i.e; Autoimmune Disorders, Inflamm. conditions, etc.

•  Children with Autism have difficultly with Methylation pathways, thereby preventing appropriate detoxification, and cellular repair. 35-45% of pop. Have MTHFR deficiency

•  Autism is a heavy metal retention disorder

•  Chelation, either topical rectal, oral or intravenous, (best way) helps bind the toxins to allow for appropriate excretion

What is Chelation Therapy

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•  I have safely incorporated IV Chelation therapy in my practice since 1994, in conjunction with various other holistic approaches. (ie Osteopathy- HBO)

•  Many of my CV patients have been able to avoid or delay coronary and carotid bypass or stents, with great reduction in blood pressure and cholesterol seen

•  Exercise capacity, Neuropathic pain reduction and Erectile dysfunction have been greatly improved. HTN / DM too. Insulin needs reduced

•  Heavy metal and mercury burdens diminish and thereby the patients immune system combats chronic fatigue and illnesses with greater ease

•  Many of my Parents report GREAT advances in their kids behaviour, speech, and socialization skills after each round of Chelation completed

Chelation Therapy Uses

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•  Various forms of chelating agents are available

•  DMSA oral or transdermal (supp.)

•  EDTA- Calcium or disodium IV (Ca-supp.)

•  DMPS IV,(with IV vitamins to follow), PO, supp.

•  Vitamin C IV, is also a Chelator and Immune Booster

•  Pre & Post Urine challenges with chelating agents help monitor the response to therapy. Measure serially to determine persistence of the heavy metal burden, every 8-10 treatments

Chelation Therapy

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•  When safely administered, has been proven extremely beneficial in 73-75% of the time, when ASD parents have been questioned. (DAN!-ARI poll 2007-2012)

•  It has the best rating from parents for all forms of therapy offered in the DAN! Protocol

•  When combined with Hyper baric Therapy - amazing results seen in many kids and adults with inflammatory disorders

Chelation Therapy

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HEAVY METAL URINE CHALLENGE Lead decreased from 22-7.8

All levels of heavy metals reduced Excellent response clinically from Chelation

© IH

A 2012

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•  Use natural, biodegradable and perfume free detergents and cleaning agents, do not dry clean clothes. Remove Plastic bag from clothes ASAP allow to off-gas.

•  Avoid chlorine: use water filters, limit pool and hot tubs •  Wear 100% cotton clothes, avoid flame retardant materials (antimony) •  Use fluoride-free toothpaste, avoid Fluoride treatments •  Avoid playing on pressure treated wood (arsenic) •  Eliminate exposure to Mercury and thimerosal products •  Use an air purifier, especially in the bedroom •  Avoid prolonged exposure to batteries (light up shoes) •  No plastic furniture (polyvinyl chloride) •  Use aluminum-free baking powder, deodorant. Do not cook in aluminum foil or drink

from aluminum cans. No TEFLON, no food touching aluminum foil or take out tins! •  Avoid use of herbicides or pesticides, on lawns, garden, or home •  Use natural shampoos, soaps, and make-up (lipstick-Pb, foundation-Bi) •  Avoid # 3, 6, 7 on plastic bottles or containers. (#7 is BPA and Antimony)

Reduce the Toxic Burden

Time for Hyperbaric Therapy

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Before and After Hyperbaric 02

Brain makes up 2% of body weight but uses 20% of body O2 Small increases on O2 pressures w HBOT, markedly improve Oxygen delivery to the peripheral tissues and Mitochondria.

According to Henry’s Law of Physics, an increase in atmospheric pressure allows for more gas to be dissolved into any given liquid. Henry’s law is displayed in every can/bottle of soda. When soda is canned at the factory, it is put under pressure so that more carbon dioxide can be dissolved into the soda, causing it to be carbonated. • Hyperbarics will allow for oxygen gas bubbles to be concentrated into the plasma, synovial fluid, and across the blood brain barrier easier, delivering O2 to the deep tissues of the body easier, nourishing them and repairing them.

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•  This same principle applies to oxygen and plasma, the liquid part of blood

•  When the body is under pressure, plasma, cerebral fluid, and synovial fluid will dissolve more oxygen than they would if they were not under pressure

•  Not only does this increase the amount of available oxygen to the tissues, it allows oxygen to reach areas of the body that would normally be difficult to reach

How does Mild Hyperbaric Therapy work?

Conclusions Children with autism who received hyperbaric treatment at 1.3 atm and 24% oxygen for 40 hourly sessions had significant improvements in overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to children who received slightly pressurized room air. PMID: 19284641 BMC Pediatr. 2009 Mar 13;9(1):21. Rossignol DA, Rossignol , Smith S, Schneider C, Logerquist S, Usman A, Neubrander J, Madren EM, Hintz G, Grushkin B, Mumper EA. LW

Hyperbaric treatment for children with autism: a multicenter randomized, double blind, controlled trial

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•  Decreased cerebral perfusion

•  Increased oxidative stress

•  Increased inflammation

•  Increased Inflammatory cytokines -TNF A, NFK B

•  Neurodegenerative disorder

•  Increased cerebral perfusion- Golden et al 2002 Int J Neuoroscience 112(2)119-31

•  Decreases oxidative stress- M Yassar et al. Physiol. Res.52:111-6 2003

•  Decreases inflammation -Harrison et al 1994 Adv.Exp.Med. Biol.345:789-96

•  Decreases; TNF A, NFK B - Rossignol et al,.2007 BMC Pediatrics 7:36

•  Increases stem cell release for neurological tissue repair- Thom et.al.,2006 Am J Physiol Heart Circ Physiol 290:1378-86

HBOT EFFECTS IN AUTISM

Autism HBOT

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SPECT scans in a 4 year old Autistic child after 10 Hyperbaric therapy at 1.3 atm and 24% oxygen

BEFORE AFTER 10 mHBO tx

Heuseretal.,BestPublications2002109-15

•  When utilizing Hyperbaric Oxygen Therapy, oxygen is forced into the tissues, organs, brain and fluids throughout the body through the pressurization of the hyperbaric chamber

•  Oxygen floods areas that are oxygen starved to stimulate cell growth

and regeneration

•  Hyperbaric oxygen increases neural brain function due to oxygen saturation

O2 Under Pressure – Benefits

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Bridget, 58 yr with 8 year hx spinal cord C5-T2 tumor removed. Needs 1-2 quad canes to walk minimal • Severe pain in spine/entire back/arms/unable to shower or change clothes without excruciating pain • Multiple surgeries/narcotics/no significant help • HBOT sessions as last option for her • After 4th session, she shouted “this is the 1st time in 8 years that i have not used a cane” • Walked without cane after that point! Continued for 20+treatments more • Showers and changes clothes without pain!!!! • Able to walk in church to receive offering again!

Spinal cord trauma patient walks again (unaided) due to Hyperbarics

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•  Oxygen displaces toxins and other impurities to assist in detoxification of your system

•  Hyperbaric oxygen acts as an anti-viral and anti-bacterial, as bacteria and viruses typically cannot tolerate oxygen

•  Oxygen reduces tumor growth in cancer patients

More Hyperbaric Oxygen Benefits

Has been very beneficial in helping patients for “off- label indications” including: •  Autistic Spectrum Disorders; ADD / ADHD / PDD /Asp •  Parkinson's Disease •  Multiple Sclerosis •  Auto Immune disorders/ Arthritis / Scleroderma •  Crohn's disease / Inflammatory Bowel Disorders •  Chronic infections - i.e.. Yeast / Bacterial / Viral •  Lyme disease / Immune dysfunction •  Stroke / Memory loss / Traumatic Brain Injury / Migraine Headaches, CTE, •  Improve fracture healing rates - ~40% •  Myasthenia Gravis / Soft tissue injury resolution •  Cancer, cerebral palsy, CFS, Fibromyalgia, etc……. •  Duchenne’s Muscular Dystrophy- Improved cardio and pulmonary measurements-first

therapy to show improvement in 187 years •  Near Drowning case Eden Carlson age 2. Now Neurotypical after 15 minutes submerged!

Mild Hyperbaric Oxygen Therapy

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Another LYME CASE Markedly helped with adding mild HBOTI just wanted to shoot you this quick note to thank you for everything you and your staff have done for me! After being misdiagnosed by 4 doctors, you were the one LLMD that properly diagnosed me with Lyme. 5 months later, I'm feeling so much better! I also saw a huge improvement after starting the Hyperbaric Oxygen Therapy and have continued to improve daily. Initially I didn't see a difference for a little over a week, but I did double HBOT sessions every day that I could for at least 1 hour and 15 minutes, and I think that helped me progress quicker. It has been a long battle, but I feel that it's almost over. I was barely being able to walk up the stairs, not able to focus enough to determine where the doorknob was to leave the room, and being frustrated and angry all the time. Every muscle in my body was achy and felt overworked. I had no energy and no motivation to do anything. Today, I can run around and play with my kids, my focus is back and I can run my business and I'm not miserable any longer. My strength is almost 100% back! I haven't felt this good in over 7 months! Both my family and I thank you so much for helping me, and actually listening to my issues along the way and providing me with solutions. Thanks for recommending the HBOT and I will continue to recommend you and the hyperbaric oxygen therapy to anyone in need. Thank you so much!-Chris M., January 9, 2012

•  Improves circulation- wounds diminish •  Diabetic and peripheral neuropathy - (Leg pains improve) amputations

reduced •  Stroke, MS. and Parkinson’s disease patients, have greater strength,

balance, coordination etc. •  Spinal cord trauma and sports related injuries greatly improved. Mogul

skiers happier! •  Memory enhancement. Add/ ASD much improved •  Chronic fatigue and Viral illness greatly reduced •  Lymes / joint pains / digestive problems helped

Hyperbaric Therapy Advantages

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•  Sequential treatments of mHBOT, 4-5 times per week for 40 treatments at least, is what is recommended

•  Many; Autistic, ADD, ADHD, Aspergers, and PDD children will see great benefit and continue for further treatments as their communication skills / behavior / focus ability / and personalities improve steadily

•  Fractures, MS, Peripheral Vascular and Neuropathies, Interstitial cystitis, Crohn’s, CFS, Wounds, Parkinson’s, post op memory loss, TBI, etc. will respond with less treatments

Mild Hyperbaric Oxygen Therapy

John-43 y.o. male twisting fall on stairway

• Ortho. Eval- Cast x 5-6 weeks expected w PT/OT to follow

• John --borrowed my chamber for his house

• mHBOT 2-3x day-w 4hr pause between sessions

• 2 week x-ray showed FRACTURE resolution!

• 1 week more “for safety” –Ortho stunned!

• Cast removed in 3 weeks! No PT /OT needed!

• Orthopedist sends referrals now for mHBOT

Complex Spiral fracture of 4th Metacarpal

© IHA 2012

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MeniscussurgeryrecoveryexpeditedgreatlywithmHBOT

hb

Dave@55torePost.HornMed.Meniscusduetoskiing-Jan.11,2013Surgery4/11/13Friday-Immediatepostop.mHBOTsessionsinseries26hrsintermittent-oversixdayperiod2-3x/DayWorked10-11hourdaysMon–Weds.InMedicalofficew/OMTOrthoeval-Thurs.“IHAVENEVERSEENANYONERECOVERTHISFAST”MinimalEffusion,GreatROM.NoBracingorAceneededNoPTneeded!Recommendednowaterskiingx3moreweeks!

•  Many professional players incorporate Hyperbaric therapies to enhance their performance and tissue repair

•  Baseball greats; Ken Griffey JR, John Smoltz, Ryan Klesko, Ryan Howard, Tori Hunter, etc.

•  S. Stallone talks about his films and says " I had to spend a couple of nights in a hyperbaric chamber to get oxygen back in me. It helps repair injuries quicker..."

Evander Holifield used Hyperbaric Therapy before his last winning fight against Hasim Rahman Brett Dustin Keller NY Ken Lucas SEA Reggie Bush NO Kellen Winslow TB Troy Polamalu PIT Donavan McNabb MN Zach Thomas DAL Dante Stallworth WA Tony Parrish SFO Ryan Fowler TN Heinz Ward PIT Lebron James Clev. Brett Farve GB

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•  Terrell Owens returns to Super Bowl 39 --6.5 weeks after suffering broken ankle

•  Hines Ward has Vitaris 320 in home and hotel room for playoffs and Super Bowl 43-centerfold sports illustrated

•  Dwight Freeney Colts defensive Lineman owns Vitaris

•  Santonio Holmes owns 1 “Fountain of Youth”

•  Hockey team “Canucks” use mHBOT for healing

•  Santana Moss owns 1- “speeds recovery from injuries”

•  Tiger Woods owns 1“heals faster from multiple injuries”

Some Famous sports stars with HBOT Improvements

Multiple one hour sessions at 4.2 psi with a four hour break between sessions

YOU CAN SAFELY USE, AND CONVENIENTLY RENT A HYPERBARIC CHAMBER FOR YOUR HOME

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Whether You’re above the trees...

Or taking a plunge below...

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Fix the terrain!!

Don’t let the environment bite you in the butt!

Thank you for your attentive interest

When you get a chance, please view “Mitchell’s”, “Calvin’s” and “Ron’s” video testimonials from my website/and written ones from Joshua and Mike, et. al.

David Dornfeld, DO Family Wellness Center 225 State Highway 35 Red Bank, NJ 07701

(732) 671 3730 www.familywellnesscenternj.com

Drdavedornfeld@gmail.com

I will try to answer any questions now