gnipst bulletin 29.3
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4th
October , 2013 Volume No.: 29 Issue No.: 03
Contents Message from GNIPS
Letter to the Editor News Update
Health awareness
Disease Outbreak Ne
Forth Coming Events
Drugs Update
Campus News
Students Section
Editors Note
Archive
Vision
TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD O
PHARMACEUTICAL AND BIOLOGICAL SCIENCE
EDITOR: Soumya BhattacharyaGURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND
TECHNOLOGY
GNIPST Photo Gallery
For your comments/contributionORFor Back-Issues,
mailto:[email protected]
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MESSAGE FROM GNIPSTGNIPST BULLETIN is the official publication of Guru Nanak
Institute of Pharmaceutical Science & Technology. All the members
of GNIPST are proud to publish the 29th Volume of GNIPSTBULLETIN. Over the last two years this bulletin updating readers
with different scientific, cultural or sports activities of this
prestigious institute and promoting knowledge of recent development
in Pharmaceutical and Biological Sciences. Students section is
informing readers about some curious facts of drug discovery, science,
sports and other relevant fields. We look forward to seeing your
submission and welcome comments and ideas you may have.
LETTER TO THE EDITOR.
NEWS UPDATE
Nano-Dissectiontechninque for kidney disease
(4th
October, 2013)
A new method developed by researchers at Princeton University and
the University of Michigan called "in silico nano-dissection" uses
computers rather than scalpels to separate and identify genes from
specific cell types, enabling the systematic study of genes involved in
diseases. The team used the new method to successfully identify genes
expressed in cells known as podocytes the "work-horses" of the
kidney that malfunction in kidney disease.Read more
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Norovirus vaccine reduces symptoms of illness by
more than half (4thOctober, 2013)
An investigational vaccine appears generally well tolerated andeffective against the most common strain of norovirus, reducing themain symptoms of the gastrointestinal (GI) infection, vomiting and/or
diarrhea, by 52 percent, suggests a research.Read more
High-Dose Statins Reduce Gum Inflammation in
Heart Disease Patients(3 rd October, 2013)
Statins, commonly prescribed medications for lowering cholesterol,also reduced inflammation associated with gum disease in a new
study published in the Journal of the American College of Cardiology. The
study suggests that steps taken to reduce gum disease may also
reduce inflammation in the arteries and vice versa.Read more
Anti-Cancer drug benefits women with breast
cancer who have failed previous treatments (27thSeptember, 2013)
First results from a phase III clinical trial of the combination drug, T-DM1, show that it significantly improves the length of time before thedisease worsens in women with advanced HER2 positive breastcancer whose cancer has recurred or progressed despite previous
treatments, including trastuzumab and lapatinib.Read more
Prostacyclin Analogs and PDE 5 Inhibitors
synergistically stimulate ATP release from human
RBCs (20th September, 2013)
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Researchers at Saint Louis University School of Medicine have
discovered a novel interaction between prostacyclin (PGI2) analogs
and phosphodiesterase 5 (PDE5) inhibitors, two groups of drugs used
in the treatment of pulmonary arterial hypertension (PAH). They
found that, in combination, these drugs stimulate enhanced release of
a potent vasodilator adenosine triphosphate (ATP) from human red
blood cells (RBCs).Read more
Proteins identified that may help brain tumors
spread (20th September, 2013)
Scientists at the University of Alabama at Birmingham have identifieda molecular pathway that seems to contribute to the ability of
malignant glioma cells in a brain tumor to spread and invade
previously healthy brain tissue.Read more
Digoxin use associated with higher risk of death
for heart failure patients (20th September,2013)
Digoxin, a drug commonly used to treat heart conditions, wasassociated with a 72 percent higher rate of death among adults withnewly diagnosed systolic heart failure, according to a KaiserPermanente study that appears in the current online issue ofCirculation. These findings suggest that the use of digoxin should bereevaluated for the treatment of systolic heart failure in contemporary
clinical practice.Read more
Imaging technique detects pediatric liver disease
without needle biopsy (20thSeptember, 2013)
A new, non-invasive imaging technique, magnetic resonanceelastography (MRE), can now help physicians accurately detect
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fibrosis (scarring) in children with chronic liver disease, a growing
problem due in part to increasing obesity rates.Read more
Blood 'Marker' may predict diabetes risk in older
women(20thSeptember, 2013)
Older women's age and lifestyle habits may be associated with levels
of a protein possibly linked with type 2 diabetes risk, researchers say.
There is growing evidence that relatively low levels of the protein
called sex hormone binding globulin (SHBG) can indicate an
increased risk of type 2 diabetes years in advance.Read more
FDA finalizes new system to identify medical
devices(20thSeptember, 2013)
U.S. Food and Drug Administration announced a final rule for the
unique device identification system (UDI) that, once implemented,
will provide a consistent way to identify medical devices. The UDI
system has the potential to improve the quality of information in
medical device adverse events reports, which will help the FDA
identify product problems more quickly, better target recalls, and
improve patient safety. The FDA has worked closely with industry,
the clinical community and patient and consumer groups in the
development of this rule.Read more
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HEALTH AWARENESS
Rabies-a neglected diseaseOn 28th September World Rabies Day was observed globally.
Although prevalence and death due to this disease is really significant,Rabies is still a less concerned disease. Rabies is a zoonotic disease (adisease that is transmitted to humans from animals) that is caused bya virus. The disease affects domestic and wild animals, and is spreadto people through close contact with infectious material, usuallysaliva, via bites or scratches.
Rabies is present on all continents with the exception ofAntartica, but more than 95% of human deaths occur in Asia andAfrica. Once symptoms of the disease develop, rabies is nearly alwaysfatal.
Rabies is a neglected disease of poor and vulnerable populationswhose deaths are rarely reported. It occurs mainly in remote ruralcommunities where measures to prevent dog to human transmissionhave not been implemented. Under-reporting of rabies also preventsmobilization of resources from the international community for theelimination of human dog-mediated rabies.
Symptoms
The incubation period for rabies is typically 13 months, but may varyfrom 1 year. The initial symptoms of rabies are fever andoften pain or an unusual or unexplained tingling, pricking or burningsensation (paraesthesia) at the wound site.
As the virus spreads through the central nervous system, progressive,fatal inflammation of the brain and spinal cord develops.
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Two forms of the disease can follow. People with furious rabiesexhibit signs of hyperactivity, excited behaviour, hydrophobia andsometimes aerophobia. After a few days, death occurs by cardio-respiratory arrest.
Paralytic rabies accounts for about 30% of the total number of humancases. This form of rabies runs a less dramatic and usually longercourse than the furious form. The muscles gradually becomeparalyzed, starting at the site of the bite or scratch. A coma slowlydevelops, and eventually death occurs. The paralytic form of rabies isoften misdiagnosed, contributing to the under-reporting of thedisease.
Diagnosis
No tests are available to diagnose rabies infection in humans beforethe onset of clinical disease, and unless the rabies-specific signs ofhydrophobia or aerophobia are present, the clinical diagnosis may bedifficult. Human rabies can be confirmed intra-vitam and postmortem by various diagnostic techniques aimed at detecting wholevirus, viral antigens or nucleic acids in infected tissues (brain, skin,
urine or saliva).Transmission
People are usually infected following a deep bite or scratch by aninfected animal. Dogs are the main host and transmitter of rabies.They are the source of infection in all of the estimated 50 000 humanrabies deaths annually in Asia and Africa.
Bats are the source of most human rabies deaths in the Americas. Batrabies has also recently emerged as a public health threat in Australiaand western Europe. Human deaths following exposure to foxes,raccoons, skunks, jackals, mongooses and other wild carnivore hostspecies are very rare.
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Transmission can also occur when infectious material usually saliva comes into direct contact with human mucosa or fresh skinwounds. Human-to-human transmission by bite is theoreticallypossible but has never been confirmed.
Rarely, rabies may be contracted by inhalation of virus-containingaerosol or via transplantation of an infected organ. Ingestion of rawmeat or other tissues from animals infected with rabies is not a sourceof human infection.
Post-exposure prophylaxis (PEP)
Post-exposure prophylaxis (PEP) consists of:
local treatment of the wound, initiated as soon as possible afterexposure;
a course of potent and effective rabies vaccine that meets WHOrecommendations; and
the administration of rabies immunoglobulin, if indicated.
Effective treatment soon after exposure to rabies can prevent theonset of symptoms and death.
Local treatment of the wound
Removing the rabies virus at the site of the infection by chemical orphysical means is an effective means of protection. Therefore, promptlocal treatment of all bite wounds and scratches that may becontaminated with rabies virus is important. Recommended first-aidprocedures include immediate and thorough flushing and washing ofthe wound for a minimum of 15 minutes with soap and water,
detergent, povidone iodine or other substances that kill the rabiesvirus.
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Post Exposure Prophylaxis
Categories of contact withsuspect rabid animal
Post-exposure prophylaxismeasures
Category I touching orfeeding animals, licks on intactskin
None
Category II nibbling ofuncovered skin, minorscratches or abrasions withoutbleeding
Immediate vaccination andlocal treatment of the wound
Category III single or
multiple transdermal bites orscratches, licks on broken skin;contamination of mucousmembrane with saliva fromlicks, contacts with bats.
Immediate vaccination and
administration of rabiesimmunoglobulin; localtreatment of the wound
All category II and III exposures assessed as carrying a risk ofdeveloping rabies require PEP. This risk is increased if:
the biting mammal is a known rabies reservoir or vector species; the animal looks sick or has an abnormal behaviour; a wound or mucous membrane was contaminated by the animals
saliva; the bite was unprovoked; and the animal has not been vaccinated.
In developing countries, the vaccination status of the suspectedanimal alone should not be considered when deciding whether to
initiate prophylaxis or not.
Prevention
Eliminating rabies in dogs
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Rabies is a vaccine-preventable disease. The most cost-effectivestrategy for preventing rabies in people is by eliminating rabies indogs through vaccination. Vaccination of animals (mostly dogs) hasreduced the number of human (and animal) rabies cases in several
countries, particularly in Latin America. However, recent increases inhuman rabies deaths in parts of Africa, Asia and Latin Americasuggest that rabies is re-emerging as a serious public health issue.
Preventing human rabies through control of domestic dog rabies is arealistic goal for large parts of Africa and Asia, and is justifiedfinancially by the future savings of discontinuing post-exposureprophylaxis for people.
Preventive immunization in people
Safe, effective vaccines can be used for pre-exposure immunization.This is recommended for travellers spending a lot of time outdoors,especially in rural areas, involved in activities such as bicycling,camping, or hiking as well as for long-term travellers and expatriatesliving in areas with a significant risk of exposure. Pre-exposureimmunization is also recommended for people in certain high-risk
occupations such as laboratory workers dealing with live rabies virusand other rabies-related viruses (lyssaviruses), and people involved inany activities that might bring them professionally or otherwise intodirect contact with bats, carnivores, and other mammals in rabies-affected areas.
(Based on WHO factsheet)
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DISEASE OUTBREAK NEWS
Middle East respiratory syndrome coronavirus
(MERS-CoV) (20th September,2013)Two patients earlier reported as laboratory-confirmed with Middle
East respiratory syndrome coronavirus (MERS-CoV) infection in
Italy in the Disease Outbreak News on 2 June 2013 are being
reclassified as probable cases.Read more
FORTHCOMING EVENTS
GNIPST will organize pre puja celebration programme, Saaranyaon 7th October, 2013 in college Auditorium.
GNIPST Intra college football tournament will be held on 7th -9th
October,2013The 2nd Pharm. Tech IAPST International Conference on "New insights into
diseases and recent therapeutic approaches" from 17th to 19th January 2014 in
Kolkata, India.Read more
DRUGS UPDATES
FDA approval expands access to artificial heart
valve for inoperable patients(23th September, 2013)
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The U.S. Food and Drug Administration approved revised labeling for
the Sapien Transcatheter Heart Valve (THV), making the device
available to an expanded group of patients who have inoperable aortic
valve stenosis, a disease of the heart valves that causes narrowing of
the aortic valve, restricting blood flow from the heart.Read more
FDA approves Abraxane for late-stage pancreatic
cancer(6th September, 2013)
The U.S. Food and Drug Administration today expanded theapproved uses of Abraxane (paclitaxel protein-bound particles forinjectable suspension, albumin-bound) to treat patients with late-
stage (metastatic) pancreatic cancer.Read more
CAMPUS NEWS
GNIPST organized a garment distribution programme
on 28th September, 2013 at Dakshineswar Kali Temple and
Adyapith, Kolkata. On this remarkable event about hundredpeople have received garments. More than hundred
students and most of the faculties participated on that day
with lot of enthusiasm.
GNIPST celebrated World Heart Day(29th September) andPharmacists Day(25th September)on 25thand26th September,
2013 in GNIPST Auditorium. A seminar on Violence againstwoman and female foeticide was held on GNIPST Auditorium on
25th September organized by JABALA Action Research
Organization. On 26th September an intra-college Oral and Poster
presentation competition related to World Pharmacists day and
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Heart day was held in GNIPST. Ms. Purbali Chakraborty of
B.Pharm 4th year won the first prize in Oral Presentation. The
winner of Poster presentation was the group ofMs. Utsa Sen, Mr.
Koushik Saha and Niladri Banerjee (B.Pharm 4
th
year). A goodnumber of students have participated in both the competition
with their valuable views.
Teachers day was celebrated on 5th September, 2013 by
the students of GNIPST in GNIPST Auditorium.
Azalea (exotic flower ) , the fresher welcome programme fornewcomers of GNIPST in the session 2013-14 was held on 8th
August in GNIPST Auditorium.
One day seminar cum teachers development programme forschool teachers on the theme ofRecent Trends of Life Sciences
in Higher Education organized by GNIPST held on 29th June,
2013 at GNIPST auditorium. The programme was inaugurated by
Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy
Director of JIS Group and Dr. Abhijit Sengupta, Director cum
Principal of GNIPST with lamp lighting. The programme started
with an opening song performed by the B.Pharm students of this
institute. The seminar consists of a series of lectures, video
presentations and poster session. On the pre lunch session 4
lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata
Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty
respectively. On their presentation the speakers enlighten therecent development of Pharmacy, Genetics and Microbiology and
their correlation with Life Sciences. On the post lunch session, Ms.
Saini Setua and Ms. Sanchari Bhattacharjee explained the recent
development and career opportunities in Biotechnology and
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Hospital Management. The programme was concluded with
valedictory session and certificate distribution.
About 50 Higher secondary school teachers from different
schools of Kolkata and North& South 24 Parganas district of
West Bengal participated in this programme. A good interactive
session between participants and speakers was observed in the
seminar. The seminar was a great success with the effort of
faculties, staffs and students of our Institute. It was a unique
discussion platform for school teachers and professional of the
emerging and newer branches of Life Science.
STUDENTS SECTION
WHO CAN ANSWER FIRST????
Name of which disease was derived from Latin
word for madness?
Which famous scientists death anniversary isobserved as World Rabies Day?
Answer of Previous Issues Questions:A) Charles Dotter B)ECG
Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for StudentsSection& answers of this Section [email protected]
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EDITORS NOTE
I am proud to publish the 3rd
issue of 29th
Volume of GNIPST
BULLETIN. GNIPST BULLETIN now connected globally through
facebook account GNIPST bulletinI want to convey my thanks to all the GNIPST members and the
readers for their valuable comments, encouragement and supports.
I am thankful to Dr. Abhijit Sengupta, Director of GNIPST for his
valuable advice and encouragement. Special thanks to Dr. Prerona
Saha andMr. Debabrata Ghosh Dastidar for their kind co-operation
and technical supports.
An important part of the improvement of the bulletin is thecontribution of the readers. You are invited to send in your write ups,
notes, critiques or any kind of contribution for the forthcoming special
and regular issue.
GNIPST BULLETIN wishes all the readers a happy Autumn
Festival.
ARCHIVE
The following B.Pharm. final year students have qualified,
GPAT-2013. We congratulate them all.
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The general body meeting of APTI, Bengal Branch has been conducted
at GNIPST on 15th June, 2012. The program started with a nice
presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products,
JU on the skill to write a good manuscript for publication in impact
journals. It was followed by nearly two hour long discussion among
more than thirty participants on different aspects of pharmacy
education. Five nonmember participants applied for membership on
that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years post graduate course (M.Pharm) in
P H A R M A C O L O G Y . The approved number of seat is 18.The number of seats in B.Pharm. has been increased from 60 to 120.
AICTE has sanctioned a release of grant under Research Promotion
Scheme (RPS) during the financial year 2012-13to GNIPST as per the
details below:
a. Beneficiary Institution: Guru Nanak Institution of PharmaceuticalScience & Technology.
b.Principal Investigator: Dr. LopamudraDutta.
c. Grant-in-aid sanctioned:Rs. 16,25000/- only
d.Approved duration: 3 years
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e. Title of the project: Screening and identification of potential
medicinal plant ofPurulia & Bankura districts of West Bengal with
respect to diseases such as diabetes, rheumatism, Jaundice,
hypertension and developing biotechnological tools for enhancingbioactive molecules in these plants.