gil 2012 stem cell cocktail

Providing the Cure

In Strategic Partnership with :

Frost & Sul l ivan Inst i tute

GIL 2012: RUSSIA The Global Community of Growth, Innovation and Leadership

A Novel Therapy for the Treatment of

Leukemia and Cancer

“The Stem-Cell Cocktail”

Steve Shor Founder & Executive Director NCLF Cancer Research Center

Brian Denker Vice President & Global Head

Growth, Innovation and Leadership Frost & Sullivan

w w w . l e u k e m i a f o u n d a t i o n . o r g

Providing the Cure



Why is cancer so challenging?

Cancer is dynamic & adaptive.

Cancer is strong & resilient.

Cancer is complex & innovative.

Cancer is opportunistic.


Providing the Cure



The Typical Question:

In what ways does the typical cancer cell differ from the normal cell?

The NCLF Question • What are the mechanisms that

foster growth in cancer cells?

• Are there multiple pathways of growth?

• How does the cancer cell harness the energy of the human body to facilitate growth?

The BIG Question…


Providing the Cure



NCLF Bio Medical Research Center


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Frost & Sul l ivan Inst i tute Adult Stem Cells

Cancer/Leukemia cells The Stem Cell & Cancer

Interaction Paradigm Molecular pathways analysis

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Unleashing the Potential of Stem Cells in Cancer Therapy

Addressing the complexity of cancer development and diversity

Cancer -Stem cell Interaction Paradigm

Identify target molecular pathways regulating cancer cell growth & development

Design of interventions using multiple target molecular pathways


Providing the Cure



Combination Therapy Approach

Pathway #2

Pathway #3

Pathway #1


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• Multiple Pathways • Multiple Targets • Multiple Compounds

Compound # 3

Compound #2

Stem Cells


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Growth Inhibition of Leukemia Cells using “Stem Cell Cocktail” Therapy

(in vitro results)

Growth inhibition of Leukemia cells after 72h of culture

1.31.351.4

1.451.5

1.551.6

1.651.7

1.751.8

Control

Compound A

Compound B

Compound C

"Cock

tail"

(A+B

+C)

Viab

le c

ell n

umbe

r (O

D)


Providing the Cure



“Stem Cell Cocktail” A Therapy to Treat Cancer

(in vivo results) Survival of Leukemia harboring animals treated with Adult stem cells

0 10 20 30 40 50 60 700.00.10.20.30.40.50.60.70.80.91.01.1

controlSC treated

P<0.0001

Days

Frac

tion

surv

ival


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National Children’s Leukemia Foundation

Use of Mesenchymal Stem Cells for the Treatment of Leukemia

United States Provisional Patent Application #61/564,317 November 29, 2011

A Cure IS POSSIBLE in our Generation


Providing the Cure



Trajectory of Progress

*Testing Additional Combinations *Creating additional “Cocktails” *Expanding the paradigm to other cancer types.

Pre-Clinical Trials

Clinical Trials


Providing the Cure



• Explore these advancements in cancer research further, be apart of it.

• Determine how you too can help NCLF to contribute to these advancements.

• Make a Difference – Find your visionary innovation, support each other, members of the GIL Community and it’s global partners contributing and changing the world.

The Cure IS Within Our Reach


GIL 2012: Beyond the Journey to Visionary Innovation Next Steps

Develop Your Visionary and Innovative Skills Growth Partnership Service

Leverage the GTL in your monthly GIL Community Newsletter (GCN)

Schedule a one-on-one Growth Strategic Dialogue

Envision Your Future and Succeed with Growth Workshops

Get Your Entire Team Innovating to Zero with an on-site Mega Trends Workshop

Share, Engage and Inspire 24x365 via the online GIL Community

Presenter

Presentation Notes

Ask for a Growth Partnership proposal: It’s for discussion purposes only and will give you a clearer idea of how we work with our partners to accelerate growth. Our MindXchange events are career-focused. Please check out the programs which line up with your career or industry. As a Growth Partner you are free to attend any event Frost & Sullivan holds worldwide. All our events are focused on growth strategies by industry and career. Everybody on the Growth Team must attend the annual GIL event…. This year in the Bay Area? We will be having Industry think tanks, career round tables, and CEO panel discussions. Its totally unique and very value packed. See the video clip…. Register your team to the CSG. Start to build some teamwork and consensus on how your company can get on the growth track, be best in class in terms of growth innovation and leadership… Register for the industry and career based newsletters which support you. These keep you exposed to a fantastic flow of ideas, information and best practices which will change your life. If your company is truly struggling with the recession, schedule some time to talk to us about your strategic options. We can help coach you through the recession and prepare you for accelerated growth. If raising capital is a concern our Financial Services team can help you with your financing strategy. If you like what we have covered but, don’t know what to do next. Lets set up some time for a Growth Strategy Dialog,,,, These sessions provide a clearer diagnostic of your situation and can give some fast insights into the next steps. We can do this in person or over the phone. There is no charge for the first session.

gil 2012 stem cell cocktail

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