GF 5 - inser t for ProCell LabSystem

Plug flow in the laboratory unitWith the GF 5 several process steps are

possible. The solid raw material is con-

tinuously supplied. It moves in a circle

through the processing chamber, which

is divided into four sections. The first

three can be equipped with nozzles for

spray granulation, agglomeration, encap-

sulation and coating. In the final chamber

the product is dried before leaving the unit.

Continuous dryingThe GF 5 can work as a continuous dryer.

Wet raw material dries while moving

through the processing chamber from inlet

to discharge. Therefore the GF 5 is the ideal

equipment downstream of continuous wet

granulators.

Small production equipmentUp to 15 kg/h wet granules can be dried in

the GF 5. Within one day up to 400 kg dry

granules can be produced. Hence the

GF 5 can be used as small production unit.

Flexible ProCell LabSystemThe GF 5 is once more enhancing the

flexibility of the ProCell LabSystem. Batch

sizes between 1.4 and 38 liter, continuous

capacities between 0.2 and 15 kg/h and

multiple process possibilities making it the

most versatile equipment on the market.

Glatt Ingenieurtechnik GmbH • Nordstraße 12 • 99427 Weimar/Germany • Phone: +49 3643 47 0 • eMail: info@glatt-weimar.de

NEW!

ENCAPSULATION

DRYING

SPRAY GRANULATION

COATING

AGGLOMERATION

ProCell

GF

AGT

Rotor

We set the standard

P r o C e l l L a b S y s t e m

SPOUTED BED

continuous

FLUID BED

batch

POWDER LAYERING

SPRAY GRANULATION

AGGLOMERATION

ENCAPSULATION

COATING

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The ProCell LabSystem is designed

for testing of spouted bed and

fluid bed processes in the single

kg-scale:

• spray granulation

granules and pellets from liquids

• agglomeration

granules from powder

• coating

of particles with liquids

• encapsulation

of liquids

• powder layering

coating of particles with powder

Spouted bedUsing the unique and patented spou-

ted bed technology the particles

within the ProCell are fluidized with-

out a bottom screen and directed to

the spraying nozzle. By this means

it is possible to work with very low

product temperatures and short resi-

dence times. As a result temperature

sensitive materials are treated very

gently. Proteins, enzymes and micro-

organisms were dried in the ProCell

with very little loss of activity.

The process air velocity declines

rapidly in the process chamber of the

ProCell and allows the production of

very fine particles. On the other hand

large particles, like catalyst carrier

rings can be fluidized without using

prohibitive quantities of process air.

The high air velocities in the slot en-

sure a very robust process, especially

when processing sticky materials.

Lumps that may have formed are still

moved, break down again and are

carried out of the process chamber.

Fluid bedUsing different process chambers

– AGT and GF – allows the evaluation

of fluid bed processes.

Inlet air chamber and process cham-

ber are separated by a bottom screen

and the product is homogenously

fluidized.

The cylindrical AGT insert allows high

fluidizing velocities.

The conical GF insert is designed for

the production of agglomerates and

for coating processes, also with the

option Wurster-process.

RotorIn this process inlet air chamber and

process chamber are separated by

a moving rotor plate. The particles in

the process are spheronized by the

rotating movement. Simultaneously

liquid and powder can be introduced

by means of a tangential spray nozzle

to coat particles with powder.

FlexibilityBy means of the side discharge and

the zig-zag sifter all processes can

be run continuously. All particles

below the desired particle size are

returned to the process chamber.

Alternatively, the discharge can be

closed and all processes can be run

in batch mode.

In all process chambers, liquid can

be sprayed either from top or from

bottom.

The capacities depend on the size of

the process chambers, the inlet air

volume and inlet air temperature.

P r o c e s s e s

micro-organisms, spray granulation, ProCell

fungicide, spray granulation, AGT

proteine, spray granulation, ProCell

olive, agglomeration, GF

enzyme, coating, GF

vitamin, spray granulation, ProCell

F l e x i b l e U n i t : P r o C e l l – G F – A G T –

ProCell system– for spray granulation, encapsulation,

agglomeration and coating in the

spouted bed

ProCell 5 - insertworking volume 0.4 – 8 l

ProCell 10 - insertworking volume 0.8 – 16 l

AGT system– for spray granulation and

encapsulation in the fluid bed

AGT 150 - insertworking volume 1.4 – 5.8 l

spraying rate

ca. 0.2 –18 l/h (depending on product)

performance

max. 250 m3/h air flow

at max. 200° C inlet air temperature

optional:

- max. 500 m3/h air flow

(external fan)

- max. 300° C inlet air temperature

utility requirements

compressed air 6 bar (g)

power 31 kW

dimensions

weight 1300 kg

main measurements refer to drawing

GF system– for spray granulation, encapsulation,

agglomeration and coating in the

fluid bed as well as Wurster-coating

GF 3 - insertworking volume 2.5 – 10 l

GF 7 - insertworking volume 10 – 38 l

1000

1610

920

2830

2350

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R o t o r

Rotor system– powder layering, pelletizing and

direct pelletization with the rotor

Rotor 300 - insertworking volume 1 – 3 l

fertilizer, coating, ProCell

tomato, agglomeration, GF

ceramic, spray granulation, AGT

lavender oil, encapsulation/spray granulation, ProCell

PUFA, encapsulation/spray granulation, ProCell

sugar and starch, powder layering, Rotor

Closed loop processIn addition to the exhaust gas treat-

ment by internal or external filter or

by cyclone and external filter a full

closed loop is available. The process

gas is dried with a condenser and a

desiccant wheel before returning to

the process. The desiccant wheel

may also be used alone in order to

control the inlet gas moisture.

Internal bag filterIn order to work with smaller product

volumes the ProCell LabSystem is

equipped with a bag filter. The

smaller surface of the filter means

that less product is collected in the

filter. Easy cleanability of the bags in

the laundry machine is an additional

advantage.

WIP-filterFor improved cleaning the ProCell

LabSystem can be equipped with a

WIP-filter. WIP nozzles are integrated

in the filter plate and automatically

clean the filter housing and the filter

cartridges or filter bags.

Threefold nozzleIn some special applications, two

liquids must be sprayed in parallel.

Therefore the ProCell LabSystem can

be equipped with a threefold nozzle.

Two liquids are pumped separately

to the tip of the nozzle and atomized

by compressed air.

P r o d u c t F l o w i n t h e P r o C e l l L a b S y s t e m

Spraying of meltsHeated hoses, atomizing air heater

and insulated nozzles allow for

spraying of melts of products with a

melting point of up to 100°C. This

process is used for example to coat

particles with fat to protect them

against moisture.

bag filter

processingchamber

insulated spray nozzle spray nozzle - two pipe designatomizing air heater

externalfilter(option)

dust

exhaust

supply of liquids

heating(option)

process airfiltrationheating

discharge of solids

zig-zagsifter

product-discharge

internal filter

feed of solids

compressed air

closed loopprocess gas

(option)

dust recycle

cyclone(option)

We set the standard

A d d r e s s e s

Worldwide service to the customer

Glatt GmbH Process TechnologyWerner-Glatt-Straße 179589 Binzen/GermanyPhone: +49 7621 6 64 0Fax: +49 7621 6 47 23eMail: info@glatt.com

Glatt Maschinen- & Apparatebau AGKraftwerkstrasse 64133 Pratteln 1/SwitzerlandPhone: +41 61 8 26 47 47Fax: +41 61 8 26 48 48eMail: info@glatt.com

Glatt Systemtechnik GmbHGrunaer Weg 2601277 Dresden/GermanyPhone: +49 351 25 84 0Fax: +49 351 25 84 328eMail: info@glatt.com

Glatt Air Techniques Inc.20 Spear RoadRamsey, NJ 07446 USAPhone: +1 201 8 25 87 00Fax: +1 201 8 25 03 89eMail: info@glattair.com

Glatt Pharmatech SASUParc Technologique6, rue Louis Néel21000 Dijon/FrancePhone: +33 3 80 74 32 64Fax: +33 3 80 74 43 95eMail: info@glatt-pharmatech.fr

Glatt Norden ApS.Skøjtevej 27-312770 Kastrup/DenmarkPhone: +45 48 14 22 44Fax: +45 48 14 22 55eMail: info@glattnorden.dk

Glatt Protech Ltd.Swannington Rd.Cottage Lane Ind. Est.Broughton AstleyLeicester LE9 6TU/Great BritainPhone: +44 1455 28 58 58Fax: +44 1455 28 55 10eMail: info@glatt-protech.co.uk

Glatt Ingenieurtechnik GmbHMoskau/Russlandул. Обручева, 23 - корп. 3

117630 Москва/Россия

Phone: +7 495 78742-89Fax: +7 495 78742-91eMail:info.glatt-moscow@mastertelecom.ru

www.glatt.com

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T e c h n o l o g y C e n t r e

Testing – analyzing – scale-upSeveral laboratory units are available for

trials in our technology centre. Therefore

you are flexible to find the ideal process

for your product.

The characteristics of your products e.g.

particle size, particle size distribution, par-

ticle shape, residual moisture, bulk density,

angle of repose, attrition, steam sorption etc.

can be tested and evaluated in detail in our

modern analysis laboratory.

After successful lab trials, pilot scale trials in

our technology center are the next step.

Based on the pilot trials we will design your

production plant.

Rent or buyIt's your choice. Configurate your ProCell

LabSystem according to your product

requirements. We will support you with

installation, commissioning and training

of your personnel.

Glatt Ingenieurtechnik GmbHNordstraße 12

99427 Weimar/Germany

Phone: +49 3643 47 0

Fax: +49 3643 47 12 31

eMail: info@glatt-weimar.de

analytical laboratory

pilot plant ProCell/GF 25

C o n t i n u o u s T e c h n o l o g i e s

W e s e t t h e s t a n d a r d

● S p r a y G r a n u l a t i o n

● A g g l o m e r a t i o n

● C o a t i n g

● I n s t a n t i a t i o n

● P e l l e t i z i n g

● E n c a p s u l a t i o n

● D r y i n g

GF

AGT

ProCel l

G l a t t . D i f f i c u l t p r o c e s s e sm a n a g e d b y e x p e r i e n c e a n dk n o w h o w .

What is now Glatt Ingenieurtechnik

Weimar was founded in 1981 as

innovation group “Continuous Fluid Bed

Technology” within the research

department of a large East German

machine manufacturer. The task of the

group was the introduction of the

newly developed AGT technology in

the industry. Already in 1983, the first

production sized unit, an AGT for the

granulation of potash solution was

commercialized.

When the East German industry

was privatized this group was

taken over by the Glatt company and

founded as Glatt Ingenieurtechnik

in 1991. This was the start of a success

story. The staff quadrupled within

10 years.

In 1996, Glatt developed the Glatt

Fluid Bed (GF) in order to increase

the flexibility of the continuous fluid

bed processes. Originally used for

drying and cooling of solids, today

difficult agglomeration and coating

processes can be accomplished with

the GF technology.

The combination of 50 years

experience with Glatt batch units

in Binzen and 20 years continuous

processing in Weimar results in a

powerful know-how.

Besides equipment for the chemical

industry, Glatt Ingenieurtechnik

Weimar offers high quality equip-

ment for the food industry. Designed

according to GMP rules these units

reach the well known quality of Glatt

equipment and can be cleaned with

WIP/CIP systems.

AGT 400, constructed in 1981

B a c k g r o u n d

C o n t e n t s

Product Advantages 3

Continuous Fluid Bed

– GF 4

Continuous Fluid Bed

– AGT 6

Continuous Spouted Bed

– ProCell 7

Explosion Protection 8

Cleaning Systems 9

Process Development 10

Engineering 11

Technical Data 12

Product References 14

Glatt Service Program 15

Addresses 16

We s e t t h e s t a n d a r d

3

P r o d u c t A d v a n t a g e s

T h e p l u s p o i n t s o f c o n t i n u o u sp r o c e s s e s .

● constant product

quality

● narrow grain size

distribution

● dustfree and compact

granules

● well dispersable

and excellent soluble

agglomerates

● easy to dose and to

transport due to

good free flowing

properties

● constant filling

weight and volume

for packaging and

pressing due to

constant bulk density

● good storage properties

due to a clear reduction

of hygroscopicity

● no segregation of

the components of a

mixture

Granules

Agglomerates

Coated crystals

A g g l o m e r a t i o n .S p r a y g r a n u l a t i o n .C o a t i n g .O n e u n i t f o r a l lp r o c e s s e s .

Afluid bed is formed when an

upward flow of process air lifts

small solid particles. As a result

the small particles move rapidly within

the fluid bed and ensure a very efficient

heat and material exchange between

the bed and the fluidizing air. The

temperature in the fluid bed is constant

across the whole height of the bed.

This ensures a gentle drying

of temperature-sensitive products.

Besides simple drying and cooling

processes fluid bed equipment

is used to build particles from

powder - agglomeration - or from

liquids - granulation - and to coat

particles - coating.

The continuous Glatt fluid bed GF can

accomplish all these processes.

Since the inlet air plenum is divided

into multiple chambers it is possible

to introduce air with different velocities

and different temperatures into the

processing chamber. By this means

and by correct placement of the

nozzles in the fluid bed, it is

possible to set completely different

conditions in different sections

of the processing chamber.

In the process, shown in the principle

picture, agglomerates are formed from

powder above the first two inlet air

chambers. The agglomerates are dried

above the third inlet air chamber and

are cooled above the forth before they

are discharged as finished product.

4

Principle of the continuous Glatt fluid bed process

Glatt fluid bed granulator GFG 1200

C o n t i n u o u s F l u i d B e d – G F

F l e x i b l e p r o c e s s e sa n d f l e x i b l e d e s i g n .

Glatt units offer significant process

and construction flexibility.

The standard unit consists of structural

components – processing chamber,

internal filter, feeding device, discharge

device and spraying system. These

components can be changed indepen-

dently to meet the demands of the

process.

If necessary the internal filter is

replaced by a lid and installed ex-

ternally.

The design of the spraying system

allows a change of the installation of the

nozzles even after the commissioning of

the plant. Hence the unit can be easily

adjusted to new process demands and

product properties.

Depending on the quality require-

ments of the end product Glatt offers

two versions:

● Standard chemical plant design

For plants with only one product or

plants were product change is

possible without special hygienic

requirements.

Simple construction.

For high inlet air temperatures

and large throughputs.

● Standard food plant design

For plants with high requirements

on cleanability, demand for frequent

product changes.

High surface quality of product

wetted parts to meet hygienic

demands.

Low inlet air temperatures for

temperature sensitive products.

5

F l e x i b l e C o n s t r u c t i o n

Glatt fluid bed granulator GFG 500,chemical plant design

Glatt fluid bed coater GFC 750

ProCell 20, food plant design

T h e r i g h t m i x t u r e w i t h i n t h e A G T .

The AGT (unit for continous granu-

lation drying) has a round bottom

screen. The entire fluid bed is always

ideally mixed.

The product is discharged by means

of a centrally arranged discharge pipe.

The grain size of the product is

determined by the velocity of the

discharge air.

In most AGT processes a liquid raw

material is dried while building up

particle size. It is also possible to add

continuously solid raw material. The

fluid bed guarantees that all raw

materials are mixed homogeneously

in the final product.

The exhaust air is cleaned externally.

All dust is recycled into the processing

chamber were it is needed as seed

material for the granulation process.

6

C o n t i n u o u s F l u i d B e d – A G T

Processing chamber, AGT 400

Unit for granulation drying AGT 2700

Principle of theAGT process

E f f i c i e n t p r o c e s -s i n g o f d i f f i c u l tf l u i d i z a b l ep r o d u c t s

Particles in the Glatt Spouted Bed

are fluidized by a flow of upwards

streaming process air.

The process air enters the processing

chamber through slots at the side and

not through a bottom screen, like in fluid

bed processes.

The cross section of the processing

chamber is significantly increasing

towards the top, resulting an a sharp

decrease of the fluidizing velocity of the

process air. This results in a controlled

flow pattern of the particles in the pro-

cessing chamber.

Nozzles in the processing chamber can

be arranged in top spray or bottom

spray position. Since they are arranged

in the middle of the two slots they spray

at the point of the highest energy input.

Features of the ProCell

● no bottom screen

● highest process air velocity in the

center of the spouted bed

● sharp decrease of the fluidizing

velocity along the height of the

processing chamber

Advantages of the ProCell

● fine particles can be fluidized

● large particles and irregularly

formed particles can be fluidized

● gently drying of temperature-

sensitive products

● process air volume can be adjusted

to the energy demand of the process

● high process stability due to resis-

tance against stickiness and lumps

● short processing times at high spray

rates

7

View into the processing chamber

Region of operation for fluidized bed (blue)and extended region of operation forProCell (red)

transportvolume

processair volume

particel size

fluidizingvolume

Principle of ProCell process

Pilot plant ProCell 20

C o n t i n u o u s S p o u t e d B e d – P r o C e l l

8

S e c u r i n g a s a f e s o l u t i o n .

Mixtures of dust and air do

frequently provide an explosion

risk. Glatt equipment can therefore

be equipped with explosion protection

measures.

Continuous units usually offer explosion

suppression systems. The pressure

inside the unit is constantly monitored.

A developing explosion will

cause a very fast pressure

rise inside the processing

chamber. If such a sharp

pressure rise is monitored,

pressurized vessels with

extinguishing powder

are emptied into the

processing chamber.

A developing explosion is by this means

stopped in a matter of milliseconds. The

fluid bed equipment needs to withstand

only a pressure of less than 1 bar.

For equipment in the food industry

the explosion protection system can also

be equipped with hygienic flanges and

food compatible powder.

Alternatively, Glatt equipment can be

equipped with explosion venting

devices.

E x p l o s i o n P r o t e c t i o n

AGT 400 with explosion protection system

1. ignition

time: 0 ms

2. sensors sense the pressure rise

time: 20 ms

3. extinguishing powder is discharged

time: 30 ms

4. the extinguishing powder extinguishes theexplosion flametime: 50 ms

9

A s c l e a n a sy o u l i k e .

Simple cleaning is a cornerstone

in the design of all Glatt equipment.

Easy access to all parts of the machi-

nery, correctly placed revision doors

and cleaning water drains as well as

the installation of cleaning nozzles are

part of this philosophy.

Units for the food industry which have

to be cleaned frequently for hygienic

reasons are offered with comprehensive

wash in place systems. Glatt has many

years of experience with the design of

WIP and CIP systems.

Many design criteria need to be

addressed to ensure an automatic

cleaning e.g.:

● high surface quality of all

product contact parts

● easily detachable spray

nozzles

● special flanges without gaps

● special sensors for process

parameters

● correct arrangement of

cleaning nozzles

● optimal drainage of

cleaning water

In every unit the cleanability of the fil-

ter is decisive for the cleaning system.

Glatt offers three designs to meet diffe-

rent demands:

● two sets of filters which are

exchanged and cleaned outside

● sintered ceramic filters which can

be cleaned in place but need to

be checked afterwards

● Glatt metal cartridge filters

SC SuperClean® which can be

cleaned in place and guarantee

absolute cleanness

C l e a n i n g S y s t e m s

Glatt metal cartridge filter SC SuperClean®

Principle of automatic cleaning

Flush mounted, hydraulically extendingwashing nozzle

WIP skid

L o n g e x p e r i e n c e – S h o r t p r o c e s s .

Process development is per-

formed in Glatt laboratories

where the experience of the customer

with his product is combined with

the process know how of the Glatt

engineers.

First feasibility trials are carried

out in small batch and continuous

units with a throughput of 1-2 kg/h.

Further process development is

done on pilot scale units with up to

50 kg/h throughput. Based on the

determined parameters our engineers

scale up and size the production

equipment for the desired throughput.

Fifty years experience and the

process simulation program

ChemCAD are the powerful tools

used when scaling up.

After a thorough process develop-

ment experience Glatt guarantees

certain product and process

parameters.

The laboratory units are mobile.

Customers can rent the units

for product development in their

own laboratory.

P r o c e s s D e v e l o p m e n t

Laboratory unit ProCell 5 for spouted and fluid bed processes

Pilot plant ProCell 20 Analytical laboratory

10

S e r v i c e a s r e q u e s t e d ,e n g i n e e r e d s u c c e s s p r o v i d e d .

Besides the core unit GF or AGT,

Glatt delivers all peripheral

equipment necessary for the operation

of the process, like fans, pumps and

transport systems.

Further equipment needed for an opti-

mal handling of the raw materials and

the product can also be commissioned,

like mixers, dosing devices and

packaging machines.

Modern software tools, like CAD and

FEM are used to provide an excellent

service to the customer. For simulation

of the process gas flow in our equipment

we are using EFD.lab.

Glatt also works as a prime contractor,

designing and commissioning entire

plants, including the building.

Control system as desired.

Standard Glatt equipment is controlled

with a PLC by SIEMENS (Europe)

or by ALLAN BRADLEY (USA).

On request different control systems

can be used. Several other systems

have successfully been installed,

such as Mitsubishi and Freelance.

The process visualization is generally

done using the desired program.

Installation, start up and training.

Glatt offers expertise in the installation

and commissioning of the plant.

Glatt engineers start the plant up and

train the customer staff.

Good technical support and a prompt

spare part service provide long term

customer satisfaction.

11

E n g i n e e r i n g

Production plant, GFG 850

Simulation of the process gas flow withEFD.Lab

12

T e c h n i c a l D a t a

Continuous Fluid Bed – GF and Continuous Spouted Bed – ProCell

main dimensions

agglomeration processes

spray granulation processes

Continuous Fluid Bed – AGT

main dimensions

spray granulation processes

type 20 50 125 250 350 500

processing chamber m2 0.2 0.5 1.25 2.5 3.5 5.0

processes spray granulation, agglomeration, coating, instantiation, pelletizing, drying,

raw materials liquid solutions, suspensions, melts

solid powder, granules, cristals, extrudates

width B 3) mm 780 910 1200 1400 1600 1800

lenght L mm 1000 1400 2300 3300 3900 5000

height H 3) 4) mm 3300 3500 4800 5000 5200 5300

filter system cartridge filter / bag filter / sinter plate filter

inlet air temperature 1) °C 90

water evaporation 2) kg/h 15 40 100 195 275 385

inlet air temperature1) °C 175

water evaporation 2) kg/h 30 80 200 400 560 800

remarks: 1) value for standard design2) estimated value for common air flow rates3) depending on product and process, normally smaller in case of agglomeration, higher in case of spay granulation4) depending on filter system, normally smaller in case of cartridge filter and sinter plate filter, higher in case of bag filter

type 400 800 1200 1500 2200 2600

bottom screen area m2 0.1 0.5 1.1 1.8 3.8 5.3

processes granulation, agglomeration

raw materials liquid solutions, suspensions, melts

solid powder, granules, crystals

diameter processing chamber D1 mm 400 800 1200 1500 2200 2600

diameter expansion chamber D2 mm 800 1500 2200 2700 3800 4500

height H mm 3600 4300 5000 5500 6800 7800

inlet air temperature 1) °C 250

water evaporation 2) kg/h 60 240 540 840 1800 2500

remarks: 1) value for standard design2) estimated value for common air flow rates

13

750 1000 2000

7.5 10 20

cooling and combinations

2100 2300 2800

6500 7700 12500

5500 5600 6300

580 770 1540

1200 1600 3200

3000

7.1

3000

5200

8500

3400

14

We s e t t h e s t a n d a r d

P r o d u c t R e f e r e n c e s

E x p e r i e n c e w i t h m a n y p r o d u c t s .

C o n t i n u o u s q u a l i t y f o r :

Chemical industry

aluminum oxide

aluminum sulfate

antacid

copper hydroxide

detergent

detergent components

epoxide

hexamine

polymers

potash

potassium acetate

potassium benzoate

potassium formiate

potassium phosphate

potassium sulfate

silica

silica carbide

sodium acetate

sodium phosphate

surfactant

waterglass

xanthane

zeolithe

zirconium oxide

Food industry

baby food

chocolate drink

citric acid

coffee powder

cocoa powder

dextrose

dietary food

flavors

fructose

gelatine

glutamate

gravy

instant tea

lactose

malt extract

milk powder

soups

sweetener

whey powder

yeast

Ceramic industry

electrical ceramics

glaze-pigment

porcelain

special ceramics

catalysts

Agriculture

fertilizer

lysine

pesticides

yeast

Biotechnology

amino acids

antibiotics

choline chloride

enzymes

micro-organisms

proteins

vitamins

15

E q u i p m e n t , e n g i n e e r i n g a n ds e r v i c e s , o u t o fo n e s o u r c e .

G l a t t e q u i p m e n t

Batch fluid bed equipment

as dryer, with spraying system

as granulator, with Wurster

insert for coating, with rotor

insert for powder layering.

Pan coater

for film coating of tablets.

Vertical granulator

for wet granulation of powders.

Pelletizer

for spheronization of extrudates.

Basket extruder

for extrusion of powder mixes.

Sieves

for reducing of oversized granules

to a defined grain size.

Product handling

containers, container blenders,

lifting systems, transport and

pneumatic conveying systems,

filling and discharging systems,

docking systems, isolation flap

systems, component weighing

systems, dosing systems,

washing systems, validation and

documentation.

E n g i n e e r i n g a n d s e r v i c e

Product development

development and optimization

of your products in Glatt

laboratories.

Engineering

Glatt engineers and commissions

production lines up to turn key

plants.

Qualification and validation

Glatt supplies all documents

needed for a comprehensive

qualification and validation of the

equipment.

Toll manufacturing

Glatt also manufactures product

with Glatt equipment. So you

can considerably shorten your

time to market.

Training

Glatt offers courses on specific

subjects or organizes individual

training programs.

G l a t t S e r v i c e P r o g r a m

Technology center, Binzen

Wo r l d w i d e s e r v i c e t o t h e c u s t o m e r .

Glatt Pharmatech SASUParc Technologique6, rue Louis Neel21000 Dijon/FrancePhone: +33 3 80 74 32 64Fax: +33 3 80 74 43 95eMail: info@glatt-pharmatech.fr

Glatt Protech Ltd.Swannington Rd. Cottage Lane Ind. Est.Broughton AstleyLeicester LE9 6TU/Great BritainPhone: +44 1455 28 58 58Fax: +44 1455 28 55 10eMail: info@glatt-protech.co.uk

Glatt Norden ApS.Skøjtevej 27-312770 Kastrup/DenmarkPhone: +45 48 14 22 44Fax: +45 48 14 22 55eMail: info@glattnorden.dk

Glatt Ingenieurtechnik GmbHMoscow/Russia119034 г. Москва/РоссияГагаринский пер., 3 – под. 3, 4-ый этажPhone: +7 495 787 2408Fax: +7 495 787 2409eMail: info.glatt-moscow@sovintel.ru

www.glatt.com

Glatt Air Techniques Inc.20 Spear RoadRamsey, NJ 07446 USAPhone: +1 201 8 25 87 00Fax: +1 201 8 25 03 89eMail: info@glattair.com

Glatt Maschinen- & Apparatebau AG Kraftwerkstrasse 64133 Pratteln 1/SwitzerlandPhone: +41 61 8 26 47 47Fax: +41 61 8 26 48 48eMail: info@glatt.com

Glatt Ingenieurtechnik GmbHNordstraße 1299427 Weimar/GermanyPhone: +49 3643 47 0Fax: +49 3643 47 12 31eMail: info@glatt-weimar.de

Glatt GmbH Process TechnologyWerner-Glatt-Straße 179589 Binzen/GermanyPhone: +49 7621 6 64 0Fax: +49 7621 6 47 23eMail: info@glatt.com

Glatt Systemtechnik GmbHGrunaer Weg 2601277 Dresden/GermanyPhone: +49 351 25 84 0Fax: +49 351 25 84 328eMail: info@glatt-dresden.de

We s e t t h e s t a n d a r d

A d d r e s s e s

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We set the standard

From the ideato turnkey production Consulting

Engineering

Implementation

P ro c e s s a n d P l a n t E n g i n e e r i n g

Pharmaceutical industryBiotechnologyFood industryFeed industryFine chemical industryChemical industry

2

G l a t t - y o u r p a r t n e r f o r p l a n t e n g i n e e r i n g

From the idea to turnkey production

In the last two decades, Glatt Engineering has imple-

mented a variety of projects for different industries all

over the world. Our track record includes both exten-

sion or modification of existing and also construction

of new production facilities - in parts or completely.

Incorporated in the international Glatt Group we have

unrestricted access to comprehensive expert know-

ledge from more than 50 years pioneering and ex-

periences in process technology.

Many processes in today's solid pharmaceuticals

production would not be imaginable without Glatt‘s

technologies – Glatt owns patents in many fields.

Innovation and continual further development of our

equipment, up-to-date market-oriented services for

product development of new dosage forms, authority

approved contract production at Glatt-owned produc-

tion sites, but also a close contact to international

research institutions and to researching industrial

partners enable us to solve even the complexest

implementation of formulation requirements for and

with our customers.

As a reliable project partner we offer full GMP and

environmental compliance in all fields. Applying them

ourselves we are familiar to latest regulations. We

anticipate market trends at an early stage and help to

develop them. All of which enables us to provide

sophisticated, customer-specific and tailored solutions

and to guarantee smooth processes by professional

project management.

Our projects are not only focussed on processes for

the production of solid pharmaceuticals but also on

the production of liquid pharmaceuticals by sterile

and non-sterile processes.

Apart from these longstanding traditions in the phar-

maceutical industry, Glatt Engineering is increa-

singly active in the food/feed, fine chemical and

chemical fields where an increasing demand for

well-aimed product refinement opens new markets

that can benefit from gathered experiences and the

use of proven technologies.

Process EquipmentProduct Development

3

Contract Manufacturing Process and Plant Engineering Qualification/Validation

ServicesConsulting, engineering and implementation

also as general contractor

ProjectsProcesses, production lines and complete

production facilities

FocusPharmaceutical industry with solid and liquid

dosage forms by sterile and non-sterile

processes

Biotechnology

Food and feed industry

Fine chemical and chemical industry

4

Glatt – a reliable project partnerEfficient processes, future-oriented technologies, high-

quality products, flexibility, security and time to market.

The success of your investment depends on a variety of

factors. These parameters are both guidelines and motivation

for us. Together with you we will find and implement an

integrated and tailored solution that ensures your

competitiveness on tomorrow's markets.

We develop, engineer and implementStandalone systems and equipment for research,

development and production up to complete plants

• New construction

• Modification and modernization

• Extension

Our service portfolio• Consulting and support in the project development phase

• Conception and engineering of processes and buildings

• Purchase and expediting

• Project management for engineering and implementation

• Authority approval management

• Licence procurement

• Construction scheduling, management and supervision

• Installation and installation supervision

• Commissioning and commissioning supervision

• Qualification and validation

• Operator training

• Complete project documentation

• After-sales services (maintenance/upkeeping)

Individual service or complete packageIt is your decision how much responsibility you grant us.

We are your reliable partner in all project stages as:

• Engineering contractor

for individually selected engineering contents such

as process engineering/optimization, qualification/

validation, no matter whether feasibility studies,

concepts, basic and/or detail engineering is involved

• General contractor

with general engineering from project concept up to

constuction with overall project responsibility including

EPCM services up to turnkey implementation

O u r s e r v i c e p o r t f o l i o

5

Glatt Engineering

6

FeasibilityStudies

ConceptualDesign

BasicEngineering

DetailEngineering

ProcurementDelivery

ConstructionInstallationSupervision

Start-up(Qualification)(Validation)

After-Sales-Service

P r o j e c t r e a l i z a t i o n w i t h G l a t t c o m p e t e n c e

Independent engineeringbased on state-of-the-art technology

Engineering

Procurement and Delivery

Supervision and Training S

After-Sales-Service

consulting,

concept-, basic & detail

engineering

spare parts, maintenance,

trouble-shooting,

modifications

process equipment

construction, installation,

commissioning, start-up

(qualification/validation)

Project Management:

an

an

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7

ervices

Licensor

other detail engineering

services, e.g. architecture,

civil engineering, logistics

process equipment,

logistic, media, etc.

construction, installation,

commissioning, start-up

(qualification/validation)

start-up

spare parts, maintenance

costs, resources, time & risks

licenses,

technology transfer

Partners

Suppliers

Suppliers Licensor

Suppliers

Profit from the complete know-how of theGlatt group of companies

nd and

or

nd

or

nd and

nd

or

new dosage forms, based on our own

technologies

Product Development

own, approved and GMP conform production

(pharmaceutical, food and feed industry)

over 50 years experience in the design and

construction of fluid bed systems, high shear

mixers, drum coaters, sieves and various

systems for solid product handling

in Binzen (D), Pratteln (CH), Dresden (D),

Weimar (D), Ramsey (USA)

as well as the TTC Technology Trainings Center

in Binzen (D)

Contract Manufacturing

Process Equipment

Technology Centers

8

P h a r m a c e u t i c a l i n d u s t r y

Solid and semisolid dosage forms fromsterile and non-sterile processes- Tablets/film-coated tablets, sugar-coated pills,

capsules, sachets, powders, ointments/cremes,

suppositories

Liquid proprietary medicinal productsfrom sterile and non-sterile processes- Infusion solutions in bottles/bags

- Injection solutions in ampoules, phials, vials,

carpules, prefilled syringes

- Tinctures, extracts, juices, drops

GMP solid productsWithin the scope of 3 turnkey projects

for the contract manufacturer IPC Inter-

national Processing Center GmbH,

Germany, in Dresden several produc-

tion buildings were built for granulation,

coating, classifying, mixing, grinding,

weighing and packaging including raw

material and product logistics as well

as an individual cleanroom concept

with ventilation and air-conditioning

equipment including a plasma incinera-

tion plant. Project period: 2004 – 2009

Plot area: 60 000 m2, therefrom

approx.. 3 000 m2 for production

Infusion solutions (LVP)As EPCM contract partner for

OOO Gematek from Moscow Glatt

engineered and constructed a new

production facility for infusion solution

in Tver, Russian Federation. It uses

blow-fill-seal technology in PE bottles

with capacities of 500, 250 and 100 ml

and can produce 2 400 bottles per hour

(12 to 16 million bottles/year).

Project period: 08/2002 – 10/2004

Overal plot area: 2 300 m2,

(reconstruction of a production hall)

API of an X-Ray Contrast AgentDue to a request from GE Healthcare

AS, Norway, of changing from batch to

a cost efficient continuous processing,

Glatt was awarded with the contract

for engineering and delivery of the

total process equipment. The implemen-

tation work at site, including qualifi-

cation and support during validation,

was done during running production.

The product line is unique since it’s

FDA approved for continuous produc-

tion of an API for parenteral drugs.

Capacity: 270 kg/h

Project period: 05/2005 – 09/2006

360 m2 on 3 floors

9

Blood plasma products- Albumin

- Immunoglobulin

- Factors VIII and IX

Vaccines- Injection solutions in ampoules, phials, vials,

carpules, prefilled syringes

Insulin- Solutions and suspensions in vials Blood plasma products

On behalf of ROSPLASMA and within

the scope of a turnkey project Glatt is

engineering and implementing a new

production facility for plasma fractio-

nation (600 000 l blood plasma/year)

and diverse products in Kirov, Russian

Federation. Establishing a network of

plasma collection and pheresis centres

in the Kirov region with project plan-

ning, delivery and installation of pre-

fabricated modules.

BCG vaccineIn 2000, under the management of

Glatt as general contractor for Biomed

from Kiev, a new production plant for

BCG vaccine was constructed on

their Lwow site, Ukraine, by the re-

construction of an existing building.

Behring Werke AG, Marburg,

Germany, was the licensor.

Insulin (SVP)Glatt as general contractor for Bio-

med, a Kiev-head-quartered pharma

producer, performed comprehensive

engineering services for the new

construction of a production and

bottling plant for ultrapure insulin.

Capacities: 6 000 vials/h up to 12 million

vials/year. For this, an existing building

in Kiev, Ukraine, was reconstructed.

Hoechst AG, Frankfurt, Germany, was

the licensor.

B i o t e c h n o l o g y

10

F o o d a n d f e e d i n d u s t r y

Granules and pellets as intermediate andfinal products- Instant products as quick-soluble agglomerates

- Food and feed ingredients such as flavors,

enzymes, proteins, vitamins

Yeast- Soft and dry yeast as baking additive

Dairy products- Baby food, yogurts, quark, milkshakes

Baker's yeastAl Shaba Yeast Factory is a Syrian

yeast producer. From 2003 to 2006,

this company appointed Glatt with the

modernization and extension of their

production site in Aleppo, Syria, to

increase the daily output of soft and

dry yeast from 32 tons to 50 tons. Glatt

implemented this project as EPCM

service provider from the survey of

existing plant up to production hand-

over.

Baby and children foodThe Russian company GP VVO Selk-

hospromexport appointed Glatt to be

the general contractor for enginee-

ring and construction of a new milk

processing and dairy line in Brjansk,

Russian Federation. In 2004, a modern

production facility for liquid and

pasteous baby and children food

products, yogurt and fruit juices pro-

cessing up to 30 000 litres raw milk per

day was accomplished by the recon-

struction of an existing building.

FlavorsPhytosynthese in Riom Cedex, France,

produce encapsulated flavors for food

and feed applications. Glatt delivered

a spouted bed granulator ProCell 125

for spray granulation and incapsulation

of emulsified oils as a complete plant

and headed its commissioning.

Production capacity: 50 – 100 kg/h,

Project period: 01/2007 – 11/2007.

11

F i n e c h e m i c a l a n d c h e m i c a l i n d u s t r y

Granules and pellets as intermediate andfinal products- Fertilizers, pesticides, detergents and detergent

components, enzymes, potash, polymers and

many more

Chemical products- manufactured, prepared and processed, e.g. to

improve storage and transport properties PotashWithin the scope of a turnkey project,

Pottaschewerk Staßfurt, Germany,

appointed Glatt with engineering and

construction of the most advanced

potash production plant in the world at

that time with a fluid bed spray gra-

nulation plant and a yearly output of

20 000 tons potash (potassium

carbonate K2CO3).

Project period: 1999 – 2001

Detergent componentsZschimmer & Schwarz, Germany,

produce water softeners. Glatt

delivered a fluid bed granulator

GFG 500 including building for the

spray granulation of these products

as a turnkey project. All that the client

provided were media and liquid raw

materials. Water evaporation capacity

approx. 700 kg/h

Project period: 10/1999 – 07/2000

Sodium cyanide as briquettesIn Saratov, Russian Federation, Glatt as

general contractor for the Russian

Lukoil group, implemented a produc-

tion facility for sodium cyanide (NaCN),

which is an important raw mateial for

gold mining, with DuPont, USA, as

licensor.

Produced NaCN having a purity >98%

is pressed to briquettes and packed

into 50 kg steel drums

Plant capacity: 15 000 t/year

Project period: 30 months (2005 – 2008)

Our Headquarter

Our PresenceGlatt Engineering is a business unit of Glatt Ingenieurtechnik GmbH

headquartered in Weimar with branch offices in Wiesbaden, Scandinavia,

France, Switzerland, Russia, India and the USA.

At present, the Glatt Group employs approx. 1500 employees in more than

20 companies worldwide.

Numerous representative offices are at your disposal, offering Glatt's

complete services. This means: reliability, financial security, and worldwide

service for your projects.

Certified according to DIN EN ISO 9001

© GL

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G l a t t E n g i n e e r i n g

We set the standard

Glatt Ingenieurtechnik GmbHNordstraße 1299427 Weimar/GermanyPhone: +49 3643 47-0Fax: +49 3643 47-1231eMail: info@glatt-weimar.de

International located:

GermanyGlatt Ingenieurtechnik GmbHNordenstadter Str. 3665207 Wiesbaden/GermanyPhone: +49 611 89069-7Fax: +49 611 89069-88eMail: info@glatt-wiesbaden.de

RussiaGlatt Ingenieurtechnik GmbHул. Обручева, 23 - корп. 3

117630 Москва/Россия

Phone: +7 495 78742-89Fax: +7 495 78742-91eMail: info.glatt-moscow@mastertelecom.ru

IndiaGlatt (India) Pharma Engineering Pvt. Ltd.13 Ground Floor Palam Marg, Vasant ViharNew Delhi – 110057/IndiaPhone: +91 11 46052960Fax: +91 11 46052964eMail: info@glatt-india.com

SwitzerlandPharmatronic AGHohenrainstraße 104133 Pratteln/SwitzerlandPhone: +41 61 826-9726Fax: +41 61 826-9727eMail: info@pharmatronic.ch

USARamsey Design Group(Division of Glatt Air Techniques Inc.)20, Spear Road, Ramsey, NJ 07446/USAPhone: +1 201 825-1391Fax: +1 201 825-0389eMail: info@ramseydesign.com

www.glatt.com