gewodin® tabletten للعرض
TRANSCRIPT
The interpretation of methamphetamine and
amphetamine positive test results in biological samples
Omar Zourob
104/11/23
04/11/23 2
The interpretation of methamphetamine and amphetamine positive test results in biological samples is a challenge to clinical and forensic toxicology for several reasons:◦The effects of pH◦Dilution of urine samples◦Illicit sources ◦Legal prescription of amphetamines
Omar Zourob
04/11/23 3
Many substances metabolize to methamphetamine or amphetamine in the body:Amphetaminil Fencamine
Benzphetamine fenethylline
Clobenzorex fenproporex
Deprenyl furfenorex
Dimethylamphetamine mefenorex
Ethylamphetamine mesocarb
Famprofazone prenylamine
Omar Zourob
04/11/23 4
One of the 14 different drugs known to be metabolized to methamphetamine and/or amphetamine is famprofazone.
famprofazone a component in the multi-ingredient formulation Gewodin®.
Omar Zourob
04/11/23 5
Generic Name :◦Gewodin® Tabletten
Drug description :◦One tablet contains:
Famprofazon 25 mg, Paracetamol 250 mg, Propyphenazon 75 mg, Caffeine 30 mg.
Omar Zourob
04/11/23 6
Multiple doses of famprofazone were administered to healthy volunteers.
Following administration, urine samples were collected for nine days, and pH, specific gravity, and creatinine values were determined.
Using a cutoff of 500 ng/mL, all subjects had individual urine samples that tested positive.
Omar Zourob
04/11/23 7
Peak concentrations of
◦Methamphetamine :5327 to 14,155 ng/mL
◦Amphetamine : 833 to 3555 ng/mL
Both enantiomers of methamphetamine and amphetamine were present
Omar Zourob
04/11/23 8
Famprofazone
Methamphetamine
Amphetamine
H
H
H
Omar Zourob
04/11/23 9Omar Zourob