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Please see Important Safety Information on page 4. Click here for Medication Guide and click here for full Prescribing Information.

What is ONGLYZA?ONGLYZA is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

ONGLYZA should not be used to treat people with type 1 diabetes or diabetic ketoacidosis (increased ketones in the blood or urine).

Who should not take ONGLYZA?Do not take ONGLYZA if you: • are allergic to any of its ingredients. Serious allergic reactions can occur with ONGLYZA and may include swelling of the face, lips or throat, difficulty swallowing or breathing,

swelling of the skin, hives, rash, itching, flaking, or peeling. If you have these symptoms, stop taking ONGLYZA and contact your doctor right away

Get ready for your doctor appointment— your input is important.Voicing your opinions is an important part of having a discussion with your doctor. Together you can decide on a treatment that’s best for you. Ask your doctor if ONGLYZA may be the right option for you.

How ONGLYZA has been shown to helpClinical study results help doctors decide which medicine may be right for you. ONGLYZA has been tested in multiple clinical studies including thousands of adult patients with type 2 diabetes. In all of these studies, ONGLYZA in addition to diet and exercise has been shown to lower A1C. Your results may vary.

This information is intended for US consumers only.

Talk to your doctor about ONGLYZA.Read this guide, print it out, and refer to it at your next doctor visit.

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Please see Important Safety Information on page 4. Click here for Medication Guide and click here for full Prescribing Information.

There are many treatment options for lowering A1C. When talking to your doctor, you may want to ask: 1. What is my A1C level? Where should it be?

2. Should I consider making changes to my diet or exercise plan?

3. If my medicine doesn’t seem to be working, are there additional medicines that could help lower my A1C?

4. Can ONGLYZA be used with other type 2 diabetes medicines?

5. Can ONGLYZA help lower my A1C?

6. How does ONGLYZA work?

7. How is ONGLYZA taken?

8. Can ONGLYZA cause low blood sugar (hypoglycemia)?

9. What if I have kidney problems?

10. Does ONGLYZA cause weight gain?

11. What are the most common side effects of ONGLYZA?

What is the most important information you should know about ONGLYZA?Serious side effects can happen in people who take ONGLYZA:

• Inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Before taking ONGLYZA, tell your doctor if you ever had pancreatitis, gallstones, history of alcoholism, or high triglyceride levels. Stop taking ONGLYZA and contact your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis

“ I need to lower my A1C while considering other factors, too. I am going to talk to my doctor about ONGLYZA.”

All images in this brochure are actor portrayals and not actual patients, health care professionals, or caregivers.

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Please see Important Safety Information on page 4. Click here for Medication Guide and click here for full Prescribing Information.

Remember, your appointment is about YOU.At the end of the day, this is your medical condition, so you shouldn’t shy away from sharing your thoughts with your doctor. Think of yourself and your doctor as a team. Working together may help you find a treatment that’s right for you.

Get ready for your appointment:

• Make a list of any changes to your medical history since your last visit. That includes medications, injuries, and allergic reactions

• Bring your notes about your treatment options to discuss with your doctor

• Ask your doctor if ONGLYZA is an appropriate treatment option for you

• Ask about side effects. You can read the Important Safety Information for ONGLYZA on the next page and bring your questions with you

• By the end of your appointment, make sure you understand what the next steps are:

1. Will you need additional testing?

2. Will you be changing your treatment?

3. When should you schedule your next appointment?

What are the possible side effects of ONGLYZA?Serious side effects can happen in people who take ONGLYZA:

• Heart Failure. Before taking ONGLYZA tell your doctor if you have ever had heart failure or problems with your kidneys. Contact your doctor right away if you have any of the following symptoms of heart failure: increasing shortness of breath or trouble breathing, especially when you lie down; an unusually fast increase in weight; swelling or fluid retention, especially in the feet, ankles or legs; unusual tiredness “ I look forward to talking with my doctor to learn

more about ONGLYZA.”

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What is ONGLYZA? ONGLYZA is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

ONGLYZA should not be used to treat people with type 1 diabetes or diabetic ketoacidosis (increased ketones in the blood or urine).

Important Safety Information for ONGLYZA® (saxagliptin)Do not take ONGLYZA if you:

• are allergic to any of its ingredients. Serious allergic reactions can occur with ONGLYZA and may include swelling of the face, lips or throat, difficulty swallowing or breathing, swelling of the skin, hives, rash, itching, flaking, or peeling. If you have these symptoms, stop taking ONGLYZA and contact your doctor right away

Serious side effects can happen in people who take ONGLYZA:

• Inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Before taking ONGLYZA, tell your doctor if you ever had pancreatitis, gallstones, history of alcoholism, or high triglyceride levels. Stop taking ONGLYZA and contact your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis

• Heart Failure. Before taking ONGLYZA tell your doctor if you have ever had heart failure or problems with your kidneys. Contact your doctor right away if you have any of the following symptoms of heart failure: increasing shortness of breath or trouble breathing, especially when you lie down; an unusually fast increase in weight; swelling or fluid retention, especially in the feet, ankles or legs; unusual tiredness

• Low blood sugar. When ONGLYZA is used with certain other diabetes medicines to treat high blood sugar, such as a sulfonylurea or insulin, the risk of low blood sugar (hypoglycemia) is higher. Symptoms of low blood sugar include shaking, hunger, sweating, headache, rapid heartbeat, change in mood, and change in vision. Follow your doctor’s instructions for treating low blood sugar

• Joint Pain. Some people who take medicines called DPP-4 inhibitors, like ONGLYZA, may develop joint pain that can be severe. Call your doctor if you have severe joint pain

• Skin reaction. Some people who take medicines called DPP-4 inhibitors, like ONGLYZA, may develop a skin reaction called bullous pemphigoid that can require treatment in a hospital. Tell your doctor right away if you develop blisters or the breakdown of the outer layer of your skin

• Peripheral edema. When ONGLYZA is used with a thiazolidinedione (TZD), such as pioglitazone or rosiglitazone, to treat high blood sugar, peripheral edema (fluid retention) may become worse. If you have symptoms of peripheral edema, such as swelling of hands, feet, or ankles, call your doctor

Before you take ONGLYZA:

• Tell your doctor if you have kidney problems. Your doctor should test your blood to measure how well your kidneys are working before and during treatment with ONGLYZA. You may need a lower dose if your kidneys are not working well

• Tell your doctor if you are pregnant, breast-feeding, or plan to become pregnant or breast-feed

• Tell your doctor if you start or stop taking other medications, including antibiotics, antifungals or HIV/AIDS medications, as your doctor may need to change your dose of ONGLYZA

The most common side effects with ONGLYZA include upper respiratory tract infection, urinary tract infection, and headache.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA 1088.

Click here for Medication Guide and click here for full Prescribing Information.

For adults with type 2 diabetes in addition to diet and exercise

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Please see Important Safety Information on page 4. Click here for Medication Guide and click here for full Prescribing Information.

Save on your ONGLYZA prescription • Your savings will continue for as long as your doctor prescribes ONGLYZA

and you remain eligible

• Your card saves you money even when you fill your prescription through a mail-order pharmacy

• You’ll save on every prescription for ONGLYZA—paying as little as $0 a month

Learn more at www.onglyzasavings.com

Eligible patients may get ONGLYZA® (saxagliptin)

for as little as

$0 a month!*

*ELIGIBILITY REQUIREMENTS AND TERMS OF USE:ELIGIBILITY: You may be eligible for this offer if you are insured by commercial insurance and your insurance does not cover the full cost of your prescription, or you are not insured and are responsible for the cost of your prescriptions. Patients who are enrolled in a state or federally funded prescription insurance program are not eligible for this offer. This includes patients enrolled in Medicare Part D, Medicaid, Medigap, Veterans Affairs (VA), Department of Defense (DOD) programs or TRICARE, and patients who are Medicare eligible and enrolled in an employer-sponsored group waiver health plan or government-subsidized prescription drug benefit program for retirees. If you are enrolled in a state or federally funded prescription insurance program, you may not use this savings card even if you elect to be processed as an uninsured (cash-paying) patient. This offer is not insurance, is restricted to residents of the United States and Puerto Rico, and to patients over 18 years of age.

TERMS OF USE: Eligible commercially insured patients with a valid prescription for ONGLYZA®

(saxagliptin) who present this savings card at participating pharmacies will pay as low as $0 per 30-day supply maximum savings limit applies; patient out-of-pocket expense may vary. If you pay cash for your prescription, AstraZeneca will pay up to the first $150, and you will be responsible for any remaining balance, for each monthly prescription. Other restrictions may apply. Patient is responsible for applicable taxes, if any. Non-transferable, limited to one per person, cannot be combined with any other offer. Void where prohibited by law, taxed or restricted. Patients, pharmacists, and prescribers cannot seek reimbursement from health insurance or any third party for any part of the benefit received by the patient through this offer. AstraZeneca reserves the right to rescind, revoke, or amend this offer, eligibility and terms of use at any time without notice. This offer is not conditioned on any past, present or future purchase, including refills. Offer must be presented along with a valid prescription at the time of purchase. For additional details about this offer, please visit www.onglyzasavings.com. If you have any questions regarding this offer, please call 1-855-907-3197.BY USING THIS CARD, YOU AND YOUR PHARMACIST UNDERSTAND AND AGREE TO COMPLY WITH THESE ELIGIBILITY REQUIREMENTS AND TERMS OF USE.

Subject to eligibility. Restrictions apply.*Not available for government-insured patients.Eligible patients may save up to $150 for a 30-day supply.

For commercially insured patients

Subject to eligibility. Restrictions apply. Not available for government-insured patients. See back of card for details.

CO-PAYs AS LITTLE AS $0*

Program managed by PSKW, LLC, on behalf of AstraZeneca. ONGLYZA is a registered trademark of the AstraZeneca group of companies.©2016 AstraZeneca. All rights reserved. 3231115 Last Updated 4/16

* As low as $0 for as long as your doctor prescribes any available dose of ONGLYZA. No activation required.

onglyzasavings.com

BIN# 004682PCN# CNGRP# EC00000000 ID# XXXXXXXXXXX

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There’s help available to you when starting a new treatment.Type 2 diabetes is a lot to handle. That’s why it’s important to get help whenever possible. If you and your doctor decide that ONGLYZA is the right treatment for you, you’ll have a place to turn to for questions about your medicine and any cost concerns you may have. Our goal is to help make managing your type 2 diabetes a little easier. Remember, our team is here for you every step along the way.

What is ONGLYZA?ONGLYZA is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

ONGLYZA should not be used to treat people with type 1 diabetes or diabetic ketoacidosis (increased ketones in the blood or urine).

Who should not take ONGLYZA?Do not take ONGLYZA if you: • are allergic to any of its ingredients. Serious allergic reactions can occur

with ONGLYZA and may include swelling of the face, lips or throat, difficulty swallowing or breathing, swelling of the skin, hives, rash, itching, flaking, or peeling. If you have these symptoms, stop taking ONGLYZA and contact your doctor right away

Surrounding you with support

ONGLYZA is a registered trademark of the AstraZeneca group of companies.©2017 AstraZeneca. All rights reserved.US-15765 Last Updated 11/17

ONGLYZA Care Partners*When you talk to one of our ONGLYZA Care Partners, you’ll connect to a broader network of patient support.

* ONGLYZA Care Partners cannot provide medical advice and can only provide information about AstraZeneca medications. Decisions regarding your health and treatment of your condition should be made with your own health care provider.

ONGLYZA Prescription Coverage Counselors†

We have Prescription Coverage Counselors that you can talk to on the phone about your ONGLYZA coverage and benefit verification. They can help you determine your co-pay amount and what information you’ll need to process your benefit verification.

† Prescription Coverage Counselors do not file claims or appeals on behalf of patients or health care professionals. Coverage or co-pay amounts may change prior to the time of actual prescription fill.

Please see Important Safety Information on page 4. Click here for Medication Guide and click here for full Prescribing Information.

For adults with type 2 diabetes in addition to diet and exercise