George Ntaios MD, MSc (ESO Stroke Medicine), PhD, FESO

University of Thessaly, Larissa, Greece

Nice 08/05/2014

A short introduction on

European Stroke Conference / Stroke Guidelines

Disclosures

Scholarships: European Stroke Organization; Hellenic Society of Atherosclerosis.Honoraria: Medtronic; Quintiles.Speaker fees: Sanofi; Boehringer-Ingelheim.Consultant fees: Boehringer-Ingelheim.Support to attend conferences: Bayer; Sanofi-Aventis; Pfizer; Lundbeck; Boehringer-Ingelheim; Galenica; Elpen; Bristol Myers Squibb. Participation in trials:

ENOS / National co-ordinator (Greece). BPREVISE / Principal investigator. FOURIER / Sub-investigator. GLORIA / Sub-investigator.

Grading of

Recommendations,

Assessment,

Development and

Evaluation

GRADE

Population In children during summertime

Intervention chocolate ice-cream

Comparator studying mathematics

Outcome* happiness

Specify the PICO question(s)

Assessment of quality of studies

RCTs start high

Observational studies start low

Assessment of quality of studies (downgrade)

Study design and execution (bias)

Inconsistency (heterogeneity, I2)

Indirectness

Imprecision (number of events, confidence intervals)

Publication bias (funnel plot)

Assessment of quality of studies (upgrade)

Large magnitude of the effect

Dose – response relation

Grade of evidence

Summary of Findings (SoF) tables

Panel discussionOverview