Genomics and Pediatric Cancers

Outline

Childhood cancer

Mortality rates

Pediatric cancers

Gene expression

Gene expression

Gene expression

Human genome

Genomic research

Gene measurement

First generation tools

Microarrays

Next-generation sequencing

Massively Parallel Sequencing

Genomic Alterations

Genomic Alterations

Properties

Cancer Genomes

Clinical Vignette

Wilms tumor

Cancer diagnosis

Diagnosis

Rearrangement

Pediatric cancer mutations

Clinomics for precision medicine

Study design

Mutations

Multi-omics integrated landscape

Fusion genes

Somatic mutations

Match criteria

Tumor mutations

Germline mutations

Summary

Future Trials

ClinOmics program

Operational goals

Exome vs. Panel

Clinomica Wesite

QC report

QC report

Mutation view

Conclusions

Acknowledgements