Genomes To LifeUser Facilities for 21st Century Systems Biology

A Joint Initiative of the Office of Advanced Scientific Computing Research and the Office of Biological and

Environmental Researchhttp://DOEGenomesToLife.org

Dr. Marvin FrazierDecember 3, 2002

Biological and Environmental Research Advisory Committee Meeting

Growing Mandate to Move Biology Forward “Molecular Level Understanding of Life Processes” is a National

Science Priority. — OMB/OSTP FY 2004 Budget Guidance Memo

“Instrument development & new facilities are critical needs in microbial science.” — American Academy of Microbiology 2001 Colloquium, “Microbial Ecology and Genomics: A Crossroads of Opportunity”

“DOE should now create unique, high throughput research facilities and resources to translate the new biology, embodied in the Genomes to Life (GTL) program, into a reality for the nation.” —Biological and Environmental Research Advisory Committee

Agency Comments

R. Aebersold and J. D. Watts, “The Need for National Centers for Proteomics,” Nature Biotechnology, 20: 651 (July 2002).

GTL User Facilities - Introduction

Planning Update

Description of facilities

Path Forward

Dr. Abigail Salyers, Past President, American Society of Microbiology

GTL User Facilities Planning Update

BERAC Report – April

San Francisco Workshop – June

Dr. Orbach’s Call for Office of Science - August

Chicago Workshop – August

Gaithersburg Workshop – October

Report to Orbach – November

BERAC Presentations - December

Workshop Participants Eric Ackerman, PNNL Kritsin Balder-Froid, LBNL Jim Bixler, PNNL Jim Brainard, LANL Elbert Branscomb, LLNL Michelle Buchanan, ORNL Steve Colson, PNNL Mike Colvin, LLNL Brian Davison, ORNL Graham Fleming, LBNL Jim Fredrickson, PNNL Paul Gilna, LANL Gary Jacobs, ORNL Michael Kennedy, PNNL Michael Knotek, Consultant Lee Makowski, ANL Betty Mansfield, ORNL Bob Marianelli, Consultant

Ken Nealson, USC Rick Stevens, ANL Jill Trewhella, LANL Ed Uberbacher, ORNL

DOE Participants Dan Drell Brendlyn Faison Marvin Frazier Teresa Fryberger John Houghton Peter Kirchner Noelle Metting Ari Patrinos Mike Riches Michael Teresinski David Thomassen Mike Viola

Genomes to Life: User Facilities for 21st Century Systems Biology

Biotechnology Revolution offers DOE mission solutions

The genome is the key to major advancements in understanding and applications

Microbes are Us: Major Discoveries and Diverse Beneficial Capabilities

The Genomic Approach: High-Tech, High-Throughput, and High-Quality Data to free the scientist to do science

Pilot Projects and Technology Development: We have already established the bases for facilities

We have a plan: Science, Technologies, Facilities, and Management

DOE R&D Contributed to:

•Decreased Cost

•Increased Throughput

Providing the Paradigm for Genomes to Life Facilities

Human Genome Project Making the Impossible Routine

Cost per base in dollars. Millions of bases finished.

GTL Facilities Funding ProfileTotal Project + Operations

$0

$50

$100

$150

$200

$250

FY03 FY04 FY05 FY06 FY07 FY08 FY09 FY10 FY11 FY12 FY13

$M's

Total Facility I Facility II Facility III Facility IV

Critical Decisions 0, 1, 2, 3, 4noted for each facility

0 0

1

2

3

41

2

3

4

1

2

3

4

1

3

4

00

• Facility cost estimates are based on New Construction and will meet the elimination of excess facility requirements.

• Cost estimates are for a fully equipped and completely functional facility.

• Upon approval of the concept other external funding sources (e.g., third party, multiple agency, etc.) will be considered as appropriate.

Facility Cost Estimates=$885M

Management Principles for Genomes to Life User Facilities

An open-acquisition process that encourages broad involvement of the national laboratories, academia, and industry in innovation and technology development, facility design and development, as well as host site selection

Peer-review process for determining the target and products of the facilities

An open availability of facilities capabilities and free dissemination of data, tools, and materials

GTL Facilities HallmarksOpen, Rapid User Access to Data and Facilities

Advanced Technologies

Microbial Genomics

High-Throughput Analysis and Production

Biosystems Training

Informatics and Databases

Computing and Simulation

Technology Integration for

Tomorrow’s Biology