genetic control of temperature preference in the nematode caenorhabditis elegans akiko mohri, elji...

18
Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno and Ikue Mori

Post on 19-Dec-2015

221 views

Category:

Documents


1 download

TRANSCRIPT

Page 1: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Genetic Control of TemperaturePreference in the Nematode

Caenorhabditis elegans

Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno and Ikue Mori

Page 2: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Background

• Worms will migrate to cultivation temperature when on a temperature gradient (H&R, 1975)

• Worm will avoid temperatures paired with starvation

• If E. coli paired with new temperature, take 2-4 hours before worms will migrate to the new temperature

Page 3: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Neural circuit

Mori 1995

Page 4: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

25˚C

15˚C

Thermotaxis Phenotypes

Isothermic

ThemophilicCryophilic

Athermotactic

N2aho-2hen-1

No ablation

ttx-3nsc-1

AFD/AIY ablation

lin-11

AIZ ablation

tax-2tax-4sel-12

RIA ablation

25˚C

15˚C

25˚C

15˚C

25˚C

15˚C

Page 5: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 1

Page 6: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Table 1

Page 7: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 2

Page 8: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 3

Page 9: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 4

Page 10: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 5

Page 11: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 6

Page 12: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 7

Page 13: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 8

Page 14: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno
Page 15: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 10

Page 16: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 11

Page 17: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Figure 12

Page 18: Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans Akiko Mohri, Elji Kodama, Koutarou Kimura, Mizuho Koike, Takafumi Mizuno

Conclusions

• Respond differently to changes in temperature vs. feeding state

• aho-2 defective thermotactic avoidance