genes and function: the rewriting of our textbooks of pathology
DESCRIPTION
Genes and Function: The Rewriting of our Textbooks of Pathology. Presented By David Hafler at 2014 ASCO Annual Meeting. Slide 2. Presented By David Hafler at 2014 ASCO Annual Meeting. Slide 3. Presented By David Hafler at 2014 ASCO Annual Meeting. Slide 4. - PowerPoint PPT PresentationTRANSCRIPT
Genes and Function: The Rewriting of our <br />Textbooks of Pathology
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 2
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 3
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 4
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 5
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 6
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 7
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 8
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 9
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 10
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 11
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 12
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 13
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 14
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 15
Presented By David Hafler at 2014 ASCO Annual Meeting
Glioblastoma multiforme
Presented By David Hafler at 2014 ASCO Annual Meeting
Treatments
Presented By David Hafler at 2014 ASCO Annual Meeting
WHO Classification
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 19
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 20
Presented By David Hafler at 2014 ASCO Annual Meeting
PD-1 Expression CD4 T effectors in on Glioblastoma
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 22
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 23
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 24
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 25
Presented By David Hafler at 2014 ASCO Annual Meeting
Patient survival linked to Tumor-associated Tregs
Presented By David Hafler at 2014 ASCO Annual Meeting
Increase numbers of regulatory T Cells in Glioblastoma
Presented By David Hafler at 2014 ASCO Annual Meeting
Tregs and CD4 T effector cells in glioblastoma are Tim3+PD-1+
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 29
Presented By David Hafler at 2014 ASCO Annual Meeting
PD-1+Tim3+ Tregs restricted to grade 4 glioblastoma
Presented By David Hafler at 2014 ASCO Annual Meeting
Absence of Tim3+PD-1+ Tregs in the blood of healthy controls
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 32
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 33
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 34
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 35
Presented By David Hafler at 2014 ASCO Annual Meeting
Blocking monoclonal antibodies increase CD4 T effector proliferation but not Treg suppression
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 37
Presented By David Hafler at 2014 ASCO Annual Meeting
Impaired suppression by GBM-Treg and proliferative response by GBM-Teff
Presented By David Hafler at 2014 ASCO Annual Meeting
PD-1+Tim3+ Tregs have decreased suppressor function
Presented By David Hafler at 2014 ASCO Annual Meeting
PD-1+ CD4 effector cells and Tregs have shortened telomeres
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 41
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 42
Presented By David Hafler at 2014 ASCO Annual Meeting
Slide 43
Presented By David Hafler at 2014 ASCO Annual Meeting