Upload File

general structure of ion channels

13
General Structure of Ion Channels Satadru De M.Phil 1 st year

Upload: satadru-dey

Post on 17-Feb-2017

565 views

Category:

Documents


2 download

Report

TRANSCRIPT

Page 1: General Structure of Ion Channels

General Structure of Ion Channels

Satadru DeM.Phil 1st year

Page 2: General Structure of Ion Channels

Voltage gated ion channels:• Na+ channel• K+ channels• Ca2+ channel• Cl- channel

Ligand gated ion channels:• Nicotinic Ach-R• GABAA –R• Glycine – R• Ionotropic Glutamate – R• Purinoceptor P2X

Page 3: General Structure of Ion Channels

Voltage Gated Sodium Channel

Page 4: General Structure of Ion Channels

Voltage Gated Calcium Channel

Page 5: General Structure of Ion Channels

Voltage Gated Potassium Channels

KA / Fast or Early

KV / Delayed Rectifier

KS / Serotonin dependant

KCa / Calcium dependant

Kir / Inward rectifying

KATP / ATP dependant

Kach / GIRK-1

K leak channels

Page 6: General Structure of Ion Channels
Page 7: General Structure of Ion Channels

Chloride Channel (ClC)Chloride-nucleotide Channel (Cln)Phospholemman

Voltage Gated Chloride Channel

Page 8: General Structure of Ion Channels

Ligand Gated Ion channels

Page 9: General Structure of Ion Channels

Nicotinic Ach Receptor GABAA Receptor

Page 10: General Structure of Ion Channels

Glycine Receptor

Page 11: General Structure of Ion Channels

Ionotropic Glutamate Receptor

NMDA-Receptor

Page 12: General Structure of Ion Channels

Purinoceptor – P2X

Page 13: General Structure of Ion Channels

-End-


ION CHANNELS - u-szeged.hu · Ion channel pharmacology. Camerino DC, Tricarico D, Desaphy JF. Because ion channels are involved in many cellular processes, drugs acting on ion channels

Gated Ion Channels

Ligand-Gated Ion Channels

Extracellular receptors Ion channels

Ion Channels and Active Transport

Contribution of Ion Channels in Pain Sensation of Ion Channels in Pain Sensation.pdf · Contribution of Ion Channels in Pain Sensation Ofra Gohar, Ph.D. the restoration of normal

Single Ion Channels

Ion Channels

Probing solution structure of the pentameric ligand-gated ion … · ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels

Sperm Ion Channels

Biological Membrane Ion Channels - Dynamics, Structure and Applns - S. Chung, et al., (Springer, 2007) WW

Ion Channels and Channelopathies

Inverse Problems in Ion Channels

H.Gaub / SS 2007BPZ§4.31 All pore-forming ion channels are similar in structure

Pentameric viral ion channels: from structure to function viral ion... · School of Biological Sciences, Nanyang Technological University, Singapore Correspondence: Jaume Torres hepatitis

Ion express Lecture 4 Channels

Second Messenger-gated Ion channels CNG Ion Channels: Matulef and Zagotta. 2003. Cyclic nucleotide-gated Ion channels. Annu. Rev. Cell Dev. Biol. 19: 23-44

4.ion channels & secondary messengers

Self-Energy PBE Ion Channels

Ion channels and transporters - EMBO · Ion channels and transporters: From molecule to man meetings.embo.org/event/20-ion-channels 17 – 23 May 2020 | Erice, Italy CONTACT Stephan

Light gated ion channels

Ion Channels. Active Transporters: The proteins that created and maintain ion gradients Ion channels : give rise to selective ion permeability changes

ion channels and resting potential

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

Ion Channels and Electrical Activity

Second-Messenger Gated Ion Channels

Voltage-Gated Ion Channels and Hereditary Disease · this review, basic patterns of structure and function of voltage-gated ion channels as well as functional changes brought about

Ion channels as drug target

ION CHANNELS - Purdue Engineering · studies of ion channels 1 NigelUnwin Structure ofthe acetylcholine-gated channel 5 Discussion 15 KatjussaBrejc,WillemJ.vanDijk,AugustB.SmitandTitiaK.Sixma

Transcription & Translation Molecular Structure of Ion Channels

The Cardiac Ion Channels

Review Viral ion channels: structure and functionwfischer/pdf/bba2002.pdfReview Viral ion channels: structure and function Wolfgang B. Fischer a;*, Mark S.P. Sansom b a Department

Ligand gated ion channels

Expression and Analysis of Recombinant Ion Channels - · PDF fileExpression and Analysis of Recombinant Ion Channels ... Expression and Analysis of Recombinant Ion Channels. ... Zara

Ion Channels and Receptors - MITreveals evolutionary relationships But primary structure alone is not sufficient to define functional properties of channels/receptors (e.g. subunit