General Intensive Care

Current Awareness Newsletter

April 2015

Outreach Your Outreach Librarian can help facilitate evidence-based

practise for all ICU members of staff, as well as assisting with academic study and research. We can help with literature searching, obtaining journal articles and books, and

setting up individual current awareness alerts.

Literature Searching We provide a literature searching service for any library member. For those embarking on their own research it is advisable to book some time with one of the librarians for a 1 to 1 session where we

can guide you through the process of creating a well-focused literature research and introduce you to the health databases

access via NHS Evidence.

Critical Appraisal Training We also offer one-to-one or small group training in

literature searching, accessing electronic journals, and critical appraisal/Statistics. These are essential courses that teach how to

interpret clinical papers.

Books Books can be searched for using SWIMS our online catalogue at

www.swims.nhs.uk. Books and journals that are not available on site or electronically may be requested from other locations. Please email requests to: thomas.osborne@uhbristol.nhs.uk

Contents

1: Tables of Contents from March’s

Intensive Care journals

2: New NICE Guidance

3: NHS Behind the Headlines

4: Quick Exercise

Tables of Contents from Paediatric & Critical Care journals

If you require full articles please email me @ Thomas.Osborne@UHBristol.nhs.uk

Critical Care Medicine - April Vol 43 Issue 4

Hospital-Based Acute Care Use in Survivors of Septic Shock*

Frequency, Cost, and Risk Factors of Readmissions Among Severe Sepsis Survivors*

Tissue Oxygen Saturation and Finger Perfusion Index in Central Hypovolemia: Influence of Pain*

Characteristics and Outcomes of Patients Admitted to ICU Following Activation of the Medical Emergency

Team: Impact of Introducing a Two-Tier Response System

The Role of Systemic Antibiotics in Acquiring Respiratory Tract Colonization With Gram-Negative Bacteria in

Intensive Care Patients: A Nested Cohort Study*

Lung Recruitability Is Better Estimated According to the Berlin Definition of Acute Respiratory Distress

Syndrome at Standard 5 cm H2O Rather Than Higher Positive End-Expiratory...

Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery*

Prehospital Aspirin Use Is Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically

Ill Patients: A Propensity-Adjusted Analysis*

Morbidity and Survival Probability in Burn Patients in Modern Burn Care*

Differences in Vital Signs Between Elderly and Nonelderly Patients Prior to Ward Cardiac Arrest

A Qualitative Study Exploring Moral Distress in the ICU Team: The Importance of Unit Functionality and

Intrateam Dynamics*

Is Long-Axis View Superior to Short-Axis View in Ultrasound-Guided Central Venous Catheterization?*

Chest Compression Rates and Survival Following Out-of-Hospital Cardiac Arrest*

Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Facilitates Intra-Arrest Therapeutic

Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation*

Derivation and Validation of the Acute Organ Failure Score to Predict Outcome in Critically Ill Patients: A

Cohort Study

Clinical and Psychological Effects of Early Mobilization in Patients Treated in a Neurologic ICU: A Comparative Study*

The Formation, Elements of Success, and Challenges in Managing a Critical Care Program: Part I

Current Opinion in Critical Care - April -Vol 21 Issue 2

Recommendations for management of large hemispheric infarction

Blood pressure management in acute intracerebral hemorrhage: current evidence and ongoing controversies

Recommendations for the use of multimodal monitoring in the neurointensive care unit

Rationale for lumbar drains in aneurysmal subarachnoid hemorrhage

Reversal of the novel oral anticoagulants dabigatran, rivoraxaban, and apixaban

Diarrhoea in the critically ill

Acute, nonvariceal upper gastrointestinal bleeding

Liver transplantation in the context of organ shortage: toward extension and restriction of indications

considering recent clinical data and ethical framework

Critical Care – March 2015

Intertwining extracorporeal membrane oxygenation and continuous renal replacement therapy: sense or

nonsense?

Applicability of pulse pressure variation: how many shades of grey?

Colistin and tobramycin resistance during long- term use of selective decontamination strategies in the

intensive care unit: a post hoc analysis

Increase in cerebral oxygenation during advanced life support in out-of-hospital patients is associated

with return of spontaneous circulation

Gastro-oesophageal reflux disease increases the risk of intensive care unit admittance and mechanical

ventilation use among patients with chronic obstructive pulmonary disease: a nationwide population-

based cohort study

Timing for deep vein thrombosis chemoprophylaxis in traumatic brain injury: an evidence-based

review

Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced

intensive care unit mortality: a prospective analysis

Detection of acute traumatic coagulopathy and massive transfusion requirements by means of

rotational thromboelastometry: an international prospective validation study

Continuous renal replacement therapy in critically ill patients does not affect urinary neutrophil

gelatinase-associated lipocalin levels

Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and

network meta-analysis

Identification of haplotype tag SNPs within the nuclear factor-κB family genes and their clinical

relevance in patients with major trauma

Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a

simulated intensive care unit environment: which might be a more promising strategy for ICU sleep

deprivation?

Closed-loop assisted versus manual goal-directed fluid therapy during high-risk abdominal surgery: a

case–control study with propensity matching

6% Hydroxyethyl starch versus other fluids for non-septic patients in the intensive care unit: a meta-

analysis of randomized controlled trials

A regional trauma system to optimize the pre-hospital triage of trauma patients

Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney

injury requiring continuous renal replacement therapy: a randomized controlled trial

Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute

pancreatitis

Efficacy and safety of 6% hydroxyethyl starches 130/0.4 (Voluven®) for perioperative volume

replacement in children undergoing cardiac surgery: a propensity-matched analysis

Prehospital endotracheal intubation: elemental or detrimental?

β-blockers in critically ill patients: from physiology to clinical evidence

State of the art review: the data revolution in critical care

Update on the role of extracorporeal CO2 removal as an adjunct to mechanical ventilation in ARDS

Rapid response systems: are they really effective?

Cooling techniques for targeted temperature management post-cardiac arrest

Long-term sequelae from acute kidney injury: potential mechanisms for the observed poor renal

outcomes

Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review

Angiotensin II in septic shock

A simple prognostic index based on admission vital signs data among patients with sepsis in a

resource-limited setting

An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a

propensity-matched analysis

Effects of terlipressin as early treatment for protection of brain in a model of haemorrhagic shock

A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic

pharmacokinetics

Short term amino ac id infusion improves protein balance in critically ill patients

Trauma induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs

Postoperative pneumonia following cardiac surgery in non-ventilated patients versus mechanically

entilated patients: is there any difference?

The ratio of Th17/Treg cells as a risk indicator in early acute respiratory distress syndrome

Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest

Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature

Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients

Safety evaluation on low-molecular-weight hydroxyethyl starch for volume expansion therapy in

pediatric patients: a meta-analysis of randomized controlled trials

β1-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA

and enhancing CaMKII and IκBα phosphorylation

Early brain injury after aneurysmal subarachnoid hemorrhage a multimodal neuromonitoring study

Prognostic value of procalcitonin in respiratory tract infections across clinical settings

An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers

susceptibility to the development of sepsis

Advanced age is associated with worsened outcomes and a unique genomic response in severely

injured patients with hemorrhagic shock

Benefit profile of recombinant human soluble thrombomodulin in sepsis-induced disseminated

intravascular coagulation: a multicenter propensity score analysis

Human metabolic response to systemic inflammation: assessment of the concordance between

experimental endotoxemia and clinical cases of sepsis/SIRS

Does intermediate care improve patient outcomes or reduce costs?

Dynamic changes of microbial flora and therapeutic consequences in persistent peritonitis

Levosimendan affects oxidative and inflammatory pathways in the diaphragm of ventilated

endotoxemic mice

The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in

patients with systemic inflammation

Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator

interaction

Perceptions of the appropriateness of care in California adult intensive care units

Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically

ill adults and children: a cochrane systematic review and meta-analysis

Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and

traumatic shock

Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children

presenting with malaria and non-malaria febrile illness

Superior vena cava drainage improves upper body oxygenation during veno-arterial extracorporeal

membrane oxygenation in sheep

Transferring the critically ill patient: are we there yet?

Do corticosteroids reduce the mortality of influenza A (H1N1) infection? a meta-analysis

Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care – an

economic evaluation

Propofol increases morbidity and mortality in a rat model of sepsis

Assessment of patient-ventilator breath contribution during neurally adjusted ventilatory assist in patients

with acute respiratory failure

Neurally adjusted ventilatory assist (NAVA) allows patient-ventilator synchrony during pediatric

noninvasive ventilation: a crossover physiological study

Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic

review and meta-analysis

Intensive and Critical Care Nursing

Monitoring and optimising outcomes of survivors of critical illness

Psychoeducational support to post cardiac surgery heart failure patients and their partners—A randomised pilot study

Evaluation of postgraduate critical care nursing students’ attitudes to, and engagement with, Team-Based

Learning: A descriptive study

Parents’ experiences of family functioning, health and social support provided by nurses – A pilot study in

paediatric intensive care

Administration of enteral nutrition to adult patients in the prone position

Simulation-based paediatric intensive care unit central venous line maintenance bundle training

Families’ experiences of their interactions with staff in an Australian intensive care unit (ICU): A qualitative

study

Chest X-ray quiz

New NICE Guidance

Medicines optimisation: the safe and effective use of medicines to

enable the best possible outcomes(NG5)

...another, to support high‐quality care. This includes transfers within...example,

when a person moves from intensivecare to a hospital ward – or from one... Stephen

Dean Consultant in Intensive Care and Anaesthesia, Leeds Teaching...

The Sherlock 3CG Tip Confirmation System for placement of

peripherally inserted central catheters(MTG24)

...central catheter in a non‐intensive care setting. When the Sherlock 3CG...analysis

based on the results for intensivecare patients presented in the studies by

Johnston...Assessment Centre considered that intensive care patients may be a

subgroup for...

Axitinib for treating advanced renal cell carcinoma after failure of

prior systemic treatment (TA333)

...because it had no best supportive care comparator as defined in the scope...of

axitinib with best supportive care. 3.2 Patients were eligible to enter...Dr Daniele

Bryden Consultant in Intensive Care Medicine and Anaesthesia, Sheffield..

Insertion of a balloon device to disimpact an engaged fetal head

before an emergency caesarean section(IPG515)

...group (p=0.55). 4.9 Admission to an intensive care unit for more than 24 hours was

needed for 6...extension of the uterine incision, reducing intensive care unit or

neonatal intensive care unit admission and reducing postoperative..

NHS Behind the Headlines

Study finds link between air pollution and stroke risk

Wednesday Mar 25 2015

"Air pollution is linked to an increased risk of stroke," BBC News reports, prompted by a

large global study in The BMJ. Researchers found an association even with brief upsurges in

air pollution levels…

Following UK dietary advice may cut heart disease risk

Thursday Mar 19 2015

"Sensible diet cuts heart attack risk in months," The Times reports after a randomised

controlled trial found evidence that following current UK diet guidelines can reduce

cardiovascular disease risk factors…

Damage to 'heart health' may start in childhood

Wednesday Mar 18 2015

"Children are suffering damage to their hearts as early as 12 due to poor diets, a study has

warned," the Mail Online reports. A US study suggests that an unhealthy diet in childhood

can quickly lead to a deterioration in "heart health"…

All teens should be vaccinated against rare strain of meningitis

Monday Mar 16 2015

"A vaccination for meningitis is to be offered to all 14-18 year-olds in England and Wales,

after a spike in a rare strain of the disease," The Guardian reports. The strain – meningitis W

(MenW) – is described as rare, but life-threatening…

UK Ebola case confirmed but risk remains low

Thursday Mar 12 2015

The Scottish nurse found to have Ebola after arriving in Glasgow from Sierra Leone has

recovered after specialist care at the Royal Free Hospital in London ...

HRT review finds increased risk of blood clots and stroke

Tuesday Mar 10 2015

'Women on HRT pills should be aware that there is a small chance of an increased risk of

blood clots and possibly stroke' BBC News report. A major review, involving over 40,000

patient records, found an increase in risk of clotting….

Quick Exercise

Have a play with Uptodate. Log in via Athens (if you don’t have an Athens

account register using your UHBristol email address here:

https://openathens.nice.org.uk/

Library Opening Times

Staffed times 8.00 am—17.00 pm

Monday to Friday

Swipe Access 7.00 am—23.00pm

7 days a week

Level 5,

Education Centre

University Hospitals Bristol

Contact your outreach librarian @

Thomas.Osborne@UHBristol.nhs.uk