garland science catalog 2017 - taylor &...

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CATALOG 2017GARLAND SCIENCE

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CONTENTS

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Cell & Molecular Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . 4Neuroscience . . . . . . . . . . . . . . . . . . . . . 10 Genetics & Evolution. . . . . . . . . . . . . . . . . . . . . 12 Microbiology. . . . . . . . . . . . . . . . . . . . . . . . . . 19 Immunology. . . . . . . . . . . . . . . . . . . . . . . 22 Structural Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Biophysics. . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Computational Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . 34Chemistry. . . . . . . . . . . . . . . . . . . . . . 36Plant & Marine Biology. . . . . . . . . . . . . . . . . . 37 Title Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Author Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41

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Dear Reader,

Garland Science is one of the leading textbook publishers in the life sciences, particularly in the fields of cell and molecular biology, immunology, genetics and protein science. Our exceptional authors, who are highly respected leaders in their fields, make the science accessible to students through clear and elegant writing that illuminates core concepts. Each textbook is beautifully illustrated, and every figure is carefully explained through detailed figure legends. Our books are supported by a wide array of ancillary resources for students and instructors. Some books are additionally supported by the Garland Science Learning System, which offers high-quality homework and assessment content designed to complement our textbooks.

This catalogue includes all of our major textbooks and highlights new textbooks published in 2017. We hope it serves as an effective introduction to our publications and that you will also explore our website or contact us directly for more information.

Best wishes,The Team at Garland Science

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CELL & MOLECULAR BIOLOGYMolecular Biology of the Cell, Sixth Edition

Bruce Alberts, University of California, San Francisco, USA,Alexander Johnson, University of California, San Francisco, USA,Julian Lewis, formerly of Cancer Research UK, David Morgan, University of California, San Francisco, USA, Martin Raff, University College London, UK, Keith Roberts, Emeritus, University of East Anglia, UK, andPeter Walter, University of California, San Francisco, USA

Garland Science December 2014: 1,464pp: 1,492 illus Hardback: 978-0-8153-4432-2: £147.00 Paperback: 978-0-8153-4464-3: £75.00

As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning.

The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

NEW IN THE SIXTH EDITION• Incorporates important new discoveries into a logical and cohesive narrative that provides a

conceptual framework for cell biology.• Explains newly discovered functions for RNA molecules.• Includes the latest findings on the structure and function of the human genome.• Explains recent insights into how low-complexity protein sequences help organize the cell interior.• Describes powerful new methods, many invented since the last edition, that scientists use to

visualize subcellular structures and analyze genes and proteins—with a new section emphasizing the need for mathematics to unravel the complexities of cell function.

• Incorporates new results that refine our understanding of intracellular organization, membrane structure, dynamics, and transport.

• Focuses on the fundamental concepts in cell signaling, with emphasis on key principles underlying the circuitry of signaling systems.

• Describes how the latest discoveries in cytoskeletal protein dynamics apply to key questions in cell structure and polarity.

• Covers new insights into the causes, genetics, and treatments of cancer—including a discussion of personalized therapies.

• Adds new sections on timing, growth control, and morphogenesis in the development of multicellular organisms.

Molecular Biology of the Cell, Sixth Edition was

Highly Commended for the Undergraduate Textbook at the Royal Society of Biology 2015

Book Awards.

http://www.garlandscience.com/product/isbn/9780815344322?utm_source=shared_link&utm_medium=post&utm_campaign=170302090

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CELL & MOLECULAR BIOLOGYMolecular Biology of the Cell, Sixth EditionCONTENTS:INTRODUCTION TO THE CELL 1. Cells & Genomes 2. Cell Chemistry and Bioenergetics3. Proteins BASIC GENETIC MECHANISMS 4. DNA, Chromosomes, and Genomes5. DNA Replication, Repair, and Recombination 6. How Cells Read the Genome: From DNA to Protein 7. Control of Gene Expression WAYS OF WORKING WITH CELLS 8. Analyzing Cells, Molecules, and Systems 9. Visualizing CellsINTERNAL ORGANIZATION OF THE CELL 10. Membrane Structure 11. Membrane Transport of Small Molecules and

the Electrical Properties of Membranes

12. Intracellular Compartments and ProteinSorting

13. Intracellular Membrane Traffic 14. Energy Conversion: Mitochondria and

Chloroplasts 15. Cell Signaling 16. The Cytoskeleton 17. The Cell Cycle 18. Cell Death CELLS IN THEIR SOCIAL CONTEXT 19. Cell Junctions and the Extracellular Matrix 20. Cancer 21. Development of Multicellular Organisms22. Stem Cells and Tissue Renewal 23. Pathogens and Infection24. The Innate and Adaptive Immune Systems

Molecular Biology of the Cell: The Problems Book, Sixth Edition John Wilson, Emeritus Baylor College of Medicine, USA, and Tim Hunt, Emeritus Researcher at The Francis Crick Institute, London

The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems.The Problems Book has been designed to correspond with the first twenty chapters of Molecular Biology of the Cell, Sixth Edition.

Garland ScienceDecember 2014: 560pp: 511 illus Paperback: 978-0-8153-4453-7: £30.00

"A quarter of a century after the first edition revolutionized cell biology

textbooks, the new edition is as fresh, comprehensive and above

all, as readable as ever."

British Society for Developmental Biology Newsletter

"MBoC has only improved over its several editions, growing with the rapid advances in the

field to become an essential resource for students at all levels and a trusted first stop for researchers transitioning into unfamiliar areas of cell biology….

the MBoC5 package is a fantastic resource and well worth the upgrade."

Development

PRAISE FOR THE FIFTH EDITION


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CELL & MOLECULAR BIOLOGYEssential Cell Biology, Fourth EditionBruce Alberts, University of California, San Francisco, USA, Dennis Bray, University of Cambridge, UK, Karen Hopkin, Science Journalist and Biochemist, USA, Alexander Johnson, University of California, San Francisco, USA, Julian Lewis, formerly of Cancer Research, UK, Martin Raff, University College London, UK, Keith Roberts, Emeritus, University of East Anglia, UK, and Peter Walter, University of California, San Francisco, USA

Essential Cell Biology provides a readily accessible introduction to the central concepts of cell biology, and its lively, clear writing and exceptional illustrations make it the ideal textbook for a first course in both cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive conceptual framework for the basic science that underlies our current understanding of all of biology, including the biomedical sciences. Garland Science Learning System homework modules are available for Essential Cell Biology, Fourth Edition, and are sold separately.

Garland Science November 2013: 864pp: 860 illusHardback: 978-0-8153-4454-4: £121.00Paperback: 978-0-8153-4572-5 : £68.00

Essential Cell Biology, Fourth Edition is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students’ needs precisely and efficiently. For more information and sample material, visit http://garlandscience.rocketmix.com/.

Praise for the Fourth Edition"[Essential Cell Biology] really ought to be an

intrinsic part of every bioscience undergraduate's essential reading."

The Biochemist

CONTENTS:1. Cells: The Fundamental Units of Life 2. Chemical Components of Cells 3. Energy, Catalysis, and Biosynthesis 4. Protein Structure and Function 5. DNA and Chromosomes 6. DNA Replication, Repair, and Recombination 7. From DNA to Protein: How Cells Read the Genome 8. Control of Gene Expression 9. How Genes and Genomes Evolve 10. Modern Recombinant DNA Technology 11. Membrane Structure 12. Transport Across Cell Membranes 13. How Cells Obtain Energy from Food 14. Energy Generation in Mitochondria and Chloroplasts 15. Intracellular Compartments and Protein Transport 16. Cell Signaling 17. Cytoskeleton 18. The Cell Division Cycle 19. Sexual Reproduction and the Power of Genetics 20. Cellular Communities: Tissues, Stem Cells, and Cancer


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CELL & MOLECULAR BIOLOGYMolecular Biology Structure and Dynamics of Genomes and ProteomesJordanka Zlatanova, Emeritus University of Wyoming, USA, Kensal E. van Holde, Emeritus Oregon State University, USA

Molecular Biology illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. This textbook emphasizes the experimental basis of discovery and the most recent advances in the field while presenting a structural, mechanistic understanding of molecular biology that is rigorous, yet concise. This text is written for advanced undergraduate or graduate-level courses in molecular biology and is additionally supported by the Garland Science Learning System.


CONTENTS: 1. To the Cell and Beyond: The Realm of Molecular Biology 2. From Classical Genetics to Molecular Genetics 3. Proteins 4. Nucleic Acids 5. Recombinant DNA: Principles and Applications 6. Protein-Nucleic Acid Interactions 7. The Genetic Code, Genes, and Genomes 8. Physical Structure of the Genomic Material 9. Transcription in Bacteria 10. Transcription in Eukaryotes 11. Regulation of Transcription in Bacteria 12. Regulation of Transcription in Eukaryotes 13. Transcription Regulation in the Human Genome 14. RNA Processing 15. Translation: The Players 16. Translation: The Process 17. Regulation of Translation 18. Protein Processing and Modification 19. DNA Replication in Bacteria 20. DNA Replication in Eukaryotes 21. DNA Recombination 22. DNA Repair

Cell SignalingWendell Lim, University of California San Francisco, USA, Bruce Mayer, University of Connecticut Health Center, USA, and Tony Pawson formerly of University of Toronto, Canada

Garland ScienceJune 2014: 412pp: 340 illus Paperback: 978-0-8153-4244-1: £64.99

Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the con-ceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate. By emphasizing the common design principles, com-ponents, and logic that drives all signaling, the book develops a conceptual framework through which students can understand how thousands of diverse signaling proteins interact with each other in vast interconnected networks.

CONTENTS: 1. Introduction to Cell Signaling 2. Principles and Mechanisms of Protein Interactions 3. Signaling Enzymes and Their Allosteric Regulation 4. Role of Post-translational Modifications in Signaling 5. Subcellular Localization of Signaling Molecules 6. Second Messengers: Small Signaling Mediators 7. Membranes, Lipids, and Enzymes that Modify Them 8. Information Transfer Across the Membrane 9. Regulated Protein Degradation 10. Modular Architecture and Evolution of Signaling Proteins 11. Information Processing by Signaling Devices and Networks 12. How Cells Make Decisions 13. Methods for Studying Signaling Proteins and Networks



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CELL & MOLECULAR BIOLOGYThe Biology of Cancer, Second EditionRobert A. Weinberg, Whitehead Institute for Biomedical Research, MIT, USA

The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology. The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years, including current information on the tumor microenvironment, mutation of cancer cell genomes, epigenetic contributions, and a greatly expanded treatment of traditional therapy.

Garland ScienceJune 2013: 960pp: 583 illusHardback: 978-0-8153-4219-9: £116.00 Paperback: 978-0-8153-4528-2 : £68.99

CONTENTS:1. The Biology and Genetics of Cells and Organisms 2. The Nature of Cancer 3. Tumor Viruses 4. Cellular Oncogenes 5. Growth Factors, Receptors, and Cancer 6. Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer 7. Tumor Suppressor Genes 8. pRb and Control of the Cell Cycle Clock 9. p53 and Apoptosis: Master Guardian and Executioner 10. Eternal Life: Cell Immortalization and Tumorigenesis 11. Multistep Tumorigenesis 12. Maintenance of Genomic Integrity and the Development of Cancer 13. Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis 14. Moving Out: Invasion and Metastasis 15. Crowd Control: Tumor Immunology and Immunotherapy 16. The Rational Treatment of Cancer

Praise for previous edition"The Biology of Cancer is no doubt the

definitive statement on its topic today." Science

Cell Biology by the Numbers

Garland ScienceJan 2016: 400pp: 181 illus Paperback: 978-0-8153-4537-4: £30.99

Ron Milo, Weizmann Institute of Science, Israel, Rob Phillips, California Institute of Technology, USA

How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation? Cell Biology by the Numbers explores these questions—and dozens of others—providing a richly illustrated and handy reference for students and researchers in molecular and cell biology, chemistry, and biophysics. The book features question-driven vignettes and “back of the envelope” calculations that investigate some of the key num-bers in cell biology. Readers will learn about the sizes, concentrations, rates, energies, and other numbers that describe and drive the living world.

CONTENTS: 1. Size and Geometry 2. Concentrations and Absolute Numbers 3. Energies and Forces 4. Rates and Duration 5. Information & Errors 6. A Quantitative Miscellany



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CELL & MOLECULAR BIOLOGY

NEW EDITIONCellular Signal Processing, Second Edition An Introduction to the Molecular Mechanisms of Signal Transduction

Garland ScienceApril 2017: 640pp: 483 illus Paperback: 978-0-8153-4534-3: £57.00

Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker, all at University of Heidelberg, Germany

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

Biology of AgingRoger B. McDonald, Emeritus University of California Davis, USA

Biology of Aging presents the biological principles that have led to a new understanding of the causes of aging and longevity and describes how these basic principles help one to understand the uniquely human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity.

Garland ScienceJuly 2013: 360pp: 241 illusPaperback: 978-0-8153-4213-7: £49.99CONTENTS:

1. Basic Concepts in the Biology of Aging 2. Measuring Biological Aging 3. Evolutionary Theories of Longevity and Aging 4. Cellular Aging 5. Genetics of Longevity 6. Plant Senescence 7. Human Longevity 8. The Physiology of Human Aging 9. Age-Related Disease in Humans 10. Modulating Aging and Longevity

CONTENTS: 1. The “Brain of the Cell”: Data Processing by Protein Networks 2. Supplying the Network with Energy: Basic Biochemistry of Signal Transduction 3. Evolution of Cellular Data Processing 4. Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases 5. Signal Transduction by Receptors with Seven Transmembrane Domains 6. Signal Transduction by Serine/Threonine Kinase-Coupled Receptors 7. Signal Transduction by Tyrosine Kinase- and Protein Phosphatase Coupled Receptors 8. Eukaryotic Gene Transcription: The Ultimate Target of Signal Transduction 9. Signals Controlling mRNA Translation 10. Signal Transduction by Small G-Proteins: The Art of Molecular Targeting 11. Mitogen-activated Protein Kinase and Nuclear Factor κB Modules 12. Regulation of Cell Division 13. Signal Transduction by Proteolysis, and Programmed Cell Death 14. Signal Transduction by Ions 15. Sensory Signal Processing 16. Signaling at Synapses: Neurotransmitters and their Receptors 17. Putting Together the Pieces: The Approach of Systems Biology


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CELL & MOLECULAR BIOLOGY / NEUROSCIENCE

Garland Science November 2017: 384pp: 275 illus Paperback: 978-0-8153-4482-7: £48.00

Lynne M. Bianchi, Oberlin College, USADevelopmental Neurobiology NEW

Developmental Neurobiology tells the extraordinary process of neural development by showing how the scientific discoveries were made and how the hypotheses evolved over time. Each chapter explores the specific mechanisms of development while highlighting the key experiments and methods used to make those discoveries—including descriptions of, and experiments utilizing, both invertebrate and vertebrate animal models. This distinctive approach provides the essential facts while strengthening the reader’s appreciation of the scientific method. Discussions of neurodevelopmental disorders and therapeutic approaches to them will captivate those interested in the more clinical aspects of the field. With its clear illustrations and easy-to-follow writing style, Developmental Neurobiology presents an accessible approach to neural development for undergraduate students.

CONTENTS:1. An Introduction to Developmental Neurobiology 2. Neural Induction 3. Segmentation, Boundary Formation, and Regionalization along the Anterior-Posterior Axis 4. Segmentation and Patterning of the Dorsal-Ventral Axis 5. Proliferation and Migration of Neurons in the Developing Vertebrate Nervous System 6. Mechanisms for Determining Cell Fate in the Nervous System 7. Neurite Outgrowth, Axonal Pathfinding, and Initial Target Selection 8. Mechanisms Regulating Neuronal Survival and Programmed Cell Death 9. Synaptic Formation and Reorganization – Part I: The Neuromuscular Junction 10. Synaptic Formation and Reorganization – Part II: Synapses in the Central Nervous System

Cell MembranesLukas K. Buehler, Southwestern College, USA

Cell Membranes provides a concise introduction to the structure and function of biological membranes. The book begins by explaining the composition and dynamics of cell membranes—discussing the diversity, structure, and distribution of lipids and membrane proteins and their effect on the shape and transformation of membranes. The text then explores the role of the membrane in transport, signaling, and metabolism. Cell Membranes is a valuable resource for advanced undergraduate students, graduate students, and professionals.

Garland ScienceJuly 2015: 400pp: 263 illusPaperback: 978-0-8153-4196-3: £57.99

CONTENTS: 1. The Role of Membranes in Cells and Organisms 2. The Molecular Organization of Cell Membranes 3. The Structure of Membrane Proteins 4. The Biological Diversity of Membrane Lipids 5. The Shape of Membranes and Their Transformations 6. Separation: Membranes as Surface and Interface 7. Exchange: Membrane Crossings 8. Integration: Membranes as Gatekeepers of Information 9. Metabolism: Growing Membranes, Sustaining Cells


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NEUROSCIENCEPrinciples of NeurobiologyLiqun Luo, Stanford University, USA

Principles of Neurobiology presents the major concepts of neuroscience with an emphasis on how we know what we know. The text is organized around a series of key original experiments to illustrate how scientific progress was made and helps upper-level undergraduate and graduate students to discover the relevant primary literature. Written by a single author in a clear and consistent writing style, each topic builds in complexity from electrophysiology to molecular genetics to systems level in a highly integrative approach. Students can fully engage with the content via thematically linked chapters and will be able to read the book in its entirety in a semester-long course.

Garland ScienceAugust 2015: 645pp: 625 illusHardback: 978-0-8153-4492-6: £105.00 Paperback: 978-0-8153-4494-0: £62.99

Principles of Neurobiology is supported by the Garland Science Learning System, and is accompanied by a rich package of online student and instructor resources including animations, quizzes and tutorials, journal club suggestions, figures in PowerPoint® format, and a Question Bank for adopting instructors.

KEY FEATURES:• Integrates molecular, cellular, circuit, systems, and behavioral approaches within each subject.• Includes many cross-chapter references to further integrate concepts across chapters.• The description of key experiments, the figures with data from experiments, and the references of

primary papers provide a good resource for students to understand and utilize primary research. • Includes many examples of the use of animal models in research, including invertebrates, and of

new technologies in investigating neural circuits developed as part of the BRAIN Initiative.• Dedicated chapters on evolution and on techniques are unique among neurobiology textbooks.• Concept headings descriptively introduce each section and provide an outline of the key ideas

presented in the chapter.• End-of-chapter summaries provide an overview of material presented allowing students to review

and assess their understanding of what they have read.

CONTENTS: 1. An Invitation to Neurobiology 2. Signaling within Neurons 3. Signaling across Synapses 4. Vision5. Wiring of the Visual System 6. Olfaction, Taste, Audition, and Somatosensation 7. Wiring of the Nervous System 8. Motor and Regulatory Systems 9. Sexual Behavior 10. Memory, Learning, and Synaptic Plasticity 11. Brain Disorders 12. Evolution of the Nervous System 13. Ways of Exploring

“Luo shares with us the belief that students should not be taught just facts and knowledge but also how knowledge is obtained and how principles are derived....In 13 chapters and 645 pages,

he provides a masterpiece highlighting principles of how the nervous system transforms and governs our sensation, action, memory, and thought. Reading Principles of Neurobiology is like enjoying a beautiful piece of music....[Luo] has set an example of how an outstanding scientist

cares about education and writes a textbook to inspire students to pursue discoveries. We hope that students will follow this pied piper, happily and fruitfully.”


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GENETICS & EVOLUTION

Genomes 4

Garland ScienceJuly 2017: 700pp: 500 illus Paperback: 978-0-8153-4508-4: £57.00

CONTENTS: PART I: HOW GENOMES ARE STUDIED 1. Genomes, Transcriptomes and Proteomes 2. Studying DNA3. Mapping Genomes 4. Sequencing Genomes 5. Genome Annotation 6. Identifying Gene FunctionsPART II: GENOME ANATOMIES 7. Eukaryotic Nuclear Genomes 8. Genomes of Prokaryotes and Eukaryotic Organelles 9. Virus Genomes and Mobile Genetic Elements PART III: HOW GENOMES ARE EXPRESSED 10. Accessing the Genome 11. The Role of DNA-Protein Interactions in Genome Expression 12. Transcriptomes 13. The Proteome PART IV: HOW GENOMES REPLICATE AND EVOLVE 14. Replicating the Genome 15. Microevolution of Genomes 16. A Brief History of Genome Evolution 17. Using Genomes to Study the Evolution of Species and Populations

The Fourth Edition of Genomes has been completely revised and updated to make it a thoroughly modern textbook about genomes and how they are investigated. As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: bacteria, plants, and animals including humans and other hominids.

Genomes 4 is the ideal text for upper level courses focused on genomes and genomics.

T.A. Brown, University of Manchester, UK

NEW EDITION

Biochemical Evolution, Second Edition The Pursuit of Perfection Athel Cornish-Bowden, National Center for Scientific Research, France

Garland ScienceMay 2016: 282ppPaperback: 978-0-8153-4552-7: £31.95

Biochemical Evolution: The Pursuit of Perfection, Second Edition by Athel Cornish-Bowden describes the relationship between biochemistry and evolutionary biology, arguing that each depends on the other to be properly understood. There are many aspects of evolution that make sense only in the light of biochemical knowledge, just as there are many aspects of biochemistry that make sense only in the light of evolution.

CONTENTS: 1. Some Basic Biochemistry 2. The Nuts and Bolts of Evolution 3. Adaptation and Accidents 4. Metabolism and Cells 5. The Games Cells Play 6. The Perfect Molecule 7. Fear of Phantoms 8. Living on a Knife Edge 9. Brown Eyes and Blue 10. An Economy That Works 11. Failures of Natural Selection 12. A Small Corner of the Universe 13. Aspects of Cancer 14. The Meaning of Life 15. The Age of Endarkenment



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Mark Jobling and Edward Hollox, both at University of Leicester, UK, Toomas Kivisild, University of Cambridge, UK, Chris Tyler-Smith and Matthew Hurles, both at Wellcome Trust Sanger Institute, UK

Now in full color, the Second Edition of Human Evolutionary Genetics has been completely revised to cover the rapid advances in the field since the publication of the highly regarded First Edition. Written for upper-level undergraduate and graduate students, it is the only textbook to integrate genetic, archaeological, and linguistic perspectives on human evolution, and to offer a genomic perspective, reflecting the shift from studies of specific regions of the genome towards comprehensive genomewide analyses of human genetic diversity.

Garland ScienceJuly 2013: 650pp: 357 illus Paperback: 978-0-8153-4148-2 : £63.99

CONTENTS: 1. An Introduction to Human Evolutionary Genetics Section I: How Do We Study Genetic Variation? 2. Organization and Inheritance of the Human Genome 3. Human Genome Variation 4. Finding and Assaying Genome Diversity Section II: How Do We Interpret Genetic Variation? 5. Processes Shaping Diversity 6. Making Inferences from Diversity Section III: Where and When Did Humans Originate? 7. Humans as Apes 8. What Genetic Changes Have Made Us Human? 9. Origins of Modern Humans Section IV: How Did Humans Colonize the World? 10. The Distribution of Diversity 11. The Colonization of the Old World And Australia 12. Agricultural Expansions 13. Into New Found Lands 14. What Happens When Populations Meet? Section V: How Is An Evolutionary Perspective Helpful? 15. Understanding the Past, Present and Future of Phenotypic Variation 16. Evolutionary Insights into Simple Genetic Diseases 17. Evolution and Complex Diseases 18. Identity and Identification

Human Evolutionary Genetics, Second Edition

“This is an absolutely superb book!”American Journal of Human Genetics

Gene Control, Second EditionDavid S. Latchman, Birkbeck, University of London, UK

The new edition of Gene Control has been updated to include significant advances in the roles of the epigenome and regulatory RNAs in gene regulation. The chapter structure remains the same: the first part consists of pairs of chapters that explain the mechanisms involved and how they regulate gene expression, and the second part deals with specific biological processes (including diseases) and how they are controlled by genes. Coverage of methodology has been strengthened by the inclusion of more explanation and diagrams.


CONTENTS:1. Level of Gene Control 2. Structure of Chromatin 3. The Epigenome: Role of Chromatin Structure in Gene Control 4. The Process of Transcription 5. Transcription Factors and Transcriptional Control 6. Post-transcriptional Processes 7. Post-transcriptional Regulation 8. Gene Control and Cellular Signaling Pathways 9. Gene Control in Embryonic Development 10. Control of Cell Type-specific Gene Expression 11. Gene Regulation and Cancer 12. Gene Regulation and Human Disease 13. Conclusion and Future Prospects




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EpigeneticsLyle Armstrong, Newcastle University, UK

Epigenetics is a new textbook that brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It is a valuable source of information about all aspects of the subject for undergraduate students, graduate students, and professionals.


"...relevant to current trends in the field of epigenetics and

includes reviews of disease states related to epigenetics,

such as cancer, which are actively being researched."

WhatIsEpigeneticsCONTENTS:1. Introduction to the Study of Epigenetics 2. The Basis of the Transcription Process 3. DNA Packaging and Chromatin Architecture 4. Modifying the Structure of Chromatin 5. DNA Methylation 6. Post-Translational Modification of Histones 7. Histone Modification Machinery 8. Locus-Specific Control of Histone-Modifying Enzyme Action 9. Epigenetic Control of Cell-Specific Gene Expression 10. Epigenetic Control of the Mitotic Cell Cycle 11. The Epigenetic Basis of Gene Imprinting 12. Epigenetic Control of Cellular Differentiation 13. Reversibility of Epigenetic Modification Patterns 14. Epigenetic Predisposition to Disease and Imprinting-Based Disorders 15. Epigenetics of Memory, Neurodegeneration, and Mental Health 16. Epigenetics of Cancer


Genetics of Complex DiseasePeter Donaldson, Newcastle University, UK, Ann Daly, Newcastle University, UK, Luca Ermini, University of Copenhagen, Denmark, Debra Bevitt, Newcastle University, UK

Genetics of Complex Disease is a concise text for advanced undergraduate and first year graduate students. Healthcare professionals and other biomedical scientists adjusting to the impact of the new genetics will also find the book useful. After explaining genetic variation and defining complex diseases, the next three chapters explain how and why complex diseases are investigated (including a chapter on statistics). The text then concentrates on selected areas where there is strong evidence for the genes/alleles involved: the MHC, infectious diseases, pharmacogenetics, cancer, and diabetes. The important ethical, social, and personal consequences raised by increasing knowledge of the genetics of complex diseases are covered in a way that offers the reader the chance to think and reflect. The final chapter discusses the technology involved.

Garland ScienceAugust 2015: 450pp: 141 illus Paperback: 978-0-8153-4491-9: £52.99CONTENTS:1. Genetic Basis of Complex Disease 2. Defining Complex Disease 3. How to Investigate Complex Disease Genetics 4. Why Investigate Complex Disease Genetics? 5. Statistical Considerations for the Planning and Analysis of Genetic Studies in Complex Disease. 6. The MHC 7. Genetics of Infectious Disease 8. Pharmacogenetics 9. Cancer as a Complex Disease: Genetic Factors Affecting Cancer Susceptibility and Cancer Treatment 10. Genetic Studies on Susceptibility to Diabetes 11. Ethical, Social and Personal Consequences 12. Sequencing Technology and the Future of Complex Disease Genetics



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GENETICS & EVOLUTIONThe Principles of EvolutionSystems, Species, and the History of Life

The Principles of Evolution is a textbook designed for upper-level undergraduate and graduate students which considers evolution in the context of systems biology. Evolution needs this systems perspective for three reasons. First, most activity in living organisms is driven by complex networks of proteins and this has direct implications, particularly for understanding evo-devo and for seeing how variation is initiated. Second, it provides the natural language for discussing phylogenetic trees. Third, evolutionary change involves events at levels ranging from the genome to the ecosystem and systems biology provides a context for integrating material of this complexity.

Jonathan Bard, University of Oxford, UK

CONTENTS: 1. Approaching Evolution 2. A Potted History of Evolutionary Thinking 3. Life Today: Species Diversity and Variation 4. A Brief History of Life 5. Darwinian Descent with Modification: Cladistics 6. The Anatomical Evidence: Vertebrate Evolution 7. From Water to Land and Back 8. The Genomic Evidence: Phylogenetics 9. From Prokaryotes to Eukaryotes 10. Evo-devo 1: Embryos 11. Evo-devo 2: Functional Homologies 12. The Origins of Anatomical Variation 13. Selection 14. Speciation 15. Human Evolution 16. Conclusions Appendices: 1. Basics of Systems Biology 2. A History of Evolutionary Thinking 3. Rocks, Dates, and Fossils 4. Evolution vs Creationism

Garland ScienceSeptember 2016: 350pp: 78 illus Hardback: 978-0-8153-4539-8: £52.00

Genome Stability DNA Repair and Recombination James E. Haber, Brandeis University, USA

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining.

Garland Science Feb 2014: 396pp: 313 illus Paperback: 978-0-8153-4485-8: £61.99

CONTENTS: 1. Restarting DNA Replication by Recombination 2. Double-strand Break Repair Pathways 3. RecA/Rad51 and the Search for Homology 4. Preparation of the RecA/Rad51 Filament 5. Single-Strand Annealing 6. Gene Conversion 7. In vivo Biochemistry: Recombination in Yeast 8. Break-induced Replication 9. Sister Chromatid Repair 10. Gene Targeting 11. Site-specific Recombination 12. Cytology and Genetics of Meiosis 13. Molecular Events During Meiotic Recombination 14. Holliday Junction Resolvases and Crossing-over 15. Nonhomologous End-joining 16. DNA Damage Checkpoints and Genome Instability Appendix Evolution of Models of Homologous Recombination



16

GENETICS & EVOLUTIONHuman Molecular Genetics, Fourth EditionTom Strachan, Newcastle University, UK, and Andrew Read, University of Manchester, UK

Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics.

Garland ScienceApril 2010: 781pp: 610 illusPaperback: 978-0-8153-4149-9: £59.00

"This book is an excellent companion for

students in human genetics or for researchers

that want to gain background and knowledge

in this field."Nature

CONTENTS: 1. Nucleic Acid Structure and Gene Expression 2. Chromosome Structure and Function 3. Genes in Pedigrees and Populations 4. Cells and Cell-Cell Communication 5. Principles of Development 6. Amplifying DNA: Cell-based DNA Cloning and PCR 7. Nucleic Acid Hybridization: Principles and Applications 8. Analyzing the Structure and Expression of Genes and Genomes 9. Organization of the Human Genome 10. Model Organisms, Comparative Genomics and Evolution 11. Human Gene Expression 12. Studying Gene Function in the Post-Genome Era 13. Human Genetic Variability and its Consequences 14. Genetic Mapping of Mendelian Characters 15. Mapping Genes Conferring Susceptibility to Complex Disease 16. Identifying Human Disease Genes and Susceptibility Factors 17. Cancer Genetics 18. Genetic Testing of Individuals 19. Pharmacogenetics, Personalized Medicine, and Population Screening 20. Genetic Manipulation of Animals for Modeling Disease and Investigating Gene Function 21. Genetic Approaches to Treating Disease

Introducing Genetics, Second EditionAlison Thomas, Anglia Ruskin University, UK

The new edition of Introducing Genetics is a clear, concise, and accessible guide to inheritance and variation in individuals and populations. It first establishes the principles of Mendelian inheritance and the nature of chromosomes, before tackling quantitative and population genetics. The final three chapters introduce the molecular mechanisms that underlie genetics, including the techniques responsible for the current genetic revolution.


CONTENTS: 1. Introduction 2. Monohybrid Inheritance 3. Extensions to Monohybrid Inheritance 4. Dihybrid Inheritance 5. The Chromosomal Basis of Inheritance 6. Sex Determination and Sex Linkage 7. Linkage and Chromosome Mapping 8. Variation in Chromosomal Number and Structure 9. The Principles of Quantitative Genetics 10. An Introduction to Population Genetics 11. Heredity at the Molecular Level 12. From Genes to Proteins 13. Manipulating DNA



17


Genetics and Genomics in MedicineTom Strachan, Judith Goodship, Patrick Chinnery, all at Newcastle University, UK

Genetics and Genomics in Medicine is a new textbook written for undergraduate students, graduate students, and medical researchers that explains the science behind the uses of genetics and genomics in medicine today. Rather than focusing narrowly on rare inherited and chromosomal disorders, it is a comprehensive and integrated account of how genetics and genomics affect the whole spectrum of human health and disease.


CONTENTS: 1. Fundamentals of DNA, Chromosomes, and Cells 2. Fundamentals of Gene Structure, Gene Expression, and Human Genome Organization 3. Principles Underlying Core DNA Technologies 4. Principles of Genetic Variation 5. Single-gene Disorders: Inheritance Patterns, Phenotype Variability, and Allele Frequencies 6. Principles of Gene Regulation and Epigenetics 7. Genetic Variation Producing Disease-Causing Abnormalities in DNA and Chromosomes 8. Identifying Disease Genes and Genetic Susceptibility to Complex Disease 9. Genetic Approaches to Treating Disease 10. Cancer Genetics and Genomics 11. Genetic Testing From Genes to Genomes, and the Ethics of Genetic Testing and Therapy

Introduction to Genetics A Molecular Approach

The theme of Introduction to Genetics is the progression from molecules (DNA and genes) to processes (gene expression and DNA replication) to systems (cells, organ-isms, and populations). This progression reflects both the basic logic of life and the way in which modern biological research is structured.

Terry A. Brown, University of Manchester, UK

"The progression from molecules through

processes to systems makes eminenet sense to a

clear visual style similar to the one used for Genomes 3 should make this an attractive

proposition for adoption."Adrian Hall

Sheffield Hallam University, UK

Garland ScienceAugust 2011: 554pp: 656 illusPaperback: 978-0-8153-6509-9: £59.00

CONTENTS:PART 1 - GENES AS UNITS OF BIOLOGICAL INFORMATION 1. The Scope of Modern Genetics 2. DNA 3. Genes 4. Transcription of DNA to RNA 5. Types of RNA Molecule: Messenger RNA 6. Types of RNA Molecule: Noncoding RNA 7. The Genetic Code 8. Protein Synthesis 9. Control of Gene Expression PART 2 - GENES AS UNITS OF INHERITANCE 10. DNA Replication 11. Inheritance of Genes During Eukaryotic Cell Division 12. Inheritance of Genes in Bacteria 13. Inheritance of Genes During Virus Infection Cycles 14. Inheritance of DNA Molecules During Eukaryotic Sexual Reproduction 15. Inheritance of Genes During Eukaryotic Sexual Reproduction 16. Mutation and DNA repair 17. Inheritance of genes in Populations PART 3 - GENETICS IN OUR MODERN WORLD 18. Genes in Differentiation and Development 19. The Human Genome 20. Genes and Medicine 21. DNA in Forensics and Studies of Human History 22. Genes in Industry and Agriculture 23. The Ethical Issues Raised by Modern Genetics



18

GENETICS & EVOLUTIONGenetic Association StudiesA Practical Guide to Basic Genetic Epidemiology

Garland ScienceOctober 2016: 250pp: 75 illus Paperback: 978-0-8153-4463-6: £52.00

Genetic Association Studies will demystify the key concepts of genetic epidemiology for geneticists, medical residents, clinical researchers, and public health professionals. The focus is on genetic association studies, but taking genetic association in its broadest sense to include SNPs, copy number variations, and epigenetic changes. The role of the environment in genetic epidemiology will also be highlighted. Genetic Association Studies emphasizes practical applications rather than theoretical background and will enable readers to understand and critique genetic association studies and setting them on the way to designing, executing, analyzing, interpreting, and reporting their own.

Tefik Dorak, Florida International University, USA

CONTENTS:1. Primer on Molecular Genetics 2. Basic Medical Genetics 3. Primer on Population Genetics 4. Epidemiologic Principles of Association Studies 5. Environmental Epidemiology in the Context of Genetic Epidemiology 6. Elementary Statistical Concepts 7. Genotyping 8. Candidate Gene Studies and GWAS 9. Analysis of Genetic Association Study Results 10. Bioinformatics 11. Genetic Risk Profiling and Medical Applications of Genetic Associations

PhylogenomicsA PrimerRob DeSalle and Jeffrey Rosenfeld, both at American Museum of Natural History, USA

Phylogenomics introduces undergraduate and graduate students to the field of phylogenomics, the discipline that integrates evolutionary biology and genomics. The book presents an overview of the interlinking aspects of molecular biology, systematics, and bioinformatics; describes phylogenomic techniques such as PCR, CLUSTAL, and neighbor joining; and provides guidelines for navigating relevant databases such as GenBank, BLAST, and EDGAR.

Garland ScienceFeb 2013: 352pp: 160 illusPaperback: 978-0-8153-4211-3: £49.00

CONTENTS:1. Why Phylogenomics Matters 2. The Biology of Linear Molecules: DNA and Proteins 3. Evolutionary Principles – Populations and Trees 4. Databases 5. Homology and Pairwise Alignment 6. Multiple Alignments and Constructing Phylogenomic Matrices 7. Genome Sequencing and Annotation 8. Tree Building 9. Robustness and Rate Heterogeneity in Phylogenomics 10. Bayesian Analysis 11. Incongruence 12. Adapting Population Genetics to Genomics 13. Detecting Natural Selection in Genomes 14. Refining the Approach to Natural Selection at the Molecular Level 15. Genome-Level Analysis of Population Genetics 16. Genome Content Analysis 17. A Phylogenomic Perspective of Biological Diversity: Tree of Life, DNA Barcoding and Metagenomics 18. Microarrays in Evolutionary Studies and Functional Phylogenomics



19

ParasitologyA Conceptual ApproachEric S. Loker and Bruce V. Hofkin, both at University of New Mexico, USA

Parasitology: A Conceptual Approach focuses on the conceptual basis of parasitology, with the goal of providing students with an expanded view of parasites and their biology. Concentrating on concepts will enable readers to gain a broader perspective that will increase their ability to think critically about all kinds of parasitic associations. Studying individual parasites is an essential part of parasitology so Parasitology: A Conceptual Approach contains an appendix (the Rogues' Gallery) which provides a concise overview of the biology of important human and veterinary parasites.


CONTENTS:1. An Introduction to Parasitism 2. An Overview of Parasite Diversity 3. The Parasite’s Way of Life 4. Host Defense and Parasite Evasion 5. Parasite vs. Host: Pathology and Disease 6. The Ecology of Parasitism 7. The Evolutionary Biology of Parasitism 8. Parasites and Conservation Biology 9. The Challenge of Parasite Control 10. The Future of Parasitology ROGUES' GALLERY: Protozoa • Platyhelminths • Nematodes • Arthopods

“I shall recommend this book for anyone dealing with any aspect of parasitology. It is a rich source of updated

information on emerging issues in parasitology, including parasite-host interactions, parasite ecology and evolution.

I will certainly put my hardcopy in my bookshelf “must have books on parasitology.”

Parasites and Vectors

MICROBIOLOGY

Viruses Biology, Applications, and ControlDavid R. Harper, Biocontrol Limited, UK

Viruses: Biology, Applications, and Control is a concise, advanced undergraduate and graduate textbook covering the essential aspects of virology included in biomedicalscience courses. It is an updated and expanded version of David Harper’sMolecular Virology, Second Edition.

"...a good text for an advanced undergraduate

course in virology."

Doody's ReviewGarland ScienceJuly 2011: 346pp: 220 illusPaperback: 978-0-8153-4150-5: £57.00

CONTENTS:1. Virus Structure and Infection 2. Virus Classification and Evolution 3. Virus Replication 4. Immune Response and Evasion 5. Vaccines and Immunotherapy 6. Antiviral Drugs 7. Beneficial Use of Viruses 8. Emergence and Extinction of Viruses 9. Virus Culture, Detection and Diagnosis



20

MICROBIOLOGY

Bruce V. Hofkin, University of New Mexico, USA

As with the first edition, this new edition of Living In A Microbial World is written for students taking a general microbiology course, or a microbiology-based course for non-science majors. The conversational style and use of practical, everyday examples make the essential concepts of microbiology accessible to a wide audience. While using this approach, the text maintains scientific rigour with clear explanations spanning the breadth of microbiology, including health, evolution, ecology, food production, biotechnology, and industrial processes.

Each chapter contains a series of case studies based on microbiology in the news, in history, and in literature. There are questions at the end of each case study and the end of each chapter, as well as an online quiz with help on answering the questions. The text, questions, and

cases have been updated to reflect the changing influence of microbiology in the world today, from the microbiome, to new disease outbreaks (Ebola and Zika) and antibiotic resistance, to new biotechnology tools (CRISPR-Cas).

Garland ScienceMarch 2017: 450pp: 428 illus Paperback: 978-0-8153-4514-5: £99.00

CONTENTS:1. Living in a Microbial World 2. The Chemistry of Life 3. The Cell: Where Life Begins 4. A Field Guide to the Microorganisms 5. Life’s Grey Zone: Viruses and Prions 6. The Microbiology of History and the History of Microbiology 7. Microbial Genetics 8. Metabolism and Growth 9. Microbial Evolution: The Origin and Diversity of Life 10. A Microbiologist’s Guide to Ecology 11. The Nature of the Disease: A Pathogen’s Perspective 12. The Nature of Disease (part 2): Host Defense 13. Control of Microbial Growth 14. Epidemiology: Who, What, When, Where, and Why? 15. The Future Is Here: Microorganisms and Biotechnology 16. Guess Who’s Coming to Dinner: Microorganisms and Food 17. Better Living with Microorganisms: Industrial and Applied Microbiology

Living in a Microbial World, Second EditionNEW EDITION

NEW TO THE SECOND EDITION:

Images available in PowerPoint and JPEG Online quiz with answers and feedback provided through the Garland Science Learning System Extra modules provided through the Garland Science Learning System Help answering the end-of-chapter questions Online glossary Flashcards


21

MICROBIOLOGYMicrobiology, Second EditionA Clinical ApproachAnthony Strelkauskas, formerly of Trident Technical College, South Carolina, USA, Angela Edwards, Trident Technical College, South Carolina, USA, Beatrix Fahnert, Cardiff University, UK, Greg Pryor, Francis Marion University, USA, Jennifer Strelkauskas, Doctor of Veterinary Medicine, Oregon, USA

As with the successful First Edition, the new edition of Microbiology: A Clinical Approach is written specifically for pre-nursing and allied health students. It is clinically-relevant throughout and uses the theme of infection as its foundation. Microbiology is student-friendly: its text, figures, and electronic resources have been carefully designed to help students understand difficult concepts and keep them interested in the material. The textbook is supported by the Garland Science Learning System, with a robust ancillary package for instructors which will easily allow them to incorporate the book’s new approach into their lectures. Students working towards careers in the healthcare professions will achieve success with Microbiology: A Clinical Approach.

Garland ScienceAugust 2015: 662pp: 632 illus Paperback: 978-0-8153-4513-8: £62.99

CONTENTS: PART I FOUNDATIONS 1. What Is Microbiology and Why Does It Matter? 2. Fundamental Chemistry for Microbiology 3. Essentials of Metabolism 4. An Introduction to Cell Structure and Host–Pathogen Relationships PART II DISEASE MECHANISMS 5. Requirements for Infection 6. Transmission of Infection, the Compromised Host, Epidemiology, and Diagnosing Infections 7. Principles of Disease 8. Emerging and Re-Emerging Infectious Diseases PART III CHARACTERISTICS OF DISEASE-CAUSING MICROORGANISMS 9. The Clinical Significance of Bacterial Anatomy 10. Bacterial Growth 11. Microbial Genetics and Infectious Disease 12. The Structure and Infection Cycle of Viruses 13. Viral Pathogenesis 14. Parasitic and Fungal Infections PART IV HOST DEFENSE 15. The Innate Immune Response 16. The Adaptive Immune Response 17. Failures of the Immune Response PART V CONTROL AND TREATMENT 18. Control of Microbial Growth with Disinfectants and Antiseptics 19. Antibiotics and Antimicrobial Drugs 20. Antibiotic Resistance PART VI MICROBIAL INFECTIONS 21. Infections of the Respiratory System 22. Infections of the Digestive System 23. Infections of the Genitourinary System 24. Infections of the Central Nervous System 25. Infections of the Blood 26. Infections of the Skin and Eyes

“…it makes a real and tangible effort to put students, or better, the learning process,

center stage”British Society for Immunology


22

IMMUNOLOGYJaneway’s Immunobiology, Ninth Edition

Garland ScienceMarch 2016: 900pp: 624 illus Paperback: 978-0-8153-4551-0 : £60.00

Kenneth Murphy, Washington University School of Medicine, USA, Casey Weaver, University of Alabama Medical School, Birmingham, USA

Janeway’s Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, all students will appreciate the book’s clear writing and informative illustrations, and advanced students and working immunologists will appreciate its comprehensive scope and depth. Janeway’s Immunobiology presents immunology from a consistent point of view throughout—that of the host’s interaction with an environment full of microbes and pathogens. The Ninth Edition has been thoroughly revised bringing the content up-to-date with significant developments in the field, especially on the topic of innate immunity, and improving the presentation of topics across chapters for better continuity.

NEW IN THE NINTH EDITION

• Now organized around the concept of modular immune responses, combining innate and adaptive immunity into effector modules and explaining the integration of the innate and adaptive immune response.

• Updated with the latest developments on innate lymphoid cells and innate sensing mechanisms, including cycling GMP-SMP synthase (cGAS) and activation of the STING pathway.

• Incorporates the new mechanisms of class switch recombination involving RNA guides for AID.• Includes an expanded, updated coverage of CD4 T cell subsets, including an in-depth handling of

follicular helper T cells and their role in B cell class switching and affinity maturation.• Improved coverage of chemokine networks and their role in coordinating immunity.• Includes new content on cytoskeletal reorganization and integrin activation in antigen receptor

signaling and expanded coverage on Akt and mTOR signaling. • Revised and updated sections on mechanisms of immune evasion by pathogens and HIV/AIDS.• Updated and more detailed consideration of mechanisms of immune-mediated disease. • Expanded coverage of cancer immunotherapy, including chimeric antigen receptor T cell (CAR T cell)

therapy.• Comprehensive update to Appendix I: The Immunologist’s Toolbox, with the addition of many new

techniques, including mass spectrometry, in vivo administration of antibodies, RNAi, and the CRISPR/Cas9 system.

• Illustration program has been thoroughly updated with over 100 new figures and improved with newer and better images of protein structures and micrographs.

• Completely updated end-of-chapter questions, in a variety of types, that review each chapter’s concepts.

• New Question Bank written by Leslie Berg (University of Massachusetts Medical School) provides a comprehensive collection of questions that require the student to reflect upon and synthesize concepts in each chapter and can be used by instructors for the creation of exams.


23

IMMUNOLOGY

Case Studies in Immunology, Seventh EditionA Clinical CompanionRaif Geha, Harvard Medical School, USA, Luigi Notarangelo, National Institute of Health Bethesda, MD

Garland ScienceMarch 2016: 358pp: 255 illus Paperback: 978-0-8153-4512-1: £42.99

CONTENTS:Part I: An Introduction to Immunobiology and Innate Immunity 1. Basic Concepts in Immunology 2. Innate Immunity: The First Lines of Defense 3. The Induced Responses of Innate Immunity Part II: The Recognition of Antigen 4. Antigen Recognition by B-cell and T-cell Receptors 5. The Generation of Lymphocyte Antigen Receptors 6. Antigen Presentation to T Lymphocytes Part III: The Development of Mature Lymphocyte Receptor Repertoires 7. Lymphocyte Receptor Signaling 8. The Development of B and T Lymphocytes Part IV: The Adaptive Immune Response 9. T Cell-Mediated Immunity 10. The Humoral Immune Response 11. Integrated Dynamics of Innate and Adaptive Immunity 12. The Mucosal Immune System Part V: The Immune System in Health and Disease 13. Failures of Host Defense Mechanisms 14. Allergy and Allergic Diseases 15. Autoimmunity and Transplantation 16. Manipulation of the Immune Response

Case Studies in Immunology highlights major common disorders of immunity, including genetic disorders of the immune system, immune-complex diseases, immune-mediated hypersensitivity reactions, and autoimmune and alloimmune diseases.

1. X-linked Agammaglobulinemia 2. CD40 Ligand Deficiency 3. Activation-Induced Cytidine Deaminase Deficiency 4. Common Variable Immunodeficiency 5. X-linked Severe Combined Immunodeficiency 6. Adenosine Deaminase Deficiency 7. Omenn Syndrome 8. MHC Class II Deficiency 9. DiGeorge Syndrome 10. Acquired Immune Deficiency Syndrome (AIDS) 11. Graft-Versus-Host Disease 12. MHC Class I Deficiency 13. X-linked Lymphoproliferative Syndrome 14. Hemophagocytic Lymphohistiocytosis 15. Chediak–Higashi Syndrome 16. Wiskott-Aldrich Syndrome 17. Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED) 18. Immune Dysregulation, Polyendocrinopathy, Enteropathy X-linked Disease 19. Autoimmune Lymphoproliferative Syndrome (ALPS) 20. Hyper IgE Syndrome/STAT3 21. Ataxia Telangiectasia 22. Warts, Hypogammaglobulinemia, Infections, and Myelokathexis Syndrome (WHIM Syndrome) 23. X-linked Hypohidrotic Ectodermal Dysplasia and Immunodeficiency 24. Interferon-γ Receptor Deficiency 25. Severe Congenital Neutropenia 26. Chronic Granulomatous Disease 27. Leukocyte Adhesion Deficiency 28. Recurrent Herpes Simplex Encephalitis 29. Interleukin 1 Receptor-Associated Kinase 4 Deficiency 30. Congenital Asplenia 31. Hereditary Angioedema 32. Deficiency of the C8 Complement Component 33. Hereditary Periodic Fever Syndromes 34. Systemic-Onset Juvenile Idiopathic Arthritis 35. Rheumatoid Arthritis 36. Systemic Lupus Erythematosus 37. Systemic Lupus Erythematosus 38. Multiple Sclerosis 39. Autoimmune Hemolytic Anemia 40. Myasthenia Gravis 41. Pemphigus Vulgaris 42. Pemphigus Vulgaris 43. Acute Infectious

Mononucleosis 44. Hemolytic Disease of the Newborn 45. Toxic Shock Syndrome 46. Lepromatous Leprosy 47. Allergic Asthma 48. Drug-induced Serum Sickness 49. Contact Sensitivity to Poison Ivy 50. Dock 8 Deficiency 51. PI3K Delta Mutations 52. Increased Susceptibility to Candida Infections53. LRBA Deficiency 54. T-Cell Signaling Defects 55. Channellopathies

CONTENTS:


24

IMMUNOLOGY

The Immune System, Fourth EditionPeter Parham, Stanford University, USA

The Immune System, Fourth Edition emphasizes the human immune system and presents immunological concepts in a coherent, concise, and contemporary account of how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the book accessible and easily understandable to students. The Immune System is additionally supported by the Garland Science Learning System.

Garland ScienceOctober 2014: 532pp: 548 illus Paperback: 978-0-8153-4527-5 : £55.99

CONTENTS:1. Elements of the Immune System and their Roles in Defense 2. Innate Immunity: The Immediate Response to Infection 3. Innate Immunity: The Induced Response to Infection 4. Antibody Structure and the Generation of B-Cell Diversity 5. Antigen Recognition by T Lymphocytes 6. The Development of B Lymphocytes 7. The Development of T Lymphocytes 8. T Cell-Mediated Immunity 9. Immunity Mediated by B Cells and Antibodies 10. Preventing Infection at Mucosal Surfaces 11. Immunological Memory and Vaccination 12. Coevolution of Innate and Adaptive Immunity 13. Failures of the Body’s Defenses 14. IgE-Mediated Immunity and Allergy 15. Transplantation of Tissues and Organs 16. Disruption of Healthy Tissue by the Immune Response 17. Cancer and Its Interactions with the Immune System

NEW IN THE FOURTH EDITION:• Increased coverage of innate immunity,

now in two chapters.• New chapter dedicated to mucosal

immunology.• Immunological memory and vaccination

combined in Chapter 11, including new approaches to vaccination.

• Chapter 12 is dedicated to lymphocytes that contribute to innate and adaptive immunity.

• Parasite immunology is covered for the first time, integrated with allergy in Chapter 14.

• Appreciation of the active interaction between the immune system and commensal organisms involving co-development and co-evolution.

• New marginal icons indicate topics which correlate to Case Studies in Immunologyby Geha and Notarangelo.

• The Question Bank has been greatly revised and greatly expanded.

“...Appealing and relevant for those students who approach the study of the immune system through a clinical lens, including

students of medicine and pharmacology…it would also be appropriate in an

introductory immunology course.” Clinical Immunology

“The overall structure of the book is well thought out and follows a logical path from

basic principles to clinical applications. Written in a good, clear, easily flowing style,

it has the right balance between text and illustrations. It also contains just the right amount of clinical and laboratory science to keep it all real and interesting, and this will mean that it will appeal to the broad

spectrum of students currently enrolled in immunology classes.”

Immunology News


25

IMMUNOLOGY

Immunology: An Illustrated Outline, Fifth Edition

Immunology: An Illustrated Outline is both a review guide to the essential principles of immunology and a concise dictionary of immunological terms. It can be used as a review tool in preparation for course exams and medical licensing exams, or as a refresher when this content is encountered in related life science areas, such as microbiology and virology. The book also enables readers to look up specific terms in the index and locate the definitions, making it a powerful reference for interns, residents, and physicians in clinical practice.

Garland ScienceJuly 2013: 146ppPaperback: 978-0-8153-4501-5: £18.00

CONTENTS:1. The Immune System 2. Immune Recognition 3. Immune Responses 4. Immunopathology5. Immunological Techniques

David Male, The Open University, UK

Case Studies in Allergic DisordersHans Oettgen and Raif Geha, both at Harvard Medical School, USA

Case Studies in Allergic Disorders describes the basic cellular and molecular mechanisms involved in the pathogenesis of commonly occurring allergic diseases and introduces the rationale for targeted intervention in these mechanisms in the treatment of allergy. It is intended for medical students and undergraduate and graduate students in immunology as well as residents in internal medicine and pediatrics.

Garland ScienceJan 2013: 176pp: 100 illusPaperback: 978-0-8153-4436-0: £35.00

Case Studies in Infectious DiseasePeter Lydyard, Royal Free and University College Medical School, UK, Michael Cole, Georgetown University Medical Center, USA, John Holton, Royal Free and University College Medical School, UK, Will Irving, University of Nottingham, UK, Nino Porakishvili, University of Westminster, UK, Pradhib Venkatesan, Nottingham University Hospital, UK, and Kate Ward, Royal Free and University College Medical School, UK

Case Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine, this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis and treatment.

Garland ScienceMay 2009: 608pp: 270 illusPaperback: 978-0-8153-4142-0: £41.00




26

IMMUNOLOGY

Case Studies in Veterinary ImmunologyLaurel Gershwin, University California Davis, USA

Case Studies in Veterinary Immunology presents basic immunologicalconcepts in the context of actual cases seen in clinics. It is intended forveterinary medicine students, interns, residents, and veterinarians, and serves as a valuable supplement and companion to a variety of core immunology textbooks and courses. The book includes cases describing primary immune system defects, secondary immune system defects, and hypersensitivity and autoimmune disorders, as well as dysproteinemias and lymphoid neoplasia. Drawing on the successful approach of Geha’s Case Studies in Immunology, each representative case is preceded by a discussion of the principles underly-ing that specific immunological mechanism.


CONTENTS:1. Primary Ciliary Dyskinesia—Canine 2. Leukocyte Adhesion Deficiency—Bovine 3. Cyclic Neutropenia—Canine 4. Chediak-Higashi Syndrome—Feline 5. Severe Combined Immunodeficiency—Equine 6. Selective IgA Deficiency—Canine 7. Failure of Passive Transfer—Equine 8. Feline Leukemia Virus—Feline 9. Feline Immunodeficiency Virus—Feline 10. Bovine Viral Diarrhea Infection—Bovine 11. Mrak’s Disease—Avian 12. Infectious Bursal Disease—Avian 13. Bovine Respiratory Disease Complex—Bovine14. Allergic Asthma—Feline 15. Atopic Dermatitis—Canine 16. Culicoides Hypersensitivity—Equine 17. Systemic Anaphylaxis—Equine 18. Neonatal Isoerythrolysis—Equine 19. Immune Mediated Hemolytic Anemia—Canine 20. Evan’s Syndrome—Equine 21. Pemphigus Foleaceus—Canine 22. Acquired Myasthenia Gravis—Canine 23. Systemic Lupus Erythematosus—Canine 24. Purpura Hemorrhagica—Equine 25. Contact Dermatitis—Canine 26. Autoimmune Thryoiditis—Canine 27. Recurrent Airway Obstruction—Equine 28. Flea Allergy Dermatitis—Canine 29. Multiple Myeloma—Canine 30. Feline Infectious Peritonitis—Feline 31. Monocytic Ehrlichiosis—Canine Appendix I: Vaccines and Vaccination Schedules Appendix II: The Clinical Immunology Laboratory

NEW

Principles of Mucosal ImmunologySociety for Mucosal Immunology. Edited by Phillip D. Smith, University of Alabama Medical School Birmingham, USA, Thomas T. MacDonald, Barts and the London School of Medicine and Dentistry, UK, and Richard S. Blumberg, Harvard Medical School, USA

Principles of Mucosal Immunology is for graduate students, postdoctoral fellows and investigators in immunology and microbiology, and medical and dental students. Thirty-two chapters contained in seven sections present the basic and clinical aspects of the mucosal immune system, focusing on the major components of the mucosal barrier—the gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems.


CONTENTS:Part I. Development and Structure of Mucosal Tissue Part II. Cellular Constituents of Mucosal Immune Systems and Their Function in Mucosal Homeostasis Part III. Microbial Commensalism Part IV. Genitourinary Tract Part V. Nose, Airways, Oral Cavity, and Eyes Part VI. Infectious Diseases of Mucosal Surfaces Part VII. Specific Immune-mediated Diseases of Mucosal Surfaces



27

STRUCTURAL BIOLOGY

The Molecules of LifePhysical and Chemical PrinciplesJohn Kuriyan, University of California, Berkeley, USA, Boyana Konforti, Simons Foundation, USA, and David Wemmer, University of California, Berkeley, USA

The Molecules of Life is a textbook that provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. The book integrates fundamental concepts in thermodynamics and kinetics with an introduction to biological mechanism at the level of molecular structure.

Garland ScienceAugust 2012: 1032pp: 900 illusPaperback: 978-0-8153-4188-8: £60.00

"With its quantitative approach and step-by-step derivations of key equations, this book

prepares students in biology and health sciences well for the increasingly quantitative

approaches in biology."Quarterly Review of Biology

"The Molecules of Life certainly provides a fine reference book

for those trying to keep up with the vast amount of new

information becoming available in this important area of

biological science."The Biologist

CONTENTS:Part I. Biological Molecules 1. From Genes to RNA and Proteins 2. Nucleic Acid Structure 3. Glycans and Lipids 4. Protein Structure 5. Evolutionary Variation in Proteins Part II. Energy and Entropy 6. Energy and Intermolecular Forces 7. Entropy 8. Linking Energy and Entropy: The Boltzmann Distribution Part III. Free Energy 9. Free Energy 10. Chemical Potential and the Drive to Equilibrium 11. Voltages and Free Energy Part IV. Molecular Interactions 12. Molecular Recognition: The Thermodynamics of Binding13. Specificity of Macromolecular Recognition 14. Allostery Part V. Kinetics and Catalysis 15. The Rates of Molecular Processes 16. Principles of Enzyme Catalysis 17. Diffusion and Transport Part VI. Assembly and Activity 18. Folding 19. Fidelity in DNA and Protein Synthesis

Principles of Proteomics, Second EditionRichard M. Twyman, WriteScience, UK

Principles of Proteomics, Second Edition provides a concise and user-friendly introduction to the diverse technologies used for the large-scale analysis of proteins, as well as their applications, and their impact in areas such as drug discovery, agriculture, and the fight against disease. Principles of Proteomics has been fully updated to reflect the most recent developments in the field without losing its focus on the underlying principles.


CONTENTS:1. The Origin and Scope of Proteomics 2. Strategies for Protein Separation 3. Strategies for Protein Identification 4. Strategies for Protein Quantitation 5. The Analysis of Protein Sequences 6. The Analysis of Protein Structures 7. Interaction Proteomics 8. Protein Modification in Proteomics 9. Protein Microarrays 10. Applications of Proteomics



28

STRUCTURAL BIOLOGYHow Proteins WorkMike Williamson, University of Sheffield, UK

How Proteins Work is an up-to-date and authoritative account of protein function in living systems, explained within the governing parameters of physics, chemistry, and evolution. It will enable advanced undergraduate students in biochemistry and biophysics to understand the relationships among protein function, structure, and dynamics and will also serve as a valuable resource for graduate students and researchers.

Garland ScienceJuly 2011: 464pp: 537 illusPaperback: 978-0-8153-4446-9: £59.00

"...very good coverage of domain structure and the assembly of proteins from basic functional units, and an

excellent discussions of the evolution of proteins..."Choice

CONTENTS:1. Protein Structure and Evolution 2. Protein Domains 3. Oligomers 4. Protein Interactions in Vivo 5. How Enzymes Work 6. Protein Flexibility and Dynamics 7. How Proteins Make Things Move 8. How Proteins Transmit Signals 9. Protein Complexes: Molecular Machines 10. Multi-Enzyme Complexes 11. Techniques for Studying Proteins

Introduction to Protein Structure, Second EditionCarl Branden (deceased), and John Tooze, Cancer Research, UK

Introduction to Protein Structure provides an account of the principles of protein structure, with examples of key proteins in their biological context generously illustrated in full-color to illuminate the structural principles described in the text.

Garland ScienceDecember 1998: 410ppPaperback: 978-0-8153-2305-1: £58.00

CONTENTS:PART 1 BASIC STRUCTURAL PRINCIPLES 1. The Building Blocks 2. Motifs of Protein Structure 3. Alpha-Domain Structures 4. Alpha/Beta Structures 5. Beta Structures 6. Folding and Flexibility 7. DNA Structures PART 2 STRUCTURE, FUNCTION AND ENGINEERING 8. DNA Recognition in Procaryotes by Helix-Turn-Helix Motifs 9. DNA Recognition by Eukaryotic Transcription Factors 10. Specific Transcription Factors Belong to a Few Families 11. An Example of Enzyme Catalysis: Serine Proteinases 12. Membrane Proteins 13. Signal Transduction 14. Fibrous Proteins 15. Recognition of Foreign Molecules by the Immune System 16. The Structure of Spherical Viruses 17. Prediction, Engineering, and Design of Protein Structures 18. Determination of Protein Structures

"The strength of the book lies in its beautiful art work and its logical dissection of the baffling

complexities of protein structures…admirably concise,

lucid and accurate presentations of difficult concepts…invaluable

for students."Nature

http://www.garlandscience.com/product/isbn/?utm_source=shared_link&utm_medium=post&utm_campaign=170302090

http://http://www.garlandscience.com/product/isbn/9780815344469?utm_source=shared_link&utm_medium=post&utm_campaign=170302090


29

STRUCTURAL BIOLOGYBiomolecular CrystallographyPrinciples, Practice, and Application to Structural BiologyBernhard Rupp, q.e.d. life science discoveries, California, USA

Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Deftly illustrated in full color, the text describes mathematical and physical concepts in accessible and accurate language.

Garland ScienceNovember 2009: 800pp: 448 illusHardback: 978-0-8153-4081-2: £79.00CONTENTS:I: FROM SEQUENCE TO CRYSTALS 1. Introduction: Preparing Your Study 2. Protein Structure 3. Protein Crystallization 4. Proteins for Crystallography II: FUNDAMENTALS OF PROTEIN CRYSTALLOGRAPHY 5. Crystal Geometry 6. Diffraction Basics 7. Statistics and Probability in Crystallography III: FROM CRYSTALS TO DATA 8. Instrumentation and Data Collection IV: DETERMINING YOUR STRUCTURE 9. Reconstruction of Electron Density and the Phase Problem 10. Experimental Phasing 11. Non-Crystallographic Symmetry and Molecular Replacement 12. Model Building and Refinement V: MAKING SENSE OF YOUR STRUCTURE 13. Structure Validation, Analysis, and Presentation

"This book will be an essential part of the library

of any department that claims to make

contributions to modern biology."

Tom Blundell, Journal of Applied

Crystallography

ProteinsConcepts in Biochemistry

Proteins: Concepts in Biochemistry teaches the biochemical concepts underlying protein structure, evolution, stability and folding, and explains how interactions in macromolecular structures determine protein function. Intended for a one-semester course in biochemistry or biophysical chemistry with a focus on proteins, this textbook emphasizes the logic underlying biophysical chemical principles.Problems throughout the book encourage statistical and quantitative thinking. The text is ideal for senior undergraduates, first year graduate students, and practitioners in chemistry, biochemistry, biology, and biophysics.

Paulo Almeida, University of North Carolina Wilmington, USA

CONTENTS :1. Statistical Thermodynamics of Biological Molecules 2. Protein Structure 3. Evolution of Protein Sequence and Structure 4. Protein Stability 5. Protein Folding 6. Binding, Allostery, and Cooperativity 7. Enzyme Kinetics Appendix A. Calculation of the Excess Heat Capacity Curve of Protein Thermal Denaturation Appendix B. Calculation of the Average Helicity from the Partition Function Appendix C. Solution of Rate Equations for Two-State System




30

BIOPHYSICS

CONTENTS: 1. Proteins are Polymers that Fold into Specific Structures 2. Proteins Perform Cellular Functions 3. Proteins Have Stable Equilibrium Conformations 4. Protein Binding Leads to Biological Actions5. Folding and Aggregation are Cooperative Transitions 6. The Principles of Protein Folding Kinetics 7. Proteins Evolve 8. Bioinformatics: Insights from Protein Sequences 9. Protein Geometries and Energetics 10. Molecular Simulations and Conformational Sampling 11. Predicting Protein Structures from Sequences 12. Biological Actions Arise from Protein Motions 13. Molecular Modeling for Drug Discovery

Garland ScienceMarch 2017: 336pp: 251illus Hardback: 978-0-8153-4177-2: £60.00

Protein Actions: Principles and Modeling is aimed at researchers involved in biophysical studies of proteins and graduate students taking courses in protein biophysics. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers.

The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques,

the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.

NEWProtein Actions: Principles and ModelingIvet Bahar, University of Pittsburgh, USA, Robert Jernigan, Iowa State University, USA, Ken Dill, Stony Brook University, USA


31

BIOPHYSICS

Physical Biology of the Cell, Second EditionRob Phillips, California Institute of Technology, USA, Jane Kondev, Brandeis University, USA, Julie Theriot, Stanford University, USA, and Hernan Garcia, University of California, Berkeley, USA

Physical Biology of the Cell takes key cell biology experiments through a quantitative treatment to demonstrate how models can help refine our understanding and prediction of biological phenomena. Updated for the latest developments and now in full color, the Second Edition includes two new chapters on photosynthesis and pattern formation.

Garland ScienceNovember 2012: 1,057pp: 742 illusPaperback: 978-0-8153-4450-6: £69.00

Physical Biology of the Cell, Second Edition won Best

Undergraduate Textbook at the Society of Biology 2013 Book

Awards.

CONTENTS: Part I: The Facts of Life 1. Why: Biology by the Numbers 2. What and Where 3. When: Stopwatches at Many Scales 4. Who: “Bless the Little Beasties” Part II: Life at Rest 5. Mechanical and Chemical Equilibrium 6. Entropy Rules! 7. Two-State Systems 8. Random Walks and the Structure of Macromolecules 9. Electrostatics for Salty Solutions 10. Beam Theory 11. Biological Membranes Part III: Life in Motion 12. The Mathematics of Water 13. A Statistical View of Biological Dynamics 14. Crowded and Disordered Environments 15. Rate Equations and Dynamics in the Cell 16. Dynamics of Molecular Motors 17. Biological Electricity 18. Light and Life Part IV: The Meaning of Life 19. Organization of Biological Networks 20. Biological Patterns: Order in Space and Time 21. Sequences, Specificity, and Evolution 22. Whither Physical Biology?

Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.

Garland ScienceMarch 2016: 892pp: 819 illus Hardback: 978-0-8153-4166-6: £73.99

Molecular Biology of Assemblies and MachinesAlasdair C. Steven, Silver Spring, MD, USA, Wolfgang Baumeister, Max Planck Institute of Biochemistry, Germany Louise N. Johnson, formerly University of Oxford, UK and Richard N. Perham, formerly University of Cambridge, UK

CONTENTS: 1. The Machines and Assemblies of Life 2. Chromatin 3. DNA Replication 4. DNA Repair and Recombination 5. Transcription 6. Protein Synthesis and Folding 7. Intracellular Proteolysis: Protein Quality Control and Regulatory Turnover 8. Assembly of Viruses 9. Multienzyme Complexes: Catalytic Nanomachines 10. Transport 11. Connectivity and Communication 12. Signaling 13. The cell cycle and cell death 14. Motility 15. Bioenergetics 16. Membrane Channels and Transporters 17. Complexes of the Immune System



32

BIOPHYSICSMolecular Driving Forces, Second EditionStatistical Thermodynamics in Biology, Chemistry, Physics, and NanoscienceKen A. Dill, Stony Brook University, USA, and Sarina Bromberg, Pescadero, California, USA

Molecular Driving Forces, Second Edition is an introductory statistical thermodynamics text that describes the principles and forces that drive chemical and biological processes.

"Kenneth Dill and Sarina Bromberg were presented with the 2012 Emily M. Gray Award 'for their impact on the education and

professional formation of countless scientists by writing a textbook which is a landmark in

molecular biophysics, Molecular Driving Forces.'"

Biophysical SocietyGarland ScienceDecember 2010: 778pp: 690 illusPaperback: 978-0-8153-4430-8: £65.00

CONTENTS:1. Principles of Probability 2. Extremum Principles Predict Equilibria 3. Heat, Work & Energy 4. Math Tools: Multivariate Calculus 5. Entropy & the Boltzmann Law 6. Thermodynamic Driving Forces 7. The Logic of Thermodynamics 8. Laboratory Conditions & Free Energies 9. Maxwell’s Relations & Mixtures 10. The Boltzman Distribution Law 11. The Statistical Mechanics of Simple Gases & Solids 12. What Is Temperature? What Is Heat Capacity? 13. Chemical Equilibria 14. Equilibria Between Liquids, Solids, & Gases 15. Solutions & Mixtures 16. The Solvation & Transfer of Molecules Between Phases 17. Physical Kinetics: Diffusion, Permeation & Flow 18. Microscopic Dynamics 19. Chemical Kinetics & Transition States 20. Coulomb’s Law of Electrostatic Forces 21. The Electrostatic Potential 22. Electrochemical Equilibria 23. Salt Ions Shield Charged Objects in Solution 24. Intermolecular Interactions 25. Phase Transitions 26. Cooperativity: The Hexlix-Coil, Isling & Landau Models 27. Adsorption, Binding & Catalysis 28. Multisite & Cooperative Ligand Binding 29. Bio & Nano Machines 30. Water 31. Water as a Solvent 32. Polymer Solutions 33. Polymer Elasticity & Collapse 34. Polymers Resist Confinement & Deformation

Introduction to Cell Mechanics and MechanobiologyChristopher R. Jacobs and Hayden Huang, both at Columbia University, USA, and Ronald Y. Kwon, University of Washington, USA

Introduction to Cell Mechanics and Mechanobiology teaches advanced undergraduate students a quantitative understanding of the way cells detect, modify, and respond to the physical properties within the cell environment. Coverage includes the mechanics of single-molecule polymers, polymer networks, two-dimensional membranes, whole-cell mechanics, and mechanobiology, as well as primer chapters on solid, fluid, and statistical mechanics.

Garland ScienceDecember 2012: 350pp: 250 illusPaperback: 978-0-8153-4425-4: £57.00

CONTENTS:1. Introduction to Cell Mechanics 2. Introduction to Cell Biology3. Primer to Solid Mechanics 4. Primer to Fluid Mechanics 5. Primer to Statistical Mechanics 6. Experimental Techniques and Analyses 7. Biopolymers 8. Polymer Networks and the Cytoskeleton 9. Biomembranes 10. Mechanobiology 11. Cellular Mechanotransduction

"This excellent [book]…meets a real existing

need in contemporary bioengineering education,

and it does it effectively and successfully."

Computer Methods in Biomechanics and

Biomedical Engineering

BIOPHYSICS



33

g a r l a n d s c i e n c e . r o c k e t m i x . c o m


34

A First Course in Systems Biology, Second EditionEberhard O. Voit, Georgia Institute of Technology, USA

A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling, then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way, it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks, understanding the modern literature, and launching into specialized courses or projects that address biological questions using theoretical and computational means.

New topics in this edition include: default modules for model design, limit cycles and chaos, parameter estimation in Excel, model representations of gene regulation through transcription factors, derivation of the Michaelis-Menten rate law from the original conceptual model, different types of inhibition, hysteresis, a model of differentiation, system adaptation to persistent signals, nonlinear nullclines, PBPK models, and elementary modes.

The format is a combination of instructional text and references to primary literature, complemented by sets of small-scale exercises that enable hands-on experience, and large-scale, often open-ended questions for further reflection.


CONTENTS:1. Biological Systems 2. Introduction to Mathematical Modeling 3. Static Network Models 4. The Mathematics of Biological Systems 5. Parameter Estimation 6. Gene Systems 7. Protein Systems 8. Metabolic Systems 9. Signaling Systems 10. Population Systems 11. Integrative Analysis of Genome, Protein, and Metabolite Data 12. Physiological Modeling: the Heart as Example 13. Systems Biology in Medicine and Drug Development 14. Design of Biological Systems 15. Emerging Topics in Systems Biology

NEW EDITION

COMPUTATIONAL BIOLOGY


35

COMPUTATIONAL BIOLOGYPractical BioinformaticsMichael Agostino, Pfizer Bioinformatics and Merrimack College, USA

Practical Bioinformatics is specifically designed for biology majors and is written for courses that have a practical, hands-on element. It contains many exercises to complement the straightforward and practical topics and is focused on the analysis of DNA, RNA, and protein sequences. It is designed to be the student’s first text for learning how to perform bioinformatics sequence analysis.

Garland ScienceDecember 2012: 394pp: 240 illusPaperback: 978-0-8153-4456-8: £35.00

"This [Practical Bioinformatics] is an excellent introductory

book for bioinformatics, yet it contains enough detail to help both a serious researcher as

well as a beginner in the field."

Science Books & FilmsCONTENTS:1. Introduction to Bioinformatics and Sequence Analysis 2. Introduction to Internet Resources 3. Introduction to the BLAST suite and BLASTN 4. BLASTP 5. Messenger RNA, cDNA, BLASTX and TBLASTN 6. Advanced Topics in BLAST 7. “Laboratory” Bioinformatics Tools 8. Protein Analysis 9. Explorations in short nucleotide sequences 10. MicroRNA and Pathway Analysis 11. Multiple Sequence Alignments 12. Browsing the Genome

Understanding BioinformaticsMarketa Zvelebil, Visiting Researcher at the Institute of Cancer Research, UK, and Jeremy O. Baum, Imperial College London, UK

Suitable for advanced undergraduates and postgraduates, Understanding Bioinformatics provides a definitive guide to this vibrant and evolving discipline.

"...provides an outstanding introduction to the main

bioinformatics problems and tools, well-balanced between

applications to biological problems and theory behind data processing methods…"

Computer Methods and Programs in Bioinformatics

Garland ScienceSeptember 2007: 798pp: 414 illusPaperback: 978-0-8153-4024-9: £57.00

CONTENTS:Part 1: Background Basics 1. The Nucleic Acid World 2. Protein Structure 3. Dealing with Databases Part 2: Sequence Alignments 4. Producing and Analyzing Sequence Alignments 5. Pairwise Sequence Alignment and Database Searching 6. Patterns, Profiles, and Multiple Alignments Part 3: Evolutionary Processes 7. Recovering Evolutionary History 8. Building Phylogenetic Trees Part 4: Genome Characteristics 9. Revealing Genome Features 10. Gene Detection and Genome Annotation Part 5: Secondary Structures 11. Obtaining Secondary Structure from Sequence 12. Predicting Secondary Structures Part 6: Tertiary Structures 13. Modeling Protein Structure 14. Analyzing Structure-Function Relationships Part 7: Cells and Organisms 15. Proteome and Gene Expression Analysis 16. Clustering Methods and Statistics 17. Systems Biology Appendices : Background Theory • Appendix A. Probability, Information, and Bayesian Analysis • Appendix B. Molecular Energy Functions • Appendix C. Function Optimization



36

Clinical Chemistry

Introduction to Bioorganic Chemistry and Chemical BiologyDavid Van Vranken and Gregory A. Weiss, both at University of California, Irvine, USA

Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life.

"This book provides important information on the organ-ic chemistry of biooligomers and their interactions in the functioning of cells. Advanced undergraduate students,

graduate students in chemistry and molecular biology, as well as medical students will find this book of value."

Doody's ReviewGarland ScienceDecember 2012: 504pp: 547 illusPaperback: 978-0-8153-4214-4: £58.00

CONTENTS:1. Fundamentals of Chemical Biology 2. The Chemical Origins of Biology 3. DNA 4. RNA 5. Peptide and Protein Structure 6. Protein Function 7. Glycobiology 8. Polyketides & Terpenes 9. Chemical Control of Signal Transduction


David White, University of Nottingham Medical School, UK Nigel Lawson, Derby Royal Hospital, UK Daniel McLaughlin, Durham University School of Medicine, Pharmacy & Health, USA Paul Masters, Chesterfield Royal Hospital, UK

Clinical Chemistry is a comprehensive textbook covering the area of medical science variously known as chemical pathology, clinical chemistry, medical biochemistry and clinical biochemistry. The biochemical processes and physiological interrelationships of tissues, organs, and molecules are discussed in the context of disease processes and related to the diagnosis, monitoring, and management of disease. Also included are analytical processes, such as immunoassay, and how these relate to clinical practice.

CONTENTS:1. Introduction 2. Glucose 3. Liver 4. Kidney 5. Sodium and Water 6. Potassium 7. Acid-base 8. Hyper-tension 9. Calcium 10. Iron 11. Endocrine System 12. Pregnancy 13. Skeletal Muscle 14. GI Tract 15. Cerebrospinal Fluid 16. Haem and Porphyrins 17. Uric Acid 18. Blood Lipids 19. Immunoglobulins and Complement 20. Tumor Markers 21. Therapeutic Drug Monitoring 22. Posions and Drugs of Abuse 23. Inborn Errors of Metabolism 24. Vitamins, Essential Fatty Acids, and Trace Elements 25. Clinical Chemistry of the Acute Patient

CHEMISTRY

NEW



37

CHEMISTRY / PLANT & MARINE BIOLOGY

Medicinal Chemistry Norma K. Dunlap, Middle Tennessee State University, USA,Donna M. Huryn, University of Pennsylvania, USA


Medicinal Chemistry teaches essential concepts by focusing on how the field is actually practiced, melding real-world research experience with basic principles and modern methods. Written by practic-ing medicinal chemists, this textbook is intended for advanced undergraduates and first-year graduate students in biology, chemistry, and biochemistry. Pre-medical or pre-pharmacy students and profes-sionals entering the drug discovery field will also find it a useful reference. Building on a foundation of synthetic organic chemistry and structural biology, the book interweaves therapeutics, case studies, historical context, and techniques for discovering, developing, and optimizing new drugs. Chapters are richly illustrated and include problems and annotated journal references with accompanying exercises and answers.

CONTENTS: 1. Historical perspective and overview of drug discovery 2. Drug discovery: hit and lead discovery 3. Drug discovery: optimization of lead properties 4. Medicinal chemistry strategies used in lead optimization 5. The process of developing a drug from an optimized lead 6. Receptors as drug targets 7. Enzymes as drug targets 8. Protein-protein interactions and lipids as drug targets 9. DNA and RNA as drug targets 10. Anti-cancer drugs 11. Infectious diseases I: antiviral and antifungal drugs 12. Infectious diseases II: antibacterial and antiparasitic drugs 13. Drugs acting on the CNS

NEW

Plant BiologyAlison M. Smith, John Innes Centre, UK, George Coupland, Max Planck Institute, Germany, Liam Dolan, University of Oxford, UK, Nicholas Harberd, University of Oxford, UK, Jonathan Jones, John Innes Centre, UK, Cathie Martin, John Innes Centre, UK, Robert Sablowski, John Innes Centre, UK, and Abigail Amey, Science Editor, London, UK

Plant Biology is a textbook written for upper-level undergraduate and gradu-ate students. Plant Biology is a ‘where we are now’ account of plant science. It acknowledges the distinguished history of the subject, but its approach is strongly influenced by the radically new outlook that has emerged in the last twenty years. Many of the recent advances in Plant Biology the authors describe are useful in the understanding of modern biology as a whole.


"...abundantly and lavishly illustrated with original colour

line drawings, and photographs and

micrographs from leading plant laboratories and

practitioners from around the world..."

Nigel ChaffeyBath Spa University

CONTENTS:1. Origins 2. Genomes 3. Cells 4. Metabolism 5. Development 6. Environmental Signals 7. Environmental Stress 8. Interactions with Other Organisms 9. Domestication & Agriculture


38

PLANT & MARINE BIOLOGYEnvironmental Plant Physiology

Marine Microbiology, Second EditionEcology and ApplicationsColin Munn, University of Plymouth, UK

Marine Microbiology brings together microbial biology and ecology to cre-ate an integrated approach that addresses environmental, human health, and economic concerns. The Second Edition takes into account many new discoveries in the field. It is ideally suited for upper-level undergraduate and graduate students, and researchers.

Garland ScienceApril 2011: 320pp: 131 illusPaperback: 978-0-8153-6517-4: £57.00

"...it is about as perfect as any text could get..."

Leigh OwensJames Cook University

CONTENTS:1. Microbes in the Marine Environment 2. Methods in Marine Microbiology 3. Metabolic Diversity and Ecophysiology 4. Marine Bacteria 5. Marine Archaea 6. Marine Eukaryotic Microbes 7. Marine Viruses 8. Ocean Processes - Marine Microbes and the Carbon Cycle 9. Nutrient Cycles - Nitrogen, Sulphur and Phosphorus 10. Symbiotic Associations 11. Microbial Diseases of Marine Organisms 12. Marine Microbes as Agents of Human Disease 13. Microbial Aspects of Marine Biofouling, Biodeterioration and Pollution 14. Marine Microbes and Biotechnology


Neil Willey, University of the West of England, UK

Environmental Plant Physiology uses recent advances in molecular, ecological and environmental research to elucidate plant-environment interactions ranging from genetic, epigenetic, and cell signalling advances to advances in ecological economics, pollution science, and climate change. It deals with the majority of the most important environmental topics facing humankind including sustainable food production, water resources, pollution, climate change, and the conservation of biodiversity.

CONTENTS:1. Contexts, Perspectives, and Principles 2. Light 3. Carbon Dioxide 4. Water 5. Nitrogen 6. Phosphorus 7. Essential and Beneficial Elements 8. Temperature 9. Salinity 10. Soil pH 11. Flooding 12. Inorganic Toxins 13. Organic Toxins 14. Air Pollutants 15. Synopsis and Outlook



39

PLANT & MARINE BIOLOGYField Methods in Marine ScienceFrom Measurements to ModelsScott P. Milroy, University of Southern Mississippi, USA

Field Methods in Marine Science: From Measurements to Models is an authoritative guide of the methods most appropriate for field research within the marine sciences, from experimental design to data analysis. Written for upper-level undergraduate and graduate students as well as early-career researchers, this textbook also serves as an accessible introduction to the concepts and practice of modeling marine system dynamics.This textbook trains the next generation of field scientists to move beyond the classic methods of data collection and statistical analysis to contemporary methods of numerical modeling; to pursue the assimilation and synthesis of information, not the mere recording of data.

Garland ScienceSeptember 2015: 288pp: 185 illus Paperback: 978-0-8153-4476-6: £48.99

CONTENTS:Unit 1 First Principles 1. The Foundations of Scientific Inquiry 2. Introduction to Statistical Inference Unit 2 Methods of Data Acquisition 3. Experimental Design 4. Oceanographic Variables 5. Common Hydrologic Census Methods 6. Census Methods for Benthic Organisms 7. Census Methods for Pelagic Organisms Unit 3 Methods of Data Analysis 8. Introduction to Univariate Analysis 9. Introduction to Multivariate Analysis Unit 4 Methods of Data Assimilation (Modeling) 10. Fundamental Concepts in Modeling 11. Model Structure 12. Modeling Simple Dynamics 13. Modeling Complex Dynamics 14. Modeling Large System Dynamics • Appendix A Symbols and Abbreviations • Appendix B Numerical Constants and Equivalents for Common Units of Measure • Appendix C Common Algorithms for the Estimation of Important Water Properties • Appendix D Exercises in Unit Conversion • Appendix E Oceanographic Sampling Equipment • Appendix F Compendium of Routine Oceanographic Methodologies Glossary

Biology of Fishes, Third EditionQuentin Bone, Marine Biological Association of the UK, Plymouth, UK, and Richard Moore, Coastal Carolina University, USA

The Third Edition of Biology of Fishes is chiefly about fish as remarkably efficient machines for coping with the many problems that life in water entails, and looks at many such special cases. Fishes form the largest group of vertebrates, with around 20,000 known species, and they display a remarkable diversity of size, shape, internal structure and ecology to cope with environments ranging from transient puddles to the abyssal depths of the sea.

Taylor & FrancisMarch 2008: 450pp: 280 illusPaperback: 978-0-4153-7562-7: £55.00

CONTENTS:1. Diversity of Fishes 2. Fishes and their Habitats 3. Swimming 4. Buoyancy 5. Gas Exchange, Blood and the Circulatory System 6. Osmoregulation and Ion Balance 7. Food and Feeding 8. Reproduction and Life Histories 9. Endocrine Systems 10. Sensory Systems and Communication 11. Nervous System 12. Immune System 13. Behavior and Cognition 14. Fisheries and Aquaculture



40

TITLE INDEX

GARLAND SCIENCE A First Course in Systems Biology. . . . . . 34Atlas of Immunology. . . . . . . . . . . . . . 25Basic Genetic Epidemiology. . . . . . 11 Biochemical Evolution . . . . . . . . . 12Biology of Aging . . . . . . . . . . . . . 9Biology of Cancer, The . . . . . . . . . . . . . . 8Biology of Fishes. . . . . . . . . . . . . . . 39Biomolecular Crystallography. . . . . . . . .. . . 29Case Studies in Allergic Disorders . . . . 25Case Studies in Immunology. . . . . . . . . . . 23Case Studies in Infectious Disease . . . . . . . . 25Case Studies in Veterinary Immunology . . . . . 26Cell Biology by the Numbers . . . . . 8Cell Membranes . . . . . . . . . . . . . . . . . 10Cell Signaling . . . . . . . . . . . . . . . . 7 Celllular Signal Processing . . . . . . . . . 9Clinical Chemistry . . . . . . . 36 Developmental Neurobiology . . . . . . 10Environmental Plant Physiology . . . . . . 38Epigenetics . . . . . . . . . . . . . . . . . . 14Essential Cell Biology . . . . . . . . . . . . . 6Field Methods in Marine Science . .. . . . . . . 39Gene Control. . . . . . . . . . . . . . . . 13 Genetic Association Studies . . .. . . . . 18Genetics of Complex Disease. . . . . . . . . . . . . . . .14Genetics and Genomics in Medicine.. . . . . . . . . . . 17 Genomes 4 . . . . . . . . . 12Genome Stability . . . . . . . . . . . . . . . . . 15How Proteins Work . . . . . . . . . . . 28Human Evolutionary Genetics. . . . . . . . . . 13Human Molecular Genetics. . . . . . . . . . . . . 16Illustrated Dictionary of Immunology. . . . . . . . . . . . 21Immune System, The . . . . . . . . . . . . . 24Immunology: An Illustrated Outline. . . . . . . . . . . . 25Introducing Genetics. . . . . . . . . . . . . . . . . . . 16Introduction to Bioorganic Chemistry and Chemical Biology 36Introduction to Cell Mechanics and Mechanobiology 32Introduction To Genetics. . . . . . . . . . . . . . . . 17Introduction to Protein Structure . . . . . . . . . . 28Janeway’s Immunobiology . . . . . . . . . . 22,23Living in a Microbial World . . . . . . . . . . . . . . 20Marine Microbiology . . . . . . . . . . . . . . 38 Medicinal Chemistry . . . . . . . . 37Microbiology. . . . . . . . . . . . . . . 21Molecular Biology. . . . . . . . . . . . . . 7Molecular Biology of Assemblies and Machines. . . . 31Molecular Biology of the Cell . . . . . . . . . . . . . . . . 4, 5 Molecular Biology of the Cell - The Problems Book . . . 5 Molecular Driving Forces . . . . . . . . . . . . 32Molecules of Life, The . . . . . . . . . . . 27Parasitology . . . . . . . . . . 19Phylogenomics . . . . . . . . . . . 18Physical Biology of the Cell . . . . . . . . . . 31

Plant Biology . . . . . . . . . . . . . . . 37Practical Bioinformatics . . . . . . . . . . . . . . 35 Principles of Evolution . . . . . . 15Principles of Mucosal Immunology . . . . .. . 26Principles of Neurobiology . . . . . . . . . 11Principles of Proteomics. . . . . . . . . . . . 27Proteins . . . . . . . . . . . . . . . . . . . . . 29 Protein Actions . . .. . . . .30Understanding Bioinformatics . . . . . . . . 35 Viruses . . . . . . . . . . . . . . . . . . . 19

41

GARLAND SCIENCE Agostino, Michael . . . . . . . . 35 Alberts, Bruce . . . . . . . . 4,6 Almeida, Paulo . . . . . . . . . 29Amey, Abigail . . . . . . . . . 37Armstrong, Lyle . . . . . . . . . 14

Bahar, Iven . . . . . . . . 30 Bard, Jonathan. . . . . . . . 15Baum, Jeremy O. . . . . . . . 35Baumeister, Wolfgang. . . . . . 31Bevitt, Debra . . . . . . . . . 14 Bianchi, Lynne M. . . . . 10Blumberg, Richard S. . . . . . 26Bone, Quentin . . . . . . . . 39Branden, Carl . . . . . . . . 28Bray, Dennis . . . . . . . . . 6Bromberg, Sarina . . . . . . 32Brown, Terry A. . . . . . . . . .12, 17Buehler, Lukas. . . . . . . . . 10

Chinnery, Patrick. . . . . . . . . 17Cole, Michael . . . . . . . . . 25 Cornish-Bowden, Athel . . . . . .12Coupland, George . . . . . . . 37Cruse, Julias M. . . . . . . 21

Daly, Ann. . . . . . . . . . 14DeSalle, Rob . . . . . . . . . 18Dill, Ken A. . . . . . . . . . 30, 32Dolan, Liam . . . . . . . . . 37Donaldson, Peter . . . . . . . . 14Dorak, Tefik. . . . . . . . . 18Dunlap, Norma K. . . . . . . .37

Edwards, Angela . . . . . . 21Ermini, Luca . . . . . . . . 14

Fahnert, Beatrix . . . . . . 21

Garcia, Hernan . . . . . . . . 31Geha, Raif . . . . . . 23,25 Gershwin, Laurel. . . . . . . 26Goodship, Judith. . . . . .17

Haber, James E. . . . . . . . 15Harberd, Nicholas . . . . . 37Harper, David R. . . . . . . 19Hofkin, Bruce . . . . . . . 19,20Hollox, Edward . . . . . . . 13Holton, John . . . . . . . 25Hopkin, Karen . . . . . . . . 6Huang, Hayden . 32Hunt, Tim . . . . . . . . . 5 Hurles, Matthew . . . . . . . 13 Huryn, Donna M. . . . . . .37

Irving, Will . . . . . . . . . 25

Jacobs, Christopher R. . . . . . 32 Jernigan, Robert . . . . . . . 30Jobling, Mark . . . . . . . .13Johnson, Alexander . . . . . . 4,6Johnson, Louise N. . . . . . . 31Jones, Jonathan . . . . . . . 37

Kivisild, Toomas . . . . . . . 13 Klingmüller, Ursula . . . . . . . 9Kondev, Jane . . . . . . 31Konforti, Boyana . . . . . . 27Kuriyan, John . . . . . . . . 27Kwon, Ronald Y . . . . . . . . 32Latchman, David . . . . . . 13Lawson, Nigel . . . . . . . . 36Lewis, Julian . . . . . . . . . . . 4,6 Lewis, Robert E.. . . . . . . .21Lim, Wendell . . . . . . . . . 7 Luo, Liqun . . . . . . . . . . . . 11Loker, Eric. . . . . . . . . . 19Lydyard, Peter. . . . . . . . 25

MacDonald, Thomas T. . . . . .26Male, David. . . . . . . . . .25Masters, Paul. . . . . . . . 36Matthews, Karl R. . . . . . . .45 Marks, Friedrich . . . . . . 9 Martin, Cathie . . . . . . 37Mayer, Bruce . . . . . . . . . 7 McDonald, Roger B . . . . . . . 9 McLaughlin, Daniel. . . . . . . 36Milo, Ron. . . . . . . . . . 8Milroy, Scott P. . . . . . . 39Moore, Richard . . . . . . . 39Morgan, David . . . . . . 4 Müller-Decker, Karin . . . . . 9 Munn, Colin . . . . . . . 38Murphy, Kenneth M . . . . . . 22

Notarangelo, Luigi . . . . . . . . 23

Oettgen, Hans . . . . . . . 25

Parham, Peter . . . . . . . . . .24Pawson, Tony . . . . . . . . 7Perham, Richard N. . . . . . 31Phillips, Rob . . . . . . . 8,31Porakishvili, Nino. . . . . . 25Pryor, Greg. . . . . . . . . . . . 21

Raff, Martin . . . . . . . . 4,6 Read, Andrew . . . . . . . 16Roberts, Keith . . . . . . . 4,6 Rosenfeld, Jeffrey . 18

Rupp, Bernhard. . . . . . 29

Sablowski, Robert . . . . . . 37Smith, Alison M . . . . . 37Smith, Phillip D. . . . . . 26 Society for Mucosal Immunology 26Steven, Alasdair C. . . . . . 31Strachan, Tom . . . . . . . 16,17Strelkauskas, Anthony . . . . 21Strelkauskas, Jennifer . . . 21

Theriot, Julie . . . . . . . 31Thomas, Alison. . . . . . .16Tooze, John . . . . . . . . 28Twyman, Richard . . . . . . . 27Tyler-Smith, Chris . . . . . 13

van Holde, Kensal E. . . . . 7 van Vranken, David . . . . 36Venkatesan, Pradhib . . . 25Voit, Eberhard . . . . . . . 34

Walter, Peter . . . . . . . . 4, 6 Ward, Kate . . . . . . . . . 25Weaver, Casey. . . . . . . 22Weinberg, Robert A . . . . . . 8 Weiss, Gregory A . . . . . . 36Wemmer, David . . . . . . . 27White, David. . . . . . . 36Williamson, Mike . . . . . . . 28Willey, Neil . . . . . . . . . 38Wilson, John . . . . . . . . . 5

Zlatanova, Jordanka . . . . . 7 Zvelebil, Marketa . . . . . 35

AUTHOR INDEX

42

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