g3 workshop north america leadership conference march 3, 2006 this material has been prepared by...
TRANSCRIPT
G3 Workshop
North America
Leadership Conference
March 3, 2006
This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.
Mark R. Bartlett Ph.D.
Sr. Director, Pharmanex New Product Development
Science &Tradition
MSNBC.com
Spartan diet may slow agingNIH launches study to test practicalityBy Rob SteinThe Washington PostAs the rest of the nation has been supersizing, a small cadre of Americans such as Francesca Skelton have been radically downsizing their diets — not to slim down their physiques but to slow down the hands of time. Skelton is an adherent to the theory that "caloric restriction" can hold back the aging process by fundamentally altering basic metabolic functions in ways that protect the body from decaying as quickly.So for years, the District grandmother and others like her have been eating often radical diets carefully calibrated to slash calories they consume each day while still providing their bodies with the nutrients they need.
Green Tea and Longevity
66
68
70
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80
82
Mea
n A
ge
of
Dea
th
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Men Women
3 or less
4 to 9
over 10
Green TeaConsumption(Cups/Day)
Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission
Antioxidants Addresses the Root Cause of Aging:
DNA Damage• DNA (DeoxyriboNucleic Acid) is your
genetic blueprint • DNA enables healthy cell renewal into old
age
Aging Symptoms
Most Vulnerable to free radicals…
Free Radical Sources• Environmental pollution (smog, ozone, NO2) • Radiation exposure:
– sunlight (UV-light), X-rays, etc.
• Smoking: – 10,000,000,000,000,000 free radicals/cigarette!
• Eating and Breathing: metabolism in your mitochondria
Mitochondria – The Energy Furnaces of the body
Free Radicals
SOD CAT
• Starve Your Way to HealthIt works for mice and fruit flies, but can ultra-low-calorie diets extend the life of humans?
• By Jerry Adler and Anne Underwood• Newsweek• Jan. 19 issue - If the world is divided into people who live to eat and those who
eat to live, perhaps there ought to be a third category for Brian Delaney. At 5 feet 11 inches and 139 pounds, Delaney, 40, is really, really thin. Thin, and hungry. He limits his calories to 1,800 a day, in part by eating just two meals, except when he has a dinner date, in which case that's the only meal he eats. After 10 years on this regimen—actually, he started out at 1,400 calories a day, less than half of what the average American male consumes—he still experiences "the same pit in my stomach" every afternoon, but now finds it "easier to deal with." Especially when he thinks of all the diseases he's avoiding. If Brian Delaney is right, he may well have the last laugh on the rest of humanity ... sometime in the 22d century.
MSNBC.com
Aging so far…
• DNA damage
• Cell membrane damage
• Uncontrolled free radical leakage from Mitochondria
The most common link?
Free Radicals
“… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.”
“It appears prudent for all adults to take vitamin supplements.”
Journal of the American Medical Association
Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard UniversityJournal of the American Medical Association 2002; 287: 3127-3129
Antioxidant Health Benefits
–R&D evaluated hundreds of fruits for…• Extraordinary antioxidant power
–Measurable (Scanner)–Protect cells, (DNA, Membranes)–Enhance internal antioxidant
production
3 years ago…Pharmanex began Searching
the World for Superfruits
Fruit Phytonutrients
• At least 1,000 phytochemicals identified with cell protective effects
• Very few (25) studied
• Fruits and vegetables – more than meets the eye
• We don’t eat enough fruits and vegetables
Families of Antioxidants• Vitamin E: 8 natural forms
Families of Antioxidants
• Vitamin E: 8 natural forms
• Vitamin C:
Families of Antioxidants• Vitamin E: 8 natural forms
• Vitamin C
• (Metallo-enzyme cofactors)– Selenium, Zinc, Manganese, Copper
Enzyme Protein
Zinc
Families of Antioxidants
• Vitamin E: 8 natural forms• Vitamin C: 500 mg• (Metallo-enzyme cofactors)
– Selenium, Zinc, Manganese
• Flavonoids:–Catechins, –polyphenols etc
Families of Antioxidants• Vitamin E: 8 natural forms• Vitamin C • (Metallo-enzyme cofactors)
– Selenium, Zinc, Manganese
• Flavonoids:– Catechins, polyphenols etc
• Carotenoids:– Β-carotene, lutein, lycopene, α-carotene
Your Antioxidant Network
• Vitamin E: 8 natural forms• Vitamin C • Metallo-enzymes (cofactors)
– SOD, Catalase, Glutathione per.
– Selenium, Zn, Mn, Cu
• Flavonoids:– Catechins, polyphenols etc
• Carotenoids:– Β-carotene, lutein, lycopene, α-carotene
More than just One…
1.Provo R&D Center 2.Shanghai R&D Center3.Beijing R&D Center
Pharmanex Research Centerswere involved…
–Almost all failed Selection criteria–All but Four (g+3) very special
fruits
years of searching
1. Gâc fruit (Chinese Bitter Cucumber)2. Chinese Lycium (Wolfberry)3. Cili fruit 4. Siberian Pineapple (Seabuckthorn)
3 Years of Searching and R&D3 +1 Superfruits
3 Pharmanex Research Centers
• Indigenous to Southern AsiaBangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam
• Traditionally used internally and externally*Topical: wound healingInternally: eye health, and to promote growth in children*
Gâc - “Fruit From Heaven”
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Antioxidants in Gâc Pulp
• Extraordinarily rich in antioxidants, esp. lycopene, beta-carotene, vitamin E
• Unique fatty acids → Lipocarotenes™
Fruit flesh(mesocarp)
Pulp(aril)
Seeds
Gac Fruit Lycopene Content
31 41 54
2227
0
500
1000
1500
2000
2500
Tomato Watermelon Guava Gac aril
mcg/g wet weightIshida et al., J Agric Food Chem 52:274, 2004
70 x morethan tomatoes!
Gac Fruit Beta-Carotene Content
48 76 79
718
0
100
200
300
400
500
600
700
800
Spinach Carrot Sw.Potato Gac arilmcg/g wet weightIshida et al., J Agric Food Chem 52:274, 2004
10 x morethan carrots!
Zeaxanthin in Chinese Lycium Fruit
18
800
0100200300400500600700800900
1000
Yellow Corn Ch.Lycium
40 x more thanyellow corn!
mcg/g wet weight
Vitamin C in Cili Fruit
30 45 71
2500
0
500
1000
1500
2000
2500
Mandarin Orange Kiwi Cili
60 x morethan oranges!
mg/100g wet weight
Antioxidant protection
Vitamin C
Betacarotene
Carotenoid protection
Lutein
BetacaroteneCarotenoid protection
Lutein
Lycopene
Betacarotene
Carotenoid protection
Antioxidant protection
Vitamin C
Lutein
Lycopene
Betacarotene
Carotenoids and DNA damage (2006)
Carotenoids• First line of defense antioxidants*
• Protect cell membranes*
• Protect DNA*
• Enhance communication in cell membranes*
• Found in a diet rich in fruits and vegetables
• Indicator of overall antioxidant health*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Carotenoids Predict Antioxidant Status• Recent paper published in the Journal of Nutrition
– Carotenoids (blood) are indicator of total antioxidant status – Carotenoids interact with the antioxidant network– Vitamin E (blood) is not a good indicator of antioxidant status
Raman SpectroscopyIntense monochromatic light (one color only) interacts with molecules that have vibrational energy (e.g., carotenoids) and gets scattered at a higher wavelength (color). Sir C. V. Raman, Nobel Prize in Physics, 1930
Carotenoid molecules shift blue laser light color to green:
from 473 nm to 510 nm
Pharmanex BioPhotonic Scanner
• Measures skin carotenoids –an indication of your personal antioxidant protection
• Easy & non-invasive• Scientifically and clinically
validated• Gold standard
Measure antioxidant effect of g3 in your own body!
Rel
ativ
e ri
sk
Servings
0.60
0.70
0.80
0.90
1.00
1.10
0 1 2 3
tomato juicetomato juice
tomato fruitstomato fruits
pizzapizza
tomato saucetomato sauce
from Giovanucci et al. J. of Natl. Canc. Inst. 87, 1767 (1995)from Giovanucci et al. J. of Natl. Canc. Inst. 87, 1767 (1995)
Effect of tomato food products on prostate health risk
Bioavailability
g3 Increased Antioxidant Network Scores ~9,500 in 8 Weeks
10,000
20,000
30,000
40,000
50,000
Week 0 Week 8
An
tio
xid
ant
Net
wo
rk S
core
1234567891011
0
2,000
4,000
6,000
8,000
10,000
Week 0 Week 2 Week 4 Week 6 Week 8
An
tio
xid
an
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co
re
Tahitian Noni XanGo
Noni & Xango vs. g3
Chinese Lycium(Wolfberry; Lycium chinense)
2000 years TCM history in China• Longevity, wellness, vision
• Cellular rejuvenation:* protects DNA*– antioxidant (SOD, GPX)
*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Other Ingredients
Cili Fruit(Rosa roxburghii)• Cardiovascular, antioxidant benefits:*
– ↓ oxLDL, increases SOD*
• Addresses symptoms of Aging*
g3 activates SOD and Catalase*– the body's catalytic antioxidant system – antioxidant protection inside the cell, where it is
needed the most
SOD: Superoxide Dismutase– most important antioxidant enzyme– requires copper, zinc & manganese (LifePak)
Is Catalytically Active
*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Vulnerable to Oxidation
Vitamin CLutein
Lycopene
Betacarotene
SOD CAT
SOD
Catalase
Internal Antioxidants
You have the 3 most powerful tools of the entire nutritional supplement industry worldwide:lifepak nano: The best multi-nutrient supplement. : The best functional fruit juice.BioPhotonic SCANNER: The best consumer test
for antioxidant nutrition.
The Measurable Difference
Key Business Takeaways• G3™ supports your body’s antioxidant network*
• Lipocarotenes™ naturally increase absorption of antioxidants*
• SCS Certified ~ 9,500 increase in 8 weeks• 6 times more powerful than Noni or Xango™*
• Proprietary and patent pending
*Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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