fungal endophthalmatits
TRANSCRIPT
FUNGALENDOPHTHALMATITS
Kamal thakur
2nd year bsc opto
FUNGAL ENDOPHTHALMATITS
It is suppurative inflammation of inner ocular
coats and their adjacent structure, with
involvement of anterior chamber and vitreous
fluid.
It is caused by various fungal agents
FUNGAL ENDOPHTHALMITIS
Clinically two types
Endogenous due to hematogenous spread
Exogenous due to trauma or post operative
ENDOGENOUS ENDOPHTHALMITIS
The first description of endogenous fungal
endophthalmitis was by Dimmer in 1913.
ENDOGENOUS ENDOPHTHALMITIS
Predisposing factors
Malignancy
IVDU (intravenous drug use)
Chemotherapy
Systemic antibiotics
Alcoholism & Diabetes
CAUSATIVE AGENTS OF ENDOGENOUS
ENDOPHTHALMITIS
Candida albicans
Fusarium species
Aspergillus species
Histoplasma capsulatum
Coccidioides immitis
Blastomyces dermatitidis
Cryptococcus neoformnas
CANDIDA ALBICANS
Infection usually starts from Choroid and then
spreads to retina
Candida endogenous fungal
endophthalmitis manifesting
as multiple chorioretinal
lesions..
ASPERGILLUS ENDOPHTHALMITIS
Spreads from lungs to eye
Aspergillus
endophthalmitis
(infection of the
retina of the eye),
following
dissemination from
the lung.
CRYPTOCOCCAL ENDOPTHALMITIS
From lung,
disseminated haematogenesouly and can affect CNS
causing fungal meningitis & endophthalmitis in eye.
Choroids is the probably first site of ocular infections
CAUSATIVE AGENT OF EXOGENOUS
ENDOPHTHALMITIS
Aspergillus spp.
C. albicans,C. glabrata, C. tropicalis, C.
parapsilosis
Fusarium spp.
Acremonium spp.
Curvularia spp.
PATHOGENESIS: EXOGENOUS
Direct introduction of the organisms following
Surgery(Catarct removal with placement of IOL
mainly Candida spp)
Trauma(Mainly Fusarium spp. )
spread from Fungal keratitis
CLINICAL FEATURES
Symptoms
Visual loss
Red eye.
Photophobia.
Pain.
Floaters.
Scotoma
LABORATORY DIAGNOSIS
Sample collection and transport
AC tap
Vitreous tap Fluids
CONVENTIONAL TECHNIQUES Direct microscopy Rapid and cost effective
10% KOH preparation .
Gram stain .
Calcoflour Stain – Easy and fast.
Culture SDA, Blood agar.
Susceptibility testing
CULTURE
Vitreous fluid inoculated on routine fungal culture media .
Vitreous sample should be concentrate either by
centrifugation Millipore filtration
All the culture checked everyday during first week and
twice a week during next 3 weeks.
Positive culture are more convincing when growth is
obtained on more than one occasion.
ENDOGENOUS ENDOPHTHALMITIS
Systemic antifungal agents:
Fluconazole,
voriconazole (azole compounds)
Systemic antifungal agents:
Amphotericin B: Parenteral ± intravitreal
EXOGENOUS ENDOPHTHALMITIS
Intraocular (intracameral ± intravitreal) amphotericin B
Intravitreal voriconazole or miconazole
Subconjunctival antifungal agents: when associated with
keratitis
Systemic antifungal agents: fluconazole, ketoconazole,
voriconazole, itraconazole, miconazole, and amphotericin
B: