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Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Darragh Duffy, Vincent Rouilly, Valentina Libri, Milena Hasan, Benoit Beitz, Mikael David, Alejandra Urrutia, Aurélie Bisiaux, Samuel T. LaBrie, Annick Dubois, Ivo G. Boneca, Cécile Delval, Stéphanie Thomas, Lars Rogge, Manfred Schmolz, Lluis Quintana-Murci, Matthew L. AlbertLaurent Abel, Andres Alcover, Philippe Bousso, Ana Cumano, Marc Daëron, Cécile Delval, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Antonio Freitas, Ivo Gomperts-Boneca, Serge Hercberg, Olivier Lantz, Claude Leclerc, Hugo Mouquet, Sandra Pellegrini, Stanislas Pol, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Vassili Soumelis, Frédéric Tangy, Eric Tartour, Antoine Toubert, Marie-Noëlle Ungeheuer, Lluis Quintana-Murci, Matthew L. AlbertDarragh Duffy, Vincent Rouilly, Valentina Libri, Milena Hasan, Benoit Beitz, Mikael David, Alejandra Urrutia, Aurélie Bisiaux, Samuel T. LaBrie, Annick Dubois, Ivo G. Boneca, Cécile Delval, Stéphanie Thomas, Lars Rogge, Manfred Schmolz, Lluis Quintana- Murci, Matthew L. AlbertLaurent Abel, Andres Alcover, Philippe Bousso, Ana Cumano, Marc Daëron, Cécile Delval, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Antonio Freitas, Ivo Gomperts-Boneca, Serge Hercberg, Olivier Lantz, Claude Leclerc, Hugo Mouquet, Sandra Pellegrini, Stanislas Pol, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Vassili Soumelis, Frédéric Tangy, Eric Tartour, Antoine Toubert, Marie-Noëlle Ungeheuer, Lluis Quintana- Murci, Matthew L. Albert Immunity Volume 40, Issue 3, Pages 436-450 (March 2014) DOI: 10.1016/j.immuni.2014.03.002 Copyright © 2014 Elsevier Inc. Terms and Conditions

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Page 1: Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Darragh Duffy,

Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli 

Darragh Duffy, Vincent Rouilly, Valentina Libri, Milena Hasan, Benoit Beitz, Mikael David, Alejandra Urrutia, Aurélie Bisiaux, Samuel T. LaBrie, Annick Dubois, Ivo G. Boneca, Cécile Delval, Stéphanie Thomas, Lars Rogge, Manfred Schmolz, Lluis Quintana-Murci,

Matthew L. AlbertLaurent Abel, Andres Alcover, Philippe Bousso, Ana Cumano, Marc Daëron, Cécile Delval, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Antonio Freitas, Ivo Gomperts-Boneca, Serge

Hercberg, Olivier Lantz, Claude Leclerc, Hugo Mouquet, Sandra Pellegrini, Stanislas Pol, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Vassili Soumelis, Frédéric Tangy, Eric Tartour, Antoine Toubert, Marie-Noëlle

Ungeheuer, Lluis Quintana-Murci, Matthew L. AlbertDarragh Duffy, Vincent Rouilly, Valentina Libri, Milena Hasan, Benoit Beitz, Mikael David, Alejandra Urrutia, Aurélie Bisiaux, Samuel T. LaBrie, Annick Dubois, Ivo G. Boneca, Cécile Delval, Stéphanie Thomas, Lars

Rogge, Manfred Schmolz, Lluis Quintana-Murci, Matthew L. AlbertLaurent Abel, Andres Alcover, Philippe Bousso, Ana Cumano, Marc Daëron, Cécile Delval, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Antonio Freitas, Ivo Gomperts-Boneca, Serge Hercberg, Olivier Lantz, Claude Leclerc, Hugo Mouquet, Sandra Pellegrini, Stanislas Pol, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Vassili Soumelis, Frédéric Tangy, Eric Tartour,

Antoine Toubert, Marie-Noëlle Ungeheuer, Lluis Quintana-Murci, Matthew L. Albert 

Immunity Volume 40, Issue 3, Pages 436-450 (March 2014)

DOI: 10.1016/j.immuni.2014.03.002

Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 2: Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Darragh Duffy,

Figure 1

Immunity 2014 40, 436-450DOI: (10.1016/j.immuni.2014.03.002) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 3: Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Darragh Duffy,

Figure 2

Immunity 2014 40, 436-450DOI: (10.1016/j.immuni.2014.03.002) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 4: Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Darragh Duffy,

Figure 3

Immunity 2014 40, 436-450DOI: (10.1016/j.immuni.2014.03.002) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 5: Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Darragh Duffy,

Figure 4

Immunity 2014 40, 436-450DOI: (10.1016/j.immuni.2014.03.002) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 6: Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Darragh Duffy,

Figure 5

Immunity 2014 40, 436-450DOI: (10.1016/j.immuni.2014.03.002) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 7: Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli Darragh Duffy,

Figure 6

Immunity 2014 40, 436-450DOI: (10.1016/j.immuni.2014.03.002) Copyright © 2014 Elsevier Inc. Terms and Conditions