full spectrum cell analysistm - lianke) bio...cd125 cd126 fcεr1 il-33r (st-2) pan markers cd11b...
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Full Spectrum Cell AnalysisTM
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in immunology and cellular analysis, driving progress in the areas
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Table of Contents
Format Abbreviations References UniProt: The Universal Protein Resource http://uniprot.org
Human Cell Differentiation Molecules http://www.hcdm.org
Leukocyte and Stromal Cell Molecules by Zola, H., et al., 2007. John Willey & Sons, Inc.
Alexa Fluor® is a registered trademark of and licensed under patents assigned to Molecular Probes, Inc. for research use only.
eFluor® is a registered trademark of eBioscience, Inc.
All designated trademarks used are the property of their respective owners.
Abbreviations Act Activated ASV Alternative Splice Variants ADCC Antibody-Dependent Cellular Cytotoxicity AML Acute Myeloid Leukemia APC Antigen Presenting Cells BM Bone Marrow CCRSF Complement Component Receptor Superfamily CD Cluster of Differentiation CHO Carbohydrate Moiety CNS Central Nervous System CRSF Cytokine Receptor Superfamily CTL Cytotoxic T Lymphocytes DC Dendritic Cells ECM Extracellular Matrix Endoth Endothelial Cells Epith Epithelial Cells ESC Embryonic Stem Cells FDC Follicular Dendritic Cells GPI Glycophosphatidylinositol Gran Granulocytes HEV High Endothelial Venule HUVEC Human Umbilical Vein Endothelial Cells HSC Hematopoietic Stem Cells IgSF Immunoglobulin Superfamily Intra/Txn Intracellular/Transcription Factors
kD KiloDalton KO Knock-out LAK Lymphokine Activated Killer Leuk Leukocytes LPS Lipopolysaccharide LRRF Leucine Rich Repeat Family Lymph Lymphocytes Mac Macrophages MHC Major Histocompatibility Complex Mono Monocytes NK Natural Killer Cells PBMC Peripheral Blood Mononuclear Cell pDC Plasmacytoid Dendritic Cell PNS Peripheral Nervous System RBC Red Blood Cells RTK Receptor Tyrosine Kinase Th T Helper Cells TF Transcription Factor TM Transmembrane TM12SF 12-Transmembrane Spanning Protein Superfamily TM4SF 4-Transmembrane Spanning Protein Superfamily TM7SF 7-Transmembrane Spanning Protein Superfamily TNFRSF TNF Receptor Superfamily TNFSF TNF Superfamily w/ Associates With
FG Purified Functional Grade Purified (sterile & azide-free)
FG Biotin Functional Grade Biotin (sterile & azide-free)
FITC Fluorescein Isothiocyanate
PE Phycoerythrin
PE-eFluor® 610 Phycoerythrin-eFluor® 610 Tandem
PE-Cyanine5 Phycoerythrin-Cyanine5 Tandem
PerCP-Cyanine5.5 Peridinin Chlorophyll Protein-Cyanine5.5 Tandem
PerCP-eFluor® 710 Peridinin Chlorophyll Protein-eFluor® 710 Tandem
PE-Cyanine7 Phycoerythrin-Cyanine7 Tandem
APC Allophycocyanin
APC-eFluor® 780 Allophycocyanin-eFluor® 780
B Cell Markers . . . . . . . . . . . . . . 4
CD4 T Cell Markers . . . . . . . . . . . . 6
CD8 T Cell Markers . . . . . . . . . . . . 8
Dendritic Cell Markers. . . . . . . . . . 10
Endothelial Cell Markers . . . . . . . . 12
Granulocyte Markers . . . . . . . . . . 14
Macrophage/Monocyte Markers . . . . . 16
Megakaryocyte/Platelet Markers . . . . 18
NK/ILC Markers . . . . . . . . . . . . . 20
NKT/γδ T Cell Markers . . . . . . . . . 22Stem Cell Markers. . . . . . . . . . . . 24
Other Cell Type Markers. . . . . . . . . 26
Human CD Antigens . . . . . . . . . . 28
Human Non-CD Antigens . . . . . . . . 48
Mouse CD Antigens . . . . . . . . . . 52
Mouse Non-CD Antigens . . . . . . . . 68
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B Cell MarkersHuman
Intra/TxnAIDBach2Bcl-6IRF8Pax5
Memory
Follicular
SurfaceCD45R (B220)CD81
SurfaceCD9CD19low/neg
CD20low/neg
CD27CD31CD38CD81
CD133 CD138 CD184 (CXCR4)CD252 (OX40 Ligand)CD269 (BCMA)
SurfaceCD27IgG
SurfaceCD1dCD9CD21/35high
CD45R (B220)CD81CD103CD180 (RP105)CD268 (BAFF Receptor)CD307d (FcRL4)IgM
SurfaceCD20CD21CD22CD23hCD24CD40hCD45R (B220)CD69hCD80h
CD81CD86hCD137 (4-1BB)hCD275 (B7-H2)CD279 (PD-1)CD360 (IL-21 Receptor)HLA-DRIgDhigh
IgMlow/int
Intra/TxnBlimp1IRF4XBP-1
SecretedIgAIgEIgG
SecretedIgAIgEIgG Plasma
Cell
Germinal Center
MarginalZone
Intra/TxnBcl-6EBF1FoxO1IkarosPax5
Intra/TxnEBF1Notch2Pax5
Intra/TxnCBF1Pax5Spi-B
Pan MarkersCD19 CD20 CD22CD70hCD79α/β Igκ/λ
4
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B Cell Markers
SurfaceCD1dCD5low CD9CD21/CD35high
CD23low/neg
CD24 (HAS)low
CD36CD81CD180 (RP105)FcRL3IgDlow/neg
IgMhigh SurfaceCD9CD16/32CD19low
CD81CD138IgG
SurfaceCD45R (B220)low
CD267 (TACI)CD269 (BCMA)IgG
Memory
SurfaceCD19CD81CD95GL7IgG
SurfaceCD20CD21/CD35low/neg
CD22CD23CD24 (HSA)low
CD25hCD36hCD40hCD69h
CD80hCD81CD86hCD180 (RP105)CD252 (OX40 Ligand)hIgDhigh
IgMlow/int
Follicular
Germinal Center
MarginalZone
Mouse
Pan MarkersCD20CD21/CD35low/neg
CD22CD23CD24 (HSA)low
CD25hCD36hCD40hCD69hCD80hCD81CD86hCD180 (RP105)CD252 (OX40 Ligand)h IgDhigh
IgMlow/int
Intra/TxnAIDBach2Bcl-6IRF8Pax5
Intra/TxnBlimp1IRF4XBP-1 Intra/Txn
CBF1Spi-B
Intra/TxnEBF1Notch2
Intra/TxnBcl-6EBF1FoxO1IkarosPax5
PlasmaCell
5 h = Up-regulated i = Down-regulated = Subset
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SecretedIFNγIL-2 TNFαTNFβ (LTα)
SecretedIL-21
SurfaceCD183 (CXCR3) CD185 (CXCR5) CD278 (ICOS) CD279 (PD-1)
Intra/Txn BATFBcl-6c-MafIRF4STAT3
SecretedAmphiregulin IL-4IL-5 IL-13
SecretedIL-10TGFβ
SurfaceCD25CD39CD73CD101CD121aCD121b
CD137 (4-1BB)CD152 (CTLA-4)CD357 (GITR/AITR)GARPhLAPhTIGIT
SurfaceCD184 (CXCR4)CD194 (CCR4)CD198 (CCR8)CD294 (CRTH2)CD365 (TIM1)IL-25R (IL-17RB)IL-33R (ST2)
SurfaceCD121aCD161CD194 (CCR4)CD196 (CCR6) CD360 (IL-21R)CD212 (IL-12β1)IL-23R
Intra/TxnBATF GATA-3IRF4STAT6
SurfaceCD94CD119 (IFNγR1)CD183 (CXCR3)CD186 (CXCR6)CD191 (CCR1)CD195 (CCR5)CD212 (IL-12Rβ1)CD218a (IL-18Rα)CD254 (RANKL)CD366 (TIM3)
SecretedGM-CSFIL-17AIL-17AFIL-17FIL-21IL-22
Th1
Th2
Th17
Treg
Tfh
Intra/Txn STAT1STAT4T-bet
Intra/TxnAHRBATFc-MafIκBζ IRF4RORαRORγtSTAT3
Intra/Txnc-RelEosFoxp3HeliosSTAT5
CD4 T Cell MarkersHuman
6
Pan MarkersCD2CD3CD4CD5CD7CD25hCD27CD28CD45RA (naïve)CD45RO (memory)CD62L (naïve:high, effector:low, memory:high)CD69hCD127 (IL7Rα)CD134 (OX40)hCD137 (4-1BB)hCD152 (CTLA-4)hCD154 (CD40L)hCD272 (BTLA)hCD279 (PD-1)h
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CD4 T Cell Markers
7
Intra/Txn BATF Bcl-6c-MafIRF4STAT3
SecretedAmphiregulinIL-4IL-5IL-13
SecretedIFNγIL-2TNFαTNFβ (LTα)
Intra/TxnSTAT1STAT4T-bet
SurfaceCD184 (CXCR4)CD194 (CCR4)CD198 (CCR8)CD294 (CRTH2)CD365 (TIM1)IL-25R (IL-17RB)IL-33R (ST2)
SurfaceCD94CD119 (IFNγR1)CD183 (CXCR3)CD186 (CXCR6)CD191 (CCR1)
SecretedIL-21
SecretedIL-10TGFβ
Intra/Txnc-RelEosFoxp3HeliosSTAT5
SecretedGM-CSFIL-17AIL-17AFIL-17FIL-21IL-22
Intra/TxnAHRBATFc-MafIκBζIRF4RORαRORγtSTAT3
Intra/TxnBATF GATA-3IRF4STAT6
Tfh
Treg
Th17
Th2
Th1
SurfaceCD194 (CCR4)CD196 (CCR6)CD121aCD212 (IL12β1)CD360 (IL-21R)IL-23R
SurfaceCD185 (CXCR5)CD278 (ICOS)CD279 (PD-1)
Mouse
SurfaceCD25 CD137 (4-1BB)CD39CD73CD101CD121aCD121bCD152 (CTLA-4)CD304 (Neuropilin-1)CD357 (GITR)FR4GARPhLAPhTIGIT
Pan MarkersCD3CD4CD5CD7CD25hCD27CD28CD44hCD62L (naïve:high, effector:low, memory:high)CD69hCD127 (IL7Rα)CD134 (OX40)hCD137 (4-1BB)hCD152 (CTLA-4)hCD154 (CD40L)hCD272 (BTLA)hCD278 (ICOS)hCD279 (PD-1)h
CD195 (CCR5)CD212 (IL-12Rβ1)CD218a (IL-18Rα)CD254 (RANKL)CD366 (TIM3)
h = Up-regulated i = Down-regulated = Subset
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CD8 T Cell MarkersHuman
SurfaceCD197 (CCR7)CD127 (IL7Rα)CD27CD45RACD62L
SurfaceCD25hCD69hCD30CD122hCD137 (4-1BB)CD134 (OX40)
CD223 (LAG-3)CD272 (BTLA)CD278 (ICOS)CD279 (PD-1)CD366 (TIM3)KLRG1
SurfaceCD45ROKLRG1
SurfaceCD27CD28CD45ROCD62LCD127 (IL7Rα)CD197 (CCR7)
Intra/TxnEomesint
T-betint
SecretedGranzyme BIFNγIL-2PerforinTNFα
SecretedCCL3 (MIP-1α)CCL4 (MIP-1β)CCL5 (RANTES)Granzyme BIFNγIL-2PerforinTNFα
Intra/TxnT-bet
Intra/TxnEomesint
T-betint
Naïve
Effector
Effector Memory
Pan MarkersCD2CD3CD5CD7CD8CD25hCD27CD28
CentralMemory
8
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CD8 T Cell Markers
Mouse Intra/TxnEomesint
T-betint
SecretedGranzyme BIFNγIL-2PerforinTNFα
SecretedCCL3 (MIP-1α)CCL4 (MIP-1β)CCL5 (RANTES)Granzyme B
IFNγIL-2PerforinTNFα
SurfaceCD25hCD30CD44CD69hCD122h
CD134 (OX40)CD137 (4-1BB)CD223 (LAG-3)CD272 (BTLA-4)CD278 (ICOS)CD279 (PD-1)CD366 (TIM3)KLRG1
Intra/TxnBlimp1Id2T-bet
Intra/TxnEomesint
T-betint
Naïve
Effector
CentralMemory
Pan MarkersCD3CD5CD8CD27CD28
SurfaceCD62LCD127 (IL-7Rα)CD197 (CCR7)CD183 (CXCR3)
SurfaceCD44CD57KLRG1Effector
Memory
SurfaceCD44CD62LCD127 (IL-7Rα) CD197 (CCR7)
9 h = Up-regulated i = Down-regulated = Subset
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Dendritic Cell MarkersHuman
PlasmacytoidDendritic Cell
Conventional Dendritic Cell
SecretedIDOIL-1βIL-6IL-8IL-12IL-15IL-23
SecretedIFNαIFNβ
Intra/TxnCD287 (TLR7)CD289 (TLR9)E2-2IRF8Intra/Txn
CD289 (TLR9)
SurfaceCD85g (ILT7)CD123CD303 (BDCA-2)CD304 (BDCA-4)
SurfaceCD1aCD1bCD1c (BDCA-1)CD11cCD14iCD40hCD49dCD141 (BDCA-3) CD197 (CCR7)CD205 (DEC-205)CD207 (Langerin)CD209 (DC-SIGN)CD273 (B7-DC)CD282 (TLR2)CD284 (TLR4)CD304 (BDCA-4)CD369 (Dectin-1)
10
Pan MarkersCD80hCD83CD86hMHCIIh
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Dendritic Cell Markers
Mouse
PlasmacytoidDendritic Cell
SecretedIDOIL-1βIL-6IL-8IL-12IL-15IL-23
SecretedIFNαIFNβ
Intra/TxnCD287 (TLR7)CD289 (TLR9)E2-2IRF8
Intra/TxnCD289 (TLR9)
Pan MarkersCD11c CD80h CD86h MHCIIh
SurfaceCD45R (B220)CD317 (BST2,PDCA-1)Siglec-H
Surface33D1CD4CD8 CD11blow CD40hCD83CD197 (CCR7)CD205 (DEC-205)CD207 (Langerin) CD209 (DC-SIGN)CD273 (B7-DC)CD369 (Dectin-1)
Conventional Dendritic Cell
11 h = Up-regulated i = Down-regulated = Subset
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SurfaceCD31CD34CD54 (ICAM-1)CD61 (Integrinβ3)CD62E (E-Selectin)CD105 (Endoglin)CD106 (VCAM-1)hCD144 (VE-Cadherin)CD146CD202b (Tie2)CD309 (FLK1)Podoplanin
Endothelial Cell MarkersHuman
12
-
Mouse
Endothelial Cell Markers
SurfaceCD31 (PECAM-1)CD34CD54 (ICAM-1)CD61 (Integrinβ3)CD62E (E-Selectin)CD105 (Endoglin)CD106 (VCAM-1)hCD144 (VE-Cadherin)CD146CD202b (Tie2)CD309 (FLK1)PodoplaninVEGF Receptor 3
13 h = Up-regulated i = Down-regulated = Subset
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Human
Granulocyte Markers
Intra/TxnCD281 (TLR1)CD289 (TLR9)
SurfaceCD9CD15CD24CD35CD43CD64
CD116CD123CD125CD126CD244FcεR1
Eosinophil
Neutrophil
Mast
Intra/TxnC/EBPαCD281 (TLR1)CD289 (TLR9)GATA2
SurfaceCD10CD15CD17CD24CD35CD43CD66aCD66bCD66cCD66dCD89CD93
CD112 CD114CD116CD157CD177CD181 (CXCR1)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)
SurfaceCD9CD15CD24CD35CD43CD64CD116
CD117 (c-kit)CD123CD125CD126FcεR1IL-33R (ST-2)
Pan MarkersCD11bCD13CD15CD32CD33
SurfaceBasophil MarkerCD9CD11aCD13CD16CD25CD33CD38CD43CD88CD123CD125
CD154CD192CD203cCD218 (IL-18R)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)CD294FcεR1
Basophil
SecretedMPO
Human
14
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Granulocyte Markers
15 h = Up-regulated i = Down-regulated = Subset
Mouse
SurfaceCD10CD15CD17CD24CD35CD43CD66aCD66bCD66d
CD89CD93 CD112 (Nectin-2)CD114 (G-CSFR)CD116CD157CD177CD181 (CXCR1)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)
SurfaceCD9CD15CD24CD35CD43CD64CD116CD117 (c-kit)CD123CD125CD126FcεR1IL-33R (ST2)
SurfaceCD9CD11aCD13CD25CD33CD38CD43CD88 (C5a Receptor)
CD123CD125CD154 (CD40 Ligand)CD192 (CCR2)CD218 (IL-18 Receptor)CD282 (TLR2)CD284 (TLR4)CD286 (TLR6)CD294 (CRTH2)FcεR1
Intra/TxnCD281 (TLR1)CD289 (TLR9)
SurfaceCD9CD15CD24CD35 CD43 CD64
CD116CD123CD125CD126CD170CD244FcεR1
Mast
Neutrophil
Pan MarkersCD11bCD16/CD32Gr-1 (Ly6G)
Eosinophil
Basophil
Intra/TxnCD281 (TLR1)CD289 (TLR9)C/EBPαGATA-2
SecretedMPO
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Macrophage/Monocyte MarkersHuman
Monocyte
M1 Macrophage
M2 Macrophage
SurfaceCD11c CD14CD33
SurfaceCD163CD206 (MMR)CD209 (DC-SIGN)FcεR1
Intra/Txn IRF5STAT1
Intra/TxnIRF4STAT6
SecretedIFNγIL-1αIL-1βIL-6IL-12IL-23TNFα
SecretedIDOIL-10TGFβ
SurfaceCD16CD16/CD32CD32CD64CD80CD86CD369 (Dectin-1) Mer (MerTK)MHCII
Pan MarkersCD11bCD15CD33CD40CD63CD68 (mature)CD80hCD85CD86hCD105hCD115CD169CD195 (CCR5)CD282 (TLR2)CD284 (TLR4)CD354 (Trem-1)CXCL10CXCL11CXCL9Mature Macrophage MarkerMIP-2α (CXCL2)
16
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Macrophage/Monocyte Markers
17 h = Up-regulated i = Down-regulated = Subset
Mouse
Pan MarkersCD11bCD16/CD32CD40CD64CD68CD107 (Mac3)CD115CD282 (TLR2)CD284 (TLR4)F4/80Galectin-3 (Mac2)GITRLLy6G (Gr-1)MHC Class IIh
SecretedArginaseIDOIL-10TGFβ
Intra/TxnIRF4 STAT6
Intra/TxnIRF5NOS2STAT1
SecretedIFNγIL-1IL-6IL-12IL-23TNFα
M2 Macrophage
M1 Macrophage
Monocyte
SurfaceCD14 CD16/CD32CD32CD64CD80
CD86CD204CD369 (Dectin-1)Mer (MerTK)MHCII
SurfaceCD14CD163CD204CD206 (MMR)CD209 (DC-SIGN)FcεR1
SurfaceLy6c
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SurfaceCD9CD23CD31CD36CD41CD42aCD42bCD42cCD42dCD49fCD51
CD60aCD61CD84CD92CD110CD147CD151CD173CD226GARPLAP
Megakaryocyte/Platelet MarkersHuman Megakaryocyte
Platelet
SurfaceCD41CD42aCD42bCD42cCD42dCD49fCD51CD61CD110CD112CD123
18
-
19 h = Up-regulated i = Down-regulated = Subset
Megakaryocyte/Platelet Markers
Mouse
SurfaceCD9 CD31 CD41 CD42b CD51 CD61 CD62PhLAP
SurfaceCD9 CD41 CD61 CD62Ph
Platelet
Megakaryocyte
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HumanNK
ILC2
ILC1
ILC3
LTi
SecretedGranulysinGranzyme AGranzyme BGranzyme KIFNγIL-10PerforinTNFα
SurfaceCD11bCD16CD56CD69 hCD94CD122CD161CD244CD226 (TIGIT) CD314 (NKG2D)CD335 (NKp46)CD336 (NKp44)CD337 (NKp30)CD158 family (KIRs)
SurfaceCD56CD103CD183 (CXCR3)CD335 (NKp46)CD336 (NKp44)CD337 (NKp30)Linneg
SecretedCCL3 (MIP-1α)IFNγ
SecretedIL-4IL-5IL-9IL-13Amphiregulin
SecretedIL-17AIL-17AFIL-17FIL-22
SecretedIL-17LTβTNFβ (LTα)
Intra/TxnE4BP4EomesGATA-3Id2Runx1T-betTOX
Intra/TxnId2Tbet
Intra/TxnArginase-1GATA-3Gfi1Id2RORαTCF1
Intra/TxnAHRId2RORγtT-betTCF1
Intra/TxnAHRId2RORγtRunx1TOX
SurfaceCD25CD45CD117CD127 (IL-7Rα)CD161CD184 (CXCR4)CD186 (CXCR6)CD199 (CCR9)
CD278 (ICOS) CD294 (CRTH2)IL-25R (IL-17RB)IL-33R (ST2)Linneg
TSLP Receptor
SurfaceCD56CD117CD127 (IL-7Rα)CD335 (NKp46)CD336 (NKp44)CD337 (NKp30)IL-23R Linneg
SurfaceCD7CD25CD117CD127 (IL-7Rα)CD161CD196 (CCR6)IL-23RMHCII
NK/ILC Markers
20
-
NK/ILC Markers
Mouse
ILC3
ILC2
LTi
NK
SecretedIL-17AIL-17AFIL-17FIL-22
SecretedAmphiregulinIL-4IL-5IL-9IL-13
SecretedIL-17LTβTNFβ (LTα)
SecretedIFNγCCL3 (MIP-1α) Secreted
Granzyme A Granzyme BGranzyme KIFNγ
IL-10PerforinTNFα
Intra/TxnAHRId2RORγtT-betTCF1
Intra/TxnAHRId2RORγtRunx1TOX
Intra/TxnArginase-1GATA-3Gfi1Id2RORαTCF1
Intra/TxnId2Tbet
Intra/TxnE4BP4EomesGATA-3Id2Runx1T-betTOX
SurfaceCD103CD183 (CXCR3)CD335 (NKp46)Linneg
Ly-6A/E (Sca-1)
SurfaceCD117CD127 (IL-7Rα)CD196 (CCR6) CD335 (NKp46)IL-23RLinneg
SurfaceCD11bCD16CD25hCD49b (DX5)CD94CD122
CD161c (NK1.1)CD226CD314 (NKG2D)CD335 (NKp46)Ly-49 FamilyTIGIT
SurfaceCD4CD25CD117CD127 (IL-7Rα)CD185 (CXCR5)CD186 (CXCR6)CD196 (CCR6)IL-23RMHCII
SurfaceCD25CD117CD127 (IL-7Rα)CD184 (CXCR4)CD186 (CXCR6)CD199 (CCR9)CD278 (ICOS)CD294 (CRTH2)IL-25R (IL-17RB)Linneg
Ly-6A/E (Sca-1)IL-33R (ST2)TSLP Receptor
ILC1
21 h = Up-regulated i = Down-regulated = Subset
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Pan MarkersCD3
NKT
γδ T Cell
SecretedIL-4hIL-10hIL-13hIFNγhTNFαh
SecretedGM-CSFGranzyme BIFNγIL-4IL-5IL-17APerforinTNFα
Intra/TxnPLZFId2
SurfaceCD4 CD8 CD16CD56CD69CD160TCR Vα24
SurfaceCD5CD16CD27CD28CD45RACD56CD57CD62L
CD69CD70hCD107aCD314 (NKG2D)γδ TCRTCR Vδ1TCR Vδ2TCR Vδ3
NKT/γδ T Cell MarkersHuman
22
-
NKT/γδ T Cell Markers
23 h = Up-regulated i = Down-regulated = Subset
Mouse
NKT
Intra/TxnPLZFEgr2HEBHobit
SurfaceCD4CD8CD44hCD49bCD94CD160CD183 (CXCR3)CD184 (CXCR4)CD186 (CXCR6)CD314 (NKG2D)DX5Ly-49 NK1.1 (on C57BL/6)TCR Vα14
SecretedIFNγhIL-4hIL-10hIL-13hIL-17hIL-21hIL-22hTNFαh
Pan MarkersCD3
γδ T
Cell
SecretedGranzyme BIFNγIL-4IL-5IL-17APerforinTNFα
Intra/TxnEomes RORγtT-bet
SurfaceCD25hCD27CD28CD44CD45R (B220)hCD45RBCD62LCD69hCD71hCD103CD122CD127 (IL-7Rα) CD150CD196 (CCR6)γδ TCRIL-1R1NK1.1 (on C57BL/6)TCR Vγ1TCR Vγ4TCR Vγ5TCR Vγ6TCR Vγ7
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Stem Cell MarkersHuman
HSC
CMP
CLP
Intra/TxnIkarosPU.1
Intra/TxnGATA-2TdT
Intra/TxnAiolosc-mybGATA-3PU.1TdT
SurfaceCD38low/neg
CD59CD133CD135 (Flt3)CD338Linneg
SurfaceCD33CD45RACD123low
CD131CD135 (Flt3)CD173CD174Linneg
SurfaceCD7CD38CD45RACD90low
CD110CD117 (c-kit)low
CD127 (IL-7Rα)HLA-DRLinneg
Pan MarkersCD34CD117 (c-kit)CD164
24
-
Stem Cell Markers
Mouse
HSC
CMP
CLP
Intra/TxnIkarosPU.1
Intra/TxnAiolosc-mybGATA-3PU.1TdT
SurfaceCD34CD123 (IL-3R)Linneg
SurfaceCD34CD43CD135 (Flt3)CD127 (IL-7Rα)Linneg
Intra/TxnGATA-2TdT
SurfaceCD38low/neg
CD59CD117 (c-kit)CD133 (Prominin-1)CD135 (Flt3)CD150 (SLAM)Linneg
Ly-6A/E (Sca-1)
25 h = Up-regulated i = Down-regulated = Subset
-
Other Cell Type MarkersHuman
26
CD24 CD49f CD66a CD75 CD104 CD121a CD133 CD167a CD326 (EpCAM) Cytokeratin
CD45neg CD51 CD61 CD235a/Glycophorin
CD10 CD29 CD47 CD81 CD91 CD121a CD140a/PDGFRa CD140b/PDGFRb Vimentin
CD6 CD24 CD90 CD143CD166 CD171 CD200 CD230 (Prion Protein) CD271 (NGFR) CD304 (Neuropilin) Nestin
CD10 CD34 CD157 Podoplanin/p38 Stro-1
Erythrocytes Fibroblasts NeuronsEpithelialCells
StromalCells
-
+
Erythrocytes Fibroblasts NeuronsEpithelialCells
StromalCells
Other Cell Type Markers
Mouse
CD24 CD49f CD66a CD75 CD104 CD121a CD133 CD167a CD326 (EpCAM) Cytokeratin
CD24 CD45neg CD51 CD61 Ter119
CD10 CD29 CD47 CD81 CD91 CD121a CD140a/PDGFRa CD140b/PDGFRb Vimentin
CD6 CD24 CD90 CD143 CD166 CD171 CD200 CD230 (Prion Protein) CD271 (NGFR) CD304 (Neuropilin) Nestin
CD10 CD34 CD157 Podoplanin/p38 Stro-1
27 h = Up-regulated i = Down-regulated = Subset
-
6
Human CD Antigens
6
Antigen Name Alternative Name MW Distribution Function
CD1a T6, Leu-6, R4, HTA1 49kD cortical thymocytes, Langerhans cells, DC antigen presentation, w/ β2m
CD1b R1, T6 45kD cortical thymocytes, Langerhans cells, DC antigen presentation, w/ β2m
CD1c BDCA-1, R7, T6, M241 43kD cortical thymocytes, Langerhans cells, DC, B subset antigen presentation, w/ β2m
CD1d R3 49kD intestinal epith, B subset, monolow, DC antigen presentation, w/ β2m
CD1e R4 28kD DC antigen presentation, w/ β2m
CD2 T11, LFA-2, SRBC-R 50kD thymocytes, T, NK CD58 ligand, adhesion, T cell activation
CD2R T11-3 50kD Tact activation-dependent form of CD2
CD3γ, CD3δ T3 20, 25kD T, thymocyte subsetw/ TCR, TCR surface expression/signal transduction
CD3ε T3 20kD T, thymocyte subsetw/ TCR, TCR surface expression/signal transduction
CD4 T4, Leu3a 55kD thymocyte subset, T subset, mono, macMHC class receptor, HIV receptor, T cell differentiation/activation
CD5 T1, Tp67, Leu1, Ly-1 67kD thymocytes, T, B subset, B-CLLCD72 receptor, TCR or BCR signaling, T-B interaction
CD6 T12 100-130kD thymocytes, T, B subsetCD166 receptor, T cell differentiation/ costimulation
CD7 Leu9, gp40 40kD hematopoietic progenitors, thymocytes, T, NK T costimulation
CD8a T8, Leu-2, Ly-2 32-34kD thymocyte subset, T subset, NKMHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation/activation
CD8b Lyt-3 30-32kD thymocyte subset, T subset
CD9 p24, MRP-1, DRAP-27 22-27kDpre-B, eosinophils, basophils, platelets, Tact, and neurons and glial cells in the peripheral nervous system
cellular adhesion and migration
CD10 CALLA, NEP, gp100 100kD B precursors, T precursors, neutrophilszinc-binding metalloproteinase, B cell development
CD11a LFA-1, integrin αL 180kD lymph, gran, mono, macCD11a/CD18 receptor for ICAM-1,-2,-3, intercellular adhesion, T costimulation
CD11b Mac-1, integrin αM 170kD myeloid cells, NK binds CD54, ECM, iC3b
CD11cp150, 95, CR4, integrin αX, LeuM5
150kDB cells, dendritic cells, granulocytes, leukemia cells, lymphocytes, macrophages, monocytes, myeloid cells, NK cells, T cells
binds CD54, fibrinogen and iC3b
CD12 90-120kD mono, gran, platelets
CD13 Aminopeptidase N, APN, GP150 150-170kDmono, gran, some macrophages, and connective tissue
zinc-binding metalloproteinase, antigen processing, receptor for corona virus strains
28
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Human CD Antigens
29
Antigen Name Alternative Name MW Distribution Function
CD14 LPS-R 53-55kD mono, mac, Langerhans cells, granlow receptor for LPS/LBP, LPS recognition
CD153-FAL, X-hapten, LeX antigen, SSEA-1
gran, neutrophils, eosinophils, mono adhesion
CD15s Sialyl Lewis Xneutrophils, eosinophils, mono, memory helper T, Tact
and B, NK, HEVCD62L and CD62P ligand, adhesion
CD15u Sulfated Lewis X myeloid subset adhesion
CD16a FcγRIIIA 50-65kD neutrophils, mac, NKcomponent of low affinity Fc receptor, phagocytosis and ADCC
CD16b FcγRIIIB 48kD neutrophilscomponent of low affinity Fc receptor, phagocytosis and ADCC
CD17 lactosylceramide neutrophils, mono, platelets lactosyl ceramide
CD18 Integrin β2, ITGB2 95kD broad, all leukocytes w/ CD11a, b & c, adhesion
CD19 B4 95kD B, FDCcomplex w/ CD21and CD81, BCR coreceptor, B cell activation/ differentiation
CD20 B1, Bp35, Ly-44 33-37kD B, T subset B cell activation
CD21 C3DR, CR2, EBV-R110, 145kD
B, FDC, T subsetcomplement C3d and EBV receptor, complex w/ CD19 and CD81, BCR coreceptor
CD22 BL-CAM, Siglec-2, Leu-14 150kD B adhesion, B-mono, B-T interactions
CD23 FcεRII, BLAST-2 45kD B, activated mac, eosinophils, FDC, plateletsCD19-CD21-CD81 receptor, IgE low affinity receptor, signal transduction
CD24 BA-1, HSA, Heat-Stable Antigen 35-45kDthymocytes, erythrocytes, peripheral lymph, myeloid, B-lineage cells
binds P-selectin
CD25 Tac, p55 55kD Tact, Bact, lymph progenitorsIL-2Rα, w/ IL-2Rβ and γ to form high affinity complex
CD26 DPP IV, Ta1 110kD thymocyte subset, Tact, soluble form dipeptidyl peptidase, T costimulation, HIV entry
CD27S152, S152. LPFS2, T14, TNFRSF7, Tp55
50-55kD medullary thymocytes, T, B subset, NK subset CD70 receptor, T costimulation
CD28 Tp44, T44 44kD most T, thymocytes, plasma cells CD80, CD86 receptor, T costimulation
CD29Integrin β1, platelet GPIIa, MSK12, VLAB
130kDlymph, mono, granlow, platelets, mast cells, fibroblasts, endoth, nerve, connective tissue
w/ CD49a (VLA-1) receptor for VCAM-1, MAdCAM-1 and ECM
CD30 Ki-1, Ber-H2, TNFRSF8105-120kD
Bact, T and NK, Reed-Sternberg cells, anaplastic large cell lymphoma
CD153 receptor, lymph proliferation/ apoptosis
CD31 PECAM-1, endocam 130-140kD mono, platelets, gran, endoth, lymph subset CD38 receptor, adhesion, signal transduction
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Human CD AntigensAntigen Name Alternative Name MW Distribution Function
CD32 FcγRII 40kD mono, gran, B, plateletslow affinity Fc receptor for aggregated Ig and immune complexes
CD33 p67, Siglec-3 67kD myeloid progenitors, mono, gran, DC, mast cells, Tact adhesion
CD34 MY10, Mucosialin, gp 105-120105-120kD
hematopoietic precursors, capillary endoth, embryonic fibroblasts
stem cell marker, adhesion, CD62L receptor
CD35 CR1 250kDerythrocytes, B, mono, neutrophils, eosinophils, FDC, T subset
complement receptor 1, binds C3b and C4b, adhesion, phagocytosis
CD36GPIV, GPIIIb, fatty acid translocase, SCARB3, GP88
88kD platelets, mono, mac, endoth, early erythrocytes ECM receptor, adhesion, phagocytosis
CD37 gp40-52 40-52kD B, Tlow, granlow, mono, DC signal transduction
CD38 T10, cyclic ADP ribose hydrolase 45kDvariable levels on majority of hematopoietic cells, high expression on plasma cells, B and Tact
ecto-ADP-ribosyl cyclase, cell activation, cyclase & hydrolase activity
CD39 ENTPD-1, Gp80, EC3.6.1.5 78kD NK, mac, Langerhans cells, DC, Bact, TregB cell adhesion, protects activated cells from lysis, ecto-apyrase
CD40 Bp50, TNFRSF5 48kD B, mono, mac, FDC, endoth, T subsetCD154 receptor, B differentiation/ costimulation, isotype-switching, rescues B cells from apoptosis
CD41 gpIIb, αIIβ integrin, ITGA2B 22, 125kD platelets, megakaryocytesw/ CD61 forms GPIIb, binds fibrinogen, fibronectin, vWF, thrombospondin, platelet activation and aggregation
CD42a Glycoprotein IX, GP9 22kD platelets, megakaryocytescomplex w/ CD42b, c and d, receptor for vWF and thrombin, platelet adhesion to subendothelial matrices
CD42b GPIba 145kD platelets, megakaryocytescomplex w/ CD42a, c and d, binds to vWF and thrombin, platelet adhesion/activation
CD42c GPIbb 24kD platelets, megakaryocytes complex w/ CD42a, b, d
CD42d gpV 82kD platelets, megakaryocytes complex w/ CD42a-c
CD43 Leukosialin, sialophorin 115-135kD leukocytes, except resting B, plateletslow inhibition of T cell interaction, CD54R, adhesion
CD44
H-CAM, Pgp-1, Hermes Ag, lymphocyte homing receptor, ECM-III, Hyaluronate receptor, HUTCH-1
80-95kDhematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis
binds hyaluronic acid, adhesion
CD44std (SFF-2) CD44 variant 1-10CD44 variants heterogeneous expression, constitutively on epith, mono, up-regulated on activated leukocytes
adhesion, metastasis
30
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Antigen Name Alternative Name MW Distribution Function
CD44std (SFF-304)
CD44var (v4)
CD44var (var10)
CD44var (v7-v8)
CD44 (v6)
CD44 (v3)
CD44 (v6)
CD44 (v5)
CD44 (v7)
CD45LCA, PTPRC, Protein tyrosine phosphatase receptor type C
180-240kD
hematopoietic cells, multiple isoforms from alternative splicing
tyrosine phosphatase, enhanced TCR & BCR signals
CD45R B220
CD45RA T200, gp220205-220kD
B, T subsetnaive, mono exon A isoforms of CD45
CD45RB LCA190-220kD
B, T subset, mono, mac, gran exon B isoforms of CD45
CD45RC190-220kD
B, T subset, NK exon C isoforms of CD45
CD45RO T200, gp180, UCHL1 180kD Tact, memory T, B subset, mono, mac, granisoform of CD45 lacking A, B, C exons, ligand for CD22
CD46MCP, Membrane Cofactor Protein
56, 66kD nucleated cellsmembrane cofactor protein, binds C3b & C4b allowing degradation by Factor I, measles virus receptor
CD47 IAP, integrin associated protein 47-52kDhematopoietic cells, epith, endoth, fibroblasts, other tissues
leukocyte adhesion, migration, activation, thrombospondin receptor
CD47R MEM-133 120kDnew designation for CDw149, similar distribution as CD47 but dimmer
CD48 Blast-1, BCM1, Sgp-60, SLAMF2 45kD broad, all leukocytes cell adhesion
CD49a VLA-1, Integrin α1 210kD Tact, monointegrin α1, adhesion, CD49a/CD29 binds collagen and laminin
CD49b VLA-2, Integrin α2 165kD B, mono, platelets, Tact, megakaryocytesintegrin α2, adhesion, CD49b/CD29 binds collagen and laminin
31
Human CD Antigens
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Antigen Name Alternative Name MW Distribution Function
CD49c VLA-3, Integrin α3 125kD B and Tlow, most adhesive cell linesintegrin α3, adhesion, CD49c/CD29 binds laminin, fibronectin and collagen
CD49d VLA-4, Integrin α4 150kD T, B, NK, thymocytes, mono, eosinophils, mast, DCintegrin α4, adhesion, CD49d/CD29 binds fibronectin, VCAM-1 & MAdCAM-1
CD49e VLA-5, Integrin α5 25, 135kD thymocytes, T, mono, platelets, early and Bactintegrin α5, adhesion, CD49e/CD29 binds fibronectin
CD49f VLA-6, Integrin α6 125kDmemory T, thymocytes, mono, platelets, megakaryocytes, epith
integrin α6, adhesion, CD49f/CD29 binds laminin
CD50 ICAM-3 110-120kD hematopoietic, endoth, epidermal Langerhans cells adhesion, costimulation
CD51 Vitronectin receptor, integrin αV 24, 125kD plateletslow, endoth, osteoblasts, melanomasintegrin αv, adhesion, CD51/CD61 binds vitronectin, vWF, fibrinogen and thrombospondin
CD52 CAMPATH-1, HE5 21-28kD thymocytes, T, B (not plasma cells), mono, mac unknown
CD53 OX-44 35-42kD leukocytes, DC, osteoblasts, osteoclasts signal transduction
CD54 ICAM-1 90-110kD endoth, mono, lymph (high upon activation)receptor for CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1) and rhinovirus
CD55 DAF, Decay accelerating factor 60-70kD hematopoietic, endoth, soluble in plasma binds C3b, complement regulation
CD56 NCAM, Leu-19, NKH-1 175-185kDNK, T subset, neurons, some large granular lymphocyte leukemias, myeloid leukemias
adhesion
CD57 HNK-1, Leu-7 110kD NK subset, T subset
CD58 LFA-3 55-70kD hematopoietic, non-hematopoietic cells CD2 receptor, adhesion
CD59
Protectin, H19, 1F-5Ag, HRF, MAC-inhibitor protein, MAC-IP, membrane inhibitor of reactive lysis, MIRL
19kD hematopoietic, non-hematopoietic cellsbinds complement C8 and C9, blocks assembly of membrane attack complex
CD60a GD3 90-120kD T subset, platelets, thymic epith, astrocytes costimulation
CD60b 9-O-sialyl GD3 T subset, Bact
CD60c 7-O-sialyl GD3 T subset
CD61 GPIIIa, Integrin β3 105kD platelets, megakaryocytes, mac, endothintegrin β3, adhesion, CD41/CD61 or CD51/CD61 mediate adhesion to ECM
CD62E E-selectin, ELAM-1, LECAM-297, 107-115kD
endoth binds CD15s, cell rolling, metastasis
CD62L L-selectin, LECAM-1, LAM-1 74, 95kD B, naïve and memory T, mono, gran, NK, thymocytesCD34, GlyCAM, and MAdCAM-1 receptor, leukocyte homing, tethering, rolling
Human CD Antigens
32
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Antigen Name Alternative Name MW Distribution Function
CD62P P-selectin, GMP-140, PADGEM 140kD activated platelets, endothCD162, CD15s receptor, adhesion, neutrophil rolling, platelet-neutrophil and platelet-mono interactions
CD63 LIMP, MLA1, LAMP-3 53kD activated platelets, mono, maclysosomal membrane protein, moves to cell surface after activation
CD64 FcγRI 72kD mono, mac, DC, Interferon or G-CSF activated granhigh affinity receptor for IgG, phagocytosis and ADCC
CD65VIM2, Ceramide-dodecasaccharide
gran, mono subset, myeloid leukemias CHO
CD65s VIM2 gran, mono, myeloid leukemias phagocytosis, CHO
CD66a BGP-1, NCA-160160-180kD
neutrophils, epith cell adhesion
CD66b CD67, CGM6, NCA-95 95-100kD gran cell adhesion, neutrophil activation
CD66c NCA 90kD neutrophils, colon carcinoma cell adhesion
CD66d CGM1 35kD neutrophils, gran putative role in cell adhesion and signaling
CD66e CEA180-200kD
colon epith, colon cancer cell adhesion
CD66f PSG, Sp-1 54-72kDpregnancy specific glycoprotein, placental syncytiotrophoblasts, fetal liver
immune regulation, protects fetus from maternal immune system
CD68 Macrosialin, gp110 110kDintracellularly in mono, mac, neutrophils, basophils, large lymph, mast cells, DC, myeloid progenitors, liver
scavenger receptor
CD69 AIM, VEA 28, 32kDTact, B, NK and gran, thymocytes, platelets, Langerhans cells
signal transduction
CD70 Ki-24, CD27L, TNFSF750, 70, 90, 160kD
Bact and Tact CD27 ligand, T and B cell costimulation
CD71 TfR, T9 95kD proliferating cells, reticulocytes, erythroid precursors transferrin receptor, iron uptake
CD72 Lyb-2 42kD B, FDC CD5, CD100 receptor, B proliferation
CD73 NT5E, Ecto-5'-nucleotidase 69kD B subset, T subset, FDC, epithecto-5’-nucleotidase, nucleoside uptake, T costimulation, lymph adhesion
CD74
Ii, invariant chain, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain
33, 35, 41, 43kD
B, mac, mono, Langerhans cells, DC, TactMHC class II traffic and function, binds MIF, maturation of follicular B cells
CD75 lactosamines 67, 85kD B subset, epith lactosamines, CHO
33
Human CD Antigens
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Antigen Name Alternative Name MW Distribution Function
CD75s siliated lactosamines B subset, T subseta-2,6-sialylated lactosamines (previously CDw75 and CDw76)
CD77 Gb3, Pk blood group 1kDgerminal center B, Burkitt’s lymphomashigh, follicular lymphomaslow
apoptosis, CHO
CD79a Iga, MB-1 33, 45kD B component of BCR, BCR surface expression and signal transduction
CD79b Igb, B29 37kD B component of BCR, BCR surface expression and signal transduction
CD80 B7, B7-1, BB1 60kD Bact and Tact, mac, DC binds to CD28, CD152, T costimulation
CD81 TAPA-1 26kDT, B, NK, thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas
complex w/ CD19 & CD21, signaling, T costimulation
CD82 R2, 4F9, C33, Kai1 50-53kD leukocytes, fibroblast, epith, endoth signal transduction
CD83 HB15 43kD Bact and Tact, DC, Langerhans cells dendritic cell marker
CD84 GR6, SLAMF5 73kD mono, platelets, B, T subset, mac subset putative role in adhesion, costim
CD85a LIR-3, ILT-5, HL-9, LILRB3 110kD mono signaling through FCg
CD85d LIR-2, ILT-4, MIR10, ILT8 110kD NK, mono, mac suppression of NK cell-mediated cytotoxicity
CD85g LIR4, ILT-7 55kD pDC signaling for cytokine production
CD85h LIR-7, ILT-1, LILRA2 53kD mono receptor for MHC class I antigens
CD85j LIR-1, ILT-2, MIR-7 110kD NK, DC, mono, T cells inhibitory receptor for MHC class I antigens
CD85k LIR-5, ILT-3, HM18, LILRB4 60kD DC, mac, mono, pDC thought to be an inhibitory receptor
CD86 B70, B7-2 80kD mono, DC, Bact and Tact binds to CD28, CD152, T costimulation
CD87 UPA-R 39-66kD gran, mono, NK, Tact, endoth, fibroblastsurokinase plasminogen activator receptor, inflammatory cell invasion, metastasis
CD88 C5aR 40kD gran, mono, DC C5a receptor, granulocyte activation
CD89 FcαR 55-75kD mono, mac, gran, neutrophils, B subset, T subsetIgA receptor, phagocytosis, degranulation, respiratory burst
CD90 Thy-1 25-35kD CD34+ hematopoietic subset, neuronshematopoietic stem cell and neuron differentiation, adhesion, signal transduction
CD91 α2MR 600kD mono, mac, neurons, fibroblasts receptor for α-2-macroglobulin
CD92 p70, CHTL1 70kD neutrophils, mono, platelets, endoth, fibroblasts putative ligand transporter
CD93 C1qRp 120kD neutrophils, mono, endoth clearance of apoptotic cells
CD94 KP43, KLRD1 43kD NK, T subset complex w/ NKG2, inhibits NK function
Human CD Antigens
34
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Antigen Name Alternative Name MW Distribution Function
CD95 Apo-1, Fas, TNFRSF6 45kD lymph (high upon activation), mono, neutrophils FasL (CD178) receptor, apoptosis
CD96 TACTILE 160kD NK, Tact adhesion of activated T and NK
CD97 BL-KDD/F1274, 80, 90kD
Bact and Tact, mono, gran
CD98 4F2, CD98hc 40, 80kD T, B, NK, gran, all human cell lines cellular activation
CD99 MIC2, E2 32kD leukocytes T cell activation, adhesion
CD99R E2 32kD T, NK, myeloid cells isoform of CD99
CD100 Sema4D 150kDhematopoietic cells except immature bone marrow cells, RBC and platelets
cell adhesion, cellular activation
CD101 V7, p126 120kD mono, gran, DC, Tact T cell activation
CD102 ICAM-2 55-65kD leuk, endoth binds CD11a/CD18, costimulation
CD103 HML-1, α6, integrin αE 25, 150kD intraepithelial lymph, lymph subset, activated lymphw/ integrin β7, binds E-cadherin, lymph homing/retention
CD104 β4 integrin 220kD epith, Schwann cells, keratinocytes, some tumor cellsw/ integrin α6 (CD49f), cell adhesion, differentiation, metastasis
CD105 Endoglin 95kD endoth, bone marrow subset, activated maccellular response to TGF-β1, adhesion, embryonic angiogenesis
CD106 VCAM-1 110kD activated endoth, FDCVLA-4 (CD49d/CD29) receptor, leukocyte adhesion, migration, costimulation
CD107a LAMP-1 110kD activated platelets, T, endoth, metastatic tumors a lysosomal membrane protein
CD107b LAMP-2 120kD activated platelets, T, endoth, metastatic tumors a lysosomal membrane protein
CD108 SEMA7A 80kD erythrocytes, lymphoblasts, resting lymphlow putative role in inflammation
CD109 Platelet specific Gov antigen 170kD Tact and platelets, CD34+ subset, endoth negative regulator of TGF-β in keratinocytes
CD110 TPO-R, C-mpl 82-84kD megakaryocytes, platelets, some CD34+ stem cellslowthrombopoietin receptor, megakaryocyte progenitor cell growth/differentiation
CD111 PRR1, Nectin-1 64-72kD stem cell subset, mac, neutrophils intercellular adhesion
CD112 PRR2, Nectin-2 64-72kDmono, neutrophils, CD34+ subset, megakaryocytes, endoth, epith
intercellular adhesion
CD113 PVRL3, Nectin3 83kD testis, placenta adhesion molecule that interacts with afadin
CD114 G-CSFR 95, 139kD myeloid progenitors, endoth myeloid differentiation/proliferation
CD115 M-CSFR, c-fms 150kD mono, mac, monocytic progenitors CSF-1R, monocytic differentiation/ proliferation
CD116 GM-CSFRa 70-85kD mono, gran, DC, endothw/ common b, myeloid differentiation/proliferation
35
Human CD Antigens
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Antigen Name Alternative Name MW Distribution Function
CD117 c-kit, SCFR 145kD hematopoietic progenitors, mast cellsSCF receptor, hematopoietic progenitor development/differentiation
CD118 LIFR, gp190 190kD epithelial cells in adult and embryomembrane-bound involved in signal transduction, soluble form inhibits activity of LIF
CD119 IFN-γRα 90-100kD mac, mono, B, T, NK, neutrophils, endoth IFN-γRα, w/ IFN-γ AF-1, host defense
CD120a TNFR-I, p55 50-60kD hematopoietic, non-hematopoietic cells receptor for both TNF-α and TNF-β
CD120b TNFR-II, p75 75-85kD hematopoietic, non-hematopoietic cells receptor for both TNF-α and TNF-β
CD121a IL-1R, type I 80kD dimly expressed on many cells binds IL-1α and IL-1β, IL-1 signaling
CD121b IL-1R, type II 60-70kD B, mac, mono, T subset binds IL-1α and IL-1β, negative signals
CD122 IL-2Rβ 75kD NK, T, B, mono IL-2Rβ and IL-15Rβ, signal transduction
CD123 IL-3R 70kDlymph subset, basophils, hematopoietic progenitors, mac, DC, megakaryocytes
IL-3Rα, w/ CDw131
CD124 IL-4R 140kDlymphlow, mono, hematopoietic precursors, fibrobroblast, epith
IL-4Rα, w/ CD132 or IL-13Rα, T cell growth/differentiation
CD125 IL-5R 60kD eosinophils, basophils IL-5Rα, w/ CDw131
CD126 IL-6R 80kD Bact and plasma cells, Leuk (maj)low, fibroblasts IL-6Rα, w/ CD130
CD127 IL-7R 65-75kD T, pro-B, down-regulated on Treg IL-7Rα, w/ CD132, B and T cell development
CD128 see CD181 & CD182
CD130 IL-6Rβ, gp130 130kD Bact and plasma cells, Leuk (maj)low, endoth IL-6Rβ, IL-6, IL-11, LIF, CNF signals
CD131 IL-3R common β 95-120kD mono, gran, early Bw/ a subunits of IL-3R, IL-5R, and GM-CSFR, signal transduction
CD132 Common γ 64kD T, B, NK, mono, gransubunit of IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R, signal transduction
CD133 AC133, prominin-like 1 120kDhematopoietic stem cell subset, epith, endoth, leukemias
unknown
CD134 OX-40 48-50kD Tact T cell activation, differentiation, apoptosis
CD135 Flt3/Flk2130-150kD
myelomonocytic, primitive B progenitorstyrosine kinase, binds FLT3 ligand, early lymph development
CD136 MSP-R, RON 180kD epith, CNS, PNS, hematopoietic subsetmigration, morphological change and proliferation of different target cells
CD137 4-1BB 30kD Tact T costimulation
CD138 Syndecan-1 80-150kDplasma cells, pre-B, basolateral surface of epith, neurons
receptor for ECM, cell morphology
CD139 228kD B, mono, gran, erythrocyteslow, FDC
Human CD Antigens
36
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Antigen Name Alternative Name MW Distribution Function
CD140a PDGFRa 180kD fibroblasts, smooth muscle & glial cells, chondrocytes binds PDGF A and B, tyrosine kinase receptor
CD140b PDGFRb 180kD fibroblasts, smooth muscle & glial cells, chondrocytes binds PDGF B, tyrosine kinase receptor
CD141 Thrombomodulin 100kD mono, neutrophils, endoth, smooth muscle cells initiation of protein C anticoagulant signal
CD142 Tissue Factor 45kD mono, endoth, keratinocytes, epith binds clotting factor VIIa, initiator of clotting
CD143 ACE 170kD endoth, epith, neurons, fibroblasts, activated macangiotensin converting enzyme, angiotensin II & bradykinin metabolism
CD144 VE-Cadherin, Cadherin-5 130kD endoth, stem cells adhesion, endothelium biology
CD145 90, 110kD endoth, some stromal cells
CD146 MUC18, S-endo 113-118kD endoth, melanomas, FDC, Tact adhesion
CD147Neurothelin, basoglin, EMMPRIN
28kD leukocytes, erythrocytes, platelets, endoth adhesion, T cell activation, thymocyte cycling
CD148 HPTP-eta240-260kD
gran, mono, DC, T (high upon activation) tyrosine phosphatase R Type III
CD150 SLAM 75-95kD T subset (high upon activation), B, DC, endothcostimulation, proliferation, Ig production, measles virus receptor, T & B cell activation
CD151 PETA-3 32kD endoth, megakaryocytes, platelets, epith cell adhesion
CD152 CTLA-4 33kD Tact and BCD80 and CD86 receptor, negative regulation of T cell costimulation
CD153 CD30L 40kD neutrophils, B, Tact and mac CD30 ligand, T costimulation
CD154 CD40L, gp39, TRAP 32-39kD Tact CD40 ligand, B and DC costimulation
CD155 PVR 80-90kD mono, mac, CD34+ thymocytes Polio virus receptor (PVR)
CD156a ADAM8 69kD neutrophils, mono leukocyte extravasation
CD156b TACE/ADAM 17 100kD broadcleaves membrane proteins (TNF, TGF-α) to generate soluble forms
CD156c ADAM10 98kDlymphoid organs, peripheral blood leukocyte, cartilage, chondrocytes and fetal liver
proteolytic cleavage of cell-surface molecules including Notch, TNF-α, APP and ephrin-A2
CD157 BST-1 42-45kD gran, mono, B progenitors, endothADP-ribosyl-cyclic ADP-ribose hydrolase activities, pre-B cell growth
CD158a p58.1 50-58kD NK subset, T subsetinhibition of NK cell cytolytic activity, MHC class-I specific NK receptor
CD158b p58.2 50-58kD NK subset, T subsetinhibition of NK cell cytolytic activity, MHC class-I specific NK receptor
CD158f KIR2DL5 50-58kD NK subset, T subsetinhibition of NK cell cytolytic activity, MHC class-I specific NK receptor
37
Human CD Antigens
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Antigen Name Alternative Name MW Distribution Function
CD159a NKG2A 43kD T subset, NK w/ CD94, NK cell receptor
CD159c NKG2C 40kD NKw/ MHC class I HLA-E molecules, forms heterodimer with CD94
CD160 BY55 27kD NK subset, T subset costimulation
CD161 NKR-P1A 40kD T subset, NK NK cell-mediated cytotoxicity
CD162 PSGL-1 120kD mono, gran, most lymph CD62P, CD62L ligand, adhesion, rolling
CD162R PEN-5 110-140kD NK subset homing receptor for NK cells
CD163hemoglobin scavenger receptor, macrophage marker
130kD mono, mac, poss HSC clearance of hemoglobin
CD164 MGC-24 80kD hematopoietic progenitor cell-stromal cell interaction putative role in intracellular adhesion
CD165 AD2, gp37 42kD adhesion, thymocyte-thymic epith interaction putative role in intracellular adhesion
CD166 ALCAM 105kD neurons, mono, epith, fibroblasts, Tact CD6 ligand, adhesion
CD167a DDR1 120kD epith, myoblasts tyrosine kinase, adhesion to collagen
CD168 RHAMM 84-88kDmono, T subset, thymocyte subset, intracellularly in breast cancer cells
adhesion, tumor migration, metastasis
CD169 sialoadhesin, Siglec-1 185kD tissue mac subsetadhesion, cell-cell and cell-matrix interactions, binds CD227 on breast cancer cells and CD43 on T cells
CD170 Siglec-5, CD33-like2 140kD mac subset, neutrophils adhesion
CD171 L1200-210kD
CNS, PNS, glial cells, mono, T subset, B, DC, several human tumor cells
kidney morphogenesis, lymph node architecture, T costimulation, neurohistogenesis, homotypic interaction, binds CD9, CD24, CD56, CD142, CD166, integrins
CD172a SIRPg 110kD mono, T subset, stem cells adhesion, complex w/ CD47
CD172b SIRPb, SIRB1 50kD mono and DC negative regulation of RTK-coupled signaling
CD172g SIRPg, SIRPB2 45-50kD mRNA: liver and at lower levels in many tissues binds CD47
CD173 Blood group H type 2 erythrocytes, stem cell subset, plateletsputative role in homing immature stem cells to bone marrow
CD174 Lewis Y stem cells subset, epith putative role as co-factor to pro-coagulant y
CD175 Tn stem cells subset CD175 precursor for ABO antigen
CD175s Sialyl-Tn erythroblasts, myeloid leukemias, carcinoma cells putative role in tumor metastasis
CD176 Thomson Friedrenreich Ag stem cell subset, carcinoma cells putative role in tumor metastasis
CD177 NB1 56-62kD neutrophil subset
Human CD Antigens
38
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Antigen Name Alternative Name MW Distribution Function
CD178 FasL, CD95L 38-42kD Tact, testis, neutrophil, mono, NK CD95 ligand, apoptosis, immune privilege, soluble form in serum
CD179a V pre B 16-18kD pro- and pre-B B cell differentiation/signaling, w/ IgM
CD179b Lambda 5 22kD pro- and pre-B B cell differentiation/signaling, w/ IgM
CD180 RP-105 95-105kD B subset, mono, DC B cell activation, LPS signaling, w/ MD-1
CD181 CXCR1, IL-8RA 39kD neutrophils, basophils, NK, T subset, monobinding of IL-8 induces chemotaxis of neutrophils, phospholipase D activation, repiratory burst
CD182 CXCR2, IL-8RB 40kD neutrophils, basophils, NK, T subset, mono binding of IL-8 induces chemotaxis of neutrophils
CD183 CXCR3 40kDeosinophils, Tact and NK, GM-CSF activated CD34+ progenitors
IP-10, Mig and I-TAC receptor, T cell recruitment to inflammatory sites, enhancement of Th1 response
CD184 CXCR4, fusin 45kD B, DC, T subset, mono, endothSDF-1 receptor, X4 HIV-1 coreceptor, inhibits chemotaxis & Ca flux induced by SDF1
CD185 CXCR5, BLR1 45kD mature B and Burkitt Lymphoma cellsw/ chemokine BLC, possible regulatory function in Burkitt Lymphomagenesis and/or B differentiation, activation of mature B
CD186 CXCR6, BONZO 40kD Tactreceptor for CXCL16 and coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1
CD191 CCR1, MIP-1aR, RANTES-R 39kD T, mono, stem cell subsetbinds C-C type chemokines and transduces signal by increasing intracellular calcium ion levels
CD192 CCR2, MCP-1-R 40kDactivated NK and mononuclear phagocytes, T subset, B, endoth
binds MCP-1, MCP-3 & MCP-4, alternative coreceptor with CD4 for HIV-1 infection
CD193 CCR3, CKR3 45kDeosinophils, lower expression in neutrophils and mono, T subset
binds eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1d, alternative coreceptor w/ CD4 for HIV-1 infectiongg
CD195 CCR5 45kD mono, T subsetMIP-1a, MIP-1b and RANTES receptor, R5 HIV-1 coreceptor
CD196 CCR6, LARC receptor, DRY6 45kD T subset, B, DC subset binds MIP-3a/LARC
CD197 CCR7, EBI-1 45kD T subset, DC subset6Ckine and MIP-2b receptor, CCL19 & CCL21 receptor, T cell migration
CD198 CCR8, GPRCY6, TER1 50kD T, high expression in Th2, NK, monoallergic inflammation, alternative coreceptor with CD4 for HIV-1 infection
CD199 CCR9, GPR-9-6 43kD subset of memory T, lamina propria mononuclear cellsbinds SCYA25/TECK, alternative coreceptor with CD4 for HIV-1 infection
CD200 OX-2 45-50kD thymocytes, endoth, B, Tact inhibition of immune response
39
Human CD Antigens
-
Antigen Name Alternative Name MW Distribution Function
CD200R 48kD hematopoietic inhibitory receptor, inhibits TNFα secretion
CD201 EPC-R 50kD endoth subset activated protein C receptor
CD202b Tie2, Tek 150kD stem cells, endoth angiopoietin-1 receptor
CD203c NPP3/PDNP3, ENpp1, PD-1b130-150kD
basophils, mast cells, glioma cells, megakaryocytesectoenzyme, binding to and clearance of extracellular nucleotides
CD204 Macrophage scavenger-R 220kD mac endocytosis of macromolecules
CD205 DEC-205 205kD DC, thymic epith DC, thymic epith
CD206 macrophage mannose-R 180kD DC subset, mac, monophagocytosis and pinocytosis of mannose containing molecules
CD207 Langerin 40kD Langerhans cells endocytic receptor
CD208 DC-LAMP 70-90kD DCact, interdigitating DC putative role in sorting MHC Class II
CD209 DC-SIGN 44kD DC subset ICAM-3 receptor, HIV-1 binding protein
CD210 IL-10-R 90-110kD T, B, NK, mono, mac IL-10 receptor, signal transduction
CD212 IL-12Rβ1 100kD Tact and NKbinds IL-12 w/ high affinity, associates w/ IL-12 receptor β2
CD213a1 IL-13Rα1 65kD B, mono, fibroblasts, endoth binds IL-13 w/ low affinity, w/ CD124
CD213a2 IL-13Rα2 65kD B, mono binds IL-13 w/ high affinity
CD215 IL15RA, interleukin 15 receptor, α 28kD brain tissue high affinity receptor for IL-15
CD217 IL-17R 120kD broad IL-17 receptor
CD218a IL-18Rα, IL-1Rrp 70kD T, NK, DCs binds IL-18, activation of NF-κB
CD218b IL-18Rβ, IL18RAP 70kD T, NK and DCsheterodimeric receptor with IL-18Ra to enhance IL-18 binding
CD220 Insulin-R 140, 70kD broad insulin receptor
CD221 IGF-1 R 70, 140kD broadbinds IGF w/ high affinity, signaling, cell proliferation/ differentiation
CD222 IGF-II R, mannose-6 phosphate-R 250kD broad, 90-95% intracellularadhesion, tumor growth, a receptor for TGFβ-LAP, plasminogen, proliferin, truncated form (220kD) found in serum
CD223 LAG-3 70kD Tact and NK MHC class II ligand
CD224 GGT 27, 68kD leukocytes, stem cells maintain cellular redox
CD225 Leu-13 17kD broad B cell activation
CD226 DNAM-1, PTA-1, TLiSA1 65kD T, NK, mono, platelets, activated HUVECactivation of cell-mediated cytotoxicity, soluble form (50kD) found in normal serum
Human CD Antigens
40
-
Antigen Name Alternative Name MW Distribution Function
CD227 MUC1, EMA 300kDepith, stem cell subset, FDC, mono, B subset, some myelomas
adhesion, signaling, binds CD169, CD54, & selectins
CD228 Melanotransferrin 80-95kD stem cells, melanomas iron transport, migration of endoth
CD229 Ly-9 95, 110kD T, B adhesion
CD230 Prion protein 35kD lymphocytes, monos w/ TSE
CD231 TALLA-1, A15 30-45kD T leukemias, neuroblastomas, brain neurons marker for T cell acute lymphoblastic leukemia
CD232 VESP-R 200kD broad
CD233 Band 3, SLC4A1 90kD erythrocytesanion exchanger pump, transport of CO2, linking red cell membrane to cytoskeleton
CD234 Duffy, DARC 35-45kD erythrocytes Duffy antigen chemokine receptor
CD235a Glycophorin A 36kD erythrocytes major glycoprotein of erythrocyte cell membrane
CD235b Glycophorin B 20kD erythrocytesmajor sialoglycoprotein of erythrocyte membrane maintain erythrocyte structure
CD236 Glycophorin C/D 32, 23kD erythrocytes, stem cell subset
CD236R Glycophorin C 32kD erythrocytes, stem cell subset
CD238 Kell 93kD erythrocytes, stem cell subset zinc endopeptidase
CD239 B-CAM 78-85kD erythrocytes, stem cell subset
CD240CE Rh30CE 30-32kD erythrocytes
CD240D Rh30D 30-32kD erythrocytes
CD241 RhAg, Rh50 50kD erythrocytes complex w/ CD47, LW, glycophorin B
CD242 ICAM-4 42kD erythrocytes adhesion, Landsteiner-Wiener blood group
CD243 MDR-1, p170, P-gp 180kDstem cells, small intestine, kidneystem cells, small intestine, kidney
ion pump
CD244 2B4, p38 70kD T subset, mono, basophils, NK, mast, eosinophils NK activation, CD48 ligand
CD245 p220/240220-240kD
gran, resting PBLs, platelets, mono, NK signal transduction, costim T & NK cells
CD246 ALK 80kDanaplastic T cell leukemias, small intestine, testis, brain, not on normal lymph
brain development, implicated in ALK lymphomas
CD247 TCRζ 16kD T, NK TCR complex subunit, coupling of antigen recognition to signalingCD248 TEM1, Endosialin 175kD endothelial tissue, stromal fibroblasts tumor progression and angiogenesis
CD249 Aminopeptidase A 160kD epith, endoth renin-angiotensin system
CD252 OX-40Ligand, gp34 34kD Bact, cardiac myocytes T costimulation
41
Human CD Antigens
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Antigen Name Alternative Name MW Distribution Function
CD253 TRAIL, Apo-2L, TL2, TNFSF10 32kD Tact, many tissues, B, NK death, binds Apo-2
CD254 TRANCE, RANKL, OPGL 35kD lymph node & BM stroma Tactbinds OPG and RANK, osteoclast differentiation, enhances DC to stimulate naïve-T proliferation, regulates Bcl-XL expression
CD256 APRIL, TALL-2 16kD mono, macbinds TACI & BCMA, B proliferation, induces cell death
CD257 BLyS, BAFF, TALL-1 31kD monoact, soluble formB cell growth factor & costimulator of Ig production, binds TACI & BCMA
CD258 LIGHT, HVEM-L 28kD Tact, immature DC binds LTBR, T proliferation, receptor for HVEM
CD261 TRAIL-R1, DR4 57kD Tact, peripheral blood leukocytescontains death domain, apoptosis via FADD & caspase-8, binds TRAIL
CD262 TRAIL-R2, DR5 60kD widely expressed, peripheral blood lymphocytescontains death domain, apoptosis via FADD and caspase-8, binds TRAIL
CD263 TRAIL-R3, DcR1, LIT 65kD peripheral blood lymphocytes receptor for TRAIL but lacks death domain
CD264 TRAIL-R4, TRUNDD, DcR2 35kD peripheral blood leukocytes binds TRAIL but contains truncated death domain
CD265 RANK, TRANCE-R, ODFR 97kD broad expression, DC binds TRANCE, osteoclastogenesis, T-DC interactions
CD266 TWEAK-R, FGF-inducible 14 14kD heart, placenta and kidney, HUVECTWEAK receptor, cell-matrix interactions and endoth growth and migration
CD267 TACI, TNFR SF13B 32kD B, Tact binds BAFF & APRIL
CD268 BAFFR, TR13C 25kD B binds BLyS, mature B survival
CD269 BCMA, TNFRSF13B 20kD mature B (membrane and perinuclear) APRIL & BAFF receptor, B survival & proliferation
CD270
TNFRSF14, tumor necrosis factor receptor superfamily, member 14 (herpes virus entry mediator), TR2, ATAR, HVEA, HVEM, LIGHTR
30kD lung, spleen, thymus receptor for BTLA, LIGHT and LT-α
CD271 NGFR, p75 (NTR) 45kDneurons (schwann cells, growing neurites), BM mesencymal cells
NGF, BDNF, NT-3, & NT-4 receptor, tumor suppressor, cell survival and death
CD272 BTLA 33kD Tact, B, remains on Th1 HVEM receptor, inhibitory response
CD273 B7DC, PD-L2, PDCD1L2 25kD DC subset, mono, macPD-1 receptor, costimulation or suppression of T proliferation
CD274 B7-H1, PD-L1 33kD leukocytes, broad PD-1 receptor, costimulation of lymphocytes
CD275 B7-H2, ICOSL, B7-RP1, GL50 60kD B, DC, mono costimulation, cytokine production
42
Human CD Antigens
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Antigen Name Alternative Name MW Distribution Function
CD276 B7-H3 40-45kD in vitro cultured DC and mono, Tact, mammary tissue costimulation, T activation
CD277 BT3.1, butyrophilin SF3 A1, BTF5 56kDT, B, NK, mono, DC, endoth, CD34+ cells, tumor cell lines, CD14+ cells
T activation
CD278 ICOS, AILIM 55-60kD Tact, Th2 binds ICOS-L, T costimulation
CD279 PD1, SLEB2 55kD Tact and BactB7-H1 & B7-DC receptor, autoimmune disease and peripheral tolerance
CD280 ENDO180, UPARAP 180kD chondrocytes, fibroblasts, endothelial, macmannose receptor, collagen matrix remodeling and endocytic recycling
CD281 TLR1 90kD low levels in PBMC, mono and possibly DC innate immunity, w/ TLR2
CD282 TLR2 90kD mono, neutrophil, up-regulated in macbinds dsRNA, response to bacterial lipoproteins, innate immunity
CD283 TLR3 100kD derived moDC (may be intracellular) binds dsRNA, innate immunity
CD284 TLR4 100kD PBMC (weak in mono, immature DC & neutro)binds LPS, innate immunity, associates with MD2 & CD14
CD289 TLR9 120kD pDC (intracellular) binds CpG-DNA, innate immunity
CD292 BMPR1A, ALK3 57kD bone progenitor BMP 2 & 4 receptor, bone development
CD293 BMPR1B, ALK6 57kD bone progenitor BMP receptor, bone development
CD294 CRTH2, GPR44 55-70kD Th2, eosinophils, basophilsbinds prostaglandin D2, stimulatory effects on Th2, allergic inflammation
CD295 LeptinR, LEPR 132kD broadadipose metabolism, immune dysfunction in obesity
CD296 ART1, RT6, ART2 37kD heart and skeletal muscle, peripheral T, NK subsetmodifies integrins during differentiation, ADP ribosylation of target proteins
CD297 ART4, dombrock blood group 38kD erythroid, monoact ADP ribosylation of target proteins
CD298 Na+/K+-ATPase b3 subunit 52kD broadtransport sodium & potassium ions across membrane
CD299DC-SIGN-related, LSIGN, DC-SIGN2
45kD endothelial subsetbinds ICAM3, HIV-1 gp120, coreceptor w/ DC-SIGN, HIV infection
CD300aCMRF35H, IRC1, IRp60 CLM-8, MAIR-1, LMIR-1
60kDNK, mono, neutrophils, T and B subset and lymphocytic cell lines, AML
unknown
CD300c CMRF35A, LIR 23kD mono, neutrophils, monocytic cell lines, B & T subsets unknown
CD300e CMRF35L 45kD mono, mac, DC unknown
CD300f IREM1, MAIR-V 60kD myeloid inhibitory receptor
43
Human CD Antigens
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Antigen Name Alternative Name MW Distribution Function
CD301MGL, HML2 DCASGPR, CLECSF13, CLECSF14, GalNAc
38kD immature DC binds Tn antigen, uptake of glycosylated antigens
CD303 BDCA2, HECL CLEC4C 38kD plasmacytoid dendritic cells inhibit IFN-α production
CD304 BDCA4, neuropilin 1 VEGF165R 130kDneurons, CD4+/CD25+ Treg, pDC, endothelial and tumor cells
interacts w/ VEGF165 & semaphorins, co-receptor with plexin, axonal guidance, angiogenesis, cell survival, migration
CD305 LAIR1 32-40kD NK, B, T, mono DCs, eosinophils, basophils mast cells inhibitory receptor on NK and T cells
CD307 IRTA2 FcRL5 CD307e BXMAS1 55-105kD B subset, B lymphomaB cell development, translocation in some lymphomas
CD309 VEGFR2, KDR 230kD endothelial, angiogenic precursor cells, hemangioblastbinds VEGF, regulates adhesion and cell signaling (ANNEXIN A5 and SHC1 binding also published)
CD302 DCL1, BIMLEC 19-28kD some myeloid and Hodgkin’s cell linesa fusion protein in Hodgkin’s lymphoma w/ DEC-205
CD306 LAIR2 16kD mono soluble, mucosal tolerance
CD307aFCRL1, Fc receptor-like 1, FCRH1, IFGP1, IRTA5, FCRL1
50kD mature B cellmay have role in B cell activation and differentiation
CD307bFCRL2, Fc receptor-like 2, FCRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C
55kD memory B cell may have role in B cell development
CD307cFCRL3, Fc receptor-like 3, FCRH3, IFGP3, IRTA3, SPAP2
89kD B cell, NK
CD307dFCRL4, Fc receptor-like 4, FCRH4, IGFP2, IRTA1
57kD memory B cell may inhibit B cell receptor
CD307eFCRL5, Fc receptor-like 5, CD307, FCRH5, IRTA2, BXMAS1, PRO820
106kD B cellmay have role in B cell development and differentiation
CD312 EMR2 90kD mono, mac, moDC, granslow cell adhesion and migration for phagocytosis
CD314 NKG2D, KLR 42kD NK, CD8+ activated, NK1.1+ T, some myeloid cellsbinds MHC class I, MICA, MICB, Rae1 & ULBP4, activates cytolysis and cytokine production, costimulation
CD315 CD9P1, SMAP6, FPRP, PTGFRN 135kD B subset, monoact w/ CD81 and CD9
CD316 EWI2, PGRL, CD81P3, KASP 63-75kD B, T cells, low on NK cells w/ CD81 & CD9, involved in cell migration
CD317 BST2, HM1.24 30-36kD B, T, NK, mono, DC, fibroblast cell line, myelomapre-B cell growth, overexpressed in multiple myeloma
CD318 CDCP1, SIMA135 135kD HSC (subset of CD34+), tumors cell adhesion with ECM
44
Human CD Antigens
-
Antigen Name Alternative Name MW Distribution Function
CD319 CRACC, SLAMF7 66kD T, B and DC subset, NK, up-regulated in DC regulate T and NK cells
CD320 8D6A, 8D6 30kD follicular DC, germinal centers B proliferation, tumor formation
CD321 JAM1, F11 receptor 35kD platelet receptor, epithelia and endothelial, plateletstight junctions, involved in retrovirus entry into cells
CD322 JAM2, VE-JAM 43kD HEV, other endothcell adhesion, lymphocyte homing to secondary lymphoid organs
CD324 E-Cadherin, Uvomorulin 120kD non-neural epithcell adhesion, homotypic interaction & binds αE/β7
CD325 N-Cadherin, NCAD 140kD brain, skeletal and cardiac muscle cell adhesion, neuronal recognition
CD326Ep-CAM, Ly74 Tumor-associated calcium signal transducer 1 (TACSTD1)
35-40kD most epith cell membranes some tumors cell adhesion, metastatic carcinoma cell marker
CD327 SIGLEC6 49kD placenta, spleen, B . sialic-acid dependentadhesion, membrane- bound & secreted forms sialic-acid dependent
CD328 SIGLEC7, AIRM-1 75kDresting and activated NK, placenta, liver, spleen, lower in gran & mono
sialic-acid dependent adhesion, inhibit NK activation, hemopoiesis
CD329 SIGLEC9 50kD neutrophils and mono sialic-acid dependent adhesion molecule
CD331FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM
30kD fibroblasts, epithelialbinds FGF, high affinity receptor for fibroblast growth factors
CD332 FGFR2, BEK, KGFR115-135kD
fibroblasts, epithelialbinds FGF, high affinity receptor for fibroblast growth factors
CD333 FGFR3, ACH, CEK2 115kD fibroblasts, epithelialbinds FGF, high affinity receptor for fibroblast growth factors
CD334 FGFR4, JTK2, TKF 110kD fibroblasts, epithelialbinds FGF, high affinity receptor for fibroblast growth factors
CD335 NKp46, Ly-94 homolog 46kD NK activates NK cells upon non-MHC ligand binding
CD336 NKp44, Ly-95 homolog 44kD NK activates NK cells upon non-MHC ligand binding
CD337 NKp30, Ly117 30kD NK activates NK cells upon non-MHC ligand binding
CD338 ABCG2, BCRP, Bcrp1, MXR 73kD stem cell subset (side population) multi-drug resistance transporter
CD339 Jagged-1, JAG1, JAGL1, hJ1 135kD stromal cells, epithelial, AML binds Notch, hematopoiesis
CD340 HER2/neu, ERBB2, p185HER2 185kD BM, mesenchymal stem cellsmember of the ERBB family of receptor tyrosines, involved in a wide range of cellular responses
CD344 frizzled-4, Fz-4, hFz-4, FzE4 59kDadult kidney, lung, brain, liver, fetal neuronal intestinal cells
act of the Wntb-catenin pathway, regulation of tissue and cell polarity
45
Human CD Antigens
-
Antigen Name Alternative Name MW Distribution Function
CD349 frizzled-9, Fz-9, hFz-9 65kDadult and fetal brain, testis, eye, skeletal muscle, and kindey, BM mesenchymal stem cells
act of the Wntb-catenin pathway, regulation of tissue and cell polarity
CD350 frizzled-10, Fz-10, hFz-10 65kD placenta and kidney, fetal lung and brainact of the Wntb-catenin pathway, regulation of tissue and cell polarity
CD351FCAMR, Fc receptor, IgA, IgM, high affinity, FCA/MR, FKSG87
57kD mesangial cell Fc receptor for IgA and IgM
CD352SLAMF6, SLAM family member 6, KALI, NTBA, KALIb, Ly108, NTB-A, SF2000
37kD NK, T, B triggers cytolyic activity of NK cells
CD353SLAMF8, SLAM family member 8, BLAME, SBBI42
32kD lymph node, spleen, thymus and bone marrowmay have role in B cell signalling and differentiation
CD354TREM1, triggering receptor expressed on myeloid cells 1, TREM-1
26kD liver, lung, spleen stimulates neutrophils and monos
CD355CRTAM, cytotoxic and regulatory T cell molecule
45kD MHC-I-restricted cells cytoxicity, tumor rejection
CD357TNFRSF18, tumor necrosis factor receptor superfamily, member 18, AITR, GITR, GITR-D
26kD lymph node, peripheral blood leukocytes, spleen receptor for TNSF18
CD358TNFRSF21, tumor necrosis factor receptor superfamily, member 21, DR6, BM-018
72kD fetal spinal cord, brian promotes apotosis, elevated in Alzheimer patients
CD360IL21R, interleukin 21 receptor, NILR
59kD thymus, spleen receptor for IL-21
CD361EVI2B, ecotropic viral integration site 2B, EVDB, D17S376
47kD bone marrow, PBMC, fibroblast
CD362SDC2, syndecan 2, HSPG, HSPG1, SYND2
22kDcell surface proteogylcan that bears heparan sulfate
CD363S1PR1, sphingosine-1-phosphate receptor 1, EDG1, S1P1, ECGF1, EDG-1, CHEDG1
42kD endotheial receptor for S1P, T cell migration
CD364PI16, peptidase inhibitor 16, dJ90K10.5, MGC45378, MSMBBP
49kD prostate, testis, ovary, intestine putative serine protease inhibitor
46
Human CD Antigens
-
Antigen Name Alternative Name MW Distribution Function
CD365HAVCR1, TIM-1, HAVCR-1, TIMD1
38kD activated CD4 T cellrole in T-helper development, involved in hepititis A virus entry into cells
CD366 HAVCR2, TIM-3, TIMD3 33kD Th1 inhibitory receptor on Th1 cells
CD367CLEC4A, DCIR, DDB27, CLECSF6
27kD DC, myeloid cells, B-cell inhibitory receptor on DCs and B-cells
CD368CLEC4D, MCL, CLECSF8, CLEC-6, MPCL
24kD mono, macro endocytic receptor
CD369 CLEC7A, DECTIN-1, CLECSF12, 27kD peripheral blood leukocytes, DClectin, necessary for TLR2-mediated inflammatory response
CD370CLEC9A, HEEE9341, UNQ9341, DNGR1
27kD DC subset, mono subset endocytic receptor
CD371 CLEC12A, CLL-1, MICL, DCAL-2 30kD neutrophil, eosinophil, mono, DC signal transduction
47
Human CD Antigens
-
Antigen Name Alternative Name MW Distribution Function
4-1BB Ligand CD137L Bact, DC, carcinoma cell lines T costimulation
Act1 CIKS 62kD B, Tnegative regulator of BAFFR and CD40 signaling, regulates IL-17RA signaling
AID Bact, Germinal Center BActivation-Induced Deaminase, Ig class switch recombination
AITR TNFRSF18, GITR Treg, Tact costimulation
AITRL TNFSF18, TL6, GITRL APC, endoth., peripheral mono
B7 family see CD273-276
B7-H4 B7-S1, B7x may interact with BTLA (?), inhibition
BAMBI TGFBR 29kD carcinoma cellpseudoreceptor for TGF-β (short cytoplasmic domain), growth inhibition
β-catenin 83kD broad, B, T development positively regulates Wnt-signaling
BCMA see CD269
BLIMP-1 90kD B, T B, Th1 differentiation
BLyS see CD257
BR3 see CD268
BTLA see CD272
CCR5 see CD195
CCR7 see CD197
c-Met HGFR/SFR 145kD epith, hematopoietic progenitors, early thymocytestumor growth/metastasis, Hepatocyte Growth Factor/Scatter Factor receptor, T development, hematopoiesis
CMKLR1 chemokine-like receptor 1 42kD pDC (CD123+), in vitro derived moDC binds chemerin, pDC recruitment, bone development
Cytokeratin 52-67kD epithelial intermediate filament protein, cytoskeletal formation
DcR3 TR6, TNFRSF6B 24kD tumorsFas decoy receptor, tumor evasion, secreted extracellularly
DEC-205 see CD205
DR3 TRAMP, Apo-3, WSL-1, LARD, TR3 45kD Tact, leukocytes, mono, granulocytes lymphocyte homeostasis, activates NF-κB
DR6 TR7 72kD lymph node, thymus death, Th2 response, interacts with TRADD
Eomes TBR2 70kD broad trophoblast development, CD8+ T & NK development
FcεRIa high-affinity IgE receptor mast cells, basophils triggers IgE-mediated allergic reactions
Foxp3 SCURFIN 50kD T subsets (CD4+/CD25+ subset and CD8+ subset) transcription factor, up-regulated in Tregs
48
Human Non-CD Antigens
-
49
Human Non-CD Antigens
Antigen Name Alternative Name MW Distribution Function
GATA-3 GATA binding protein 3 48 kDavarious tissues, including CNS, inner ear, and mesodermal- and endodermal-derived tissues
TF that acts as a regulatorin the following: Th2 differentiation, sympathetic neuron development, and the maintenance of the differentiated state in epithelial cells
GILZ 14kD mast cells, mono, mac, DC, T transcriptional modulator, inhibits IL-2 production
gp130 see CD130
Granulysin 9, 15kD NK, Tact kills bacteria, induces apoptosis
Granzyme B Granzyme-2, CTLA-1 30kD cytotoxic T, NKtargets cell apoptotic lysis, cell-mediated immune responses
HLA-ABC11-12, 45kD
nucleated cells cell-mediated immune response & tumor surveillance
HLA-DR APC, Tact presentation of peptides to CD4+ T lymphocytes
HVEM TNFRSF14, TR2 60kD broad expressionreceptor for LIGHT, LT-α, BTLA, Herpes Simplex Virus, lymphocyte activation
ICOS see CD278
ICOSL see CD275
IGF-1R see CD221
IL-15Rα see CD215 monoactbinds to IL-15, w/ IL-2Rβ and common γ, IL-15 trans-presentation
ILT family see CD85
Integrin β1 see CD29
Integrin β2 see CD18
Integrin β3 see CD61
Integrin β5 100kD carcinoma cell lines, fibroblast lines w/ av subunit, vitronectin receptor
Integrin β7 130kD Leuk (maj)w/ CD49d or CD103, adhesion of leukocytes to endothelial cells
LAP 65-75kD non-covalently associates with TGFβ
MD-2 30KD w/ TLR4 distribution and LPS recognition
MICA/MICB 70kD intestinal epith, some tumors unregulated on epith after shock, NKG2D receptors
mTOR 289kD broad involved in cell metabolism, survival, protein synthesis
Nanog 34kD ES cells transcription factor, self renewal of ES cells
Nestin 220-240 neural stem cells
NKG2D see CD314
-
50
Human Non-CD AntigensAntigen Name Alternative Name MW Distribution Function
NOD2 CARD-15, IBD1 115kD monocytes, intracellular
Notch-1 Lin-12, Tan 1 290kD developing embryo, variety of adult tissues cell-cell interaction, cell fate determination
OPG osteoprotegerin, TNFRSF11B 46kD lymphnode, bone marrow bone resorption
OX-40 see CD134
OX-40 Ligand see CD252
Pax5 BSAP 50kD B B cell differentiation
PD-1 see CD279
PD-L1 see CD274
PD-L2 see CD273
Perforin 70-75kD CTL, NK cytolytic protein
Podoplanin 40kD lymphatic endothelial, follicular DC platelet aggregation, cancer metastasis
RP105 see CD180
RANK see CD181
RANKL see CD182
RORγ(t) see CD183 58kD colon, muscle, lymph node, and kidney TF that plays roles in mulltiple physiological processes
SAP SLAM-associated protein 14kD T, NK negatively regulates SLAM- family receptors
Siglec-7 AIRM1, QA79 see CD328
SLP-76 LCP2, pp76 76kD T, Blow T cell receptor mediated signaling
SSEA-1 stage-specific embryonic antigen-1 ES cells, embryonic carcinomas, germ cells down-regulated by differentiation
SSEA-3 stage-specific embryonic antigen-3 ES cells, embryonic carcinomas, germ cells down-regulated by differentiation
SSEA-4 stage-specific embryonic antigen-4 ES cells, embryonic carcinomas, germ cells down-regulated by differentiation
Stro-1 BM stroma, erythroid progenitors surface marker for immature mesenchymal cells
TACI see CD267
T-bet T-box protein 21 58kD Th1 cells transcription factor, T development/differentiation
TCL1 T cell leukemia/lymphomal 13kDB cell tumors, lymphoid lineages in a developmentally controlled manner, pDC
intracellular, lymphoid proto-oncogene
TCRαβ peripheral T subset antigen recognition
TCRγδ T subset antigen recognition
Tdtterminal deoxynucleotidyl transferase
60kD immature B, Ttemplate-independent addition of nucleotides at VDJ breakpoints
TLR1-TLR4 see CD281 - CD284
-
51
Human Non-CD Antigens
Antigen Name Alternative Name MW Distribution Function
TLR5 TIL3 103kD mRNA: leukocytes, prostate, ovary, liver, lunginteracts w/ microbial lipoproteins, NF-κB, responds to Salmonella
TLR6 100kD mRNA: leukocytes, ovary, lunginteracts w/ microbial lipoproteins, protein sequence similar to hTLR1; regulates TLR2 response
TLR7 116kD mRNA: spleen, placenta, lung; up-regulated on mac innate immunity
TLR8 119kD mRNA: leukocytes, lung, neurons innate immunity
TLR9 see CD289 115kD lung, spleen innate immunity
TLR10 94kD mRNA: lymphoid tissues most closely related to TLR1 and TLR6
TNFRI see CD120a
TRA-1-60 Podocalyxin200-250kD
ES cells, embryonic carcinomas, germ cells, podocytes down-regulated by differentiation
TRA-1-81 Podocalyxin200-250kD
ES cells, embryonic carcinomas, germ cells, podocytes down-regulated by differentiation
TRAIL see CD253
TSLPR 50kD monocytes, DC, Bbinds TSLP (Thymic Stromal Lymphopoietin) to activate DC
TWEAK TNFSF12, APO3L activated monodeath, promotes IL-8 secretion, endothelial cell proliferation, and apoptosis
TWEAK Receptor see CD266
-
52
Mouse CD AntigensAntigen Name Alternative Name MW Distribution Function
CD1d CD1.1/1.2, Ly-38 43-49kD leukocytes, intestinal epith Ag presentation, mucosal immunity, w/ β2m, ligand for NKT cells
CD2 LFA-2, Ly-37, SRBC-R 45-58kD lymphocytes, pre-B, erythrocytes, myeloid, DC adhesion, T activation, CD48 receptor
CD3δ T3d 20kD T, thymocyte subset, NKT TCR subunit, TCR expression & signaling
CD3ε T3e 20kD T, thymocyte subset, NKT TCR subunit, TCR expression & signaling
CD3γ T3g 25kD T, thymocyte subset, NKT TCR subunit, TCR expression & signaling
CD4 Ly-4, L3T4 55kD thymocyte subset, T subset, DC TCR coreceptor, thymic differentiation, T activation, MHC class II receptor
CD5 Ly-1 67kD thymocytes, T, B subset (B1) T activation, T-B interaction, CD72 receptor
CD6 T12 100-130kD
thymocytes, T, neurons, not on B T differentiation & costimulation, CD166 receptor
CD7 40kD human early T marker, CD7KO has normal phenotype
CD8α Ly-2 32-34kD thymocyte subset, T subset, DC subset, not fresh NK TCR coreceptor, MHC class I receptor, T differentiation, homodimer or heterodimer w/ CD8β
CD8β Ly-3 30kD thymocyte subset, T subset, not fresh NK TCR coreceptor, MHC class I receptor, T differentiation, heterodimer w/ CD8α
CD9 p24 24-27kD myeloid, platelets, Tact, B subset, stromal cells, mesenchymal stem cells
cell adhesion, migration, T costimulation
CD10 CALLA, NEP, Mme 100kD fibroblasts, BM stromal cells non-lympoid tissuezinc-binding metalloproteinase, neutral endopeptidase ectoenzyme,
CD11a integrin aL, Ly-15, Itgal
80kD T, B, NK, gran, mono, mac, DC, thymocytes CD11a/CD18 (LFA-1) receptor for ICAM-1 and ICAM-2, adhesion, T costimulation
CD11b Mac-1, integrin αM, Itgam, CR3
170kD myeloid, NK, Tact, B subset CD11b/CD18 receptor for CD54 and CD102, adhesion to ECM, fibrinogen, & complement iC3b
CD11c p150, integrin αX, Itgax, CR4
150kD DC, myeloid, NK, T subset CD11c/CD18 receptor for fibrinogen & iC3b, adhesion
CD13 Aminopeptidase N, Lap1
150kD myeloid, endoth, DC zinc-binding metalloproteinase, antigen processing
CD14 LPS-R, Mo2 53-55kD mac, granlow receptor for LPS/LBP, LPS recognition
CD15 Lewis-X transient in brain fucosyl transferase (Fut4)
CD16 FcγRIII, Ly-17, Fcγr3 50-60kD NK, neutrophils, mast cells, mac Fcγ low affinity receptor, phagocytosis, ADCC, NK activation
CD18 Integrin β2, Itgb2 90-95kD leukocytes w/ CD11a, b and c, adhesion
CD19 B4 95kD B, FDC, good B lineage marker, not plasma cells w/ CD21 & CD81, BCR coreceptor, B activation/differentiation
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53
Mouse CD Antigens
Antigen Name Alternative Name MW Distribution Function
CD20 Ly-44, B1, Ms4a2 33-37kD B, T subset B differentiation/activation
CD21 CR2, CR1 150kD B, DC CD21/CD35 variant of CR2 gene, complement C3dR, w/ CD19 & CD81, BCR coreceptor
CD22 Lyb-8, Siglec-2 140-160kD
B adhesion, B-mono & B-T interactions, B activation, BM homing receptor for IgD+ B cells, CD75 counter-receptor
CD23 FcεRII, Ly-42, Fcεr1a 45-49kD B, mono, mac, gran, platelets, FDC, not B1 cells CD19/CD21/CD81 receptor, low affinity IgER, signaling
CD24a HSA, Ly-52, Nectadrin 35-52kD B, gran, mono, mac, Tact, erythrocytes, neurons several isoforms, B differentiation & adhesion, T costim, CD62P receptor
CD25 Ly-43, p55, IL2Rα 55kD pre-B, pre-T, Tact, Bact, DC subset, mono, mac low affinity IL-2 binding, w/ IL-2Rβ & γ forms IL-2 receptor high affinity, also soluble form
CD26 DPP4, THAM 110kD thymocyte subset, Tact, B, NK, epith dipeptidyl peptidase ectoenzyme, activation, adhesion
CD27 T14, Tnfrsf7 45kD medullary thymocytes, T, NK, B subset CD70 receptor, T costimulation
CD28 Tp44 45kD T, thymocytes, NK CD80 (B7-1) & B7-2 (CD86) receptor, T costimulation
CD29 Integrin β1, gpIIa, Itgb1
130kD leukocytes, fibroblasts, endoth, epith w/ CD49a-f (VLA-1-6), receptor for VCAM-1, MAdCAM-1 & ECM, VLAb, adhesion, embryonic development
CD30 Ki-1, Tnfrsf8 105-120kD
Tact CD153 receptor, lymphocyte proliferation, apoptosis, peripheral tolerance
CD31 PECAM-1, pgIIa 130-140kD
leukocytes, endothmultiple isoforms, CD38 receptor, signaling, platelet-endoth adhesion
CD32 FcγRII, Ly-17, Fcγr2b 40-60kD mono, mac, gran, B, Tact, not NK low affinity Fc receptor for aggregated Ig/immune complexes, ADCC
CD33 Siglec-3, gp67 67kD myeloid progenitors; gran possible role in hematopoiesis, binds sialic-acid
CD34 Mucosialin 90-120kD hematopoietic precursors, capillary endoth, BM stroma, mast cells CD62L receptor, adhesion
CD35 Cr1, Cr2 190kD B, granact, FDC CD21 & CD35 alternative splice variants of Cr2 gene, binds C3b & C4b, adhesion, phagocytosis
CD36 FAT, fatty acid translocase
88kD platelets, adipocytes, mono, mac, endoth, erythrocyte, B cells oxidized LDL receptor
CD37 mRNA: lymphoid, myeloid T-B interaction
CD38 Cd38-rs1, T10 42kD B, marginal zone B high, Tact, thymocyte subset, subsets in yolk sac, in fetal liver, in BM
Bact, CD31 receptor, ectoenzyme, ADP-ribosyl cyclase/hydrolase
CD39 Entpd1 70-100kD lymphocyteact, microglia, endoth, Treg subset ecto-nucleoside trisphosphate diphosphohydrolase
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54
Mouse CD AntigensAntigen Name Alternative Name MW Distribution Function
CD40 gp39 receptor, Tnfrsf5
45-50kD B, mono, mac, T subset, DC, endoth, thymic epith, induced on cardiac myocytes
CD154 receptor, T-B interaction, B costimulation, isotype-switching, & survival,
CD41 gpIIb, Itga2b, CD41b 110-125kD
platelets, megakaryocytes w/ CD61 forms GPIIb/IIIa, binds fibrinogen, fibronectin, vWF & thrombospondin
CD42 Gp9, GPIX 20kD platelets, megakaryocytes platelet activation, aggregation
CD43 Leukosialin, Ly-48, Spn, sialophorin
115 & 135kD
T, Tact, early B, B subset, plateletslow, not resting B, not DC isoforms, signaling, CD54R, B survival, adhesion
CD44H-CAM, Pgp-1, Hermes Ag
80-95kDhematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis
binds hyaluronic acid, adhesion
CD45 LCA, Ly-5, Ptprc 180-240kD
leukocytes, not mature erythrocytes tyrosine phosphatase, leukocyte differentiation/activation, pan-leukocyte marker
CD45.1 Ly5.1180-240kD
Ly-5.1 strains: SJL, DA, STS/A, RIII tyrosine phosphatase, signal transduction
CD45.2 Ly5.2 180-240kD
Ly-5.2 strains: BALB/c, C3H, C57BL/6, DBA/1, DBA/2, AKR, A, 129 tyrosine phosphatase, signal transduction
CD45R/CT1 cytotoxic Tact
CD45R B220 220kD B, NK progenitors, LAK, Tact, T cells with lpr/lpr mutant allele tyrosine phosphatase
CD45RA exon A isoform, tyrosine phosphatase
CD45RB 200-240kD
T subset, B, mono, mac, DC tyrosine phosphatase, signal transduction
CD45RC 200-240kD
T subset, B tyrosine phosphatase, signal transduction
CD45RO UCHL-1 180kD Tact, Bact, DC subset tyrosine phosphatase, signal transduction
CD46 MCP, membrane cofactor protein
41kD broad complement regulation, role in fertilization
CD47 IAP, Itgp, neurophilin 50kD hematopoietic cells, epith, endoth, fibroblasts, platelets w/ β3 integrins, adhesion, binds SIRP, thrombospondin receptor
CD48Blast-1, BCM-1, Sgp-60
45kD broad on lymphocytes, not fibroblasts adhesion, T costimulation, CD2 and Ly-9 receptor
CD49a VLA-1, Integrin α1, Itga1
180kD Tact, endoth adhesion, CD49a/CD29 binds collagen & laminin
CD49bVLA-2, Integrin α2, Itga2
165kD platelets, T subset, megakaryocytes, NK cells adhesion, CD49b/CD29 binds collagen & laminin
CD49cVLA-3, Integrin α3, Itga3
125kD B subset, Tlow CD49c/CD29 binds laminin, fibronectin, collagen
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55
Mouse CD Antigens
Antigen Name Alternative Name MW Distribution Function
CD49d VLA-4, Integrin α4, Itga4
150kD T, B, mono CD49d/CD29 binds fibronectin, VCAM-1, w/ b7 forms LPAM-1 & binds to MAdCAM-1, homing receptor
CD49e VLA-5, Integrin α5, Itga5
135kD thymocytes, Tact, splenic B cells adhesion, CD49e/CD29 binds fibronectin
CD49f VLA-6, Integrin α6, Itga6
120kD memory T, thymocytes, platelets adhesion, CD49f/CD29 binds laminin
CD50 Icam5, Ticn, Telencephalin
130kD brain, dopaminergic neurons adhesion
CD51 VitronectinR, Integrin αv, Itgav
125, 24kD platelets, megakaryocytes, endoth, osteoblasts, melanoma adhesion, CD51/CD61 binds vitronectin, von Willebrand factor, fibrinogen & thrombospondin
CD52 CAMPATH-1, MB7, CLS1
12kD mature lymphocytes, Treg subset
CD53 OX-44 35-42kD leukocytes, DC, osteoblasts, osteoclasts signaling
CD54 ICAM-1, Ly-47 85-110kD endoth, mono, resting lymph (high on activation) CD11a/CD18(LFA-1), CD11b/CD18(Mac-1) & CD43 receptor, adhesion, T costimulation
CD55 Decay Accelerating Factor
60-70kD broad, induced in uterus by estrogen similar to Crry, protection from autologous complement attack
CD56 NCAM 20-185kD neural tissue, multiple isoforms adhesion, neuron development, skeletal myogenesis
CD57 B3gat1, HNK-1 38kD GlucuronsyltransferaseP cell adhesion molecule; memory
CD58 (H) LFA-3 not defined in mouse
CD59 Protectin, MAC-inhibitor
19kD broad binds complement C8 & C9, blocks membrane attack complex assembly
CD60 (H) not defined in mouse
CD61 GPIIIa, Integrin β3, Itgb3
105kD platelets, megakaryocytes, mac, endoth CD41/CD61 or CD51/CD61 complexes adhere to ECM
CD62E E-selectin, ELAM-1, Sele 97
107-115kD
endoth sialyl-Lewis x receptor, leukocyte rolling & migration, tumor metastasis
CD62L L-selectin, LECAM-1, sell
74 & 95kD B, T, mono, gran, NK, thymocytes CD34, GlyCAM, & MAdCAM-1 receptor, lymphocyte homing, leukocyte tethering & rolling
CD62P P-selectin, Selp 140kD plateletsact, endoth CD162 & sialyl LewisX receptor, adhesion, neutrophil rolling, platelet-neutrophil, binds to CD24
CD63 MLA1 53kD plateletsact, mono, mac activated platelets marker, lysosomal membrane protein, translocates to surface upon activation, melanoma associated antigen
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56
Mouse CD AntigensAntigen Name Alternative Name MW Distribution Function
CD64 FcγRI 72kD mono, mac, DC, granact high affinity IgG receptor, phagocytosis, trypsin-sensitive, ADCC
CD65 (H) not defined in mouse
CD66a Ceacam1, C-Cam 140-180kD
colon, liver, hematopoietic tissues cell-cell interaction, hepatitis virus receptor
CD68 Macrosialin, gp110 87-115kD predominantly intracellular, tissue mac, DClow lysosomal associated protein
CD69 Activation Inducer Molecule, VEA
35-39kD Tact, Bact, NKact, granact, thymocytes, platelets early activation marker, thymocyte development
CD70 Ki-24, Tnfsf7 50, 70, 90, 160kD
Bact, Tact, cardiac myocytes CD27 receptor, T & B costimulation
CD71 T9, Trfr 95kD proliferating cells, reticulocytes, erythroid precursors transferrin receptor, iron uptake, cell activation
CD72 Lyb-2 40-45kD B, FDC, T subset, polymorphic extracellular portion CD5 & CD100 receptor, B costimulation
CD73 Nt5e 69kD Treg, myeloid BM, CD4+ T cells ecto-5’-nucleotidase, T costimulation, adhesion
CD74 Ii, Ia-invariant chain 33-43kD B, mac, mono MHC class II traffic & function, antigen presentation
CD75 st6Gal I 44kD BM homing of recirculating B cells, CD22 counter-receptor putative role in tumor progression
CD77 (H) not defined in mouse
CD79a Igα, mb-1, Ly-54 33 & 45kD B BCR subunit, BCR expression & signaling
CD79b Igβ, B29 37kD B BCR subunit, BCR expression & signaling
CD80 B7, B7-1, Ly-53 60kD Bact, Tact, mono, mac, DC, pancreatic β cells CD28 & CD152 receptor, costimulation, T-B interaction
CD81 TAPA-1 26kD T (double POS), B, NK, thymocytes, DC, endoth, fibroblast, melanomas, neuroblastomas, mac
w/ CD19 & CD21, signaling, T costimulation
CD82 KAI1, C33 50-53kD Tact, mRNA: spleen, kidney inhibits tumor cell mobility
CD83 H315 43kD DC, Tact, mRNA: spleen & brain regulation of T response, binds to a ligand on B cells
CD84 SLAMF5, GR6 70-85kD B, mac, mRNA: hematopoietic tissue homophilic adhesion
CD85K Gp49b, Lilrb4 37kD mast cells inflammation
CD86 B70, B7-2, Ly-58 80kD mono, Bact, Tact, DC CD28/CD152 receptor, T costimulation, T-B interaction
CD87 UPA-R, Plaur muPAR1 luminal epith of gastric mucosa PAR2 secreted uPA binding protein
CD88 C5aR, C5r1 40kD gran, neurons, astrocytes, microglia C5a receptor, neurodegeneration
CD89 FcαR, IgA receptor 55-75kD mono, mac, neutrophils, B subset, T subset phagocytosis, degranulation,
CD90 Thy-1 18kD thymocytes, T, hematopoietic subset, neuronshematopoietic stem cell & neuron differentiation, T activation
CD90.1 Thy-1.1 18kD thy1a (thy1.1) strains: AKR & RF & PL
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57
Mouse CD Antigens
Antigen Name Alternative Name MW Distribution Function
CD90.2 Thy-1.2 18kD thy1b (thy1.2) all other strains
CD91 lrp1, A2mr 600kD mono, mac, neurons, liver, fibroblasts receptor for a-2- macroglobulin, LDL, lipoprotein metabolism
CD92 (H) not defined in mouse
CD93 AA4.1 antigen, C1qRp, early B lineage marker, Ly68
130-140kD
progenitor marker for early B cells, endo, megakaryoblasts, platelets
phagocytic complement C1q receptor
CD94 KP43, klrd1 43kD NK, T subset w/ NKG2, inhibits NK function
CD95 Apo-1, Fas 35kD thymocytes, lymphocytesact, fibroblast, mono, neutrophilCD95L(CD178) receptor, apoptosis induction, immune system regulation,
CD96 TACTILE, T cell Activation Increased Late Expression
160kD mRNA: spleen, mammary gland adhesion of activated T & NK
CD97 TM7LN1 TM7S lymphoid, myeloid CD55 receptor
CD98 4F2, Ly-10 80, 40kD thymocytes, lymphocytes, mono, BM cell activation, calcium flux
CD99 Pilr-1, D4 19kD endoth neutrophil migration
CD100Sema4d, semaphorinH
150kD mRNA: lymphoid & nervous tissues CD72 receptor, role in immune & nervous systems
CD101 IgSF3 131kD meyloid, DC, T subset, Treg subset role in susceptibility to type I diabetes
CD102 ICAM-2, Ly-60 55-65kD lymphocytes, mono, platelets, endoth binds CD11a/CD18 (LFA-1), costimulation
CD