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CURRICULUM VITAE

Name: CATRAVAS, John Dennis, Ph. D.

Title: Sr. Associate Dean for Basic Research Regents’ Professor of Pharmacology and Toxicology

Director, Vascular Biology Center Acting Director, Cancer Center

Address: Vascular Biology Center, Medical College of Georgia

Augusta, GA. 30912-2500

Telephone: (706) 721-6338 FAX: (706) 721-9799

E-mail: jcatrava@mcg.edu PERSONAL

Home Address: 81 Conifer Circle, Augusta, GA 30909 Home Telephone: (706) 733-3713 Date of Birth: July 24, 1950 Place of Birth: Athens, Greece Citizenship: U.S., Greek Marital Status: Married (Dr. Christiana Dimitropoulou) Children: Joanna Elaine (9/9/86), Iro Antonia (10/15/07)

EDUCATION

High School: Athens College, Athens, Greece; 1969, Diploma

Undergraduate: Cornell College, Mt. Vernon, Iowa; 1969-1972, B.A. in Chemistry and Physics

Graduate: University of Mississippi, University, Mississippi; 1972-1975,

M.S. in Pharmacology; 1975-1978, Ph.D. in Pharmacology

Post-Doctoral: Yale University, New Haven, Connecticut; 1978-1980, Departments of Anesthesiology and Pharmacology. Pulmo-nary Endothelial Pathophysiology and Pharmacology. Mentor: C.N. Gillis, Ph.D.

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LANGUAGES Fluent in French and Greek. PROFESSIONAL ACADEMIC APPOINTMENTS

2009-Present Acting Director, Cancer Center, Medical College of Georgia, Augusta, GA

2008-Present Senior Associate Dean for Basic Research, School of

Medicine, Medical College of Georgia, Augusta, GA 2001-Present Director, Post-Doctoral training Program in Integrative

Cardiovascular Biology 1995- Present Director, Vascular Biology Center, Medical College of

Georgia, Augusta, GA 1995- Present Regents Professor of Pharmacology and Toxicology,

Medical College of Georgia, Augusta, GA

1990-1995 Professor of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA

1993 Visiting Professor, Department of Cardiothoracic Surgery,

Royal Brompton Hospital and Harefield Hospital, National Heart & Lung Institute, London, United Kingdom (Prof. Sir M. Yacoub)

1986-Present Tenured, Medical College of Georgia

1986-1990 Associate Professor of Pharmacology and Toxicology,

Medical College of Georgia, Augusta, GA

1985-1990 Established Investigator of the American Heart Association

1981-1986 Assistant Professor of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA

1980-1981 Research Associate, Department of Anesthesiology, Yale

University School of Medicine, New Haven, CT

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TEACHING ACTIVITIES Medical School Courses

PHM 5270: Survey of Pharmacology, for 2nd year medical and graduate ITD 5215: students. Three lectures annually on a) Autocoids (1 hr), b) Drugs

and Respiration (2 hrs), c) Corticosteroids (1 hr).

Research Elective on aspects of cultured endothelial cell biology (12 weeks; 1982-2000).

Live Demonstration Laboratory Exercise on Pharmacologically Active Peptides. (1982-1998)

POPS: Patient-Oriented Problem-Solving Group Leader (-2002)

ITD 585: (Elective) 3 hours annually (1981-1986) to first year medical stu-

dents on Research Applications of Microcomputers. PHM 5002: Clinical Pharmacology: Lectures on Vasodilators PHM 5001: Toxicology: Lectures on Pulmonary Toxins

Graduate School Courses

PHM 8040: Advanced Pharmacological Sciences. Organized and taught 3 segments a) Lung Pharmacology (6 weeks), b) Pharmacologically Active Peptides (4 weeks), c) Consequences of Receptor Activation (12 weeks). Organized course on "Endothelium".

PHM 8010: Molecular Pharmacology; 3 hours lecture annually on transcription

factors

PHM 8100: Same as PHM 5270, but for Ph.D. students. PHM 8120: Director and Lecturer; Pharmacologically Active Peptides, a 3

credit-hour graduate course offered every other year (1984-1992)

PHM 815: Principles of Pharmacology; 6 hours annually on a) Pharmacokinetics, b) Enzyme Kinetics. (1982-1987).

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PHM 816: Advanced Toxicology; lectures on Pulmonary Toxicology. PHM 8090: Cardiovascular Pharmacology. 6 hours lecture on endothelium-

dependent mechanisms of vascular tone.

SGS 8030: Functional Systems Biology; Lectures on Endothelial Cell Functions and Vasoactive Agents. Coordinator: Cardiovascular Block

VBI 8020 Frontiers in Vascular Biology; Course Director and Lecturer.

Research Rotations (6 weeks) for First Year Graduate Students.

Allied Health Sciences Courses

PHM 301: Undergraduate Pharmacology Course: 6-15 hours annually on a) Autonomics, b) Muscle Relaxants, c)Bronchodilators, d) Prostaglandins (1981-1988)

ADMINISTRATIVE RESPONSIBILITIES/APPOINTMENTS

International: Local Organizing Committee: International Kinin Congress - 1984.

Organizer and Director: NATO Advanced Study Institute (ASI) on "Vascular Endothelium: Receptors and Transduction Mechanisms", June 18-29, 1988, Porto Carras, Greece.

Organizer and Director: NATO Advanced Study Institute (ASI) on "Vascular Endothelium: Physiological Basis of Clinical Problems". June 18-29, 1990, Corfu, Greece

Organizer and Director: NATO Advanced Study Institute (ASI) on "Vascular Endothelium: Physiological Basis of Clinical Problems II". June 20-30, 1992, Rhodes, Greece

Organizer and Director: NATO Advanced Study Institute (ASI) on "Vascular Endothelium: Responses to Injury". June 18-27, 1994, Crete, Greece.

Organizer and Director: NATO Advanced Study Institute (ASI) on "Vascular Endothelium: Pharmacologic and Genetic Manipulations". June 22-July 1, 1996, Crete, Greece.

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Organizer and Director: NATO Advanced Study Institute (ASI) on “Vascular Endothelium: Mechanisms of Cell Signaling”. June 19-29, 1998, Crete, Greece. Organizer and Director: NATO Advanced Study Institute (ASI) on “Vascular Endothelium: Source and Target of Inflammatory Mediators”. June 24 – July 3, 2000, Crete, Greece. Organizer and Co-Director: conference on “Vascular Endothelium: Translating Discoveries to Public Health Policy” June 24-July 2, 2005, Crete, Greece.

National: Organizing Committee, American Physiology Society 1998 Fall

meeting on “Endothelial Control of Vascular Tone”, Augusta, GA September 16-19.

Chair-Elect: Cardiovascular Division, American Society for Pharmacology and Experimental Therapeutics (ASPET) (1998-1999). Chair: Cardiovascular Division, American Society for Pharmacology and Experimental Therapeutics (ASPET) (1999-2000). Past-Chair: Cardiovascular Division, American Society for Pharmacology and Experimental Therapeutics (ASPET) (2000-2001).

State/Local: Chairman, Scientific Review Group, American Lung Association of

Georgia (1989-1991)

Chairman, Research Policy Advisory Committee, American Lung Association of Georgia (1990-1991)

President Elect: Southeastern Chapter of the Society of Toxicology (1987-1988)

President: Southeastern Chapter of the Society of Toxicology (1988-1989)

President Elect: CSRA Chapter of Sigma Xi (1988)

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President: CSRA Chapter of Sigma Xi (1989)

President, Organizing Committee, 1987 Annual Meeting of the Southeast Chapter of the Society of Toxicology.

Co-chairman, Organizing Committee, 1989 Annual Meeting of the Southeast Chapter of the Society of Toxicology and SEPS.

COMMITTEE AND OTHER PROFESSIONAL ASSIGNMENTS International: Consultant, Ministry of National Education and Religion, the Greek

Government National: Member, Special Study Section of the National Heart, Lung, and

Blood Institute, to review RFP titled "Markers for Pulmonary Endothelial Injury and Repair," 84-HL-12-P in Bethesda, MD, July 12-13, 1984

Member, site visit team of the National Heart Lung and Blood Institute to review Program Project "Endothelium as a Regulatory Interface" at the University of Massachusetts, March 3-5, 1986

Member, site visit team of the National Heart Lung and Blood Institute to review SCOR in Pulmonary Vascular Disease application, Vanderbilt University, May 27-29, 1986.

Member, Ad Hoc Meeting of Pharmacology Study Section in Bethesda, MD, October 22, 1987. Member, Special Review Committee of NHLBI for RFA on "Lung Reperfusion Injury", Bethesda, MD, June 9-10, 1988.

Ad-Hoc Member, Toxicology Study Section, NIH, June 21-23, 1989.

Ad-Hoc Member, Pharmacology Study Section, NIH, October 17, 1989

Chair, Special Pharmacology Study Section, NIH, October 1993

Member, Program Committee, 1994 Annual Meeting of the American Thoracic Society / American Lung Association.

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Ad-Hoc Member, Toxicology Study Section, NIH, February 23-26, 1995

Member, Toxicology Study Section, NIH, 1990-1994.

Member, Nominating Committee, Section of Pulmonary Circulation, American Thoracic Society, 1996-1997 Member, Review Panel 4, Southern Research Consortium, American Heart Association, (1997-1998) Member, Editorial Board, American Journal of Physiology 1997-1999. Member, Scientific Council, American Society for Pharmacology and Experimental Therapeutics (ASPET) (1998-2001). Member, Special Emphasis Grant Review Panel on “ Endothelial Heterogeneity”, NIH, June 10-11, 2003. Ad Hoc member, Experimental Cardiovascular Sciences (ECS) Study Section; NIH; October 2003. Ad Hoc member, Vascular Cell and Molelclar Biology Study Section, June 20, 2004. Ad Hoc member, Gastrointestinal Cell and Molecular Biology Study Section, NIH; June 21, 2004. Ad Hoc Member Pathophysiology Fellowships (F10) Study Section; NIH; June 21, 2004.

Ad Hoc Member Physiology and Pathophysiology of the Organ Systems Study Section, NIH, October 26-27, 2004.

Ad Hoc Member National Institute of Environmental Health Sciences Special Emphasis Panel, ZES1 LWJ-B(TW), NIH, November 16, 2004. Member, Special Emphasis Grant Review Panel ZHL1 CSR-A(F1)

on “Research Career Development Program in Vascular Medicine”, NIH, July 25-26, 2006.

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Member, Special Emphasis Grant Review Panel ZES1-LWJ-G-TG on “T32 Institutional Pre- and Post-Doctoral Training Grants”, NIEHS, November 20, 2007. Member, Special Emphasis Grant Review Panel ZRG1 F10-H 21

on “Pre- and Post- Doctoral Fellowship Applications””, NIH, March 18, 2008. Member, American Heart Association, South East Affiliate, Grant Review Committee 1 (2005- present); Co-Chair: 2006; Chair: 2007-2009.

State: Member, Publications Committee of Georgia Thoracic Society

(1983-1990)

Editor, the GTS NEWSLETTER, published quarterly by the Georgia Thoracic Society and Georgia Lung Association (1983-1985)

Member, Research Endowment Planning Committee of the American Lung Association of Atlanta/Georgia

Chairman-Elect, Scientific Review Group, American Lung Association of Georgia (1988-1989)

Member, Research Policy Advisory Committee, American Lung Association of Georgia (1988-1990)

Board Member, Georgia Environmental Technology Consortium (1991-1999)

Member, Organizing Committee 1997 SEPS/Pharmacology Colloquia, Augusta, October 4-6, 1997 Research Grant Review Group, American Lung Association of Georgia, 2003-present.

Institutional: Subcommittee of Committee on Animal Use in Research and Education

(1983-1986)

Search Committee for Chairman of the Department of Anesthesiol-ogy (1984-1986)

Committee on Basic Research Starter Grants (1985-1988)

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Grant Review Committee, Medical College of Georgia Research Institute (1984-1986)

Faculty Affairs Committee, School of Graduate Studies (1983-1985)

Chairman, Faculty Affairs Committee, School of Graduate Studies (1984-1985)

Senator, School of Medicine (1985-1987)

Faculty Advisor, Phase I, School of Medicine (1983-2000)

Bylaws Review Committee, School of Graduate Studies (1986)

Representative to Graduate Faculty Assembly (1987)

Vice-Chairman, Graduate Faculty Organization (1987)

American Cancer Society Institutional Research Grant Committee (1986-1993)

Chairman-Elect, Graduate Faculty Senate (1988)

Chairman, Graduate Faculty Senate (1989)

Chairman, Nominating Committee, School of Graduate Studies (1990)

Chairman, Grant Review Committee, Medical College of Georgia, Research Institute (1989-1992)

Promotions Subcommittee Class of 1992 (1988-89)

Promotions Subcommittee Class of 1992 (1989-90)

Promotions Subcommittee Phase III (1990-1993)

Faculty Research Ethics Committee (1994-1997)

Chairman-Elect, Graduate Faculty Organization (1996) Chairman, Graduate Faculty Organization (1997)

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Chairman, Nominating Committee, Graduate Faculty Organization (1998)

Radiation Safety Committee (1997-2002) Chair, Search Committee for Vice President for Research (1998-1999). Member, LCME Self Study Governance and Administration Committee (1999-2000). Member, Biomedical Research Council (1999- 2005) Chair, Cardiovascular Disease Steering Committee (2000- 2006) Member, Search Committee for President of the Medical College of Georgia (2000-2001) Member, Search Committee for Chair of Department of Pathology at the Medical College of Georgia (2000-2001) Director, Post-Doctoral training in Integrative Cardiovascular Biology Program (2001- present) Member, Data Safety Monitoring Board, MCG FitKid Project (2003-present) Member, Admissions Committee, School of Medicine (2004-2007) Member, Search Committee for Chair of Department of Medicine at the Medical College of Georgia (2006-2008) Co-Chair, Research Planning Committee, School of Medicine (2006-present) Member, Executive Committee of the School of Medicine (2007-present) Member, Search Committee for Chair of Pathology (2008- ) Member, Search Committee for Chief of Cardiology (2008 - )

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Departmental: Committee on Higher Degrees (1983- 1995) (Pharmacology)

Library Committee (1981-1988), Chairman (1984-1987)

Chairman, Seminar Committee (1982-1986)

Committee on Undergraduate Education (1982-1984)

Toxicology Committee (1982-present)

Summer Research Fellowship Program (1985-present)

Coordinator, Cell Culture Facility (1985-1995)

Committee on Medical Education (1986-1992)

Faculty Search Committee (1990)

Faculty Search Committee (1992)

Faculty Promotion and Tenure Committee (1994-1997)

Grants Awarded (*active grants. J. Catravas is P.I. unless otherwise indicated)

"Role of Endothelial Injury in Developing Interstitial Lung Disease." Phar-maceutical Manufacturers Association Foundation Research Starter Grant, $6,500 - 1/1982-12/1982.

"Metabolic Probes of Lung Microvascular Injury." Biomedical Research Starter Grant, $5,000 - 4/1982-3/1983.

"Probes of Lung Microvascular Injury." American Heart Association, Georgia Affiliate, $39,938 - 7/82-6/84.

"Endothelial Functions in Developing Interstitial Lung Disease." American Lung Association, Georgia Affiliate, $29,020 - 7/82-6/84.

"Cholinergic Pharmacology of the Pulmonary Circulation." A Mideast Foun-dation, $3,300 - 3/1984-9/1984.

"Cholinergic Pharmacology of the Pulmonary Circulation." American Lung

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Association, Georgia Affiliate, $30,000 - 7/1/1984-6/30/1986

"Toxicology and Pharmacology of Lung Endothelial Enzymes." NIH, $193,000 - 8/1/1984-7/31/1987.

"The Therapeutic Index of 'Functional ' Bleomycin Analogs." Consortium Co-investigator with R.A. Newman, Ph.D. (University of Texas, Houston), American Cancer Society, $60,000 - 7/1/1985-6/30/1987.

"Muscarinic Systems of the Pulmonary Vasculature." American Lung Association, Georgia Affiliate, $15,000 - 7/1/1986-6/30/1987.

"Pharmacology and Toxicology of Endothelial Ectoenzymes." American Heart Association (Established Investigatorship), $175,000 - 7/1/1985-6/30/1990.

"Toxicology and Pharmacology of Lung Endothelial Enzymes." NIH, $490,000 - 8/1/1987-3/31/1993.

"Vascular Endothelium: Receptors and Transduction Mechanisms", Advanced Study Institute, June 18-29, 1988, Porto Carras, Greece; NATO, $51,400.

"Vascular Endothelium: Receptors and Transduction Mechanisms", a Conference Grant, supplement to the above; NIH $15,000. "Microvascular Permeability and Endothelial Cell Dysfunction" a training grant, Georgia Heart Association, 6/90-7/90, $1500.

"Muscarinic Systems of the Pulmonary Vasculature." NIH, $342,939 -7/1/1987-6/30/1991.

"Correlation of Angiogenesis with angiotensin converting enzyme activity" - 4/88 - 4/90, NATO International Travel Grant, $5,100.

"Vascular Endothelium: Physiological Basin of Clinical Problems", Advanced Studies Institute, June 18-29, 1990, Corfu, Greece; NATO, $64,000. "Development Heterogeneity among the great Arteries", NIH 7/1/90-6/30/95, $718, 178 TDC, T. Rosenquist, P.I., J.D. Catravas: Co-Investigator, 20% effort (salaried). "Comparisons Among Trandolapril and Enalapril in Inhibiting ACE in vivo and as Substrates for Plasma Esterases, in vitro". Knoll Pharmaceuticals Inc., $158,347; 10% effort; 11/1/91-9/30/93.

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"Vascular Endothelium: Physiological Basis of Clinical Problems II", NATO Advanced Study Institute, 6/20/1992; $80,000

"Neutrophil-Mediated Early Endothelial Dysfunction", Georgia Heart Association, 7/1/92-6/30/93, $30,000 TDC, 15% effort.

"Endothelial Enzyme Dysfunction in Lung Transplantation"; The Wellcome Foundation. Travel Grant to J.D. Catravas: 2/1/93 -4/30/93; $5,141.

"Endothelial Enzyme Dysfunction in Lung Transplantation", NIH; Fogarty Senior International Fellowship to J.D. Catravas; 4/1/93-9/1/93. "Pulmonary Permeability and Enzyme Dysfunction", NIH, 7/1/92-6/30/95 $454,457 TDC. I. Ehrhart, P.I., J.D. Catravas, Co-Investigator 35% effort.

"Vascular Endothelium: Responses to Injury", NATO Advanced Study Institute, 11/1/93-11/1/94; $85,000.

"Pulmonary ACE Activity in Trauma Patients", BRSG, M. Shapiro, P.I.; J.D. Catravas, Collaborator; 4/1/94-3/3/1-95, $5,000.

"Toxicology and Pharmacology of Lung Endothelial Enzymes”, NIH, 4/1/1993 - 3/31/97; $588,499.

"Toxicology of Nitric Oxide Synthases", NIH, 7/1/94-6/30/97; $495,000.

“Vascular Endothelium: Pharmacologic and Genetic Manipulations”, NATO Advanced Study Institute. 6/22/96 - 7/1/96; $96,000 ”Vascular Endothelium: Mechanisms of Cell Signaling”, NATO Advanced Study Institute. 6/20/1998 - 6/29/1998; $85,000. Vascular Endothelium: Source and Target of Inflammatory Mediators”, NATO Advanced Study Institute. 6/23/2000 - 7/3/2000; $58,000. "Toxicology of Nitric Oxide Synthases", NIH, 7/1/97-6/30/02; $600,000. ”Toxicology and Pharmacology of Lung Endothelial Enzymes”, NIH, 4/1/98 – 3/31/03; $502,094.

Supplement to above for minority Post-Doctoral Fellowship. NIH 9/1/98 - 3/31/03; $158,000.

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“Post-Doctoral Training Grant (T32) in Integrative Cardiovascular Biology”, NIH (NHLBI Institutional National Research Service Award) 7/1/01-6/30-06; $1,251,219 “Regulation of soluble Guanylate Cyclase in Complexes with Heat Shock Protein 90 and Nitric Oxide Synthases”. American Heart Association Grant-in-Aid 7/1/2002-6/30/2004; $77,000/yr “Regulation of sGC in sGC/Hsp90/NOS complexes”, NIH (NHLBI R01) 4/15/2003-3/31/2008; $900,000. *“Post-Doctoral Training Grant (T32) in Integrative Cardiovascular Biology”, NIH (NHLBI Institutional National Research Service Award) 7/1/06-6/30-11; $1,595,199 *“Regulation of sGC in sGC/Hsp90/NOS complexes”, American Heart Association Grant in Aid 7/1/2007-6/30/2009; $154,000.

Invitations to Seminars and Conferences (Outside the Medical College of

Georgia) 1982 Department of Pharmacology and Anesthesiology, Yale University School of Medicine 1983 Department of Anesthesiology, University of Pittsburgh School of Medicine 1984 Department of Vascular Biology, Clinical Research Center, Harrow,

England.

1986 Department of Pharmacology, Emory University School of Medicine

1987 Conference on "Pulmonary Microvascular Transport Mechanisms", University of Washington School of Medicine, Seattle, WA

1987 FASEB Conference on "Lung Pharmacology and Pathophysiology"

1987 Department of Pharmacology, University of Patras School of Medicine,

Patras, Greece

1988 NATO ASI on "Vascular Endothelium: Receptors and Transduction

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Mechanisms", Greece

1989 Department of Pharmacology, University of Pittsburgh School of Medicine

1989 Department of Medicine, University of Pennsylvania School of Medicine

1989 American Thoracic Society Annual Meeting: Symposium on "Endothelial Receptors"

1989 5th International Symposium on "Pulmonary Circulation", Prague,

Czechoslovakia

1990 NATO ASI on "Vascular Endothelium: Physiological Basis of Clinical Problems"

1990 ISACB Symposium on "Vascular Endothelium" Venice, Italy

1990 IVth Grover Conference on "Progress in Pulmonary Hypertension",

Denver, Colorado

1990 Department of Medicine, University of Ioannina School of Medicine, Greece

1991 Departments of Pharmacology and Medicine, Medical University of South

Carolina, Charleston, SC

1991 Department of Pharmacology, University of Pittsburgh School of Medicine.

1992 NATO Advanced Study Institute on "Vascular Endothelium: Physiological Basis of Clinical Problems II", Rhodes, Greece.

1992 Monsanto Company, St. Louis, MO

1992 Departments of Pharmacology and Medicine, University of Pennsylvania

School of Medicine.

1993 London Microvascular Society, King's College, London, U.K.

1993 Section of Immunology, Department of Cardiothoracic Surgery, Harefield Hospital, Imperial College, Harefield, U.K.

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1993 Department of Applied Pharmacology, National Heart & Lung Institute, Imperial College, London, U.K.

1993 Department of Experimental Physiology, University of Athens, Athens,

Greece

1994 Department of Anesthesiology, University of Alabama, Birmingham, Alabama

1994 T-Cell Sciences, Cambridge, Massachusetts

1994 Department of Pharmacology, Wright State University, Dayton, Ohio

1994 NATO Advanced Study Institute on AVascular Endothelium: Responses to

Injury@, June 18-27, Crete, Greece

1995 NATO Advanced Study Institute on “Molecular Aspects of Angiogenesis”, June 20-25, Porto Carras, Greece

1996 1st International Conference on Thrombosis and Vascular Biology, Porto,

Portugal

1996 NATO Advanced Study Institute on AVascular Endothelium: Pharmacologic and Genetic Manipulations@, Crete, Greece.

1996 Third Harveian-Texan Conference on Endothelial Pathophysiology, Berlin,

Germany 1996 Department of Physiology, University of Frankfurt, Frankfurt, Germany. 1996 Department of Experimental Physiology, University of Athens, Athens,

Greece. 1997 Department of Anesthesiology, Cornell University, New York, NY, January

31.

1997 NATO Advanced Study Institute on the Acute Respiratory Distress Syndrome, Corfu, Greece.

1997 NATO Advanced Study Institute on “Angiogenesis”, Rhodes, Greece.

1997 12th International Interdisciplinary Conference on Hypertension in Blacks,

London, United Kingdom.

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1997 Department of Internal Medicine, University of Athens School of Medicine,

Athens, Greece. 1997 5th Conference on Physical Medicine and Therapy, Cephalonia, Greece. 1998 Department of Pharmacology, University of Patras School of Medicine,

Patras, Greece.

1998 2nd Mediterranean Congress on Thoracic Diseases, Athens, Greece.

1998 2nd International Conference on Thrombosis and Vascular Biology, Porto, Portugal

1998 NATO Advanced Study Institute on "Vascular Endothelium: Mechanisms

of Cell Signaling", Crete, Greece. 1998 Department of Physiology and Microvascular Research Center, Texas

A&M University, College Station, TX. 1998 APS Fall Conference on Endothelial Control of Vascular Tone, Augusta,

GA. 1999 European Vascular Biology Association (EVBA 1999) Annual Conference,

Banden, Austria. 1999 Institute of Cellular Biology and Pathology “N. Simionescu”, Bucharest,

Romania. 1999 European Atherosclerosis Society (EAS) Congress, Athens, Greece. 1999 Cornell University Medical Center, Hospital for Special Surgery,

Department of Anesthesiology, New York, NY.

1999 American Heart Association, Atlanta, GA

1999 Department of Pharmacology, Louisiana State University, New Orleans, LA

1999 Vascular Biology Center, Albany Medical College, Albany, NY 1999 5th Biannual International Conference on Angiogenesis: From the

Molecular to Integrative Pharmacology, Agia Pelagia, Crete, Greece.

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2000 NATO Conference on Vascular Endothelium: Source and Target of

Inflammatory Mediators, Crete, Greece 2000 Ivth Mediterranean Conference on Thrombosis and Vascular Biology,

Porto, Portugal 2000 Department of Pharmacology, East Carolina University, Greenville, NC

2000 Cardiology Department, Pecs University School of Medicine, Pecs, Hungary

2000 International Vascular Biology Meeting, Geneva, Switzerland

2001 International Conference on Markers of Acute Lung Injury, Crete, Greece.

2001 Invited Speaker - Experimental Biology, Orlando, FL.

2003 National Research Foundation, Athens Greece 2003 Mercer University School of Medicine, Macon, GA 2003 27th Panhellenic Pulmonology Congress, Athens, Greece 2004 28th Pahhellenic Pulmonology Congress, Patras, Greece

2005 CDC Conference on “Vascular Endothelium: Translating Discoveries to

Public Health Policy”, Crete, Greece

2006 2nd Conference on Pulmonary Hypertension, Athens, Greece.

2006 University of Pennsylvania Medical Center; Institute for Environmental Medicine. Philadelphia, PA.

2006 Marshall University School of Medicine Department of Pharmacology,

Huntington, WV. 2006 International Conference on Endothelial Function in Hypertension, Prague,

Czech Republic.

2006 International Congress on Steroid Hormones and Hormones in Cancer, Athens Greece.

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2007 Workshop on Sepsis; University of Athens School of Medicine, Athens, Greece.

2007 International Society of Hypertension Annual Conference, Miami, Florida. 2007 Department of Medicine, University of Crete, Crete, Greece

2007 International Conference on cGMP – Dresden, Germany

2007 Ecge University, Izmir, Turkey 2007 European Respiratory Society, Stockholm, Sweden 2007 Panhellenic Cancer Congress, Athens, Greece. 2008 University of Athens Workshop: Hot Topics in Cardiovascular Disease,

Athens, Greece

2008 Center for Free Radical Research, University of Alabama School of Medicine, Birmingham, Alabama. 2008 Scientific Sessions, American Heart Association, New Orleans, LA

2008 Department of Pharmacology, University of Patras, Greece

2008 11th Conference on Intensive Care Topics, Athens, Greece 2009 Department of Physiology, University of South Alabama

2009 Cardiovascular Assist Devices, Athens, Greece 2009 Mahindol University Department of Physiology, Bangkok, Thailand

2009 Panhellenic Conference of Intensive Care Society, Athens, Greece Journal Reviews Journal of Applied Physiology, Pulmonary Pharmacology.

American Journal of Physiology, Journal of Pharmacology and Experimental Therapeutics, British Journal of Pharmacology, Circulation Research, Biochemical Pharmacology, Hypertension, Archives of Internal Medicine, Life Sciences, Journal of Immunological Methods, Journal of Clinical Investigation Arteriosclerosis, Thrombosis and Vascular Biology, Circulation, Metabolism, Critical Care Medicine, American Journal of

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Respiratory Cell and Molecular Biology, Hypertension, Journal of Biological Chemistry, Cardiovascular Toxicology.

Awards/Honors International Scholar, Cornell College, 1969-1972

ASPET Travel Award to 1984 International Pharmacology Congress in London, U.K.

Outstanding Basic Science Young Faculty Award, Medical College of Georgia, 1985.

Established Investigator of the American Heart Association,1985-1990.

Distinguished Research Award, School of Graduate Studies, Medical College of Georgia, 1989.

Outstanding Research Award, American Lung Association, Georgia Affiliate, 1991.

Fogarty Senior International Fellow, 1993

Burroughs-Wellcome Travel Award, 1993.

Regents Professorship, 1995-

Outstanding Faculty Award, School of Graduate Studies, Medical College of Georgia, 1996 – 1997.

Distinguished Faculty Award for Basic Science Research, School of Medicine, 1998. Distinguished Research Award, Medical College of Georgia Research Institute, 2006. Fellow, Council on Basic Cardiovascular Science, American Heart Association Fellow, Cardiopulmonary and Critical Care Council, American Heart Association Fellow, Cardiovascular Section, American Physiological Society

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European Respiratory Society (ERS) Visiting Professorship, 2010

Editorial Boards Vascular Pharmacology, Editor-in-Chief (1999- present) Cardiovascular Toxicology (2000- 2006) American Journal of Physiology: Lung Cell and Molecular Biology (1997-

1999) American Journal of Physiology: Heart and Circulatory Physiology

(2005-present) Pneumon (2007- present) The Open Nitric Oxide Journal (2008-present) The Journal of Experimental Pharmacology (2009-present)

Fellows/Students Trained

Gouse Shaik, Ph.D. Post-Doctoral Fellow, 2010-present Fenxue Zhang, Ph.D. Res. Assist. Professor, 2009- present Elizabeth NeSmith, Ph.D. Asst. Professor, 2009-present Intapad, Suttira PhD student, 2007-2009 Handa, Vaishali, Ph.D. Post-Doctoral Fellow, 2007-2009 Zheng, Jingmin, Ph.D. Post-Doctoral Fellow, 2006-2007 Drakopanayiotakis, Fotios, M.D. Post-Doctoral Fellow, 2005-2006 Tian Xia, M.D., Ph.D. Research Associate, 2004 – 2007 Anuran Chatterjee Ph.D. Student, 2002 - 2007

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Hera Lichtenbeld, Ph.D. Post-Doctoral Fellow, 2003 Gunay Yetik, Ph.D. Post-Doctoral Fellow, 2003 - 2005 Galina Antonova, M.D. Post-Doctoral Fellow, 2003 -2006 Renuka Mehta, M.D. Fellow, 2001 - 2004 Laryssa McCloud, Ph.D. Post-Doctoral Fellow 1998-2005 Michael M. Maragoudakis, M.D. Post-Doctoral Fellow, 2002 - 2003 Mahmood H. Khichi, M.D. Fellow 1999 – 2002 Hanfang Zhang, M.D., Ph.D. Research Scientist, 1996 - 2001 Lihua Zou, M.D. Post-Doctoral Fellow 1998 – 2001

Stephen Papizan, M.D. Fellow, 1998 -2000

Michael Theodorakis, M.D., Ph.D. Student, 1997 - 2000 Xingwu Teng, M.D. Ph.D. Student, 1996 - 2000 Ramon Rivera, M.D. Fellow, 1995 - 1998 Ivan Horvath, M.D. Post Doctoral Fellow, 1994 - 1997

Eleanora Tzoufi, M.D. Post Doctoral Fellow, 1995 -1996

Carolyn Go, Ph.D. Student, 1993 -1996

Lynn Coule, M.D., Fellow, 1994 -1996

L. Eugene Fisher, M.D., Fellow, 1992-1994

Andreas Papapetropoulos Ph.D. Student, 1991 -1994

Post Doctoral Fellow, 1994 -1995

Attila Cziraki, M.D. Post-Doctoral Fellow, 1993 -1995

Nandor Marczin,M.D.,Ph.D. Post-Doctoral Fellow, 1989 -1992

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Instructor, 1992 -1994

Stylianos Orfanos, M.D., Ph.D. Post-Doctoral Fellow, 1986-1989. Instructor, 1990-1993

Xilin Chen, M.D., Post-Doctoral Fellow, 1987-1989.

Ph.D. student 1989-1992

Stavros Topouzis, Ph.D. Post-Doctoral Fellow, 1990-1992

Alain Legrand, Ph.D., Post-Doctoral Fellow, 1986-1988.

Hassan El Kashef Ph.D. Student, 1984-1987. Post Doctoral Fellow, 1987-1988.

Hannu Toivonen, Ph.D., M.D. Post-Doctoral Fellow, 1985-87.

Scientific and Professional Societies

American Society of Pharmacology and Experimental Therapeutics American Physiological Society

American Thoracic Society Society of Toxicology North American Vascular Biology Organization Southeast Chapter of the Society of Toxicology American Heart Association Rho Chi Sigma Xi American Association for the Advancement of Science Southeast Pharmacology Society Georgia Thoracic Society Georgia Heart Association New York Academy of Sciences Society for Experimental Biology and Medicine International Society for Applied Cardiovascular Biology

Theses

Catravas, J. D. The effects of haloperidol, chlorpromazine and propranolol on acute amphetamine poisoning in the dog. M.S. Thesis, 1975.

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Catravas, J. D. Studies on the mechanism of acute cocaine lethality. Effects of chlorpromazine, pancuronium or low ambient temperatures. Ph.D. Dissertation, 1978.

Letters to the Editor 1. Catravas, J. D., Waters, I.W., Davis, W.M. and Hickenbottom, J.P. Haloperidol

for acute amphetamine poisoning: A study in dogs. JAMA. 321: 1340-1, 1975. 2. Catravas, J. D., Waters, I.W., Walz, M.A. and Davis, W.M. Antidotes for cocaine

poisoning. N Eng. J. Med. 297(22): 1238, 1977. ABSTRACTS 1. Catravas, J.D., Waters, I.W., Burdock, G.A. and Davis, W.M. Haloperidol and

Propranolol in the Treatment of Acute Amphetamine Intoxication in the Dog. Toxicol. Appl. Pharmacol. 33: 184, 1975.

2. Waters, I.W., Catravas, J.D., Guinn, M.M., Davis, W.M. and Braude, M.C.

Effects of 1-alpha-acetylmethadol (LAAM) on Various Physiological Parameters in the Conscious Dog. Amer. Pharm. Ass. Acad. Sci. 6: 158, 1976.

3. Catravas, J.D., Waters, I.W., Walz, M.A., Davis, W.M. and Braude, M.C.

Antagonism of 3,4-methylenedioxyamphetamine (MDA) Lethality by Chlor-promazine in the Conscious Dog. Pharmacologist 19: 231, 1977.

4. Catravas, J.D., Waters, I.W., Davis, W.M. and Braude, M.C. Antagonism of

MDA (3,4-methylenedioxyamphetamine) by Phenoxybenzamine in the Conscious and the Anesthetized Dog. Fed. Proc. 36: 955, 1977.

5. Waters, I.W., Catravas, J.D., Walz, M.A. and Davis, W.M. Antagonism of Acute

Cocaine Poisoning by Chlorpromazine in the Conscious Dog. Fed. Proc. 37: 659, 1978.

6. Waters, I.W., Catravas, J.D. and Walz, M.A. Studies on the Mechanism of

Acute Cocaine Poisoning in the Conscious Dog. Pharmacologist 20: 165, 1978. 7. Catravas, J.D. and Gillis, C.N. Reversible Effect of Imipramine on Pulmonary

Clearance of 14C-serotonin in the Anesthetized Rabbit. Fed. Proc. 38: 523, 1979.

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8. Catravas, J.D. and Gillis, C.N. Measurements of 3H Angiotensin I Uptake by Rabbit Lung in vivo. Fed. Proc. 39: 853, 1980.

9. Catravas, J.D. and Gillis, C.N. Lung Metabolism of 3H-benzoyl-phenylalanyl-

alanyl-proline by Angiotensin Converting Enzyme in vivo: Effects of Bradykinin, SQ 14225 or Acute Hypoxia. Fed. Proc.. 1981.

10. Lazo, J.S., Catravas, J.D. and Gillis, C.N. Reduction in Rabbit Serum and

Pulmonary Angiotensin Converting Enzyme Activity after Sub-acute Bleomycin Treatment. Proc. Amer. Assoc. Cancer Res. 22:29, 1981.

11. Dobuler, K.D., Catravas, J.D. and Gillis, C.N. Early Detection of Oxygen-

Induced Lung Injury in Conscious Rabbits: Reduced Activity of Angiotensin Converting Enzyme and Removal of 5-hydroxytryptamine. Amer. Rev. Resp. Dis., 1982.

12. Lazo, J.S., Catravas, J.D., Dobuler, K.J. and Gillis, C.N. Reversible Pulmonary Endothelial Cell Damage After Sub-acute Bleomycin Treatment. Fed. Proc., 1982.

13. Catravas, J.D., Lazo, J.S., Dobuler, K.J. and Gillis, C.N. Pulmonary Injury

Induced by Endotracheal Injection of Bleomycin to Rabbits. Fed. Proc., 1982. 14. White, R.E., Bremer, C.J. and Catravas, J.D. Simultaneous Determination of

Rabbit Pulmonary Angiotensin Converting Enzyme and 5'-nucleotidase Activities in vivo. Fed. Proc., 1982.

15. Catravas, J.D., Condos, S.G., McFarland, W. and Geha, A.S. Single-pass

Uptake of 3H-norepinephrine by Dog Heart in vivo. Proc. Georg. Heart Assn. 25, 1982.

16. Catravas, J.D., Bremer, C. and Dendle, T. Pulmonary Disposition of Adeno-

sine. Proc. SouthEast. Pharmacol. Soc., 1982. 17. Catravas, J.D., Meister, B.K. and Dendle, T. Pulmonary Disposition of

Adenosine. Proc. Soc. Exp. Biol. Med. 172: 136, 1983. 18. Catravas, J.D. and Dendle, T.W. Early Detection of Radiation-Induced Lung

Microvascular Injury. Fed. Proc. 42: 910, 1983. 19. Dendle, T.W., Catravas, J.D. and Buccafusco, J.J. Vascular Responses to

Acetylcholine in the Rabbit Lung Perfused in situ. Fed. Proc. 42: 489, 1983. 20. Catravas, J.D. and Quinn, N. Removal of Adenosine by Rabbit Lung in vivo and

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in situ. Fed. Proc. 43: 808, 1984. 21. Watkins, C.A. and Catravas, J.D. Metabolic Activities in Cultured Pulmonary

Endothelial Cells. Fed. Proc. 43: 831, 1984. 22. Quinn, N.E. and Catravas, J.D. Effects of Acidosis on Rabbit Pulmonary

Angiotensin Converting Enzyme in vivo. Proc. Georg. Acad. Sci., 1984. 23. McCormick, J.R., Chrzanowski, R., Andrieni, J. and Catravas, J.D. Early

Pulmonary Endothelial Dysfunction after Intravenous Administration of Phorbol Myristate Acetate in Rabbits. Amer. Rev. Resp. Dis. 129: A351, 1984.

24. Catravas, J.D. and Anthony, B.L. Evaluation of Angiotensin Converting Enzyme

Inhibitors in vivo. IUPHAR Abstracts, p. 195P, The MacMillan Press Ltd., London, 1984.

25. Hofman, W.F., Ehrhart, I.C. and Catravas, J.D. Prostanoid Inhibition Potentiates

the Vasoconstrictor Response to Acetylcholine in Dog Lung. Fed. Proc. 44: 1754, 1985.

26. Altiere, R.J., Cunningham, M. and Catravas, J.D. Effects of Acetylcholine on

Rabbit Pulmonary Arteries. Fed. Proc. 44: 1754, 1985. 27. Catravas, J.D., Aronstam, R.S. and Ryan, U.S. Muscarinic Binding and

Acetylcholine-Induced Reduction in Thromboxane B2 Release by Cultured Bovine Pulmonary Arterial Endothelial Cells. Fed. Proc. 44: 1788, 1985.

28. El Kashef, H. and Catravas, J.D. Prostanoid Mediation of the Vasoconstrictor

Actions of Acetylcholine in the Rabbit Pulmonary Circulation in vivo. Fed. Proc. 4: 1754, 185.

29. Anthony, B.L. and Catravas, J.D. Determinations of Ki Values for Angiotensin

Converting Enzyme Inhibitors in vivo. Fed. Proc. 44: 1754, 1985. 30. Aronstam, R.S., Catravas, J.D. and Ryan, U.S. Muscarinic Binding Sites in

Cultured Bovine Pulmonary Endothelial Cells. Fed. Proc. 45: 554, 1986. 31. El-Kashef, H.A. and Catravas, J.D. The Effects of Acetylcholine on the Feline

Pulmonary Circulatory Role of Arachidonic Metabolites. Fed. Proc. 45: 554, 1976.

32. Toivonen, H.J. and Catravas, J.D. Effects of Alterations in Ventilatory Patterns

on Pulmonary Endothelial Angiotensin Converting Enzyme Function in vivo. Fed.

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Proc. 45: 554, 1986. 33. Catravas, J.D. and Ryan, J.W. 3H-Benzoyl-Ala-Gly-Pro, a New Synthetic

Substrate of Pulmonary Endothelial Angiotensin Converting Enzyme in vivo. Fed. Proc. 45: 554, 1986.

34. Catravas, J.D. and Toivonen, H.J. Effects of Acid-Base Disturbance on Rabbit

Pulmonary Angiotensin Converting Enzyme Activity in vivo. Amer. Rev. Resp. Dis. 133: A19, 1986.

35. McCormick, J.R. and Catravas, J.D. Changes in the Kinetics of Pulmonary

Angiotensin Converting Enzyme and 5'-nucleotidase Following Endothelial Cell Injury with Phorbol Myristate Acetate. Amer. Rev. Resp. Dis. 133: A19, 1986.

36. Legrand, A.B., Aronstam, R.S., Narayanan, T.K., Ryan, U.S. and Catravas, J.D.

Acetylcholine Cyclase Activity in Membranes from Cultured Bovine Aortic and Pulmonary Arterial Endothelial Cells. Fed. Proc. 46: 1111, 1987.

37. Catravas, J.D., Watkins, C.A. and Newman, R.A. Changes in Lung Metabolism

in Response to Bleomycin-Induced Lung Injury in Rats. Amer. Rev. Resp. Dis. 135: A257, 1987.

38. Watkins, C.A. and Catravas, J.D. Effects of Pulmonary Flow on Angiotensin

Converting Enzyme Kinetics in the Rat. Amer. Rev. Resp. Dis. 135: A518, 1987. 39. Toivonen, H.J. and Catravas, J.D. Effect of Pulmonary Vascular Recruitment in

the Kinetics of Pulmonary ACE in vivo. Fed. Proc. 46: 1398, 1987. 40. El-Kashef, H. A. and Catravas, J.D. Modulation of Acetylcholine-Induced

Increase in Pulmonary Vascular Resistance and Thromboxane Release by Subtype Selective Muscarinic Antagonists. Fed. Proc. 46: 1111, 1987.

41. Legrand, A.B., Ryan, U.S., R.S. Aronstam and Catravas, J.D. Cholinergic

Modulation of cAMP Levels in Cultured Bovine Pulmonary Arterial Endothelial Cells. FASEB J. 2:A297, 1988.

42. Orfanos, S.E., Ryan, J.W. and Catravas, J.D. Angiotensin Converting Enzyme

(ACE) Kinetics Estimated with Substrates or Inhibitors Provide Measures of Pulmonary Vascular Recruitment, in vivo. FASEB J. 2:A950, 1988.

43. El-Kashef, H.A., Hofman, W.F., Ehrhart, I.C. and Catravas, J.D. Characteriza-

tion of Muscarinic Receptors Mediating the Pressor Response to Acetylcholine in the Dog Lung. FASEB J. 2:A1502, 1988.

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44. Chen, X-L, Orphanos, S.E., Ryan, J.W., Chung, A.Y.K. and Catravas, J.D.

Species Variation in Aminopeptidase P Activity in vivo and in vitro. FASEB J. 3:A1026, 1989.

45. Catravas, J.D., Aronstam, R.S. and Ryan, U.S. Muscarinic Binding Sites In

Cultured Rabbit Aortic Endothelial Cells. FASEB J. 3:A1308, 1989. 46. Orphanos, S.E., Ryan, J.W., Chung, A.Y.K., Burch, S.E. and Catravas, J.D.

Early Effects of Ionizing Radiation on Pulmonary Endothelial Functions in vivo. FASEB J. 3:A1308, 1989.

47. Catravas, J.D. and Elmore, L.A. Relationship Between Volume of Bathing

Medium and Ectoenzyme Activity in Monolayers of Cultured Calf Pulmonary Arterial Endothelial Cells. Amer. Rev. Resp. Dis. 137:365, 1988.

48. McCormick, J.R., Tzanela, M., Catravas, J.D. Thromboxane Mediates the

Hemodynamic Effects of Formyl-Methionyl-Leucyl-Phenylalanine (FMLP) on the Pulmonary Circulation of Anesthetized Rabbits. Amer. Rev. Resp. Dis. 139:A48, 1989.

49. Catravas, J.D. and Chen, X-L. Effects of Indomethacin and Pulmonary

Microvascular Recruitment on Phorbol Myristate Acetate (PMA)-Induced Pulmonary Endothelial Ectoenzyme Dysfunction in vivo. Amer. Rev. Resp. Dis. 139:A57, 1989.

50. Marczin, N., Aronstam, R.S., Ryan, U.S. and Catravas, J.D. Differences in the

Cholinergic Modulation of cAMP Accumulation Among Vascular Cells, in Culture. FASEB J. 1:A835, 1990.

51. Chen, X-L., Tzanela, M., McCormick and Catravas, J.D. PMA-Induced Early

Endothelial Ectoenzyme Dysfunction in Perfused Rabbit Lung: Role of Neutrophils and Platelets. FASEB J. 1:A839, 1990.

52. Catravas, J.D., Ryan, J.W., Chen, S-L., Orphanos, S.E., Chung A.Y.K.

Influence of Erroneous Fractional Product Extraction Values on the Estimation of Angiotensin Converting Enzyme Substrate Utilization. FASEB J. 1:A840, 1990.

53. Bustos, S.E., Catravas, J.D. and R.D. Cummings Asymmetry in Endothelial

Protein Secretion. J. Cell Bio. Vol III 5:459A, 1990. 54. Ryan, J.W. and Catravas, J.D. Angiotensin Converting Enzyme Inhibitors:

Potential Uses in Nuclear Medicine in Current Status and Future Directions of

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Immunoconjugates-Monoclonal Antibody Based Imaging and Treatment III, 1990. 55. Hess, D.C., Snead, C., Catravas, J.D., Nichols, F.T., Adams, R.J. and D. Zhang

Antibodies to Cerebral Endothelium in Autoimmune Cerebrovascular Disease. Stroke 22:134, 1991.

56. Catravas, J.D., and Marczin, N. Distribution of Guanylate Cyclase in Cultured

Pulmonary Endothelial and Smooth Muscle Cells, Am. Rev. of Resp. Dis. 143:A374, 1991.

57. Chen, X-L., Ryan, J.W., Chung, A.Y.K., and Catravas, J.D. Estimation of K-1 for

the Dissociation of RAC-X-65 from Pulmonary Endothelial-Bound Angiotensin Converting Enzyme, in vivo, FASEB J. 5:A1578, 1991.

58. Marczin, N., Ryan, U.S., and Catravas, J.D. Oxidant Stress-Induced Alterations

of cGMP Levels in Vascular Cell, In Culture, FASEB J. 5:A1419, 1991. 59. Topouzis, S., Catravas, J.D., and Rosenquist, T.H. Influence of Embryonic

Development, Origin and Anatomic Location of Smooth Muscle of Angiotensin Converting Enzyme Activity in Chicken Aorta, FASEB J, 5:A530, 1991.

60. Ryan, J.W. and Catravas, J.D. Angiotensin Converting Enzyme Inhibitors:

Potential Uses in Nuclear Medicine Current Status and Future Directions of Immunoconjugates-Monoclonal Antibody Based Imaging and Treatment III Key Biscayne, Florida, January 25-27, 1991.

61. Catravas, J.D., U.S. Ryan and N. Marczin Methylene Blue (MB) Inhibits

Nitrovasodilator-and EDRF- Induced cGMP Accumulation in Cultured Pulmonary Arterial Smooth Muscle Cells via Generation of Superoxide Anion. FASEB J. 1:A1255, 1992

62. Marczin, N., Ryan, U.S., and Catravas, J.D. Characteristics of a Simple and

Sensitive Bioassay Model for Detection of Basally Released Endothelium-Derived Relaxing Factor (EDRF). FASEB J. 1:A1255, 1992

63. Orfanos, S.E., Ehrhart, I.C., Hofman, W.E., and Catravas, J.D. Angiotensin

Converting Enzyme (ACE) Kinetics Provide Measures of Pulmonary Microvas-cular Surface Area in the Isolated Dog Lung Lobe. FASEB J. 2:A2046, 1992.

64. Chen, X-L. and Catravas, J.D. Neutrophil-Mediated Endothelial Angiotensin

Converting Enzyme (ACE) Dysfunction: Role of Oxygen-Derived Free Radicals. FASEB J. 1:A1342, 1992.

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65. Papapetropoulos, A., Burch, S.E., Topouzis, S., and Catravas, J.D. Effects of Ionizing Radiation on Angiotensin Converting Enzyme (ACE) Activity in Cultured Bovine Pulmonary Artery Endothelial Cells. FASEB J. 2:A1912, 1992.

66. Catravas, J.D., Marczin, N., Ryan, U.S. and Chen, X-L. Protection from

Neutrophil-Mediated Dysfunction of Basally Released Endothelium-Derived Relaxing Factor, in Culture. Am Rev Res Dis 145:A846, 1992.

67. Catravas, J.D., Papapetropoulos, A. and Marczin, N. Phorbol Ester Potentiates

Endotoxin-Induction of the Nitric Oxide (NO) Pathway in Vascular Smooth Muscle Cells via a Microtubule-Dependent, PKC-Independent Mechanism. FASEB J. 7:A759, 1993.

68. Papapetropoulos, A., Marczin, N. and Catravas, J.D. cGMP Accumulation in

Response to Endothelium Derived Relaxing Factor and Exogenous Nitrovasodilators in Smooth Muscle Cells from Hypertensive and Normotensive Rats. FASEB J. 7:A759, 1993.

69. Marczin, N., Jilling, T., Papapetropoulos, A. and Catravas, J.D. Role of

Microtubules in Endotoxin- and Cytokine-Induced Activation of the Nitric Oxide Pathway in Cultured Vascular Smooth Muscle Cells. FASEB J. 7: A787, 1993.

70. Ryan, J.W., Valido, F.A., Berryer, P., Chen, X-L. and Catravas, J.D. Reaction of

Pulmonary Angiotensin Converting Enzyme with an Inhibitor, in vivo. FASEB J. 7: A791, 1993.

71. Orfanos, S.E., Parkerson, J., Chen, X-L., Fisher, E. and Catravas, J.D. Chronic

Hyperlipidemia Depresses Pulmonary Endothelial Angiotensin Converting Enzyme (ACE) Activity, in vivo. FASEB J. 7:A794, 1993.

72. Antonov, A., Papapetropoulos, A., Gerrity, R.G., Ryan, J.W. and Catravas, J.D.

Ectoenzyme Activities of Human Aortic Endothelial Cells from High and Low Probability Atherosclerotic Regions. FASEB J. 7:A795, 1993.

73. Papapetropoulos, A., Marczin, N. and Catravas, J.D. Prolonged Exposure to

Endothelium Derived Relaxing Factor Attenuates Cyclic Guanosine Monophosphate Accumulation in Cultured Smooth Muscle Cells. Circulation (Suppl) 88(No 4, Part 2): I-424, 1993.

74. Papapetropoulos, A., Antonov, A., Munn, D., Virmani, R., Ryan, J.W., Gerrity

R.G. and Catravas, J.D. Effects of Monocytes on Endothelial Angiotensin Converting Enzyme Activity. Circulation (Suppl) 88(No 4, Part 2): I-424, 1993.

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75. Marczin, N., Antonov, A., Gerrity, R.G. and Catravas, J.D. Monocyte Adhesion to Cultured Endothelial Cells Suppresses Release of Biologically Active Endothelium-Derived Nitric Oxide (NO). Circulation (Suppl) 88(No 4, Part 2): I-367, 1993.

76. Go, C., Marczin, N., Dienes-Kadi I., Snead C., and Catravas, J.D. Prolonged L-

Arginine-Dependent cGMP Accumulation and Superinduction of NO Generation by Cycloheximide in Vascular Smooth Muscle Cells. Faseb J 8(4): A314, 1994.

77. Marczin, N., Papapetropoulos, A., and Catravas, J.D. Multiple Effects of N-

Acetylcysteine on NO Synthase (iNOS) Induction by Endotoxin (LPS) and Cytokines in Vascular Smooth Muscle Cells. Faseb J 8(4): A314, 1994.

78. Leszaros, L., Marczin, N., Papapetropoulos, A., and Catravas, J.D. Effects of

Calcium Modulating Agents on NO Synthase Induction by Endotoxin (LPS) in Vascular Smooth Muscle Cells. Faseb J 8(4): A315, 1994.

79. Cziraki, A., Parkerson, J., Fisher, E., and Catravas, J.D. Inhibition of Pulmonary

Capillary Endothelium-Bound ACE Activity by Trandolaprilat and Enalaprilat, in vivo. Faseb J 8(4): A330, 1994.

80. Papapetropoulos, A., Marczin, N., and Catravas, J.D. Down-regulation of

nitrovasodilator-induced cGMP Accumulation in Smooth Muscle Cells Exposed to Endotoxin and Interleukin-1∃. Faseb J 8(4): A556, 1994.

81. Catravas, J.D., Chester, A.H., Maizza, A.F., Tadjkarimi, S., Schyns, C.J.,

Khagani, A., and Yacoub, M.H. Assay of Pulmonary Capillary Endothelium-Bound Angiotensin Converting Enzyme Activity in Man. Faseb J 8(5): A796, 1994.

82. Ryan, J.W., Berryer, P., Valido, F., Chung, A., Chen, X-L, and Catravas, J.D.

Analysis of Inhibitor Binding to Pulmonary Angiotensin Converting Enzyme in vivo: Use of the Integrated Second Order Rate Equation. Faseb J 8(5): A797, 1994.

83. Ehrhart, I.C., McCloud, L.L., Ocasio H.J., Hofman, W.F., and Catravas, J.D.

Effect of Vascular Pressure Elevation on Perfused Pulmonary Microvascular Surface Area. Faseb J 8(5): A915, 1994.

84. McCloud, L.L., Ehrhart, I.C., Orfanos, S.E., Ocasio, H.J., Hofman, W.F., and

Catravas, J.D. Angiotensin Converting Enzyme (ACE) Mass is Flow Dependent in Injured Lung. Faseb J 8(5): A915, 1994.

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85. Catravas, J.D., Chester, A.H., Maizza, F.A., Tajkaremi, S., Khaghani, A., Schyns, C.J. and Yacoub, M.H. Pulmonary Capillary Endothelium-Bound Angiotensin Converting Enzyme Activity as an Index of Graft Integrity in Lung Transplantation in Man. Amer. J. Resp.. Crit. Care Med. 149: A743, 1994.

86. Marczin, N., Go, C. and Catravas, J.D. Activation of Nitric Oxide Synthase

(iNOS) by Protein Synthesis Inhibition in Aortic Smooth Muscle Cells. Circulation, 90(4):I-34, 1994.

87. Fisher, L.E., Steinhart, C.M. and Catravas, J.D. Effects of Nitroglycerin on

Segmental Pulmonary Vascular Resistances and Dynamically Perfused Capillary Surface Area. Circulation, 90(4): I-149, 1994.

88. Cziraki, A., Rubin, J.W., Finney, N.R. and Catravas, J.D. Comparison Between

Pulmonary Capillary Endothelium-Bound and Serum Angiotensin Converting Enzyme (ACE) Inhibition Caused by Enalaprilat, in Man. Circulation, 90(4): I-72-1994.

89. Cziraki, A., Rubin, J.W., Shapiro, M.B. and Catravas, J.D. Importance of

Estimating Perfused Pulmonary Capillary Endothelium-Bound Angiotensin Converting Enzyme (ACE) Activity in Patients with Lung Disease. Circulation, 90(4):I-150, 1994.

90. Fisher, L.E., Jr., Catravas, J.D. and Steinhart, C.M. Changes in Pulmonary

Segmental Pressures and Capillary Surface Area in a Serotonin – Treated Rabbit Cardiac Bypass Model. Crit. Care Med. 22(1): A140, 1994.

91. Go, C., Papapetropuolos, A., Marczin, N., and Catravas, J.D. Differential Effects

of Serum on Cycloheximide (CH)-Stimulated Inducible NO Synthase (iNOS) Activity in Rat Aortic Smooth Muscle Cells (RASM). Faseb J. (9)3: A31, 1995.

92. Catravas, J.D., Rubin, J. W., Stone, C. D., Cziraki, A., and Papapetropoulos, A.

Enzymatic Activity and Gene Expression of Soluble Guanylate Cyclase (sGC) in Human Vascular Tissue. Faseb J. (9)3: A40, 1995.

93. Papapetropoulos, A., Marczin, N., Mora, G., Millici, A., Murad, F., and Catravas,

J.D.. Regulation of Soluble Guanylate Cyclase (sGC) Activity, mRNA and Protein Levels by cAMP-Elevating Agents. Faseb J.(9)3: A314, 1995.

94. Abou-Mohamed, Kaesemeyer, W. H., Papapetropoulos, A., Catravas, J.D., and

Caldwell, R.W. Nitroglycerin (NTG), but not Sodium Nitroprusside (SNP), Increases Aortic Ring cGMP Levels via an L-arginine Dependent and L-name Sensitive Pathway. Faseb J. (9)3: A327, 1995.

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95. Langleben, D., Orfanos, S. E., Khoury, J., and Catravas, J.D. Pulmonary

Endothelial Angiotensin Converting Enzyme Activity in Human Pulmonary Hypertension. Faseb J.(9)3: A599, 1995.

96. Orfanos, S. E., Langleben, D., Khoury, J.,Schlesinger, R. D., Dragatakis, L.,

Roussos, C., and Catravas, J.D. Single Versus Double Lung Capillary Endothelial Angiotensin Converting Enzyme Activity in Man. Faseb J .(9)4: A626, 1995.

97. Cziraki, A., Ryan, J. W., Horvath, I., Fisher, L. E., Parkerson, J., and Catravas,

J.D. Comparison of the Hydrolyses of Two Synthetic Ace Substrates by Rabbit Lung, in vivo. Faseb J. (9)4: A719, 1995.

98. Horvath, I., Cziraki, A., Parkerson, J., and Catravas, J.D. The Effect of Left

Anterior Descending (LAD) Coronary Occlusion on Dynamically Perfused Coronary Capillary Surface Area in Dog. Faseb J. (9)4: A847, 1995.

99. Hoque, A., Marczin, N., Catravas, J.D., and Jones, L.F. Hemodynamic

Responses During Endotoxin Shock are Enhanced in Anesthetized Compared to Conscious Rats. Faseb J. (9)4: A886, 1995.

100. Rubin, J.W., Cziraki, A., and Catravas, J.D. Estimation of Perfused Coronary

Capillary Surface Area in Patients Undergoing Coronary Arterial Vein Bypass Grafting. 3rd International Congress on Heart Failure, Geneva, Switzerland. May 21-25, 1995.

101. Rubin, J.W., Cziraki,A., and Catravas, J.D. Importance of Estimating Perfused

Pulmonary Capillary Endothelium Bound Angiotensin Converting Enzyme (ACE) Activity in Patients with Lung Disease. 3rd International Congress on Heart Failure, Geneva, Switzerland. May 21-25, 1995.

102. Catravas, J.D., Cziraki, A., and Shapiro, M. Reduction in the Transpulmonary

Hydrolysis of 3H-Benzoyl-Phe-Ala-Pro by Capillary Endothelium-Bound Angiotensin Converting Enzyme in Patients Diagnosed with the Adult Respiratory Distress Syndrome. Am. J. Resp. Crit. Care Med. 151:A73, 1995.

103. Papapetropoulos, A., Ryan, J.W., Antonov, A., Virmani, R., Kolodgie, F.D., Munn,

D.H., Marczin, N., Gerrity, R.G., and Catravas, J.D. Human Aortic Endothelial Cell Aminopeptidase N. Fourteenth International Symposium on Kinins, Denver, CO. September 10-15, 1995.

104. Barman, S. A., McCloud, L.L., Catravas, J.D., and Ehrhart, I.C. Fractal Analysis

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of Pulmonary Blood Flow Heterogeneity in Isolated Canine Lungs. Faseb J. 10:A103, 1996.

105. Go, C., Fei, Y., Liou, G. and Catravas, J.D. Depletion of IkBa Causes Nitric

Oxide Production in Rat Aortic Smooth Muscle Cells. FASEB J. 10:A38, 1996. 106. Horvath, I.G., Parkerson, J.B., Ryan, J.W. and Catravas, J.D. Negligible Binding

of the ACE Substrate Benzoyl-Phe-Ala-Pro by Serum Proteins. FASEB J. 10: A100, 1996.

107. Orfanos, S.E., Kaltsas, P., Armaganidis, A., Catravas, J.D., Sfyras, D.,

Economidou, J. and Roussos, Ch. Endothelium-Bound Angiotensin Converting Enzyme (ACE) Kinetics Provide Measures of Pulmonary Capillary Surface Area in Man. FASEB J. 10:A100, 1996.

108. Papapetropoulos A., Go, C.Y., Murad, F. and Catravas, J.D. Mechanisms of

Tolerance to Sodium Nitroprusside in Cultured Rat Aortic Smooth Muscle Cells. FASEB J. 10:A303, 1996.

109. Fisher, L., Steinhart, C. and Catravas, J.D. Nitric Oxide Diminishes Pulmonary

Hypertension Without Affecting Capillary Surface Area. FASEB J. 10:A307, 1996. 110. Carrier, G.O., Papapetropoulos, A., Snead, M. and Catravas, J.D. Cytokine-

mediated Induction of Nitric Oxide Synthase (Type II NOS) and Cyclo-Oxygenase (COX-2) in Vascular Smooth Muscle Cells. FASEB J. 10:A437, 1996.

111. Abou-Mohamed, G., Suarez, A., Kaesemeyer, W.H., Papapetropuolos, A.,

Catravas, J.D. and Caldwell, R.W. L-arginine in the Development and Reversal of Tolerance to Nitroglycerin. FASEB J. 10:A569, 1996.

112. McCLoud, L.L., Snead, M.D., Barman, S.A., Hofman, W.F., Catravas, J.D. and

Ehrhart, I.C. PMN Sequestration in PMA Injured Lung. FASEB J. 10:A613, 1996. 113. Ju, H., Denslow, N.D., Ryan, J.W., Papapetropoulos, A., Antonov, A., Virmani,

R., Kolodgie, F.D., Gerrity, R.G. and Catravas, J.D. Human Endothelial Cell Aminopeptidase P. FASEB J. 10:A625, 1996.

114. A. Armaganidis, S.E. Orfanos, D. Sfyras, P. Kaltsas, J.D. Catravas, J.

Economidou, and Ch. Roussos. Assessment of Pulmonary Capillary Endothelial Function in an ARDS Patient on Extracorporeal CO2 Removal. 16th International Symposium on Intensive Care and Emergency Medicine, Brussels, Congress Center, March 19-22, 1996.

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115. Abou-Mohamed, G., Kaesemeyer, W.H., Papapetropoulos, A., Catravas, J.D., and Caldwell, R.W. Nitroglycerin (NTG), but not Sodium Nitroprusside (SNP), Increases Vascular cGMP Levels via an L-arginine Dependent and L-NAME Sensitive Pathway. J. Amer. Coll. Cardiol. 27(2, suppl A.): 105A, 1996.

116. Behrakis, P., Makaris, E., Frangoulidou, E., Amfilochiou, A., Varouhakis,

G.,Stavrides, J., and Catravas, J.D. Reduction in the Transpulmonary Hydrolysis of 3H-Benzoyl-Phe-Ala-Pro by Capillary Endothelium-Bound Angiotensin Converting Enzmye in Patients Diagnosed with COPD. Am. J. Resp. Crit. Care Med., 153:A813, 1996.

117. Crabbe, S., Borland, J.A., Catravas, J.D., Chester, A.H., and Yacoub, M. Tissue

Angiotensin Converting Enzyme and Its Inhibition in Human Coronary Artery Bypass Grafts. Circulation, 94(8):I-40, 1996.

118. Horvath, I., Cziraki, A., Rubin, J.W., and Catravas, J.D. Estimation of Coronary

Capillary Endothelial Angiotensin Converting Enzyme (ACE) Activity in Patients Undergoing Coronary Arterial Bypass Grafting. Circulation, 94(8): I-62, 1996.

119. Langleben, D., Orfanos, S., Khoury, J., and Catravas, J.D. Alteration in Human

Lung Capillary Endothelial Angiotensin Converting Enzyme Activity in Pulmonary Hypertension is Dependent in Etiology. Circulation, 94(8):I-647, 1996.

120. Orfanos, S., Langleben, D., Khoury, J., Catravas, J.D., and Ryan, J. The

Relationship Between Lung Capillary Endothelial Angiotensin Converting Enzyme (ACE) Metabolic Activity and Blood Flow Varies According to Etiology in Pulmonary Hypertension. FASEB J., 11(3):A36, 1997.

121. Cai, Z., Parkerson, J.B., and Catravas, J.D. Effects of Increasing Perfusion Flow

Rate on Perfused Capillary Surface Area of the Rat Lung. FASEB J., 11(3): A471, 1997.

122. Zhang, H., Snead, C., Chen, X., and Catravas, J.D. Regulation of the Inducible

Nitric Oxide Synthase (iNOS) Promoter by PMA and Cytoskeleton Depolymerizing Agents in Cultured Rat Aortic Smooth Muscle Cells. FASEB J., 11(3): A476, 1997.

123. Horvath, I., Snead, C., and Catravas, J.D. Differing Effects of Cardioplegic

Solution on Bovine Aortic v. Pulmonary Arterial Endothelial Cell (EC) ACE Activity. FASEB J., 1997.

124. Horvath, I., Snead, C., and Catravas, J.D. Differing Effects of Hypothermia on

Bovine Aortic v. Pulmonary Arterial Endothelial Cell (EC) ACE Activity.

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Microcirculation, 4(1):A294, 1997. 125. Langleben, D., Orfanos, S.E., Khoury, J., Baron, M., Palavew, M., Small, D.,

Roussos, C., and Catravas, J.D. Human Pulmonary Capillary Angiotensin Converting Enzyme Activity Correlates with Carbon Monoxide Diffusing Capacity in Autoimmune and Collagen Vascular-Induced Pulmonary Hypertension. Am. J. Resp. Crit. Care Med., 155(4): A631, 1997.

126. Tzoufi, E. and Catravas, J.D. Effects of E. Coli Septicemia on Perfused

Pulmonary Capillary Surface Area and Angiotensin Converting Enzyme Activity in Rabbits, in vivo. Am. J. Resp. Crit. Care Med., 155(4): A858, 1997.

127. Fisher, L.E., Steinhart, C.M., Catravas, J.D. Amrinone Relieves Serotonin

Induced Pulmonary Hypertension Without Affecting Dynamically Perfused Capillary Surface Area. Pediatrics 100(3): 450S, 1997.

128. Taft, A.A., Horman, W.F., Ehrhart, I.C. and Catravas, J.D. The Influence of

Hypothermia on Basal and Stimulated Nitic Oxide Release from Pulmonary Artery Endothelial Cells. FASEB J., 12:A1056, 1998

129. Zhang, H., Gaines, M., Snead, C. and Catravas, J.D. The Co-Existence of Two

NF-κB Sites and Other Elements are Required for Full Induction of Rat Type II Nitric Oxide Synthase (iNOS). FASEB J., 12:A1092, 1998

130. Teng, X., Zhang, H., Snead, C. and Catravas, J.D. Differing Effects of cAMP on

iNOS Induction in Rat Pulmonary Arterial vs. Rat Aortic Smooth Muscle Cells. FASEB J., 12:A1093, 1998

131. Marczin, N., Chen, X., Catravas, J.D. and Yacoub, M. Reduced Nitric Oxide

(NO) Release is a Sensitive Marker of Lung Cell Damage in vitro and in Lung Transplant Recipients. FASEB J., 12:A2852, 1998

132. Orfanos, S.E., Langleben, D., Khoury, J., Schlesinger, R.D., Dragatakis, L.,

Roussos, Ch., Ryan, J.W. and Catravas, J.D. Pulmonary Capillary Endothelium-Bound Angiotensin Converting Enzyme Activity in Man. FASEB J., 12:A5721, 1998

133. Theodorakis, M.J., Parkerson, J.B. and Catravas, J.D. Rat Pulmonary

Circulation Responses to High Perfusion Flows Studied by Angiotensin Converting Enzyme (ACE) Substrate Kinetics. FASEB J., 12:A5724, 1998

134. Rivera, R., Truemper, E., Fisher, L. and Catravas, J.D. Effects of Ventilatory

Strategy on Respiratory and Non-Respiratory Lung Function in a Rabbit Acute

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Lung Injury Model. Am. J. Resp. Crit. Care Med. 157(3): A45, 1998 135. Langleben, D., Dupuis, J., Orfanos, S., Khoury, J., Ryan, J. and Catravas, J.D. A

Comparison of Indices of Functional Pulmonary Vascular Surface Area Available for Angiotensin Converting-Enzyme (ACE) Activity and Endothelin-1 (ET-1) Clearance in Pulmonary Hypertension (PHYP). Am. J. Resp. Crit. Care Med. 157(3): A206, 1998

136. Horvath, I.G., Parkerson, J.B. and Catravas, J.D. Decreased Enzymatically

Active Perfused Pulmonary Capillary Surface Area During Experimental Shunt in Rabbits. Am. J. Resp. Crit. Care Med. 157(3): A348, 1998

137. Theodorakis, M.J., Parkerson, J.B. and Catravas, J.D. Responses of the

Pulmonary Capillary Bed to High Blood Flow: A Model for Studying Pulmonary Hypertension. The Physiologist. 41(4): 263, 1998

138. Orfanos, S.E., Parkerson, J.B., Fisher, L.E. and Catravas, J.D. Estimation of

Dissociation Constants for Pulmonary Endothelial Angiotensin Converting Enzyme Reactions with Trandolaprilat and Enalaprilat in vivo. The Physiologist. 41(4): 264, 1998.

139. Zhang, H., Teng, X., Gaines, M., Snead, C. and Catravas, J.D. Other Promoter

Elements, in Addition to Two NF-κB Sites, Are Required for Full Induction of Rat Type II Nitric Oxide Synthase (iNOS). The Physiologist. 41(4): 271, 1998.

140. Teng, X., Zhang, H., Snead, C. and Catravas, J.D. Differential Induction of Type

II Nitric Oxide Synthase (iNOS) by cAMP Between Rat Aortic and Pulmonary Smooth Muscle Cells. The Physiologist. 41(4): 271, 1998.

141. Julie A.A. Borland, Mohamed Amrani, John Wharton, Catravas, J.D. and

Chester, A. H. Localisation and Function of the Renin Angiotensin System in the Human Radial Artery verses the Internal Thoracic Artery. Circulation. 98 (17): I-606, 1998.

142. Teng, X., Zhang, H., Snead, M. and Catravas, J.D. Aspirin and Ibuprofen Inhibit

Type II Nitric Oxide Synthase Induction in Rat Aortic Smooth Muscle Cells. Circulation. 98 (17): I-668, 1998.

143. Zhang, H., Teng, X., and Catravas, J.D. Non-NF-κB Elements are Required for

Full Induction of the Rat Type II Nitric Oxide Synthase (iNOS). Faseb. 13(4): A132, 1999.

144. Zou, L., Yadlowski, E., Parkerson, J.B., McCloud, L., and Catravas, J.D. Effects

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of Microembolization on Endothelium-Bound Angiotensin Converting Enzyme Substrate Metabolism in the Rabbit Pulmonary Capillary Bed. Faseb. 13(5): A1112, 1999.

145. Teng, X., Zhang, H., Snead, C., and Catravas, J.D. Interferon-γ (IFN) Enhances

Induction of Type II Nitric Oxide Synthase (iNOS) in Human and Rat Aortic Smooth Muscle Cells. Faseb. 13(4): A132 1999.

146. Theodorakis, M.J., Marks, D.S., Rubin, J.W., and Catravas, J.D. Effects of

Adenosine on Coronary Capillary Endothelium-Bound (CCEB) Angiotensin-Converting Enzyme (ACE) – Substrate Hydrolysis, in vivo. Faseb. 13(5): A1114, 1999.

147. Theodorakis, M.J., Zou, L., Ocasio, H., Parkerson, J.B., and Catravas, J.D.

Unaltered Rat Pulmonary Capillary Endothelium-Bound (PCEB) Angiotensin Converting Enzyme (ACE) Activity in N-formyl-met-leu-phe (f-MLP)-induced Acute Lung Injury (ALI). Faseb. 13(5): A830, 1999.

148. Catravas, J.D. Cytokine Regulation of Vascular Nitric Oxide Synthases:

Implications in Atherosclerosis. Athero 144 (1) 87, 1999. 149. Orfanos, S.E., Vlachoyiannopoulos, P.G., Stratigis, G. A., Pakas, I., Catravas,

J.D., Kyriakidis, M.K., Moutsopoulos, H.M., and Roussos, C. Early Pulmonary Endothelial Dysfunction in Systemic Scleroderma. Circulation 100(18): 1-241, 1999.

150. McCloud, L.L., Parkerson, J. B., Yadlowski, E., Zou, L., and Catravas, J.D.

Reduced Pulmonary Endothelium-Bound Angiotensin Converting Enzyme Activity in Diabetic Rabbits. Circulation 100(18): 1-586, 1999.

151. Dimitropoulou, C., White, R.E., Fuchs, L.C., Zhang, H., Catravas, J.D., and

Carrier, J.D. Novel Mechanism of Angiotensin II (AngII)-Induced Relaxation of Rat Mesenteric Microvessels: Activation of Ang II Type 2 (AT-2) Receptor Opens BKCa Channels via Protein Kinase C (PKC). Circulation 100(18): 1-846, 1999.

152. Ehrhart, I.C., Zou, L., Parkerson, J., Ocasio, H., Theodorakis, M., and Catravas,

J.D. Nitrite Does not Potentiate Endothelial Angiotensin Converting Enzyme (ACE) Dysfunction in the in situ Lung. Experimental Biology 2000.

153. X. Teng, H. Zhang, C. Snead, and Catravas, J.D. Two, opposing actions,

mediated by a rat iNOS promoter GAS element, on promoter activation by cytokines in rat aortic smooth muscle cells. ASBMB/ASPET 2000. 388, A1377.

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154. X. Teng, H. Zhang, C. Snead, and Catravas, J.D. A C/EBP site in the rat iNOS promoter mediates iNOS induction by IL-1β in rat aortic smooth muscle cells. ASBMB/ASPET 2000. 390, A1378.

155. H. Zhang, C. Snead, and Catravas, J.D. Nitric oxide (NO) differentially regulates

type II nitric oxide syntase (iNOS) induction in rat aortic smooth muscle cells (RASMC) vs. lung macrophages (mØ). . ASBMB/ASPET 2000. 391, A1378.

156. Zou, L., Yoldlowski, E.H., Parkerson, J.B., and Catravas, J.D. Relationship

between nitroglycerin (NTG)-derived nitric oxide (NO) and pulmonary blood flow (PBF) in rabbits. . ASBMB/ASPET 2000. 392, A1378.

157. C. Dimitropoulou, RE White, LC Fuchs, HF Zang, JD Catravas and G Carrier.

Angiotensin II relaxes mesenteric microvessels via the AT-2 receptor-mediated, Ca 2+ - activated potassium channels. J. Submicrosc. Cytol. Pathol.2000, 32 (3):426, B116.

158. M.J. Theodorakis, J.B. Parkerson, E.H. Yodlowski, J.D. Catravas. Endothelin-A

receptor blockade improves lung vascular endothelial function in acute pulmonary thrombo-embolism, in vivo. J. Submicrosc. Cytol. Pathol.2000, 32 (3):416, B077.

159. J.D. Catravas, H. Zhang, C. Snead. Nitric oxide (NO) inhibits type II NO syntase

(iNOS) expression in rat macrophages, but not in vascular smooth muscle cells (VSMS). J. Submicrosc. Cytol. Pathol.2000, 32 (3):490, S103.

160. K. Jules Elysee, A. Miric, M.H. Susman, J. Zhang, L. Paroli, R.L. Kahn, J.D.

Catravas, T.J.J. Blank, T.P. Sculco. Assessment of lung injury during total knee arthroplasty. Gen. Pharm. 2000.

161. S.E. Orfanos, A. Armaganidis, C. Glynos, E. Psevdi, P. Kaltsas, P. Sarafidou,

J.D. Catravas, U. G. Dafni, D. Langleben, C. Roussos. Pulmonary capillary endothelium-bound angiotensin converting enzyme(ACE) activity in acute lung injury. Gen. Pharm. 2000.

162. Dimitropoulou, ., R.E. White, L.C. Fuchs, H.F. Zang, J.D. Catravas and G.

Carrier. Angiotensin and microvascular relaxation via the AT2 receptor and Ca 2+ -activated K+ channels. In "Vascular endothelium-source and target of inflammatory mediators" ed. By J.D. Catravas, 351, IOS Press 2001.

163. Venema, R.C., Venema, V.J., Ju, H., Harris, M.B., Snead, C., Dimitropoulou, C., Catravas, J.D. Identification of Novel Guanylate Cyclase - Heat Shock Protein 90 Complexes with the Endothelial and Inducible Nitric Oxide Synthases that

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Enhance Guanylate Cyclase Activity. Circulation. 104:63, 2001 164. Dimitropoulou, C., Carrier, G.O., Han, G., Snead, C., Catravas, J.D., Marrero,

M., White, R.E. Kinase-Stimulated Dephosphorylation Opens BKCa Channels in Coronary Arteries via Phosphoprotein Phosphatase 2A. Circulation 104 :156, 2001

165. Khichi, M.H., Parkerson, J.B., Fisher, L.E., Catravas, J.D., Airway Flow Pattern

Affects the Course of Acute Lung-Injury-Induced Endothelial Dysfunction in Mechanically Ventilated Rabbits. Pediatr Crit Care Med. 2 (4):360, 2001.

166. Mehta, R., El-Remessy, A., Snead, C., Pearson-Shaver, A., Caldwell, R. and

Catravas, J.D. Activated neutrophils increase tyropsine nitration nad decrease angiotensin converting enzyme activity in bovine pulmonary arterial endothelial cells. Circulation 106: II338, 2002.

167. Catravas, J.D., Parkerson, J.B. and Snead, C.S. Angiotensin converting enzyme

inhibition reduces lung neutrophils accumulation and edema formation in endotoxin-induced acute lung injury. Circulation 106: II340, 2002.

168. Khichi, M., Fisher, L.E., Catravas, J.D., Parkerson, J.B. and Waller, J.L.

Inspiratory flow patterns affect the course of acute lung injury induced pulmonary dysfunction in mechanically ventilated rabbits. FASEB J.16: A409, 2002.

169. McCloud, L., Parkerson, J.B., Hoffman, W.H. and Catravas, J.D. β-

hydroxybutarate induces acute pulmonary endothelial dysfunction in rabbits. FASEB J.16: A867, 2002.

170. Dimitropoulou, C., Cariier, G., Han, G., Snead, C., Catravas, J.D., Marrero, M

and White, R.E. Phosphoprotein phosphatase 2A is a key regulator of BKCa channels in coronary arteries. FASEB J.16: A936, 2002.

171. Venema, R.C., Venema, V.J., Ju, H., Harris, M.B., Snead, C., Dimitropoulou, C.

and Catravas, J.D. Interactions of eNOS with sGC in the eNOS/Hsp90/sGC complex are mediated by Hsp90. FASEB J.16: A952, 2002

172. St. Croix, C.M., Venema, R.C., Pitt, B.R., Catravas, J.D. Association of Guanyl

Cyclase with Heat Shock Protein 90 is Necessary for Guanyl Cyclase Activation in Pulmonary Arterial Endothelial Cells. Circulation. 108(17):1277, 2003

173. Giulumian, A., Fuchs, L.C., Maragoudakis, M.E., Venema, R.C., Catravas, J.D.

Association of soluble guanyl cyclase (sGC) with heat shock protein 90 (Hsp90) improves sGC activity in pulmonary arterial vessels. FASEB J. 17(4):341.14,

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2003 174. Dimitropoulou, C., Han, G., Catravas., J.D., White, R.E., Molecular basis of

estrogen action in airway muscle. FASEB J. 17(5):561.3, 2003 175. Alexander, G.D., Redd, H., Shaw, S., Snead, C., Catravas, J.D., Marrero, M.B.

High Glucose augments the angiotensin II-induced JAK/STAT signaling in rabbit pulmonary arterial smooth muscle and endothelial cells. FASEB J. 17(5):649.4, 2003

176. Snead, C., White, R.E., Catravas, J.D., Protein kinase C and protein

phosphatase 2A mediate angiotensin-induced stimulation of calcium- and voltage-dependent K channels in arterial microvascular smooth muscle cells. FASEB J. 18(4):196.25, 2004

177. Dimitropoulou, C., Snead, C., White, R.E., Catravas, J.D. Protein kinase C and

protein phosphataes 2a mediate the angiotensin-induced stimulation of calcium- and voltage- dependent potassium channels in microvascular smooth muscle cells. FASEB J. 18(4):204.5, 2004

178. Snead, C., Parkerson, J.B., Pearson-shaver, A.L., Catravas, J.D. Nitric oxide

synthase (NOS) inhibition prevents the decrease in angiotensin converting enzyme mRNA and activity by activated neutrophils in bovine pulmonary arterial endothelial cells (BPAEC). FASEB J. 18(4):402.14, 2004

179. Yetik-Anacak, G., Venema, R.C., Catravas, J.D., Inhibition of NO-donor-induced

vasorelaxation following long-term exposure to the hsp90 binding inhibitor radicicol. FASEB J. 18(4):816.4, 2004

180. Lichtenbeld, H., Snead, C., Venema, R.C., Catravas, J.D. Role of hsp90

ecomplexes in VEGF-induced tube formation by bovine aortic endothelial cells. FASEB J. 18(4):828.5, 2004

181. Antonova, G.N., Snead, C.D., Catravas, J.D. NO priming accelerates endothelial

wound healing via the hsp90-sGC pathway. FASEB J. 19(4):299.19, 2005 182. Dimitropoulou, C., Zhu, S., White, R.E., Ownby, D., Catravas, J.D. Estrogens

prevent the tracheal hyper-responsiveness to carbachol in asthma. FASEB J. 19(4):375.5, 2005

183. Yetik-Anacak, G., Padmanabhan, S., Venema, R.C., Catravas, J.D. Novobicin is

a stronger inhibitor of sGC-mediated vascular relaxation than geldanamycin. FASEB J. 19(4):663.3, 2005

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184. Chatterjee, A., Venema, R.C., Catravas, J.D. Hsp90 binding inhibitors reduce

capillary leak in a murine model of acute lung injury (ALI). FASEB J. 19(4):865.12, 2005

185. McCloud, L.L., Venema, R.C., Catravas, J.D. Hyperglycemia-induced decrease

in eNOS-sGC-Hsp90 association in endothelial cells. FASEB J. 19(4):938.12, 2005

186. Dimitropoulou, C., White, R.E., and Catravas, J.D. Estrogen Prevents

Hyperresponsiveness of Tracheal Smooth Muscle to Carbachol in Asthma. AJRCCM 2:A780, 2005

187. Dimitropoulou, C., Shrestha, K., Kotanidou, A., Catravas, J.D., and Matalon, S.

Effects of Estrogen on Proteomic Analysis of Nitrated Proteins Following Sensitization with Asthmatic Serum. Proc. Amer. Thor. Soc. 3:A457, 2006

188. Orfanos, S.E., Giovinazzo, M., Catravas, J.D., and Langleben, D. Reduced

Pulmonary Endothelial Angiotensin Converting Enzyme Activity in Patients with Pulmonary Arterial Hypertension. Proc. Amer. Thor. Soc. 3:A457, 2006

189. Dimitropoulou, C., White, R.E., Kotanidou, A., Drakopanayiotakis, F., and

Catravas, J.D. Effects of estrogen on bronchial hyperresponsiveness of ovariectomized murine tracheal rings sensitized with human asthmatic serum. FASEB J. 20(4):429.4, 2006

190. Antonova, G., Snead, C., Antonova, A., Venema, R.C., and J.D. Catravas. Nitric

oxide preconditioning protects endothelial cells against SNP-induced apoptosis via the hsp90-sGC pathway. FASEB J. 20(4):164.4, 2006

191. Zhang, Q., Church, J.E., Jagnandan, D., Catravas, J.D., Sessa, W.C., and

Fulton, D. Functional relevance of Golgi and plasma membrane localized endothelial nitric oxide synthase in reconstituted endothelial cells. FASEB J. 20(4):463.6, 2006

192. Xia, T., Antonova, G., Patterson, C., Fulton, D., Venema, R.C., and Catravas, J.D. CHIP, a novel associating partner of soluble guanylyl cyclase. FASEB J. 20(5):703.5, 2006

193. Natarajan K, Catravas J, Cannon J, Li T, Kutlar F, Sloan G, Fields S, Clair B, Kutlar A. heat Shock Protein Inhibition in Sickle Cell Disease: A Novel Approach to Attenuating the Inflammatory Response? Blood, 118(11):671a(2263), 2007.

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194. Antonov, A.S., Snead, D., Verin, A.D., Catravas, J.D., Barrier-protective effects of hsp90 inhibitors in bovine pulmonary arterial endothelial cells. FASEB J. 21(6):977.4, 2007.

195. Chatterjee, A., Snead, C., Catravas, J.D., The hsp90 inhibitor, radicicol, attenuates bacterial lipopolysaccharide- induced endothelial permeability. FASEB J. 21(6):977.5, 2007.

196. Chatterjee, A., Wheeler, D., Dimitropoulou, C., Catravas, J.D., The geldanamycin derivative, 17-AAG improves survival and attenuates inflammation in sepsis. Am J Respir Crit Care Med, 2: 30, 2007.

197. Dimitropoulou, C., Drakopanagiotakis, F., Chatterjee, A., Snead, C., Catravas,

J.D., Hsp90- Binding Inhibitors Ameliorate Pulmonary Dysfunction in Acute Lung Injury Am J Respir Crit Care Med 2: A838, 2007.

198. Chatterjee, A., Snead, C. and Catravas, J.D. Hsp90 inhibitors prevent LPS-induced endothelial hyperpermeability by inhibiting pp60src activation and maintaining adherens junction proteins. Experimental Biology Abstract #915.6, 2008.

199. Dimitropoulou, C., Snead, C., Hobbs, J., Pollock, J.S. and Catravas, J.D. Estrogen reduces inflammation of asthmatic airways by inhibiting pathways leading to oxidant stress. Experimental Biology Abstract # 929.6, 2008.

200. Intapad, S., Snead, C., Catravas, J.D. and Dimitropoulou, C. Murine trachea

rings sensitized with serum from asthmatic patients exhibit reduced relaxation to nitric oxide donors. Am J Respir Crit Care Med 117: A489, 2008.

201. Dimitropoulou, C., Cnead, C., Marrero, M.B. and Catravas, J.D. Estrogen

reduces inflammation of murine asthmatic airways via inhibition of the STAT6 pathway. Am J Respir Crit Care Med 177: A980, 2008.

PAPERS

1. Catravas, J.D., Waters, I.W., Hickenbottom, J.P. and Davis, W.M. The effects of haloperidol, chlorpromazine and propranolol on acute amphetamine poisoning in the conscious dog. J. Pharmacol. Exp. Ther. 202: 230-43, 1977.

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2. Waters, I.W., Catravas, J.D., Guinn, M.M. and Davis, W.M. Effect of l-a acetylmethadol (LAAM) on various physiological parameters in the conscious dog. Arch. Int. Pharmacodyn. Ther. 321: 157-67, 1978.

3. Catravas, J.D., Waters, I.W., Walz, W.M. and Davis, W.M. Acute cocaine intoxication in the conscious dog: Pathophysiologic profile of acute lethality. Arch. Int. Pharmacodyn. Ther. 235: 328-40, 1978.

4. Catravas, J.D. and Gillis, C.N. Pulmonary clearance of [14C]-5-hydroxytryp-tamine and [3H]norepinephrine in vivo: Effects of pretreatment with imipramine or cocaine. J. Pharmacol. Exp. Ther. 213: 120-177, 1980.

5. Catravas, J.D. and Gillis, C.N. Metabolism of [3H]Benzoyl-Phe-Ala-Pro by pulmonary angiotensin converting enzyme in vivo: Effects of bradykinin, SQ14225 or acute hypoxia. J. Pharmacol. Exp. Ther. 217: 263-270,1981.

6. Catravas, J.D. and Waters, I.W. Acute cocaine intoxication in the conscious dog: Studies on the mechanism of lethality. J. Pharmacol. Exp. Ther. 217: 350-356, 1981.

7. Catravas, J.D., Lazo, J.S. and Gillis, C.N. Biochemical markers of bleomycin toxicity: Clearance of [14]C-5-hydroxytryptamine and [3H]norepinephrine by rabbit lung in vivo. J. Pharmacol. Exp. Ther. 217: 524-529, 1981.

8. Lazo, J.S., Catravas, J.D. and Gillis, C.N. Reduction in rabbit serum and pulmonary angiotensin converting enzyme after subacute bleomycin treatment. Biochem. Pharmacol. 30: 2577-2584, 1981.

9. Gillis, C.N. and Catravas, J.D. Altered removal of vasoactive substances in the injured lung: Detection of lung microvascular injury. Ann. N.Y. Acad. Sci. 384: 458-473, 1982

10. Dobuler, K.J., Catravas, J.D. and Gillis, C.N. Early detection of oxygen-induced lung injury in conscious rabbits: Reduced in vivo activity of angiotensin converting enzyme and removal of 5-hydroxytryptamine. Amer. Rev. Resp. Dis. 126: 534-539, 1982.

11. Catravas, J.D. and Gillis, C.N. Single-pass removal of [14C]-5-hydroxytryptamine and [3H]norepinephrine by rabbit lung, in vivo: kinetics and sites of removal. J. Pharmacol. Exp. Ther. 224: 28-33, 1983.

12. Catravas, J.D., Lazo, J.S., Dobuler, K.J., Mills, L.R. and Gillis, C.N. Pulmonary endothelial dysfunction in the presence or absence of interstitial injury induced by intratracheally injected bleomycin in rabbits. Amer. Rev. Resp. Dis. 128:740-746,

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1983.

13. Lazo, J.S., Catravas, J.D., Dobuler, K.J. and Gillis, C.N. Prolonged reduction in serum angiotensin converting enzyme activity after treatment of rabbits with bleomycin. Toxicol. Appl. Pharmacol. 69: 276-282, 1983.

14. Catravas, J.D. and White, R.E. Kinetics of pulmonary angiotensin converting enzyme and 5’-nucleotidase in vivo. J. Appl. Physiol. 57(4): 1173-1181, 1984.

15. Catravas, J.D. Removal of adenosine from the rabbit pulmonary circulation, in vivo and in vitro. Circ. Res. 54:603-611, 1984.

16. Catravas, J.D., Buccafusco, J.J. and El-Kashef, H. Effects of acetylcholine in the pulmonary circulation of rabbits. J. Pharmacol. Exp. Ther. 231: 236-241, 1984.

17. Catravas, J.D. and Watkins, C.A. Plasmalemmal metabolic activities in cultured calf pulmonary arterial endothelial cells. Res. Commun. Chem. Pathol. Pharmacol. 50: 163-179, 1985.

18. Altiere, R.J., Kiritsy-Ray, J.A. and Catravas, J.D. Acetylcholine-induced contrac-tions in isolated rabbit pulmonary arteries: Role of thromboxane A2. J. Pharmacol. Exp. Ther. 236: 535-541, 1986.

19. Toivonen, H.J. and Catravas, J.D. Effects of alveolar pressure on lung angioten-sin-converting enzyme function, in vivo. J. Appl. Physiol. 61: 1041-1050, 1986.

20. Catravas, J.D., Hofman, W.F. and Ehrhart, I.E. Prostanoid inhibition potentiates vasoconstrictor response to acetylcholine in dog lung. J. Appl. Physiol. 61: 1035-1040, 1986.

21. Davis, W.M., Catravas, J.D. and Waters, I.W. Effects of an IV lethal dose of 3,4-methylenedioxyamphetamine (MDA) in the dog and antagonism by chlorproma-zine. Gen. Pharmacol. 17: 179-183, 1986.

22. Waters, I.W., Catravas, J.D. and Davis, W.M. Effects of anesthesia and phenoxybenzamine on responses of dogs to IV subtoxic doses of 3,4-methylenedioxyamphetamine (MDA). Arch. Int. Pharmacodyn. Ther. 281: 240-251, 1986.

23. El-Kashef, H. and Catravas, J.D. Prostanoid mediation of pulmonary vascular response to acetylcholine in rabbits. Amer. J. Physiol. 251: H808-H814, 1986.

24. Catravas, J.D., Buccafusco, J.J. and El-Kashef, H. Acetylcholine-Prostanoid Interaction in the Pulmonary Circulation. Adv. Behav. Biol. 30: 1119-1126, 1986.

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25. Catravas, J.D. and Anthony, B.L. In vivo determinations of Ki values for angiotensin converting enzyme inhibitors. Adv. Exp. Med. 198: 453-459, 1986.

26. Catravas, J.D. Michaelis-Menten kinetics of pulmonary endothelial angiotensin converting enzyme in the conscious rabbit. Adv. Exp. Med. 198: 445-451, 1986.

27. Catravas, J.D. and Aronstam, R.S. Muscarinic receptors on endothelial cells. In "Pulmonary Endothelium in Health and Disease", ed. by U.S. Ryan, Decker, New York, pp. 307-326, 1987.

28. Toivonen, H.J. and Catravas, J.D. Effects of acid-base imbalance on pulmonary angiotensin-converting enzyme, in vivo. J. Appl.Physiol. 63: 1629-1637, 1987.

29. McCormick, J.R., Chrzanowski, R., Andrieni, J. and Catravas, J.D. Early pulmonary endothelial enzyme dysfunction after phorbol ester in conscious rabbits. J. Appl. Physiol. 63: 1972-1978, 1987.

30. Toivonen, H.J., Makari, N. and Catravas, J.D. Monitoring of pulmonary endothelial enzyme function: an animal model for a simplified clinically applicable procedure. Anesthesiology 68: 44-52, 1988.

31. Catravas, J.D., Bassingthwaighte, J.B. and Sparks, H.V., Jr. Adenosine transport and uptake by cardiac and pulmonary endothelial cells. In "Endo-thelium," ed. by U.S. Ryan, CRC Press, pp. 65-84, 1988.

32. Catravas, J.D. Pulmonary toxicity of anticancer drugs: alterations in endothelial cell function. In "Organ Directed Toxicity of Anticancer Drugs", ed. by Hacker, Lazo and Tritton. Nijhoh pp. 118-127, 1988.

33. Catravas, J.D., Burch, S.E., Spurlock, B. and Mills, L.R. Early effects of ionizing radiations on pulmonary endothelial angiotensin-converting enzyme and 5'-nucleotidase, in vivo. Toxicol. Appl. Pharmacol. 94: 342-355, 1988.

34. Legrand, A., Narayanan, T.K., Ryan, U.S., Aronstam, R.S. and Catravas, J.D. Modulation of adenylate cyclase activity in cultured bovine pulmonary arterial endothelial cells: effects of adenosine and derivates. Biochem. Pharmacol. 38:423-430. 1989.

35. Catravas, J.D. Legrand, A.B., Ryan, U.S. and Aronstam, R.S. Muscarinic receptors on endothelial cells. In "Vascular Endothelium: Receptors and Transduction Mechanisms" ed. by J.D. Catravas, C.N. Gillis and U.S. Ryan. Plenum Press, New York, 1989.

36. Altiere, R.J., Thompson D.C. and Catravas, J.D. Dichotomous actions of endothelium-derived factors in modulating vasomotor tone in rabbit pulmonary

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arteries. Pulm. Pharmacol. 2:55-58, 1989.

37. Orphanos, S. and Catravas, J.D. Muscarinic receptor subtype (M1) identification on rabbit pulmonary vascular endothelium, in vivo. Pharmacology. 39:253-264, 1989.

38. Pipili, E., Manolopoulos, V.G., Catravas, J.D. and Maragoudakis, M. Angiotensin converting enzyme activity is present in the endothelium-denuded aorta. Brit. J. Pharmacology. 98:333-335, 1989.

39. Ryan, J.W. and Catravas, J.D. Angiotensin converting enzyme as indicator of pulmonary microvascular function. In Pulmonary Pharmacology and Toxicology; ed. by M. Hollinger, CRC Press, Boca Raton, 1990.

40. Catravas, J.D., Ryan, Chung, A.Y.K., J.W., Quinn, N.E. and Anthony, B.L. Inhibition of endothelial-bound angiotensin converting enzyme, in vivo. Brit. J. Pharmacol. 101:121-127, 1990.

41. El-Kashef, H.A. and Catravas, J.D. Effects of arachidonic acid in the rabbit pulmonary and systemic vascular bed, in vivo. Pharmacology 40:60-68, 1990.

42. Legrand, A.B., Narayanan, T.K, Ryan, U.S., Aronstam, R.S. and Catravas, J.D. Effects of adenosine and analogs on adenylate cyclase activity in cultured bovine aortic endothelial cells. Biochem. Pharmacol. 40:1103-1109, 1990.

43. Pipili-Synetos, E., Sideri, E., Catravas, J.D. and Maragoudakis, M. Endothelium removal does not abolish angiotensin converting enzyme activity from the mesenteric arterial bed of the rat. Biochem. Pharmacol. 40:1149-1151, 1990.

44. Catravas, J.D. and Orfanos, S.E. Pulmonary endothelial function in health and disease. Pneumon 3:110-114, 1990.

45. El-Kashef, H. and Catravas, J.D. The nature of muscarinic receptor subtypes mediating pulmonary vasoconstriction in the rabbit. Pulm. Pharmacol. 4:8-19, 1991.

46. Toivonen, H.J. and Catravas, J.D. Effects of blood flow on lung ACE kinetics: evidence for microvascular recruitment. J. Appl. Physiol. 71:2244-2254, 1991.

47. Chen, X-L., Orfanos, S.E., Ryan, J.W., Chung, A.Y.V. and Catravas, J.D. Species variation in pulmonary endothelial amino peptidase P activity. J. Pharmacol. Exp. Ther. 259:1301-1307, 1991.

48. El-Kashef, H.A., Hofman, W.E., Ehrhart, I.C. and Catravas, J.D. Multiple muscarinic receptor subtypes in the canine pulmonary circulation. J. Appl.

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Physiol. 71:2023-2042, 1991.

49. Catravas, J.D. Monitoring of ectoenzyme activity in the diagnosis of endothelial dysfunction, In "Vascular Endothelium: Physiological Basis of Clinical Problems", ed. by J.D. Catravas, A.D. Callow, C.N. Gillis and U.S. Ryan. Plenum Press, New York, 1991 pp. 213-223.

50. Catravas, J.D., Toivonen, H.J., Orfanos, S.E. and Chen, X-L. Endothelial function studies in Pulmonary Vascular Disease. In "The Diagnosis and Treatment of Pulmonary Hypertension", ed. by F.K. Weir, S.L. Archer and J.T. Reeves, Futura Publishing Co., New York, 1992.

51. Catravas, J.D. Endothelial ectoenzyme function is an indicator of pulmonary microvascular function. In Applied Cardiovascular Biology, 1990, ed. by P. Zilla, R. Fasol and A. Callow, Karger, Basel, 277-306, 1992.

52. Chen, X-L, Orfanos, S.E. and Catravas, J.D. Effects of Indomethacin on PMA-induced pulmonary endothelial ectoenzyme dysfunction, in vivo. Amer. J. Physiol: Lung Cell Mol. Physiol. 262:L153-L162, 1992

53. Marczin, N., Ryan, U.S. and Catravas, J.D. Effects of oxidant stress on endothelium-derivedrelaxing factor-induced and nitrovasodilator-induced cGMP accumulation in vascular cells in culture. Circ. Res. 70:326-340, 1992.

54. Aronstam, R.S., Ryan, U.S. and Catravas, J.D. Muscarinic binding sites on bovine pulmonary arterial endothelial cells in culture. Pharmacology 44:324-333, 1992.

55. Topouzis, S., Catravas, J.D. and Rosenquist, T.H. Influence of embryonic development, origin and anatomic location of smooth muscle origin on angiotensin-converting enzyme activity in chicken aorta. Circ. Res. 71: 923-931, 1992

56. Marczin, N., Ryan, U.S. and Catravas, J.D. Endothelial cGMP does not regulate basal release of endothelium-derived relaxing factor, in culture. Amer. J. Physiol. 263:L113-121, 1992

57. Chen, X-L., Tzanella, M., Baumgartner, M.K., McCormick, J.R. and Catravas, J.D. PMA-activated neutrophils decrease ectoenzyme activities in rabbit aortic endothelial cells in culture. Amer. J. Physiol. 263: L657-663, 1992.

58. Chen, X-L. and Catravas, J.D. PMA-activated neutrophils decrease pulmonary endothelial ectoenzyme activities in perfused rabbit lungs. Amer. J. Physiol.:Lung Cellular & Molecular Physiology. 263: L650-656, 1992.

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59. Marczin, N., Ryan, U.S. and Catravas, J.D. Methylene blue inhibits nitrovaso-dilator and EDRF-induced cGMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion. J. Pharm. Exp. Ther. 263: 170-179, 1992.

60. Marczin, N., Ryan,U.S. and Catravas, J.D. Sulfhydryl-depleting agents, but not deferoxamine, modulate EDRF action in cultured pulmonary arterial cells. Amer. J. Physiol. 265: L220-227, 1993.

61. Chen, X-L. and Catravas, J.D. Neutrophil-mediated endothelial angiotensin-converting enzyme dysfunction: role of oxygen-derived free radicals. Amer. J. Physiol. 265: L243-249, 1993.

62. Papapetropoulos, A., Burch S.E., Topouzis, S. and Catravas, J.D. Radiation-induced alterations in angiotensin converting enzyme activity in cultured bovine pulmonary arterial endothelial cells monolayers. Toxicol. Appl. Pharmacol. 120:96-105, 1993.

63. Marczin,N. Papapetropoulos, A., Jilling, T. and Catravas, J.D. Prevention of nitric oxide synthase induction in vascular smooth muscle cells by microtubule depolymerizing agents. Brit. J. Pharmacol. 109: 603-605, 1993.

64. Orfanos, S.E. and Catravas, J.D. Metabolic functions of the pulmonary endothelium. In Annual Cardiac Surgery 1993, ed. by M. Yacoub and J. Pepper, Current Science, London, 1993.

65. Marczin, N., Papapetropoulos, A. and Catravas, J.D. Tyrosine kinase inhibitors suppress endotoxin- and IL-1∃-induced NO synthesis in aortic smooth muscle cells. Amer. J. Physiol. 265: H1014-1018, 1993.

66. Marczin, N., Chen,X-L and Catravas, J.D. Response of endothelial cells to oxidant stress. In Vascular Endothelium: Physiological Basis of Clinical Problems II ed. by Catravas,J.D., Callow, A.D. and Ryan, U.S., Plenum Press, New York , pp.3-16, 1993.

67. Orfanos, S.E., Chen, X-L., Burch, S.E., Ryan, J.S. and Catravas, J.D. Assay of pulmonary endothelial angiotensin converting enzyme activity, in vivo:comparison of three methods. Tox. Appl. Pharm. 124:99-111, 1994.

68. Orfanos, S.E., Chen, X-L., Burch, S.E., Ryan, J.W. and Catravas, J.D. Radiation-induced early pulmonary endothelial ectoenzyme dysfunction in vivo:effect of indomethacin. Toxicol. Appl. Pharmacol. 124:112-122, 1994.

69. Papapetropoulos, A., Marczin, N., Snead, M.D., Cheng, C., Milici, A. and

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Catravas, J.D. Smooth muscle cell responsiveness to nitrovasodilators in hypertensive and normotensive rats. Hypertension 23:476-484, 1994.

70. Ehrhart, I.C., McCloud, L.L., Orfanos, S.E., Catravas, J.D. and Hofman, W.F. Effect of high blood flow on pulmonary vascular permeability to protein. J. Appl. Physiol. 76: 2342-2347, 1994.

71. Ryan, J.W., Valido, F.A., Sequeira, M.J., Chung, A.Y.K., Berryer, P., Chen, X-L. and Catravas, J.D. Estimations of rate constants for reactions of pulmonary microvascular angiotensin converting enzyme with an inhibitor and a substrate, in vivo. J. Pharmacol. Exp. Ther. 270: 260-268, 1994.

72. Papapetropoulos, A. and Catravas, J. Endothelial cell functions. In 8th European Congress of Internal Medicine. Monduzzi, Bologna, pp.349-354, 1995.

73. Douraki, T., Theodoropoulos, S., and Catravas, J.D. Measurement of enalaprilat-induced inhibitions of coronary endothelium-bound angiotensin converting enzyme in patients undergoing arterial bypass graft surgery. In 8th European Congress of Internal Medicine. Monduzzi, Bologna, pp. 527-531, 1995.

74. Ramamoorthy, D., Ramamoorthy, S., Papapetropoulos, A., Catravas, J.D., Leibach, F., and Ganapathy, V. Cyclic AMP - independent up-regulation of the human serotonin transporter by staurosporine in choriocarcinoma cells. J. Biol. Chem. 270:17189-17195, 1995.

75. Abou-Mohamed, G., Papapetropoulos, A., Ulrich, D., Catravas, J.D., Tuttle, R.R., and Caldwell, R. W., HP-228, A novel Synthetic Peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro. J. Pharm. and Exp. Therap. 275: 584-591, 1995.

76. Brandsch, M., Ramamoorthy, S., Marczin, N., Catravas, J.D., Leibach, J.W., Ganapathy, V., and Leibach, F.H., Regulation of taurine transport by Escherichia coli heat stable enterotoxin and guanylin in human intestinal cell lines. J. Clin. Invest., 96:361-369, 1995.

77. Pataki, G., Czopf, L., Jilling T., Marczin, N., Catravas, J., and Matalon, S., Regulation of fluid-phase endocytosis in alveolar macrophages. Amer. J. Physiol.: Lung Cell. and Mol. Physiol. 269(13): L-520-526, 1995.

78. Papapetropoulos, A., Marczin, N., Mora, G., Millici, A., Murad, F., and Catravas, J.D., Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA and protein levels by cAMP-elevating agents. Hypertension, 26(4):696-704, 1995.

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79. Snead, M.D., Papapetropoulos, A., Carrier, G.O., and Catravas, J.D. Isolation and culture of endothelial cells from the mesenteric vascular bed. Methods in Cell Science. 17:257-262, 1995.

80. Papapetropoulos, A., Go, C., Murad, F., and Catravas, J.D., Mechanisms of tolerance to sodium nitroprusside in cultured rat aortic smooth muscle cells. Br. J. Pharmacol.117:147-155, 1996.

81. Miyamoto, Y., Marczin, N., Catravas, J.D., and Del Monte, M.A. Cholera toxin induced enhancement of taurine uptake in the human retinal pigment epithelium. Curr. Eye. Res. 15:229-236, 1996.

82. Papapetropoulos, A., Cziraki, A., Rubin, J.W., Stone, C.D., and Catravas, J.D. cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue. J. Cell. Phys. 167: 213-221, 1996.

83. Papapetropoulos, A., Ryan, J.W., Antonov, A., Virmani, R., Kolodgie, F., Gerrity, R.G., and Catravas, J.D., Human aortic endothelial cell aminopeptidase N. Immuno. Pharm. 32:153-156, 1996.

84. Marczin, N., Jilling, T., Papapetropoulos, A., Go, C., and Catravas, J.D., Cytoskeleton-dependent activation of the inducible nitric oxide synthase in cultured aortic smooth muscle cells. Brit. J. Pharmacol. 118:1085-1094, 1996.

85. Ryan, J.W., Papapetropoulos, A., Ju, H., Denslow, N.D., Antonov, A., Virmani, R., Kolodgie, F.D., Gerrity, R.G., and Catravas, J.D., Aminopeptidase P is disposed on human aortic cells. Immuno. Pharm. 32:149-152, 1996.

86. Catravas, J.D., Cziraki, A., Chester, A., Maizza, A.F., Tajkaremi, S., Kaghani, A., and Yacoub, M. Early detection of lung endothelial dysfunction in man. In: Vascular Endothelium: Responses to Injury, Catravas, J.D., Callow, A., and Ryan, U. eds, pp. 11-21, Plenum Press, New York, 1996.

87. Papapetropoulos, A., Antonov, A., Virmani, R., Kolodgie, F., Munn, D.H., Marczin, N., Ryan, J.W., Gerrity, R.G., and Catravas, J.D., Monocyte-and cytokine-induced downregulation of angiotensin converting enzyme in cultured human and porcine endothelial. Circ. Res., 79(3):512-523, 1996.

88. Papapetropoulos, A., Elmore L., and Catravas, J.D., Relationship between volume of bathing mediums and ectoenzyme activity in monolayers of cultured bovine pulmonary artery endothelial cells. Am. J. Physiol. (Lung, Cell. Mol. Physiol.), 15:L464-L469, 1996.

89. Marczin, N., Antonov, A., Papapetropoulos, A., Munn, D.H., Virmani, R.,

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Kolodgie, F.D., Gerrity, R., and Catravas, J.D. Monocyte-induced downregulation of nitric oxide synthase in cultured aortic endothelial cells. Arterioscler Thromb Vasc Biol., 16:1095-1103, 1996.

90. Barman, S.A., McCloud, L.L., Catravas, J.D., and Ehrhart, I.C. Measurement of pulmonary blood flow by fractal analysis of flow heterogeneity in isolated canine lungs. J. Appl. Physiol., 81(5):2039-2045, 1996.

91. Papapetropoulos, A., Abou-Mohamed, G., Marczin, N., Murad, F., Caldwell, R.W., and Catravas, J.D., Downregulation of nitrovasodilator-induced cGMP accumulation in cells exposed to endotoxin of interleukin-1β. Brit. J. Pharmacol., 118:1359-1366, 1996.

92. Hoque, A.M., Marczin, N., Catravas, J.D., and Fuchs, L.C. Anesthesia with sodium pentobarbitol enhances lipopolysaccharide-induced cardiovascular dysfunction in rats. Shock, 6(5): 365-370, 1996.

93. Horvath, I.G., Tzoufi, E., and Catravas, J.D. Biochemical function of the lung: clearance of circulating, endogenous agents. In: Comprehensive Toxicology, I.G. Sipes, C.A. McQueen and A.J. Gandolfi, eds. Vol 8: Toxicology of the Respiratory System, R.A. Roth, Ed. Elsevier Sciences Inc., New York, pp. 153-158, 1997.

94. Catravas, J.D. and Orfanos, S. E. Pathophysiologic functions of endothelial angiotensin-converting enzyme. In: Vascular Endothelium: Physiology, Pathology, and Therapeutic Opportunities, C.V.R. Born and C.J. Schwartz, Eds. Schattaner, Stuttgart, pp. 193-204, 1997.

95. Walsh, D. A., Hu, D. E., Wharton, J., Catravas, J.D., Blake, D. R., and Fan, T. P. D. Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma. Br. J. Pharmacol., 120:1302-1311, 1997.

96. Orfanos, S.E., Ehrhart, I.C., Barman, S.A., Hofman, W.F., and Catravas, J.D. Endothelial ectoenzyme assays estimate perfused capillary surface area in the dog lung. Microvasc. Res., 54:145-155, 1997.

97. Cziraki, A., Parkerson, J., Fisher, E., and Catravas, J.D. Inhibition of pulmonary endothelial angiotensin converting enzyme activity by trandolaprilat, in vivo. Drug Dev. Res., 41:22 -30, 1997.

98. Abou-Mohamed, G., Papapetropoulos, A., Catravas, J.D., and Caldwell, R. W. Zn2+ inhibits nitric oxide formation in response to lipopolysaccharides: Implication in its anti-inflammatory activity. Eur. J. Pharmacol.341: 265-272, 1998.

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99. Wharton, J., Morgan, K., Rutherford, R. A. D., Catravas, J.D., Chester, A., Whitehead, B. F., De Leval, M. R., Yacoub, M. H., and Polak, J. M. Differential distribution of the angotensin AT2 reseptors in the normal and failing human heart. J. Pharmacol. Exp. Ther. 284:323-336, 1998.

100. Fisher, L. E., Cziraki, A., Steinhart, C.M., and Catravas, J. D. Unaltered Pulmonary Capillary Surface Area in the Presence of Changing Arterial Resistance. Amer. J. Physiol. 274: L264-L269, 1998.

101. Marczin, N., Go, C. Y., Papapetropoulos, A., and Catravas, J.D. Induction of nitric oxide synthase by protein synthesis inhibition in aoric smooth muscle cells. Brit. J. Pharmacol. 123:1000-1008, 1998.

102. Catravas, J.D., and Marczin, N. Control of iNOS expression in rat aortic smooth muscle cells. In: Vascular Endothelium: Pharmacologic and Genetic Manipulations, Catravas, J. D., Callow, A. D., and Ryan, U. S. Plenum Press, New York, pp. 33-46, 1998.

103. Papapetropoulos, A., Marczin, N., and Catravas, J.D. Cross-tolerance between endogenous nitric oxide and exogenous nitric oxide donors. Eur. J. Pharmacol. 344 (2-3): 313-321, 1998.

104. Chen, X. and Catravas, J.D. Release of a leukocyte activation inhibitor by staurosporine-treated pulmonary artery endothelial cells. Amer. J. Physiol. 275:L184-L192, 1998.

105. Zhang, H., Chen, X., Teng, X., Snead, C., and Catravas, J.D. Molecular cloning and analysis of the rat inducible nitric oxide synthase gene promoter in aortic smooth muscle cells. Biochem. Pharm. 55: 1873-1880, 1998.

106. Orfanos, S.E., Parkerson, J., Fisher, E. and Catravas, J.D. Estimation of the dissociation constants for pulmonary endothelial angiotensin converting enzyme reactions with trandolaprilat and enalaprilat in vivo. Drug Devel. Res. 44 (2-3): 80-86, 1998.

107. Horvath, I. G., Cziraki, A., Parkerson, J. B., Khan, S. U. and Catravas, J.D. Effect of acute coronary occlusion on the size of the dynamically perfused coronary capillary bed in the dog. Microvasc. Res. 56(2):95-103, 1998.

108. Ehrhart, I. C., Orfanos, S. E., McCloud, L. L., Sickles, D. W., Hofman, W. F., and Catravas, J.D. Vascular recruitment increases evidence of lung injury. Crit. Care Med., 1998.

109. Hoque, A. M., Papapetropoulos, A., Venema, R. C., Catravas, J.D., and Fuchs,

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Effects of antisense oligonucleotide to iNOS on hemodynamic and vascular changes induced by lipopolysaccaride. Amer. J. Physiol. 275:H1078-H1083, 1998.

110. Hafizi, S., Wharton, J., Morgan, K., Allen, S. P., Chester, A. H., Catravas, J.D., Polak, J. M., and Yacoub, M. H. Expression of functional angiotensin-converting enzyme and AT1 receptors in cultured human cardiac fibroblasts. Circulation. 2553-2559, 1998.

111. Borland, J. A., Chester, A. H., Crabbe, D. S. T., Parkerson, J. B., Catravas, J.D., and Yacoub, M. H. Differential action of angiotensin II and activity of ACE in human bypass grafts. J Thorac Cardiovasc Surg. 116(2):206-12, 1998

112. Catravas, J.D. Quality. Gen. Pharmac. 32(1): p.1, 1999.

113. Orfanos, S. E., Langleben, D., Khoury, J., Schlesinger, R. D., Dragatakis, L., Roussos, C., Ryan, J. W., and Catravas, J.D. Pulmonary capillary endothelium-bound angiotensin converting enzyme activity in humans. Circulation. 99:1593-1599, 1999.

114. Fulton, D., Papapetropoulos, A., Zhang, X., Catravas, J.D., Hintze, T.H. and Sessa, W.C. Quantification of eNOS mRNA in the cardiac vasculature by competitive PCR. Amer. J. Physiol. 278: H658-H665, 2000.

115. Orfanos, S.E., Parkerson, J.B., Chen, X., Fisher, L.E., Glynos, C. Papapetropoulos, A. and Catravas, J.D. Reduced lung endothelial angiotensin converting enzyme activity in Watanabe hyperlipidemic rabbits in vivo. Amer. J. Physiol. Lung Cell. 278: L1280-L1288, 2000.

116. Teng, X., Zhang, H., Snead, C., and Catravas, J. etc. A reverse NF-6B element in the rat type II nitric oxide synthase (iNOS) promoter mediates the induction by interleukin-1∃ and interferon-( in rat aortic smooth muscle cells. Gen. Pharmacol. 34:9-16, 2000.

117. Zhang, H., Teng, X., Snead, C., and Catravas, J. Non-NF-6B elements are required for full induction of the rat type II nitric oxide synthase in vascular smooth muscle cells. Brit. J Pharmacol. 130: 270-278, 2000.

118. Walsh, D. A., Catravas, J.D., and Wharton, J. Angiotensin converting enzyme in human synovium: Increased stromal [125I]351A binding in rheumatoid arthritis. Ann. Rheum.Dis. 59:125-131, 2000.

119. Orfanos, S., Armaganidis, A., Glynos, C., Psevdi, E., Kaltsas, P., Sarafidou, P., Catravas, J. etc. Pulmonary capillary endothelium-bound angiotensin converting

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enzyme activity in acute lung injury. Circulation. 102:2011-2018. 2000.

120. Ehrhart, I.C., Theodorakis, M.J. Caldwell, R.B. and Catravas, J.D. Effect of nitrite on endothelial function in isolated lung. Gen. Pharmacol. Vasc. Syst. 34: 401-408, 2000.

121. Dimitropoulou, C., White, R., Fuchs, L., Zhang, H., Catravas, J., and Carrier, G. Angiotensin II Relaxes Microvessels Via the AT2 Receptor and Ca2+-Activated K+ (BKCa) Channels. Hypertension. 37: 301-307, 2001.

122. Orfanos, S. E., Psevdi, E., Stratigis, N., Langleben, D., Catravas, J.D., Kyriakidis, M., Moutsopoulos, H.M., Roussos, C. and Vlachogiannopoulos, P.G. Pulmonary Capillary Endothelial Dysfunction in Early Systemic Scleroderma. Arthr Rheum 44: 902-911, 2001.

123. Zhang H., Snead C., and Catravas, J. Nitric oxide differentially regulates induction of type II nitric oxide synthase in rat vascular smooth muscle cells vs. Macrophages. Arter. Thromb. Vasc. Biol. 21:529-535, 2001.

124. Orfanos, S., Zou, L., and Catravas, J. Pharmacodynamics, tissue-specificity of ACE inhibitors. In: Milestones in Drug Therapy. ed. by D’Orléans-Juste, P., Plante, G.E., Birkhäuser, Basel 2001. pp. 163-170, 2001

125. Beswick, R., Zhang, H., Marable, D., Catravas, J.D., Hill, W.D. and Webb, R.C. Long term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response. Hypertension. 37:781-786, 2001.

126. Cziraki, A., Horvath, I., Rubin, J.W., Theodorakis, M. and Catravas, J.D. Quantification of pulmonary capillary endothelium-bound angiotensin converting enzyme inhibition in man. Gen Pharmacol. 35: 213-218, 2002.

127. Papapetropoulos, A., Andriopoulos, S., Go, C.Y., Hoque, A., Fuchs, L.C. and Catravas, J.D. Regulation of Nitric Oxide Synthase – Nitric Oxide – cGMP pathway in rat mesenteric endothelial cells. J. Appl. Physiol. 91: 2553-2560, 2001.

128. Teng, X., Zhang, H., Snead, C., and Catravas, J. Molecular mechanisms of iNOS induction by IL-1β and interferon-γ in rat aortic smooth muscle cells. Amer. J. Physiol. 282: C144-C152, 2002.

129. Teng, X., Li, D., Catravas, J.D. and Johns, R.A. C/EBP-β mediates iNOS induction by hypoxia in rat pulmonary microvascular smooth muscle cells. Circ. Res. 09: 125-127, 2002.

130. White, R.E, Han, G., Maunz, M., Dimitropoulou, C., El-Mowafy, A., Barlow, R.S.,

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Catravas, J.D., Snead, C., Carrier, G.O., Zhu, S. and Yu, X. Endothelium-independent effect of estrogen on Ca2+-activated K+ channels in human coronary artery smooth muscle cells. Cardiovasc Res. 53:650-661, 2002.

131. Abou-Mohamed, G., A. El-Marakby, J.D. Catravas, G.O. Carrier, R.W., Caldwell, and R.E. White. Estradiol relaxes rat aorta via endothelium-dependent and –independent mechanisms. Pharmacology 69(1):20-6, 2003.

132. Venema, R.C., Venema, V.J., Ju, H., Harris, M.B., Snead, C., Dimitropoulou, C., Catravas, J.D. Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthases enhance cyclase activity. Amer. J.Physiol..Heart 285: H669-H678, 2003.

133. McCloud LL, Parkerson JB, Freant L, Hoffman WH, Catravas JD. beta-hydroxybutyrate induces acute pulmonary endothelial dysfunction in rabbits. Exp Lung Res. 30(3):193-206, 2004.

134. Wheeler DS, Catravas JD, Odoms K, Denenberg AG, Malhotra V, Wong HR. Epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, inhibits IL-1-dependent proinflammatory signal transduction in cultured respiratory epithelial cells. J Nutr. 134(5):1039-44, 2004.

135. Jules-Elysee, K., Blanck, T.J.J., Catravas, J.D., Chimento, G., Miric, A., Kahn, R., Paroli, L., Sculco, T. Angiotensin converting enzyme activity: a novel way of assessing pulmonary changes during total knee arthroplasty. Anesth. Analg. 99: 1018-1023, 2004.

136. McCloud, L.L., Parkerson, J.B., Zhou, L., Rao, R.N. and Catravas, J.D. Reduced pulmonary endothelium-bound angiotensin converting enzyme activity In diabetic rabbits. Vasc. Pharmacol. 41:159-165, 2004.

137. Myers GL, Rifai N, Tracy RP, Roberts WL, Alexander RW, Biasucci LM, Catravas JD, Cole TG, Cooper GR, Khan BV, Kimberly MM, Stein EA, Taubert KA, Warnick GR, Waymack PP. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the laboratory science discussion group. Circulation 110(25):e545-9, 2004.

138. McCloud, L. Hoffman, W. and Catravas, J.D. Pulmonary endothelium-bound angiotensin converting enzyme in diabetes and diabetic ketoacidosis. In: Cellular Dysfunction in Atherosclerosis and Diabetes. Ed. by M. Simionescu, A. Sima and D. Popov ; Romanian Academy Publishing House, Buccarest, 2005. Pages: 175-188.

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139. Dimitropoulou, C., White, R. E., Ownby, D. R., and Catravas, J. D. Estrogen reduces carbachol-induced constriction of airway smooth muscle by stimulating BKCa channels. Am J Lung Cell Mol Biol. 32(3):239-47, 2005.

140. Wheeler DS, Fisher LE, Jr, Catravas JD, Jacobs BR, Carcillo JA, Wong HR. Serum HSP 70 levels in children with septic shock. Pediatr Crit Care Med. 6(3):308-11, 2005.

141. Tawfik A, Jin L, Banes-Berceli AK, Caldwell RB, Ogbi S, Shirley A, Barber D, Catravas JD, Stern DM, Fulton D, Caldwell RW, Marrero MB. Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2. Vascul Pharmacol. 43(5):320-6, 2005.

142. Papapetropoulos, A., Zhou, Z., Gerassimou, C., Venema, R.C., Roussos, C., Sessa, W.C. and Catravas, J.D. Interaction between hsp90 and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding. Mol Pharmacol. 68(4):1133-41, 2005.

143. Catravas JD. Vascular endothelium: Translating discoveries into public health practice-Part I. Vascul Pharmacol. 45(5):251-2, 2006.

144. Dimitropoulou C, Chatterjee A, McCloud L, Yetik-Anacak G, Catravas JD. Angiotensin, bradykinin and the endothelium. Handb Exp Pharmacol.176:255-94, 2006.

145. Zhang Q, Church JE, Jagnandan D, Catravas JD, Sessa WC, Fulton D. Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arterioscler Thromb Vasc Biol. 26:1015-21, 2006.

146. Yetik-Anacak G, Xia T, Dimitropoulou C, Venema RC, Catravas JD. Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxation. Am J Physiol Heart Circ Physiol. 291:H260-8, 2006.

147. Yetik-Anacak G, Catravas JD. Nitric oxide and the endothelium: history and impact on cardiovascular disease. Vascul Pharmacol. 45:268-76, 2006.

148. Antonova G, Snead C, Antonov A, Dimitropoulou C, Venema RC, Catravas JD. Nitric Oxide Preconditioning Regulates Endothelial Monolayer Integrity Via The Heat Shock Protein 90 - Soluble Guanylate Cyclase Pathway. Am J Physiol Heart Circ Physiol. 292: H893-903, 2007.

149. Hooper WC, Catravas JD, Heistad DD, Sessa WC, Mensah GA. Vascular

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endothelium summary statement I: Health promotion and chronic disease prevention. Vascul Pharmacol. 46: 268-76, 2007.

150. Mensah, G.A., Catravas, J.D., Engelgau, M.M., Hooper, W.G., Maddedu, P., Ryan, U.S., She, J-X., Reed, E., Vinicor, F. and Yacoub, M.H. Vascular endothelium summary statement VI: Research directions for the 21st century. Vasc. Pharm. 46: 330-332, 2007.

151. Wheeler DS, Lahni PM, Hake PW, Denenberg AG, Wong HR, Snead C, Catravas JD, Zingarelli B. The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and syrvival in rodent models of polymicrobial sepsis. Shock. 28:353-359, 2007.

152. Antonova G, Lichtenbeld H, Xia T, Chatterjee A, Dimitropoulou C and Catravas, J.D Functional significance of hsp90 complexes with NOS and sGC in endothelial cells. Clin Hemorheol Microcirc. 37:19-35, 2007.

153. Chatterjee A, Dimitropoulou C, Drakopanayiotakis F, Antonova G, Snead C, Venema RC, Cannon JG and Catravas JD Hsp90 inhibitors prolong survival and reduce inflammation in sepsis-induced acute lung injury. Am J Respir Crit Care Med 176:667-75, 2007.

154. Dimitropoulou C, Drakopanagiotakis F, Catravas JD. Estrogen as a new therapeutic target for asthma and chronic obstructive pulmonary disease. Drug News Perspect. 20: 241-52, 2007.

155. Xia T, Dimitropoulou C, Zeng J, Antonova GN, Snead C, Venema RC, Fulton DJ, Qian S, Patterson C, Papapetropoulos A, Catravas JD. The chaperone-dependent E3 ligase, chip, ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase. Am J Physiol Heart Circ Physiol. 293(5):H3080-7, 2007.

156. Antonov, A., Snead, C., Gorshkov, B., Verin, A.D. and Catravas, J.D. Heat shock protein 90 inhibitors protect and restore pulmonary endothelial barrier function. Am J Resp Cell Mol Biol 39: 551-59, 2008.

157. Chatterjee, A., Snead, C., Yetik, G., Antononva, G., Zeng, J. and Catravas, J.D. Heat shock protein 90 inhibitors attenuate LPS-induced endothelial hyperpermeability. Amer J Physiol Lung Cell Mol Physiol. 294(4):L755-63, 2008.

158. Orfanos SE, Hirsch AM, Giovinazzo M, Armaganidis A, Catravas JD, Langleben D. Pulmonary capillary endothelial metabolic function in chronic thromboembolic pulmonary hypertension. J Thromb Haemost. 6:1275-80, 2008.

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159. Langleben D, Orfanos SE, Giovinazzo M, Hirsch A, Baron M, Senécal JL, Armaganidis A, Catravas JD. Pulmonary capillary endothelial metabolic dysfunction: severity in pulmonary arterial hypertension related to connective tissue disease versus idiopathic pulmonary arterial hypertension. Arthritis Rheum.58(4):1156-64, 2008.

160. Maniatis NA, Kotanidou A, Catravas JD, Orfanos SE. Endothelial pathomechanisms in acute lung injury. Vascul Pharmacol. 49:119-33, 2008.

161. Chatterjee A, Black, S.M. and Catravas JD. Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul Pharmacol. 49:134-40, 2008.

162. Dimitropoulou C, Drakopanagiotakis F, Chatterjee A, Snead C, Catravas JD. Estrogen Replacement Therapy Prevents Airway Dysfunction in a Murine Model of Allergen-Induced Asthma. Lung. 187(2):116-27, 2009.

163. Lucas, R., Verin, A.D., Black, S.M., Catravas, J.D. Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem. Pharmacol. 77(12):1763-72, 2009.

164. Tian, J., Smith, A., Nechtman, J., Podolsky, R., Aggarwal, S., Snead, C., Kumar, S., Elgaish, M., Oishi, P.E., Goerlach, A., Fratz, S., Hess, J., Catravas, J.D., Verin, A.D., Fineman, J.R., She, J-X. and Black, S.M. Effect of PPARγ Inhibition on Pulmonary Endothelial Cell Gene Expression: Gene Profiling In Pulmonary Hypertension. Physiological Genomics (in press)

165. Catravas, J.D., Snead, C., Dimitropoulou, C., Chang, A.C., Lucas, R., Verin, A.D. and Black, S.M. Harvesting, identification and barrier function of human lung microvascular endothelial cells. Vascul. Pharmacol. (in press).

166. Cziraki, A., Horvath, I.G., Theodorakis, M., Rubin, J.W. and Catravas, J.D. Coronary endothelium-bound angiotensin converting enzyme activity in patients undergoing coronary arterial bypass grafting. J. Thor. Cardiov. Surg. (submitted).

167. Cziraki, A., Horvath, I., Theodorakis, M., Davis, W.B., Shapiro, M.B. and Catravas, J.D. Sequential estimations of pulmonary capillary endothelium-bound angiotensin converting enzyme activity in acute lung injury, in man. Crit. Care Med. (submitted).

BOOKS 1. Vascular Endothelium: Receptors and Transduction Mechanisms ed. by

Catravas, J.D., Gillis, C.N and Ryan, U.S. Plenum Press, New York, 1989.

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2. Vascular Endothelium: Physiological Basis of Clinical Problems ed. by Catravas,

J.D., Callow, A.D., Gillis, C.N. and Ryan U.S. Plenum Press, New York, 1991. 3. Vascular Endothelium: Physiological Basis of Clinical Problems II ed. by

Catravas, J.D., Callow, A.D. and Ryan U.S. Plenum Press, New York, 1993. 4. Vascular Endothelium: Responses to Injury ed. by Catravas, J.D., Callow, A.D.

and Ryan U.S. Plenum Press, New York, 1996.

5. Vascular Endothelium: Pharmacologic and Genetic Manipulations ed. by Catravas, J.D., Callow, A. D., and Ryan, U. S. Plenum Press, New York, 1998.

6. Vascular Endothelium: Mechanisms of Cell Signaling ed. By Catravas, J.D.,

Callow, A.D. and Ryan, U.S. IOS Press, Amsterdam, 1999. 7. Vascular Endothelium: Source and Target of Inflammatory Mediators ed. by

Catravas, J. D., Callow, A.D., Ryan, U.S., and Simionescu, M. IOS Press, Amsterdam, 2001.