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NEPHROPATHY IN DIABETES
MELLITUS
PROJECT WORK
Dissertation submitted to
ANNAMALAI UNIVERSITY
In partial fulfillment of the requirement for the award of
Master of Science in Biochemistry
By
-----Reg.No.
PG & ResearchDepartment of Biochemistry
ANNAMALAI UNIVERSITYANNAMALAI NAGAR-608 002
APRIL 2012
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ANNAMALAI UNIVERSITY
PG & RESEARCH DEPARTMENT OF BIOCHEMISTRY
Reg.No.
PROJECT WORK
Certificated that this is the bonafied record of the project work done
by Miss.---------- of II M.Sc., at the PG & Research Department of
Biochemistry, K.M.G. College of Arts and Science. R.S.Road Gudiyatham.
During 2011-2012
Head of the Department Signature of the Guide
Submitted for M.Sc., degree project work evolution held on ... at
the PG & Research Department of Biochemistry. Annamalai University
Annamalai Nagar-608 002.
Examiners
1.
Date: 2.
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DECLARATION
I here by declare that the dissertation entitled NEPHROPATHY IN
DIABETES MELLITUS submitted for the degree of MASTER OF
SCIENCE IN BIOCHEMISTRY is my original work and dissertation has not
formed the basic for the award of any Degree/ Diploma/
Associateship/Fellowship of similar other titles. It has not been submitted to
any other University or Institution for the award of Degree or Diploma.
Signature of the Guide Signature of the candidate
ABBREVIATIONS
ACE - Angiotensin Converting Enzyme LIST OF CONTENTS
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CHAPTER
NO.TITLE PAGE NO.
1. INTRODUCTION 12. REVIEW OF LITERATURE 8
3. DIABETIC NEPHROPATHY 9
4. AIM & OBJECTIVES 22
5. MATERIALS AND METHODS 23
6. RESULTS 39
7. DISCUSSION 50
8. SUMMARY 53
9. CONCLUSION 55
10. BIBLIOGRAPHY 56
LIST OF TABLES
TABLE
NO.
TITLE PAGE NO.
1. AGE DISTRIBUTION 39
2. SEX 41
3. FAMILY HISTORY 42
4. DURATION 43
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5. PERSONAL HABITS 44
6. BLOOD PRESSURE 45
7. BLOOD GLUCOSE LEVEL 46
8. LIPID PROFILE 47
9. MICROALBUMINURIA 4810. CREATININE & ALBUMIN
CREATITINE RATIO
49
ACEI - Angiotensin Converting Enzyme Inhibitor
ACR - Albumin Creatinine Ratio
ARBs - Angiotensin Receptor Blocker
ESRD - End Stage Renal Disease
HDL - High Density Lipoprotein
LDL - Low Density Lipoprotein
T.CHOL - Total Cholesterol
TGL - Triglycerides
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VLDL - Very low Density Lipoprotein
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ACKNOWLEDGEMENT
I express My Sincere thanks to the Chairman KALVITHANTHAI
Thiru.K.M.GOVINDARAJAN, Vice Chairman Thiru.
K.M.G.BALASUBRAMANIAN, Secretary Thiru. K.M.G.RAJENDIRAN,
B.Sc,. M.L., K.M.G.MUTHUKUMAR B.Com., Joint managing Trustee.
I extend my gratitude to our Principal Dr. D.GAJAPATHY, Ph.D.,
D.H.Ed., K.M.G. College of Arts and Science, R.S Road, Gudiyattam,
Vellore District, Who helped us by providing a good infrastructure for
completing my original work.
I feel immensely grateful to express my gratitude to my respected Guide
Mr.G.RAGHUVARMAN. M.Sc., M.Phil., P.G.D.M.L.T., Department of
Bio-chemistry, K.M.G. College of Arts and Science, Gudiyattam, for his
kindly help during the course of the project work.
I express my sincere thanks to Dr.R.BABUJANARTHANAM, M.Sc.,
M.Phil., Ph.D.,Head of the Department of Biochemistry K.M.G COLLEGE
OF Arts and Science, Gudiyattam, for his kindly help during the project work.
I express my thanks to All My Staff Members of Department of
Biochemistry.
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It is my pleasure to convey my whole hearty gratitude to my parents
Mr.S.JAYAKUMAR, Mrs.J.SARASWATHY, my brother Mr.J.VIGNESH
B.E., my Uncle K.SAMPATH., my sisterJ.VANITHA,M.Sc., and my whole
family who had made invaluable sacrifice encouraged and blessed me to
succeed in my efforts.
I acknowledged with great pleasure co-operation by my friends
Ms.S.SARANYA, M.Sc,. D.M.L.T., M.MADHUMATHY,B.Sc Nursing.,
throughout my project work.
Here I would bring into the notice of the help provided by
Mr.GOPI, B.Sc., Mr.BALUPRAKASH, I.T.I.,and A.KUMARESH. B.Sc.,
B-Tech., EXCEL BROWSE POINT, for their timely help during my project
work.
I finally thank LORD ALMIGHTY for showing his blessing on me
and for guiding me in all endeavours.
J.VIDHYA
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