From left to right: Francois Jacob (1920- ), Jacques Monod (1910-1976) and André Lwoff (1902-1994), awarded the Nobel Prize for Physiology or Medicine in 1965. Jacques Monod was director of the Pasteur Institute in Paris from 1971 to 1976.

Element purpose

Operator (LacO) binding site for repressor

Promoter (LacP) binding site for RNA polymerase

Repressor (LacI)gene encoding lac repressor protein

Binds to DNA at operator and blocks binding of RNA polymerase at promoter

Pi promoter for LacI

CAP binding site for cAMP/CAP complex

http://vcell.ndsu.nodak.edu/animations/lacOperon/movie.htm

 OperonLeaderLength

 Sequence

trp  14 MKAIFVLKGWWRTS

pheA  16 MKHIPFFFAFFFTFP

 his  16 MTRVQFKHHHHHHHPD

thr  21MKRISTTITTTITITTQNGAG

leu  28MSHIVRFTGLLLLNAFIVRGRPVGGIQH

ilv  32MTALLRVISLVVISVVVIIIPPCGAALGRGKA

http://employees.csbsju.edu/hjakubowski/classes/ch331/bcintro/list_of_figures.htm