from cancer detection to treatment: prof. dr. niels kuster ... · from cancer detection to...
TRANSCRIPT
From Cancer Detection to Treatment:
MagnetoTheranostics
MagnetoTheranostics RTD 2013
M. Mionic1, B. von Rechenberg2, H. Thöny3, M. Stuber4, O. Jordan5, N. Kuster6, H. Hofmann1
1 EPFL, 2 University of Zurich, 3 Inselspital, 4 CHUV, 5 University of Geneva, 6 It’IS
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Existing and New Particle composition
Functionalisation of Particle withAntibodies
CharacterisationTox screening
In vitro testsSpecific adsorption
Metastasis
Nanocompositeformulation
In vitro tests Heatingcapacity
In vivo tests tumor
treatment
In vivo tests metastasisdetection
In vivo testsTheragnosis
Improvementof mag
Generator
DevelopmentTemp.
Simulation tool
Engineering ; ITIS, ANTIA
Physics, chemistry Materialscience; EPFL, UNI GE, CHUV
In-vitro, Toxicity, imagingEPFL, ITIS, UNI GE, CHUV
Medical applicationCABMM, Inselspital
Toxi
city
Test
s
Project layout
Mo
lec
ula
r Im
ag
ing
(MR
I)
Hy
pe
rth
erm
ia
Dr. E. Neufeld
Dr. M. H. Capstick
Prof. Dr. Niels Kuster Dr. Olivier Jordan
Prof. Dr. Matthias Stuber
Prof. Dr. HeinrichHofmann
Prof. Dr. med. Harriet Thoeny
Prof. Dr. med. vet.Brigitte von Rechenberg
Prof. Dr. Daniel A. Rüfenacht
Team and competences
Engineering Physics, Material science;
In-vitro, Toxicity, Imaging Medical applications
therapeutics + diagnostics => Theranostics
AIM: Early detection (by MRI) and treatment (by hyperthermia) of lymph node metastases of prostata cancer