• Mosquito-Borne Viruses: Biology and Host Interactions• ZIKA Virus Countermeasures• Ebola Virus: Biology and Host Interactions• Ebola Virus: Vaccines and Therapeutics• Zoonotic Influenza and MERS• MERS

a 501(c)(3) nonprofit educational organization

Keystone Symposia in Hong Kong

Framin g the Response to Emerging Virus Infections The University of Hong Kong | Pok Fu Lam, Hong Kong | October 14–18, 2018 Lee Shau Kee Lecture Centre, Centennial Campus Organized in collaboration with the Croucher Foundation and The University of Hong Kong

Scientific Organizers: Ralph A. Tripp, University of Georgia, USA Suresh Mahalingam, Griffith University, Australia John W. Lowenthal, Deakin University, AustraliaAndrew G. Bean, Commonwealth Scientific and Industrial Research Organization, AustraliaMalik Peiris, The University of Hong Kong, Hong Kong

Emerging and re-emerging viruses have the potential to cause high morbidity and mortality and range from localized outbreaks to epidemics. Due to their emerging nature, most aspects of the biology and infectious potential of these viruses are poorly understood. Our continuing struggle to respond to a procession of pandemics, including SARS, avian influenza, MERS, Ebola and more recently Zika, highlights key gaps in our knowledge and should serve to motivate our re-thinking as to how we can better prepare and deal with future unknown viral threats. This conference will focus on important areas such as surveillance, diagnostics and countermeasures and other important advances in new technologies and how they are being applied to research. Furthermore, we will discuss how to facilitate the translation of research, data and candidate treatments through the development pipeline in a timely and cost-effective manner. The key themes to be covered include the need to understand why zoonotic diseases matter, their association with agriculture, the importance of surveillance and early detection, and the difficulties of dealing with diseases that involve both medical and veterinary communities. The conference will bring together experts in virology, immunology, vaccinology and epidemiology with those who seek to transfer knowledge between these groups, veterinarians and industry and government. Further, this meeting is designed to bring together individuals involved in the control of these diseases in government and non-government organizations, as well as those involved in study of zoonosis and countermeasures. The creation of global networks and sharing of information will ensure that we are better prepared for future outbreaks.

Plenary Session Topics: • Emerging Disease Detection and Surveillance• Influenza: Immunity and Vaccines• Vaccine and Therapeutic Strategies• Outbreak Preparedness

and Responses

Visit www.keystonesymposia.org/18S2 for more details.

SUNDAY, OCTOBER 14Arrival and Registration

MONDAY, OCTOBER 15Welcome and Keynote Address *Malik Peiris, University of Hong Kong, Hong KongGabriel M. Leung, University of Hong Kong, Hong KongOpening RemarksPeter Daszak, EcoHealth Alliance, USAEmerging Infectious Disease Threats

Mosquito-Borne Viruses - Biology and Host Interactions *Lisa E. Gralinski, University of North Carolina, USAScott C. Weaver, University of Texas Medical Branch, USAUrban Arboviruses: History, Evolution and Mechanisms of EmergenceSuresh Mahalingam, Griffith University, AustraliaAlphavirus Inflammatory Disease Mechanisms and Approaches toTherapyMichael S. Diamond, Washington University School of Medicine, USAHost Factors Required for Alphavirus Infection: The Identification ofMxra8 as an Entry ReceptorAli Zaid, Griffith University Gold Coast, AustraliaShort Talk: Specific Inhibition of NLRP3 in Chikungunya DiseaseReveals a Role for Inflammasome in Alphavirus-Induced InflammationKar Muthumani, Wistar Institute, USAShort Talk: Synthetic Nucleic Acid Antibody Prophylaxis + DNAVaccine Confers Rapid and Durable Protective Immunity against ZikaVirus

Poster Session 1 ZIKA Virus Countermeasures *Suresh Mahalingam, Griffith University, AustraliaRaman Rao, Takeda Pharmaceutical Company, SingaporeZika Vaccine Development Strategies for Emergency PreparednessMauro Martins Teixeira, Universidade Federal de Minas Gerais, BrazilThe Role of Glutamate Receptors in the Pathogenesis of ZikaNatalie A. Prow, University of South Australia, AustraliaA New Replication-Defective, Vaccinia-Derived, CHO-ManufacturedVaccine Vector System (SCV) Is Effective in Preclinical Studiesagainst Zika and Chikungunya VirusesMingyuan Li, University of Hong Kong, Hong KongShort Talk: Activated ADP-Ribosylation Factor 4 (ARF4) Is Requiredfor ZIKA Virus (ZIKV) Infectious Cycle

TUESDAY, OCTOBER 16Ebola Virus: Biology and Host Interactions *Erica Ollmann Saphire, La Jolla Institute for Immunology, USAYoshihiro Kawaoka, University of Wisconsin / University of Tokyo,USAHuman Ebola Virus Disease Pathogenesis Revealed by Multi-Platform‘Omics Analysis

Andrea Marzi, NIAID, National Institutes of Health, USAAnimal Models of EbolavirusesAdam Joseph Hume, Boston University, USAShort Talk: The Use of Minigenome Systems as Tools to “Fill in theBlanks” for Uncultured Emerging Viruses and Facilitate Virus Rescue:A Lloviu Virus Case StudyBeatriz Escudero Pérez, Bernhard Nocht Institute for TropicalMedicine, GermanyShort Talk: Comparative Pathogenesis of Ebola and Reston Virus inHumanized Mice

Ebola Virus: Vaccines and Therapeutics *Andrea Marzi, NIAID, National Institutes of Health, USAErica Ollmann Saphire, La Jolla Institute for Immunology, USAStructural Studies to Guide the Development of Broadly ReactiveAntibodies Against Ebolaviruses and Lassa Virus John Misasi, NIAID, National Institutes of Health, USAShort Talk: ChAd3-Based Ebola Vaccination Induces ProtectiveAntibody ClassesSarah Elliott, Wistar Institute, USAShort Talk: A Synthetic Micro-Consensus DNA Vaccine InducesPotent Immune Responses Against Diverse Strains of MarburgvirusDanielle P. Porter, Gilead Sciences, USAShort Talk: Broad Spectrum Antiviral Remdesivir for the Treatment ofEmerging Viral Infections with High Outbreak Potential

Poster Session 2 Zoonotic Influenza and MERS *Andrew G. Bean, Commonwealth Scientific and Industrial ResearchOrganization, AustraliaYi Guan, University of Hong Kong, Hong KongZoonotic Influenza Viruses from China: An Increasing PandemicThreat? Bart L. Haagmans, Erasmus MC, NetherlandsMERS-Coronavirus: From Discovery to InterventionMalik Peiris, University of Hong Kong, Hong KongMERS-Coronaviruses in Africa - Is There a Zoonotic Threat?LaiGiea Nicole Seng, University of Hong Kong, Hong KongShort Talk: Virulence Determinants of Novel Influenza A (H7N9) Virusin MammalsSabiha Jahan Akhee, University of Hong Kong, Hong KongShort Talk: Deubiquitylase OTUB1 Plays Critical Role in Influenza AVirus Infection and Immune Response

WEDNESDAY, OCTOBER 17MERS *John W. Lowenthal, Deakin University, AustraliaKY Yuen, University of Hong Kong, Hong KongHost Cellular Protein Facilitating Viral ReplicationRalph S. Baric, University of North Carolina at Chapel Hill, USARapid Response Strategies to Control Emerging Coronavirus Infections

* Session Chair † Invited but not yet accepted Program current as of May 14, 2022. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Framing the Response to Emerging Virus Infections (S2)October 14-18, 2018 • Lee Shau Kee Lecture Centre, Centennial Campus University of Hong Kong • Pok Fu Lam, Hong

Kong Scientific Organizers: Ralph A. Tripp, Suresh Mahalingam, John W. Lowenthal, Andrew G. Bean and Malik Peiris

Organized in collaboration with the Croucher Foundation and The University of Hong KongTravel Award Deadline: June 27, 2018 / Discounted Abstract & Scholarship Deadline: June 27, 2018 / Abstract Deadline: July 17, 2018 / Discounted Registration Deadline: August 14, 2018

Dong-Yan Jin, University of Hong Kong, Hong KongShort Talk: Suppression of Type I Interferon Production by MiddleEast Respiratory Syndrome Coronavirus ORF8b Accessory Proteinthrough Interaction with HSP70 ChaperoneLisa E. Gralinski, University of North Carolina, USAShort Talk: Using a Reduced Complexity Cross to Identify HostSusceptibility Factors to SARS-CoV Infection*Bart L. Haagmans, Erasmus MC, NetherlandsJohn W. Lowenthal, Deakin University, AustraliaA Strategy for Developing a MERS Camel Vaccine in Order to ProtectHumansJincun Zhao, Guangzhou Institute of Respiratory Disease, ChinaImmune Responses in MERS-CoV Infected Mice and HumansStalin Raj Victor, Indian Institute of Science Education andResearch, IndiaShort Talk: Chimeric Camel-Human Heavy Chain Antibodies ProtectMice from MERS-CoV Infection Neeltje van Doremalen, NIAID, National Institutes of Health, USAShort Talk: The Omics of Sex-Specific MERS-CoV Severity in aTransgenic Mouse Model

Emerging Disease Detection and Surveillance Marion P.G. Koopmans, Erasmus MC, NetherlandsChallenges and Opportunities in Emerging Disease DetectionGavin J.D. Smith, Duke-NUS Medical School, SingaporeSurveillance for Risk Assessment and PredictionLinfa Wang, Duke-NUS Medical School, SingaporeFrom SARS to SADS: EIDs Caused by Bat CoronavirusesAnna Uehara, Duke-NUS Medical School, SingaporeShort Talk: Serologic Evidence of Bat Orthoreovirus in SingaporeKenrie Pui Yan Hui, University of Hong Kong, Hong KongShort Talk: Tropism and Pathogenesis of the Avian Influenza A/H7N9Virus in ex vivo and in vitro Cultures of the Human Respiratory Tractand Human Airway Organoids

Poster Session 3

THURSDAY, OCTOBER 18Influenza: Immunity and Vaccines *Ralph A. Tripp, University of Georgia, USALeo Poon, University of Hong Kong, Hong KongUniversal Influenza VaccinesAndrew G. Bean, Commonwealth Scientific and Industrial ResearchOrganization, AustraliaTailoring the Avian Host Immune Response for Enhanced VaccineProductionSophie A. Valkenburg, University of Hong Kong, Hong KongShort Talk: ADCC Antibodies Are a Protective Immune Correlate in aHousehold Model of Influenza Transmission Matloob Husain, University of Otago, New ZealandShort Talk: The Identification of Human Histone Deacetylases, HDAC1and HDAC2 as Novel Anti-Influenza Viral Factors*Linfa Wang, Duke-NUS Medical School, Singapore

Ted M. Ross, University of Georgia, USABroadly Protective Influenza Vaccines: Protection Against MismatchedStrainsLi-meng Yan, University of Hong Kong, Hong KongShort Talk: Combined Use of Live-Attenuated and InactivatedInfluenza Vaccines to Enhance Heterosubtypic ProtectionTimothy Uyeki, Centers for Disease Control and Prevention, USAShort Talk: Clinical Research Is a Major Gap in the Response toEmerging Respiratory Viral Infections

Vaccine and Therapeutic Strategies *Marion P.G. Koopmans, Erasmus MC, NetherlandsStephen Whitehead, NIAID, National Institutes of Health, USAEvaluation of Live Attenuated Vaccines for Dengue and Zika Viruses(and their Challenge Models)Ralph A. Tripp, University of Georgia, USANovel Strategies to Improve Vaccine YieldAdam Taylor, Griffith University, AustraliaShort Talk: Novel Delivery of a Live-Attenuated Chikungunya VirusVaccine Candidate James Duehr, Icahn School of Medicine, USAShort Talk: Characterization of Humoral Immunity Generated againstAndes Virus GnGcDanielle E. Anderson, Duke-NUS Medical School, SingaporeShort Talk: SEC61B Is a Cellular Host Factor Required for MumpsVirus Replication in Humans and BatsLaura Riva, Sanford Burnham Prebys Medical Discovery Institute,USAShort Talk: Identification of Chemical Compounds Inhibiting EbolaVirus Replication

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

FRIDAY, OCTOBER 19Departure

* Session Chair † Invited but not yet accepted Program current as of May 14, 2022. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Framing the Response to Emerging Virus Infections (S2)October 14-18, 2018 • Lee Shau Kee Lecture Centre, Centennial Campus University of Hong Kong • Pok Fu Lam, Hong

Kong Scientific Organizers: Ralph A. Tripp, Suresh Mahalingam, John W. Lowenthal, Andrew G. Bean and Malik Peiris

Organized in collaboration with the Croucher Foundation and The University of Hong KongTravel Award Deadline: June 27, 2018 / Discounted Abstract & Scholarship Deadline: June 27, 2018 / Abstract Deadline: July 17, 2018 / Discounted Registration Deadline: August 14, 2018